• Tuberculosis and Respiratory Diseases
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• 제82권1호
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• pp.35-41
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• 2019

Background: Pulmonary tuberculosis can result in anatomical sequelae, and cause airflow limitation. However, there are no treatment guidelines for patients with a tuberculosis-destroyed lung. Recently, indacaterol effectiveness in chronic obstructive pulmonary disease (COPD) patients with Tuberculosis history (INFINITY) study revealed indacaterol provided bronchodilation and symptom improvement in COPD patients with a tuberculosis-destroyed lung. Methods: We conducted a post-hoc subgroup analysis of the randomized controlled trial, the INFINITY study, to determine factors associated with indacaterol response in a tuberculosis-destroyed lung with airflow limitation. Data from 68 patients treated with inhaled indacaterol, were extracted and analyzed. Factors associated with the response of forced expiratory volume in one second ($FEV_1$) to indacaterol treatment, were determined using linear regression analysis. Results: Of 62 patients included, 68% were male, and 52% had history of cigarette smoking. Patients revealed mean $FEV_1$ of 50.5% of predicted value with mean improvement of 81.3 mL in $FEV_1$ after indacaterol treatment for 8 weeks. Linear regression analysis revealed factors associated with response of $FEV_1$ to indacaterol included a short duration of smoking history, and high short-acting bronchodilator response. When patients with history of smoking were excluded, factors associated with response of $FEV_1$ to indacaterol included high short-acting bronchodilator response, and poor health-related quality of life score as measured by St. George's Respiratory Questionnaire for COPD. Conclusion: In a tuberculosis-destroyed lung with airflow limitation, short-acting bronchodilator response and smoking history can play a critical role in predicting outcomes of indacaterol treatment.

• Tuberculosis and Respiratory Diseases
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• 제48권4호
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• pp.522-529
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• 2000

목 적 : 최대호기유속 측정도 $FEV_1$과 함께 기도폐색의 정도를 평가할 수 있으며 기도폐색의 가역성을 평가하는 것은 기도폐쇄질환 환자들의 진단 및 치료에 중요하다. 최대호기유속은 $FEV_1$에 비해 측정이 간단하며 쉽고 빠르게 검사할 수 있는 장점이 있어 1차 진료기관에서도 쉽게 이용할 수 있다. 그러나 최대호기유속으로 기류 가역성을 평가한 연구는 매우 적다. 이에 천식 및 만성폐쇄성폐질환 환자들에게서 최대호기유속과 $FEV_1$으로 기류 가역성올 비교 평가하여 1차 진료기관에서 최대호기유속을 측정함으로써 기류 가역성을 평가하는데 기준을 마련하고자 본 연구를 시행하였다. 방 법 : 본 연구는 호흡곤란, 기침 및 천명을 주소로 계명대학교 동산병원 호흡기내과를 방문한 환자들 중 천식 및 만성폐쇄성폐질환으로 진단 받은 80명의 환자들을 대상으로 조사하였다. 베타-2 교감신경작용제(salbutamol) 흡입 직전과 15분 후 측정한 $FEV_1$의 추정정상치가 12% 이상 증가하고 노력성폐활량 또는 $FEV_1$의 절대값이 200ml 이상 증가한 경우를 기류가역성이 있는 것으로 정의하였다. 최대호기유속의 가역성은 베타-2 교감신경작용제 사용 후 절대값의 변화(1/min)로 표현하였으며 최대호기유속의 절대값의 변화에 따른 기류폐색의 가역성 평가에 대한 민감도, 특이도, 양성예측율과 음성예측율을 구하였다. 결 과 : 대상환자 80명중 36명(45%)에서 기류 가역성이 있었다. 폐활량측정법으로 기류 가역성이 증명된 환자에서 최대호기유속으로 기류 가역성을 평가하여서 최대호기유속의 민감도, 특이도, 양성예측을 그리고 음성예측율을 구하였을때 기저치보다 30 l/min 이상 증가한 경우에 가장 높게 관찰되었고 민감도 72.2%, 특이도 72.7%, 양성예측율 68.4% 그리고 음성예측율은 76.2%로 관찰되었다. 결 론 : 이상의 결과로 베타-2 교감신경작용제 사용 후 최대호기유속의 절대값의 변화는 기류 가역성을 평가하는데 간편하고 효율적인 방법으로 생각된다.

