• Journal of the Korean Society of Radiology
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• v.85 no.3
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• pp.505-519
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• 2024

MRI plays a crucial role in bone marrow (BM) assessment, and has very high sensitivity in diagnosing marrow disorders. However, for radiologists who may not frequently encounter pediatric imaging, distinguishing pathologic BM lesion from normal BM can be challenging. Conditions involving the BM in pediatric patients, such as leukemia and metastatic neuroblastoma, often manifest with diverse musculoskeletal symptoms and may be diagnosed using musculoskeletal MRI examinations. Accurate interpretation of pediatric MRI requires not only an understanding of the normal composition of BM but also an awareness of age-related developmental changes in the marrow and familiarity with conditions that commonly involve pediatric BM. We aim to describe the composition of normal BM and outline the normal and abnormal MRI findings in pediatric BM. Additionally, we aim to present clinical cases of malignant BM disorders including leukemia, neuroblastoma metastasis, and other malignant BM disorders.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.33 no.4
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• pp.447-454
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• 2023

Objective: This study aims to investigate the impact of changes in working conditions on job-related stress and musculoskeletal disorders using the results of seven surveys conducted at a single workplace from 2004 to 2022 regarding factors hazardous to the musculoskeletal system. Additionally, the study aims to propose alternative methods of investigating factors hazardous to the musculoskeletal system. Methods: A car parts manufacturing plant where the same survey was taken seven times from 2004 to 2022 was selected and the survey data was analyzed. The main contents of the survey were weekly working hours, Borg's scale, work intensity, job-related stress, and the prevalence of musculoskeletal symptoms. The statistical analysis was performed using SAS (version 9.4). Results: The results of this study are as follows. Firstly, changes in working conditions have an impact on job-related stress. Secondly, changes in working conditions have an impact on work intensity indicators. Thirdly, changes in working conditions have an impact on the prevalence of musculoskeletal symptoms. Fourthly, even with an increase in age and length of service, job-related stress and musculoskeletal symptoms were alleviated when working conditions were improved. Conclusions: In order for measures to reduce musculoskeletal disorders to be successful, working conditions must not deteriorate, and it is necessary to demand revisions to regulations, etc. to reflect these points in the investigation of hazardous factors to the musculoskeletal system.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.25 no.1
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• pp.13-19
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• 2015

Objectives: The purpose of this study was to assess excavator drivers in order to determine the proportion showing subjective symptoms of musculoskeletal disorders and to evaluate the association between the symptoms and characteristics of the subjects. Methods: A questionnaire survey was conducted to collect the information on participants' age, average working hours per day, duration of career (years), work-related musculoskeletal symptoms, and more. The final dataset included 141 excavator drivers. Frequency and percentage were summarized and then the associations between the characteristics of the subjects and symptoms were evaluated as odds ratios (ORs) and 95% confidence intervals (CIs) using multiple logistic regression analysis. Results: Seventy-six percent of the currently reported musculoskeletal symptoms. Those who have musculoskeletal symptoms attributed their symptoms to unstable posture at work, mental stress or vibrations. There was a significant association between symptoms of musculoskeletal disorders and career of excavator drivers (P for trend=0.04). Conclusions: The results of this study suggest that the prevalence of musculoskeletal disorders may be high among excavator drivers and warrants well-designed studies on work-related disorders among excavator drivers.

• Molecules and Cells
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• v.46 no.11
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• pp.675-687
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• 2023

Accumulation of pathogenic amyloid-β disrupts the tight junction of retinal pigment epithelium (RPE), one of its senescence-like structural alterations. In the clearance of amyloid-β, the autophagy-lysosome pathway plays the crucial role. In this context, mammalian target of rapamycin (mTOR) inhibits the process of autophagy and lysosomal degradation, acting as a potential therapeutic target for age-associated disorders. However, efficacy of targeting mTOR to treat age-related macular degeneration remains largely elusive. Here, we validated the therapeutic efficacy of the mTOR inhibitors, Torin and PP242, in clearing amyloid-β by inducing the autophagy-lysosome pathway in a mouse model with pathogenic amyloid-β with tight junction disruption of RPE, which is evident in dry age-related macular degeneration. High concentration of amyloid-β oligomers induced autophagy-lysosome pathway impairment accompanied by the accumulation of p62 and decreased lysosomal activity in RPE cells. However, Torin and PP242 treatment restored the lysosomal activity via activation of LAMP2 and facilitated the clearance of amyloid-β in vitro and in vivo. Furthermore, clearance of amyloid-β by Torin and PP242 ameliorated the tight junction disruption of RPE in vivo. Overall, our findings suggest mTOR inhibition as a new therapeutic strategy for the restoration of tight junctions in age-related macular degeneration.

