• 한국멀티미디어학회논문지
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• 제9권12호
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• pp.1588-1595
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• 2006

In this paper, we proposed a liver extracting procedure for computer aided liver diagnosis system. Extraction of liver region in an abdominal CT image is difficult due to interferences of other organs. For this reason, liver region is extracted in a region of interest(ROI). ROI is selected by the window which can measure the distribution of Hounsfield Unit(HU) value of liver region in an abdominal CT image. The distribution is measured by an existential probability of HU value of lever region in the window. If the probability of any window is over 50%, the center point of the window would be assigned to ROI. Actually, liver region is not clearly discerned from the adjacent organs like muscle, spleen, and pancreas in an abdominal CT image. Liver region is extracted by the watershed segmentation algorithm which is effective in this situation. Because it is very sensitive to the slight valiance of contrast, it generally produces over segmentation regions. Therefore these regions are required to merge into the significant regions for optimal segmentation. Finally, a liver region can be selected and extracted by prier information based on anatomic information.

• 한국정보과학회논문지:소프트웨어및응용
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• 제29권11호
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• pp.803-808
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• 2002

본 논문은 복부 컴퓨터단층촬영(CT) 영상에서의 자동화된 신장 및 신장암 추출에 관한 연구를 수행하였다. 필름으로 보관된 복부 CT 영상을 디지털화하여 영상분석을 수행하였으며, 명암값에 의한 임계값(Gray-Level Thresholding) 처리 기법을 사용하여 신장만을 분리하였다. 신장암의 샘플영상에 대한 텍스쳐(Texture)분석 결과를 토대로, 대표적인 통계적 모멘트 값인 평균 및 표준 편차값을 동질성 시험 기준으로 삼아 신장암의 SEED를 선택하였다. 선택된 SEED의 중앙 픽셀을 시작점으로 하여, 명암값을 동질성 시험기준으로 사용한 영역확장(Region Growing) 방법을 적용하여 신장암을 추출하였다. GE사의 Hispeed Advantage CT 스캐너를 사용하여 촬영된 9개의 예, 총 113매 영상을 Lumisys LS-40 필름 디지타이저로 디지털화 하여 적용한 결과, 85%의 신장암 추출 민감도를 가진다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권9호
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• pp.3759-3765
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• 2015

Background: Approaches in disruption of MDM2-p53 interactions have now emerged as an important therapeutic strategy in resurrecting wild type p53 functional status. The present study highlights virtual screening strategies in identification of high affinity small molecule non-peptidic inhibitors. Nutlin3A and RG7112 belonging to compound class of Cis-imidazoline, MI219 of Spiro-oxindole class and Benzodiazepine derived TDP 665759 served as query small molecules for similarity search with a threshold of 95%. The query molecules and the similar molecules corresponding to each query were docked at the transactivation binding cleft of MDM2 protein. Aided by MolDock algorithm, high affinity compound against MDM2 was retrieved. Patch Dock supervised Protein-Protein interactions were established between MDM2 and ligand (query and similar) bound and free states of p53. Compounds with PubCid 68870345, 77819398, 71132874, and 11952782 respectively structurally similar to Nutlin3A, RG7112, Mi219 and TDP 665759 demonstrated higher affinity to MDM2 in comparison to their parent compounds. Evident from the protein-protein interaction studies, all the similar compounds except for 77819398 (similar to RG 7112) showed appreciable inhibitory potential. Of particular relevance, compound 68870345 akin to Nutlin 3A had highest inhibitory potential that respectively showed 1.3, 1.2, 1.16 and 1.26 folds higher inhibitory potential than Nutilin 3A, MI 219, RG 7112 and TDP 1665759. Compound 68870345 was further mapped for structure based pharamacophoric features. In the study, we report Cis-imidazoline derivative compound; Pubcid: 68870345 to have highest inhibitory potential in blocking MDM2-p53 interactions hitherto discovered.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제11권7호
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• pp.3370-3392
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• 2017

Next Generation Beyond 4G/5G systems will rely on the deployment of small cells over conventional macrocells for achieving high spectral efficiency and improved coverage performance, especially for indoor and hotspot environments. In such heterogeneous networks, the expected performance gains can only be derived with the use of efficient interference coordination schemes, such as Fractional Frequency Reuse (FFR), which is very attractive for its simplicity and effectiveness. In this work, femtocells are deployed according to a spatial Poisson Point Process (PPP) over hexagonally shaped, 6-sector macro base stations (MeNBs) in an uncoordinated manner, operating in hybrid mode. A newly introduced intermediary region prevents cross-tier, cross-boundary interference and improves user equipment (UE) performance at the boundary of cell center and cell edge. With tools of stochastic geometry, an analytical framework for the signal-to-interference-plus-noise-ratio (SINR) distribution is developed to evaluate the performance of all UEs in different spatial locations, with consideration to both co-tier and cross-tier interference. Using the SINR distribution framework, average network throughput per tier is derived together with a newly proposed harmonic mean, which ensures fairness in resource allocation amongst all UEs. Finally, the FFR network parameters are optimized for maximizing average network throughput, and the harmonic mean using a fair resource assignment constraint. Numerical results verify the proposed analytical framework, and provide insights into design trade-offs between maximizing throughput and user fairness by appropriately adjusting the spatial partitioning thresholds, the spectrum allocation factor, and the femtocell density.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2004년도 춘계학술대회논문집
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• pp.764-769
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• 2004

