• 제목/요약/키워드: aging degree

검색결과 390건 처리시간 0.024초

노화 시계를 이용한 알츠하이머병 환자의 후성유전학적 연령 예측 (Epigenetic Age Prediction of Alzheimer's Disease Patients Using the Aging Clock)

  • 김진영;조광원
    • 통합자연과학논문집
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    • 제16권2호
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    • pp.61-67
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    • 2023
  • Human body ages differently due to environmental, genetic and pathological factors. DNA methylation patterns also differs depending on various factors such as aging and several other diseases. The aging clock model, which uses these differences to predict age, analyzes DNA methylation patterns, recognizes age-specific patterns, predicts age, and grasps the speed and degree of aging. Aging occurs in everyone and causes various problems such as deterioration of physical ability and complications. Alzheimer's disease is a disease associated with aging and the most common brain degenerative disease. This disease causes various cognitive functions disabilities such as dementia and impaired judgment to motor functions, making daily life impossible. It has been reported that the incidence and progression of this disease increase with aging, and that increased phosphorylation of Aβ and tau proteins, which are overexpressed in this disease and accelerates epigenetic aging. It has also been reported that DNA methylation is significantly increased in the hippocampus and entorhinal cortex of Alzheimer's disease patients. Therefore, we calculated the biological age using the Epi clock, a pan-tissue aging clock model, and confirmed that the epigenetic age of patients suffering from Alzheimer's disease is lower than their actual age. Also, it was confirmed to slow down aging.

전분이 합의 노화(Bread Staling)에 미치는 영향에 관한 연구 (A study of the starch′s effect on the aging of Bread)

  • 이명호
    • 한국조리학회지
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    • 제5권2호
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    • pp.165-190
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    • 1999
  • There are no reliable data about the effect on the baking industry in Korea yet. The damage caused by the product's aging is so much in the confectionary and baking industries. Therefore, the aging of bread is an economical problem which determines its commercial lifespan. In order to solve out this aging problem, this article dealt with the factors which give rise to the effect of starch on the aging and its inhibitory methods. 1. Control of the moisture content : Because the aging of starch occurs at 30~60% of moisture most frequently, controlling the moisture content above or below the above percentage can help restrain the aging to a certain degree. 2. Addition of sugars : The sugars become hydrated through hydrogenation with the moisture in the food. Thus, the sugars suppress the phenomenon of crumbling inside the food acting as a kind of dehydrator. 3. Use of an emulsifying agent : The emulsifying agent increases the stability of starch colloid liquid and suppresses the precipitation of starch molecules and the formation of crystallized range to prevent aging. 4. Method by freezing : The aging of starch does hardly occur reaching -2$0^{\circ}C$~-3$0^{\circ}C$ below zero. 5. Maintenance of warm condition : The freshness of bread is maintained at the 80% of humidity at 5$0^{\circ}C$.

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파괴 및 비파괴진단 비교분석을 통한 케이블 열화특성평가 (Insulation Aging Characteristic Assessment on the Power cables with the Comparative Analysis Between Destructive and Nondestructive Diagnosis)

  • 이동영
    • 조명전기설비학회논문지
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    • 제23권6호
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    • pp.104-108
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    • 2009
  • 본 논문에서는 지중전력케이블을 대상으로 케이블의 절연열화특성 분석시험을 통해 케이블의 절연열화와 절연 진단결과 및 파괴강도와의 상관관계에 대한 실증연구를 수행하였다. 시험대상 선로의 제조결함 여부를 확인하기 위해 가교도분석, 핫오일테스트 등을 실시한 결과 제조결함은 없는 것으로 확인되었다. 진단대상 선로는 3상 모두 장기간 사용에 의해 열화가 많이 진전되었고, 특히 B상이 수트리 길이 및 화학구조결함 농도 면에서 가장 열화된 케이블인 것으로 판단되며, C상, A상의 순으로 열화정도가 다소 감소함을 확인하였다. 상기 결과는 진단시험 및 파괴 강도시험 결과와 일치하며, 따라서 열화시정수법을 이용한 진단장치가 열화상태가 심각한 케이블의 선별에 효과적인 진단법임을 확인하였다.