• Tuberculosis and Respiratory Diseases
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• 제44권3호
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• pp.574-582
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• 1997

연구배경 : 정상인에서는 운동부하시 증가되는 환기량의 요구를 초기에는 상시호흡량의 증가로 후기에는 호흡수의 증가로 충족시키며, 호흡수 증가에 따라 유발되는 호흡주기의 감소를 보상하기 위해 흡기책임비율이 50% 이상까지 증가하는 것으로 알려져 있다. 반면 만성기도폐쇄 환자에서는 환기능력의 감소와 생리적 사강 호흡의 증가로 인해 최대운동부하시 얕고 빠른 호흡양상을 보인다고 알려져 있지만 책임비율의 변화에 대해서는 연구가 많지 않고 이와 기도폐쇄정도와의 관련성에 대해서는 보고가 없는 실정이다. 방 법 : 12명의 만성기도폐쇄 환자와 10명의 정상인을 대조로 점진적 최대운동부하검사를 실시하였다. 결과 분석은 안정시에서 최대운동부하시점까지의 시간을 100%로 하여 rest, 20%, 40%, 60%, 80%, max 등% control duration으로 분획한 후 각 시점에서 1분 환기량, 상시호흡량, 호흡수, 생리적 사강비율, 흡기책임비율 등의 지표를 양군 간에 비교하였다. 결 과 : 1분환기량과 상시호흡량의 안정시에서 최대운동시까지의 변화는 양군 간에 유의한 차이가 관찰되었으나 호흡수는 유의한 차이를 나타내지 않았다. 생리적사강 비율은 정상대조군에 비해 만성기도폐쇄군에서 그 감소가 유의하게 낮았다. 흡기책임비율은 정상대조군에서 $38.4{\pm}3.0%$에서 $48.6{\pm}4.5%$로 증가한 반면 만성기도폐쇄군에서는 $40.5{\pm}2.2%$에서 $42.6{\pm}3.5%$로 별 변화가 없어 양군간에 유의한 변화의 차이가 있음을 확인할 수 있었고 이러한 흡기책임비율의 변화는 기도폐쇄정도 (FEV1%)와 유의한 상관관계가 있음을 확인할 수 있었다. (r=0.8151, p<0.05). 결 론 : 이상의 결과에서 만성기도폐쇄 환자는 최대운동부하시 정상에서 관찰되는 흡기책임비율의 증가가 발생하지 않으며 이는 기도폐쇄의 정도와 유의한 상관성을 갖고 있음을 확인할 수 있었다.

• 대한기계학회논문집A
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• 제26권6호
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• pp.1178-1186
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• 2002

Clean stockers are being used by semiconductor and TFT-LCD manufacturers to store and buffer work in process. The only way to keep the stored product clean is to provide constant clean airflow the product and through stocker. Up to now, stockers typically have been configured to receive their laminar airflow from fan filter units that are located on the side of the stocker. This type of stocker may have such problems as complexity of structure, increment of temperature, mechanical vibration, initial investment and running cost. In this study, in order to solve the above mentioned problems, new air control system in stocker is proposed, which is to control open ratios of exits that are located on the side of the stocker without fan filter units. In this study, static pressure regain was used for the analysis of the open ratios of exits theoretically and experiment was also conducted using actual clean stocker for TFT-LCD manufacturers and CFDesign, was used for simulating airflow in stocker. As a result, open ratios of exits can be obtained by the analysis of static pressure regain and was verified by experiment and simulation results. Therefore, new air control system in stocker can be used by the semiconductor and TFT-LCD manufacturers.

• 한국산업보건학회지
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• 제11권1호
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• pp.78-84
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• 2001

A CFD simulation of airflow and temperature field in a heated room has been described in this paper. The thermal wall jet created by a radiator greatly influences the airflow pattern, temperature distribution. The area close La a heat source has a higher risk of air-borne contamination and imposes a harmful effect on occupants in that area. The predicted flow field, temperature results show good agreement with the measured data. As the results were compared with experimental data, the applicability of CFD was satisfactorily verified. Also, the CFD simulation can capture the natural convective flow features. If a CFD simulation is applied ventilation design with a heat source, An effective design will be attained. Further study is required to improve the accuracy of CFD simulation.

