• YAKHAK HOEJI
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• v.39 no.3
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• pp.337-345
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• 1995

The effects of ginkgolides(natural mixture of ginkgolides, ginkgolide B, ginkgolide C) and flavonoids(quercetin, kaempferol, myricetin), extracted from Ginkgo biloba, on ADP and PAF-induced platelet aggregation in vitro and ex vivo were investigated. In these experiments, both of ginkgolides and ginkgoflavonoids did not affect the ADP(5 $\mu{M}$) induced platelet aggregation in vitro. The IC$_{50}$ value on PAF (0.3 $\mu{M}$) induced platelet aggregation were 2.52 $\mu{M}$ (ginkgolide B) and 6.35 $\mu{M}$ (natural mixture of ginkgolides) and 2.80 $\mu{M}$ (mixture of ginkgolide B and quercetin). Oral administration of ginkgolide B (1 and 3 mg/kg) and quercetin (3 and 9 mg/kg) to rabbits inhibited ex vivo PAF induced platelet aggregation in a dose-dependent manner. Ginkomin-F tablets administered to the diabetic patients showed inhibitory activities on the ADP and PAF induced platelet aggregation in a dose and time dependent manner.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.33 no.12B
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• pp.1097-1102
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• 2008

An effective method for calculating delay bounds of flows through flow aggregations and deaggregations is given. Based on this calculation, it is suggested a simple criteria for flow aggregation whether the aggregation will induce an increased delay bound. The criteria is evaluated in a few realistic scenarios.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.9 no.4
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• pp.52-59
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• 2010

MAC frame aggregation is a method that combines multiple MPDUs (MAC protocol data units) into one PPDU (PHY protocol data units) to enhance network performance at the MAC layer. In ad hoc networks, TCP underperforms due to the congestion window overshooting problem and thus by setting CWL (congestion window limit) TCP performance can be improved. In this paper, we investigate the problem of setting CWL for TCP performance optimization in ad hoc networks with MAC frame aggregation.

• Biomolecules & Therapeutics
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• v.3 no.2
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• pp.132-135
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• 1995

Several clofibrate congeners (bezafibrate, gemfibrozil and fenofibrate) were investigated the relationship between effects on the aggregation induced by aggregating agents (thrombin, arachidonic acid, ADP and collagen) and arachidonic acid metabolism in rabbit homogenized platelet. In platelet aggregation study, all drugs produced no significant inhibition (data not shown) in arachidonic acid and thrombin. Also platelet aggregation by ADP was not changed in bezafibrate and Inhibited dose dependently in fenofibrate and gemfibrozil. Platelet aggregation by collagen was inhibited dose dependently and significantly (from p<0.5 to p<0.001) by gemfibrozil and fenofibrate at concentrations between 20 and 400 $\mu$M. In arachidonic acid metabolism study, synthesis of thromboxane $B_2$ was not changed in rabbit platelet membranes and that of prostaglandin $E_2$ and $F_{2{\alpha}}$ was slightly increased by all drugs. It was concluded that clofibrate congeners inhibited ADP and collagen induced rabbit platelet aggregation and inhibition of collagen induced aggregation was probably mediated through some mechanism (pathway) other than arachidonic acid metabolism, judging from arachidonic acid metabolites (thromboxane $B_2$, prostaglandin $E_2$and $F_{ 2{\alpha}}$) synthesis in rabbit homogenized Platelet.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.39 no.6
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• pp.1-1
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• 2002

In this paper, we focus on comparison and analysis of performance for existing Topology Aggregation algorithm. For these, we designed and implemented PNNI routing simulator which contain various TA schemes, and evaluate performance of TA schemes by this simulator. The PNNI 1.0 specification of the ATM Forum is recommended that hierarchical routing protocol and topology information is aggregated in the network constructed hierarchically Aggregating topology information is known as TA(Topology Aggregation) and TA is very important for scalability and security in network. Therefore, the performance of PNNI network would vary with TA schemes and routing algorithm. PNNI routing simulator can be applied to develope Routing algorithm and TA algorithm and can be develope these algorithms in short period.

• Korean Journal of Veterinary Research
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• v.36 no.4
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• pp.887-894
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• 1996

Cyclopiazonic acid(CPA) known as stimulating the release of intracellular calcium, aflatoxin $B_1(AFB_1)$ causing gastrointestinal hemorrhage frequently were used as model toxic mycotoxins in these studies. First of all, the effects of various mycotoxins on the platelet aggregation response were determined. The effects of mycotoxins on the ATP release from platelet by aggregating factors were investigated. The results and conclusions obtained from these studies are : 1) CPA promoted ADP, collagen, thrombin, A.A. and PAF-induced rabbit platelet aggregation. $AFB_1$ inhibited collagen, A.A. and PAF-induced rabbit platelet aggregation only. 2) CPA increased both aggregation and disaggregation time, whereas $AFB_1$ decreased in a dose dependent manner. 3) CPA increased ADP, thrombin, A.A. and PAF-induced ATP release. $AFB_1$ increased A.A.-induced ATP release and decreased PAF-induced release in a dose dependent manner. In conclusion, CPA promoted platelet aggregation by the increase of ATP. Antiaggregating effects of AFB1 may be due to decreases of ATP. These data provide the basis for the future study of roles of ATP release in platelet aggregation.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.5 no.2
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• pp.344-358
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• 2011