자가관리 프로그램이 성공적 노후에 미치는 효과 (The Effects of a Self-Management Program on Successful Aging)

  • 박지원;유혜라;권보은
    • 지역사회간호학회지
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    • 제18권4호
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    • pp.513-522
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    • 2007
  • Purpose: The purpose of this study was to gain knowledge of successful aging for the Korean elderly and to identify the effects of an intervention program on the change of the knowledge Method: Data were collected from 134 elders from 3 schools for the elderly in H City. The Successful Aging Scale was used to collect data and modified CDSMP was applied as the intervention. Descriptive statistics, t-test, ANOVA and ANCOVA were used. Results : The total score of the knowledge of successful aging among the elderly cohort was 2.44 out of 3, and the scores of the factors making up old age were 2.66 for the success of children, 2.63 for self-control, 2.56 for self-efficacy, and 2.05 for happy marriage. Life satisfaction from the success of children and self-control were strongly correlated(r=0.7036, p=0.000). Conclusion: The self-management program brought positive changes to the knowledge of successful aging through the self-control parameter, and although it could not change the degree of knowledge of the overall successful aging among the elderly cohort, the program represents the first Korean nursing intervention focused on self-management techniques needed for successful aging.

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고령친화 지속가능한 아파트단지 개발을 위한 공동생활공간에 대한 연구 (A Study on the Community Spaces for Sustainable Apartment Complex in the Aging Society)

  • 강혜경;조성희
    • 한국주거학회:학술대회논문집
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    • 한국주거학회 2011년도 춘계학술발표대회 논문집
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    • pp.141-146
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    • 2011
  • The purpose of this study is to investigate the planning of the community spaces for sustainable apartment complex under the aging society. For this, it is needed to identify the practical meaning of community spaces for elderly residents. In many cases, existing apartments' community spaces have been designed without considering the elderly. In order to develop successful environment for aging society, it is necessary for us to precisely review how elderly residents are changing their needs. Survey and depth-interview methods were used for data collection of this study. This study was performed in the five subject apartments located in Haeundae new town, Busan. In planning of community spaces for sustainable apartment complex in the aging society, 1) The population of the elderly in apartment complex has been increased with progress of the aging society, and it has been necessary to enlarge and consider the aging-friendly community space. 2) When the community space is located in a good accessibility, visual openness, multipurpose composition and the center of complex, it was investigated that the degree of its usage was high. 3) Common apartment complex for the elderly was deficient, and the composition and the layout of community spaces were needed, which included sports facility, spaces for leisure culture and study. This study could be utilized as basic data for designing community spaces in apartments from the perspective of sustainable community.

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농촌지역 재가노인의 성공적 노화, 우울과 가족기능간의 관계 (Relationship of Successful Aging, Depression, and Family Function Among Rural Community Elders Living at Home)

  • 반금옥;한혜자
    • 한국농촌간호학회지
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    • 제7권1호
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    • pp.19-27
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    • 2012
  • Purpose: This study was done to examine the relationship of successful aging, depression, and family function in rural elders. Method: A descriptive correlation study design was used and data of the study were collected from 272 people who were overn 65 years of age and lived in a rural community. Result: The mean score for successful aging was $2.28{\pm}0.46$ points of a maximum 3 points. The elders showed a moderate degree of family function ($6.98{\pm}2.83$ points out of 10 points). The mean score for depression was $6.13{\pm}3.75$ points out of 15 points. There was a statistically significant correlation between successful aging and both depression (r=-.659, p<.001) and family function (r=.621, p<.001). Stepwise regression analysis was done to verify factors influencing successful aging. Depression was the dominant factor accounting for 43.2% of the total variance, followed by family function and age in that order. Inclusion of all of the study values resulted in an explanation power of 61.7%. Conclusion: The study results suggest that the provision of individual socio-psychological, and economic measures is important to promote successful aging in rural areas which are different in terms of socio-cultural as well as regional factors compared to urban areas.