The DC Motor in a vehicle may cause noise and vibration because of high speed revolution, which can make a driver feel uncomfortable. There have been various studies attempting to solve these problems, focusing mostly on the causes of and ways to reduce noise and vibration. It is suggested that the noise in a DC Motor may be primarily due to interaction between a brush and a commutator. Brush noise, the most common noise in a DC Motor, results from a brush bounced from the surface of the commutator, fluctuation of the friction between the brush and the commutator, and the impact on the brush when passing over slots of the commutator. Based on the noise test, one of the most important design parameters was shown to be the roundness of the commutator. As the DC motor is used, the roundness of the commutator gets bigger with subsequent increase of the level of brush noise and vibration. There must be a threshold in order to prevent the brush noise from getting worse. Using the method of CAE is more efficient than the real test for purposes of looking for various design parameters to maintain the roundness of the commutator. In this study, the design process to reduce the brush noise is presented with the use of a computer model. The design parameters to reduce the brush noise and vibration are proposed by using FEM. The design parameters are used to reduce the noise and vibration of a DC motor and it is verified with the test results on a fan DC motor in a vehicle. This method may be applicable to various DC motors.

• Asian Pacific Journal of Cancer Prevention
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• 제17권4호
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• pp.2291-2295
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• 2016

Small molecule tyrosine kinase inhibitors targeting HER 2 receptors have emerged as an important therapeutic approach in inhibition of downstream proliferation and survival signals for the treatment of breast cancers. Recent drug discovery efforts have demonstrated that naturally occurring polyphenolic compounds like delphinidin have potential to inhibit proliferation and promote apoptosis of breast cancer cells by targeting HER2 receptors. While delphinidin may thus reduce tumour size, it is associated with serious side effects like dysphonia. Owing to the narrow therapeutic window of delphinidin, the present study aimed to identify high affinity compounds targeting HER2 with safer pharmacological profiles than delphinidin through virtual screening approaches. Delphinidin served as the query parent for identification of structurally similar compounds by Tanimoto-based similarity searching with a threshold of 95% against the PubChem database. The compounds retrieved were further subjected to Lipinski and Verber's filters to obtain drug like agents, then further filtered by diversity based screens with a cut off of 0.6. The compound with Pubchem ID: 91596862 was identified to have higher affinity than its parent. In addition it also proved to be non-toxic with a better ADMET profile and higher kinase activity. The compound identified in the study can be put to further in vitro drug testing to complement the present study.

• 방송공학회논문지
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• 제18권5호
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• pp.702-712
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• 2013

본 논문은 흉부 CT 영상에서 폐 흉벽에 결절 및 폐혈관이 붙어 있는 경우에도 폐 정보의 손실 없이 폐와 기관지를 분리할 수 있는 알고리즘을 제안 하였다. 마스크 영상의 활용은 폐 및 기관지 분할에서 시간 단축 및 성능을 향상 시킬 수 있었다. 또한 폐 흉벽과 밝기값이 같은 결절을 찾아 제거 하는 방법은 좌 우측폐의 외곽 영상을 2진 영상으로 변환하고, 형태학적 정보를 활용함으로써 가능 하였다. 마지막으로 제거된 부분의 외곽선 연결은 거리가 고려된 최적 화소 추가와 3차 Spline 보간법을 적용하였다. Matlab 시뮬레이션 결과 제안된 알고리즘은 기존 문제점이 보완됨을 확인 할 수 있었다.

• 전기학회논문지
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• 제66권1호
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• pp.89-99
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• 2017

Many works have attempted to solve the scalability, the availability, and the low-latency problems of peer-to-peer (P2P) live video streaming; yet, the problems still remain. While tree-based systems are vulnerable to churn, the mesh-based systems suffer from high delay and overhead. The DHT-aided chunk-driven overlay (DCO) [1] tried to tackle these problems by using the distributed hash table (DHT), which structures into a mesh-based overlay to efficiently share the video segment. However, DCO fully depends on the capacity of the users' device which is small and unstable, i.e., the users' device may leave and join the network anytime, and the video server's bandwidth can be insufficient when the number of users joining the network suddenly increases. Therefore, cloud assist is introduced to overcome those problems. Cloud assist can be used to enhance the availability, the low-latency, and the scalability of the system. In this paper, the DHT is used to maintain the location of the streaming segments in a distributed manner, and the cloud server is used to assist other peers when the bandwidth which required for sharing the video segment is insufficient. The simulation results show that by using the threshold and cloud assist, the availability and the low-latency of the video segments, and the scalability of the network are greatly improved.