• Journal of Biomedical Engineering Research
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• v.45 no.1
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• pp.26-36
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• 2024

Functional brain imaging techniques have been used to diagnose psychiatric disorders such as dementia, depression, and autism. Recently, these techniques have also been actively used to study hearing loss. The present study reviewed the application of the functional brain imaging techniques in auditory research, especially those focusing on hearing loss, over the past decade. EEG, fMRI, fNIRS, MEG, and PET have been utilized in auditory research, and the number of research studies using these techniques has been increasing. In particular, fMRI and EEG were the most frequently used technique in auditory research. EEG studies mostly used event-related designs to analyze the direct relationship between stimulus and the related response, and in fMRI studies, resting-state functional connectivity and block designs were utilized to analyze alterations in brain functionality in hearing-related areas. In terms of age, while studies involving children mainly focused on congenital and pre- and post-lingual hearing loss to analyze developmental characteristics with and without hearing loss, those involving adults focused on age-related hearing loss to investigate changes in the characteristics of the brain based on the presence of hearing loss and the use of a hearing device. Overall, ranging from EEG to PET, various functional brain imaging techniques have been used in auditory research, but it is difficult to perform a comprehensive analysis due to the lack of consistency in experimental designs, analysis methods, and participant characteristics. Thus, it is necessary to develop standardized research protocols to obtain high-quality clinical and research evidence.

• Journal of Acupuncture Research
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• v.18 no.5
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• pp.109-121
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• 2001

Objective : The purpose of This study is to analyze influence of functional and clinical improvement effect on temporomandibular disorders of Dong-Qi acupuncture treatment that often be used to temporomandibular disorder patients. Methods : We investigated to focus temporomandibular disorders in Jaseng oriental medicine hospital from September 8, 2000 to March 22, 2001. We compared to before and after treatment situation using temporomandibular disease & facial ache dolor pain and malignant function disorders & activation inhibition analysis from one cured Dong-Qi acupuncture treatment of outpatients-40 examples. Results : These results appeared that Sex distinction occurrence ratio was much more female than male of 1: 7. Age distinction occupied the most ratio in 20-30 generation. Jobs was mainly ranked students and companion. In cases treated before visiting our hospital, was mainly ranked our hospital first dignosis. the distribution interval of solider was mainly followed above 3 years. the distribution interval of treatment was mainly gone within 1 month and above 3 month, frequency of treatment was examined below 5 times, into 6 to 10 times, more than 11 times, respectively. Everything showed a very valuable effect except chewing and dentalgia in decrease of ache dolor pain and linkage pain related to mal-function. There are meaningful effect in Every part on Mal-function improvement. Every contents showed a very excellent effect except activation such as motivation ingestion and recreation in influence of activation. Conclusion : The above results showed a very valuable treatment effect of temporomandibular disorders on Dong-Qi acupuncture treatment. Therefore we are considered the necessity of continuous study and observation applying to other disease as well as temporomandibular disorders.

• Journal of the Korean society of biological therapies in psychiatry
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• v.24 no.3
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• pp.202-208
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• 2018

Objectives : The purpose of this study was to investigate the differences in forensic demographic characteristics, interpersonal problems and personality disorder between early and late onset criminal patients with schizophrenia. Methods : The participants included 187 inpatients with schizophrenia who had committed crimes. They filled out the Korean Inventory of Interpersonal Problem Personality Disorder Scales and Psychopathic Personality Inventory-Revised. They were divided into early onset group and late onset group according to onset age of schizophrenia at 26 years old(under 26 versus 26 and older) and forensic demographic characteristics, interpersonal problem and personality disorders including psychopathy were compared between two groups. Results : There were no differences in gender, education years and family history between the two groups. Early onset group was associated with lower age, earlier onset of age and earlier age at the time of the crime. Duration from onset to diagnosis was not different between the two groups. Duration from onset to crime and after diagnosis to crime was shorter in late onset group. There were no differences between the two groups in the interpersonal problems, personality disorder and psychopathic personality evaluation. Conclusion : These results suggested that there may be forensic demographic differences related to crime between early and later onset schizophrenia. Psychiatrists should consider the age at onset of schizophrenia when assessing the risk of violence in patients with schizophrenia. In the future. it will be needed other study of age classification such as admixture analysis.