고온재압밀 점토의 역학적 거동특성에 관한 연구 (Geotechnical Characteristics of Clays Reconsolidated at High Temperature)

  • 이강일
    • 한국지반공학회논문집
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    • 제19권2호
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    • pp.7-14
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    • 2003
  • 본 연구는 광양만 지역과 목포 남악지역의 점토를 이용하여 양생온도를 20$\times$, 50$\times$ , 80$\times$로 달리하고 각각의 온도에서 양생기간을 1일, 7일 14일, 40일로 하여 재성형.재압밀 시료를 제작하여 양생온도.양생기간이 연대효과 재현에 어떤 영향이 있는지를 밝히고, 불교란시료와 재압밀된 점토의 역학적 특성과 연대효과의 특성을 알아보기 위하여 1축압축시험, 3축압축시험 그리고 표준압밀시험을 실시하였다. 그 결과 압축지수비는 원지반점토의 연대효과를 나타내는데 유용한 지수임을 확인할 수 있었으며 또한 고온으로 양생한 점토가 연대효과를 잘 표현하고 연대효과의 재현에 필요한 최적의 양생온도는 80$\times$ 정도 부근이고 양생기간은 27일정도 임을 알 수 있었다.

노인의 관점에서 본 동네환경의 노인친화도 - 도시지역과 농촌지역의 비교연구 - (The Age-friendly Degree of Neighborhood Environment in aspects of the Aged - A Comparative Study of Urban Area and Rural Area -)

  • 오찬옥;김수영;강동진
    • 한국실내디자인학회논문집
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    • 제24권2호
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    • pp.217-226
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    • 2015
  • As the aging society is globally increasing, the guide for the aged-friendly city is suggested by WHO and many cities are preparing to meet with it. The base of this guide for an age-friendly city is an active aging. This study examined how degree the neighborhood environment is age-friendly from older persons' standpoints. The data were collected through the interview with old persons who aged more than 65 years, 117 persons in an urban area and 110 ones in a rural area. The age-friendly degree of neighborhood environment was examined from two aspects. One is how close 12 neighborhood facilities were from the elderly's houses. Another one is how degree the elderly were considered in 4 areas: pedestrian road, traffic, the amount of housing for the elderly, and space layouts of their houses. Findings were as follows. First, the elderly related neighborhood facilities in urban area were closer located to old persons' houses than in rural area, except the senior center. Second, in case of the age-friendly degree of their neighborhood environments, the space layout of house was the highest, and then traffic, pedestrian road, and the amount of housing for the elderly, in order. The consideration degree of wheelchair users was the lowest. Third, the age-friendly degree of pedestrian road, traffic, and room layout of house in rural area were higher than in urban area. However, the amount of housing for the elderly in urban area was higher than in rural area.

모르타르 시편의 재령에 따른 초음파를 이용한 내부탐사 (Probing of Mortar Specimens Using Ultrasonic Method Based on the Aging of Mortar)

  • 박영서;임홍철
    • 한국건축시공학회:학술대회논문집
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    • 한국건축시공학회 2019년도 추계 학술논문 발표대회
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    • pp.126-127
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    • 2019
  • Ultrasonic method is useful in determining the compressive strength of concrete as a nondestructive testing technique. As the velocity of the ultrasonic wave changes depending the aging of fresh concrete, it is possible to use the ultrasonic method to measure the degree of concrete curing on site. Recently, the use of steel reinforced concrete is ever increasing. This study is to examine the effect of aging concrete on the velocity of ultrasonic wave so that the compressive strength of concrete can be predicted in the presence of steel inclusions.

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