• Korean Journal of Radiology
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• 제2권1호
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• pp.28-36
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• 2001

Objective: To provide a systematic overview of the effects of various parameters on contrast enhancement within the same population, an animal experiment as well as a computer-aided simulation study was performed. Materials and Methods: In an animal experiment, single-level dynamic CT through the liver was performed at 5-second intervals just after the injection of contrast medium for 3 minutes. Combinations of three different amounts (1, 2, 3 mL/kg), concentrations (150, 200, 300 mgI/mL), and injection rates (0.5, 1, 2 mL/sec) were used. The CT number of the aorta (A), portal vein (P) and liver (L) was measured in each image, and time-attenuation curves for A, P and L were thus obtained. The degree of maximum enhancement (Imax) and time to reach peak enhancement (Tmax) of A, P and L were determined, and times to equilibrium (Teq) were analyzed. In the computed-aided simulation model, a program based on the amount, flow, and diffusion coefficient of body fluid in various compartments of the human body was designed. The input variables were the concentrations, volumes and injection rates of the contrast media used. The program generated the time-attenuation curves of A, P and L, as well as liver-to-hepatocellular carcinoma (HCC) contrast curves. On each curve, we calculated and plotted the optimal temporal window (time period above the lower threshold, which in this experiment was 10 Hounsfield units), the total area under the curve above the lower threshold, and the area within the optimal range. Results: A. Animal Experiment: At a given concentration and injection rate, an increased volume of contrast medium led to increases in Imax A, P and L. In addition, Tmax A, P, L and Teq were prolonged in parallel with increases in injection time The time-attenuation curve shifted upward and to the right. For a given volume and injection rate, an increased concentration of contrast medium increased the degree of aortic, portal and hepatic enhancement, though Tmax A, P and L remained the same. The time-attenuation curve shifted upward. For a given volume and concentration of contrast medium, changes in the injection rate had a prominent effect on aortic enhancement, and that of the portal vein and hepatic parenchyma also showed some increase, though the effect was less prominent. A increased in the rate of contrast injection led to shifting of the time enhancement curve to the left and upward. B. Computer Simulation: At a faster injection rate, there was minimal change in the degree of hepatic attenuation, though the duration of the optimal temporal window decreased. The area between 10 and 30 HU was greatest when contrast media was delivered at a rate of 2 3 mL/sec. Although the total area under the curve increased in proportion to the injection rate, most of this increase was above the upper threshould and thus the temporal window was narrow and the optimal area decreased. Conclusion: Increases in volume, concentration and injection rate all resulted in improved arterial enhancement. If cost was disregarded, increasing the injection volume was the most reliable way of obtaining good quality enhancement. The optimal way of delivering a given amount of contrast medium can be calculated using a computer-based mathematical model.

• Annals of Clinical Neurophysiology
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• 제12권1호
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• pp.21-26
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• 2010

Background: Although quantitative sensory test (QST) is being used with increasing frequency for measuring sensory thresholds in clinical practice and epidemiologic studies, there has been no age-matched normative data in Korean adults. The objective of this study is to evaluate the value of QST in diabetic polyneuropathy with normal range in Korean adults. Methods: The Computer Aided Sensory Examination IV 4,2 (WR Medical Electronics Co., Stillwater, Minnesota, U.S.A.), with 4,2,1 stepping algorithm was used to determine vibration and cold perception threshold in 70 normal controls and 19 patients with diabetic polyneuropathy aged from 21 to 79 years. The data were used to define age-matched upper and lower normal limits and normal range of side to side difference. We also evaluated the duration of diabetes, serum HbA1C level, and findings of nerve conduction study (NCS) and QST in patients with diabetic polyneuropathy. Results: In normal adults, sensory thresholds slightly increased with age, and a slight side-to-side difference was observed. The diagnostic sensitivity of QST was not higher than NCS in patients with diabetic polyneuropathy (36.8% vs. 42.1%, p=0.716), especially among elderly patients. Conclusions: QST might be used as a complementary test for NCS in the diagnosis of diabetic polyneuropathy. Although the QST is a simple method for the evaluation of peripheral nerve function, there are some limitations. Most of all, because the QST measuring is dependent on the subjective response of patients, the degree of concentration and cooperation of the patients can significantly affect the result. And thus, attention should be paid during the interpretation of QST results in patients with peripheral neuropathy.