• Physical Therapy Korea
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• v.21 no.1
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• pp.55-62
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• 2014

For professional drivers, there is a possibility to have musculoskeletal disorders on ankle joint due to repetitive pedaling operation. Therefore, this study have focused to examine ankle active range of motion (AROM), dorsiflexor strength, and pressure pain threshold (PPT) of tibialis anterior muscle (TA) in taxi drivers compared to a age-matched control group. Thirty male taxi drivers with at least 10 years of driving experience and thirty male sedentary workers were evaluated for ankle AROM, dorsiflexor strength, and PPT of TA. Multiple independent t-tests were used to identify significant differences between two groups. For the results, taxi drivers had significantly less AROM in dorsiflexion and greater AROM in external tibial rotation compared to the control group. Also, dorsiflexor strength and PPT of TA in taxi drivers was significantly lower than in the control group. This study indicates that the repetitive ankle movements associated with driving have an effect on ankle AROM, dorsiflexor strength, and PPT of TA and may lead to work-related musculoskeletal disorders on ankle. Professional drivers may need to be educated to prevent a potential musculoskeletal disorders associated with repetitive movement.

• Journal of the Korean Society of Safety
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• v.32 no.4
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• pp.79-88
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• 2017

The purpose of this study is to analyze the effects of personal, job, and health care characteristics of firefighters on musculoskeletal disorders (MSDs) and job stress. This survey was participated 591 firefighters in jeonnam and Busan city. The survey consisted of 1) personal, job, and health care characteristics measurement, 2) job stress measurement (KOSS, Korean Occupational Stress Scale), 3) musculoskeletal disorders symptoms mesurement. The analysis of the data was using SAS 9.1 Ver. The statistics analysis was performed the frequency, percentage, average, and standard deviation for each survey item. The Chi square analysis was performed to analyzed the effects of personal, job, and health care characteristics on MSDs and job stress. According to the results of the study on musculoskeletal disorders symptoms, 49.6% of the subjects perceived pain related to musculoskeletal diseases. The total score for job stress was 51.6 (SD 12.9), which was the highest 50% when compared to the Korean job stress standard (male). Age, department, work experience, working type, position, and sleeping time were found to affect musculoskeletal disorders and job stress.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.11 no.1
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• pp.85-91
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• 2001

Background : It goes without saying that cumulative trauma disorders is spreading to various types of occupation in many advanced countries including America, and it forms considerable rate of total occupational disorders already. and as the result of it, the seriousness of worker health problem and economic loss owing to production loss, recuperation expense, etc. are on the increasing trend through whole society. In case of Korea, the related measures as well as accurate fact-finding survey data on cumulative trauma disorders aren't prepared in detail, so it implies forward problem would be serious. Purpose : The purpose of this study is to draw the risk factor of cumulative trauma disorders in production factory, to forecast the rate of occurrence of cumulative trauma disorders on the basis of subjective symptoms, and to present forward realistic and effective prevention measures by showing the risk of cumulative trauma disorders, objecting the production factory of a domestic riding automobile assembly shop, by estimating in the aspect of human-engineering through the analysis of risk factor being a cause of cumulative trauma disorders. Methods : For this study, I investigated work type and on-duty hours, breathing time, and subjective symptoms of cumulative trauma disorders through questionnaire, objecting the workers in press. car body, coating, and outfit factory. Results : As a result of research, 81.2% of workers were in the physical burden due to present working, and the highest prevalence by part of body is an waist. The higher a rule score, The higher the number of workers complaind for working intensity, and the higher age work duration, tool used time, the higher prevalence of subjective symptoms by part of body. The number of workers complaind subjective symptom for treatment is the highest in drugstore.