Wireless tactical network (WTN) is the most important present-day technology enabling modern network centric warfare. It inherits many features from WMNs, since the WTN is based on existing wireless mesh networks (WMNs). However, it also has distinctive characteristics, such as hierarchical structures and tight QoS (Quality-of-Service) requirements. Little research has been conducted on hierarchical protocols to support various QoS in WMN. We require new protocols specifically optimized for WTNs. Control packets are generally required to find paths and reserve resources for QoS requirements, so data throughput is not degraded due to overhead. The fundamental solution is to adopt topology aggregation, in which a low tier node aggregates and simplifies the topology information and delivers it to a high tier node. The overhead from control packet exchange can be reduced greatly due to decreased information size. Although topology aggregation is effective for low overhead, it also causes the inaccuracy of topology information; thus, incurring low QoS support capability. Therefore, we need a new topology aggregation algorithm to achieve high accuracy. In this paper, we propose a new aggregation algorithm based on star topology. Noting the hierarchical characteristics in military and hierarchical networks, star topology aggregation can be used effectively. Our algorithm uses a limited number of bypasses to increase the exactness of the star topology aggregation. It adjusts topology parameters whenever it adds a bypass. Consequently, the result is highly accurate and has low computational complexity.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2009.05a
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• pp.473-476
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• 2009

Frame Aggregation is a promissing technology for improving MAC throughput in IEEE 802.11n. In IEEE 802.11n, two frame aggregation schemes, Aggregate MSDU (A-MSDU) and Aggregate MPDU (A-MPDU), are defined. In this paper, we analyze the performance the two-level frame aggregation scheme where A-MSDU and A-MPDU are combined. We develop the analytical model for the two-level frame aggregation scheme and present numerical results on the effect of bit error rate, aggregation size, and the number of nodes.

• Biomedical Science Letters
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• v.27 no.3
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• pp.170-176
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• 2021

Thapsigargin (TG), a sarco/endoplasmic reticulum (ER) Ca²⁺-ATPase (SERCA) inhibitor, has been widely used as an agonist for platelet aggregation for decades. In this study, we investigated the effect of TG on the release of lactate dehydrogenase (LDH) for platelets and elucidated its mechanism. Platelet LDH release and platelet aggregation were increased by TG treatment; 1,000 nM of TG induced the complete lysis of platelets. Other agonists such as collagen (2.5 ㎍/mL), thrombin (0.1 U/mL), and ADP (10 mM) did not induce significant platelet LDH release despite platelet aggregation. Finally, we investigated the effects of pharmacological inhibitors on TG-induced platelet aggregation and LDH release. SP600125, a JNK inhibitor, and LY294002, a PI-3K inhibitor, inhibited TG-induced platelet LDH release but not platelet aggregation. Forskolin, an adenylyl cyclase activator, also inhibited LDH release without affecting platelet aggregation by TG. These results suggest that the TG-induced platelet aggregation was accompanied by LDH release but regulated by a different signaling pathway.

• Biomedical Science Letters
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• v.25 no.2
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• pp.123-130
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• 2019

Platelet aggregation is essential for hemostatic process in case of blood vessels damages. However, excessive platelet aggregation can cause cardiovascular disorders including atherosclerosis, thrombosis and myocardial infarction. Scopoletin is usually found in the roots of genus Scopolia or Artemisia, and is known to have anticoagulant and anti-malarial effects. This study investigated the effect of scopoletin on human platelet aggregation induced by U46619, an analogue of thromboxane $A_2(TXA_2)$. Scopoletin had anti-platelet effects by down-regulating $TXA_2$ and intracellular $Ca^{2+}$ mobilization ($[Ca^{2+}]_i$), the aggregation-inducing molecules generated in activated platelets. On the other hand, scopoletin increased the levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), which are known to be intracellular $Ca^{2+}$ antagonists. This resulted in inhibition of fibrinogen binding to ${\alpha}IIb/{\beta}_3$ in U46619-induced human platelet aggregation. In addition, scopoletin inhibited the release of adenosine trisphosphate (ATP) in dose-dependent manner. This result means that the aggregation amplification activity through the granule secretion in platelets was suppressed by scopoletin. Therefore, we demonstrated that scopoletin has a potent antiplatelet effect and is highly likely to prevent platelet-derived vascular disease.