• 한국산업보건학회지
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• 제10권2호
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• pp.140-149
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• 2000

In industrial field, there are several operations where a horizontal unidirectional airflow is used to control airborne contaminants. When a worker is immersed in a uniform freestream, a recirculating airflow can be created downstream of the worker by the phenomenon of boundary layer seperation. If the contaminant source and the breathing zone are within this near-wake region, high exposure may occur. The investigation for the effect of contaminant source location on worker exposure was performed by using CFD(Computational Fluid Dynamics). The airflow field was numerically calculated by assuming a steady flow and using the standard $k-{\varepsilon}$ turbulence model. As the results were compared with experimental data, the applicability of CFD was successfully verified. Subsequently, the breathing zone concentrations of the worker were predicted and compared with experimental data. The effects of contaminant density and turbulence intensity of freestream on worker exposure were evaluated.

• 대한기계학회논문집B
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• 제30권1호
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• pp.57-66
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• 2006

The experimental and the numerical study was performed on the comparison of thermal comfort(TC) and indoor air quality(IAQ) in the lecture room for cooling loads when the operating conditions are changed. PMV value and $CO_2$ concentration of the lecture room were measured and compared with the numerical results. The numerical results showed a good agreement with the experimental one and then the numerical tool was used to analyze thermal comfort and IAQ for a couple of operating conditions. As a result it was found that the increment of the discharge angle of system air-conditioner makes TC uniformity worse, but rarely affects IAQ. Also TC and IAQ were hardly affected by the variation of the discharge airflow. Finally it turned out that TC is merely affected by the increment of the ventilation airflow, but the average $CO_2$ concentration can be satisfied with Japanese IAQ standards of classrooms when the ventilation airflow is more than $800m^3/h$ in this study.

• 한국정밀공학회지
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• 제28권6호
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• pp.745-750
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• 2011

In a hope to better understand the flow and convective heat transfer characteristics inside a ball bearing, air flow between the rolling elements and raceways at high speed bearing rotation is numerically investigated using a simplified inner geometry of bearing and a CFD technique. Flow simulation results reveal the pressure distribution of airflow and the shear stress distribution on the ball surface, of which nonuniformity becomes significant with the increasing rotational speed. Also, the local point of maximum shear stress coincides with the stagnation flow area on the surface of rolling elements. A complex pattern of three-dimensional vortex structures is found in the air flow due to the relative motion of bearing elements and three different types of vortex pairs exist around the rotating and orbiting rolling elements.

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2008년도 춘계학술대회논문집
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• pp.21-24
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• 2008

The present study numerically investigates the glottal airflow characteristics as well as acoustic features of phonation fully coupled with dynamic behavior of vocal folds. The vocal folds are described by a low-dimensional body-covered model characterized by bio-mechanical parameters such as glottal width, vocal folds stiffness, and subglottal pressure. The flow in the vocal tract is modeled as an incompressible, axisymmetric form of the Navier-Stokes equations (INS), while the acoustic field is predicted by the linearized perturbed compressible equations (LPCE). The computed result shows that a two-mass model of vocal folds is sufficient to reproduce temporal variations in oral airflow and glottis motion produced by female speakers. It is also found that i) the glottal width has a significant effect on the amplitude of glottal flow, and thus on the amplitude of acoustic wave in the vocal tract, ii) the vocal fold tension is the main control parameter for the fundamental frequency of phonation, iii) the subglottal pressure plays an appreciable role on reproduction of the self-sustained oscillation of vocal folds, and iv) the strength of pulsating airflow and vortical structures are primarily affected by glottal width and subglottal pressure, and are closely related to pitch, loudness, and voice quality. Finally, more comprehensive explanation about the difference between one- and two-mass models is presented with discussion of effectiveness of vocal folds oscillation and voice quality.

• 대한기계학회논문집B
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• 제26권7호
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• pp.1022-1030
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• 2002

The experiments were performed with a $31{\times}31{\times}7mm^3$ simulated 3-dimensional module on the thermal conductive board of a parallel plate channel. The convective thermal conductance for the path from the module surface directly to airflow and conjugate thermal conductance for the path leading from the module to the floor by way of a module support, then, to the airflow were determined with several combinations of module-support-construction(210, 0.32, 0.021 K/W)/floor-material(398, 0.236W/mK) and channel height(15-30mm). As the result, it was found that the conjugate thermal conductance and the temperature distribution around the module depend on the thermal resistance of the module support, and the channel height. These configurations were designed to investigate on the feasibility of using the substrate as an effective heat spreader in the forced convective air-cooling of surface mounted heat source. The experimental results were discussed in the light of interactive nature of heat transfer through two paths, one directed from the module to the airflow and the other via the module support and the floor to the air.