• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.9 no.1
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• pp.41-55
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• 1999

In order to evaluate the effects of knowledge, attitude and practice on noise-induced hearing loss or hearing threshold level, questionnaire survey was performed and hearing thresholds of 1 kHz and 4 kHz were measured on 1,040 subjects with workers exposed to noise, safety and health officers. industrial hygienists, analysts rind office workers. The results were as follows ; 1. The following 6 factors were obtained by factor analysis and factor rotation of 30 questionnaire of knowledge, attitude and practice about noise; knowledge of noise (F1), concern of hearing protective devices (F2), concern of noise induced hearing loss (F3), concern of noise level and hearing impairment (F4), concern of noise in workplace (F5) and recognition of noised-induced hearing loss (F6). 56.1% of variance was explained by 6 factors. 2. Significant variables influencing knowledge, attitude and practice about noise were education level and age in F1, personal protective devices (PPE) and education level in F2, age and education level in F3, education level, age and sex in F4, PPE, education level, age and work duration in F5, and work duration and PPE in F6. 3. Hearing thresholds of 4 kHz were significantly higher in workers exposed to noise than that of in the other subjects and tended to be higher in industrial hygienists, safety and health officers and analysts than that of the office workers. 4. Significant variables influencing hearing thresholds of 1 kHz were age, education level, F5 and F6 in workers exposed to noise, and F1 in industrial hygienists. 5. Significant variables influencing hearing thresholds of 4 kHz were age, F6, sex, work duration, F1, F5, F2 and F3 in workers exposed to noise, F1 and age in safety and health officers, and F6, sex and F4 in industrial hygienists. With the above results, it suggested that workers exposed to noise be needed the education of knowledge, attitude and practice about noise in hearing conservation program for the prevention of noise induced hearing loss. Also, it suggested that health managers in workplace be needed countermeasures to prevent hearing loss although they are intermittently exposed to noise.

• Journal of Animal Science and Technology
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• v.63 no.6
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• pp.1376-1385
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• 2021

Foot-and-mouth disease, one of the most contagious diseases in cloven-hoofed animals, causes significant economic losses. The pathogenesis of foot-and-mouth disease virus (FMDV) infection is known to differ with age of the animals. In this study, we aimed to reveal the difference in immunological response in the initial stage of FMDV infection between piglets and adult pigs. Peripheral blood mononuclear cells (PBMCs) were isolated from 3 piglets (8 weeks old) and 3 pigs (35 weeks old) that were not vaccinated against FMDV. O-type FMDV (2 × 10² median tissue culture infectious dose) was inoculated into porcine PBMCs and the cells were incubated at 37.0℃ under 5% CO₂ for various time periods (0, 1, 3, 6, 12, 24, and 48 h). The total RNA was obtained from the FMDV-inoculated PBMCs after each time point, and the virus titer was investigated in these RNA samples. Furthermore, dynamics of mRNA expression of the six tested cytokines (interferon [IFN]-α, IFN-γ, interleukin [IL]-6, IL-8, IL-10, and tumor necrosis factor [TNF]-α) in FMDV-inoculated porcine PBMCs were evaluated by time-series analysis to determine the differences, if any, based on the age of the pigs. The PBMCs of piglets contained the highest quantity of FMDV mRNA at 6 hours post-inoculation (hpi), and the PBMCs of pigs had the highest quantity of FMDV mRNA at 3 hpi. The mean cycle threshold-value in the PBMCs steadily decreased after the peak time point in the piglets and pigs (6 and 3 hpi, respectively). The dynamics of mRNA expression of all cytokines except TNF-α showed age-dependent differences in FMDV-inoculated PBMCs. The mRNA expression of most cytokines was more pronounced in the piglets than in the pigs, implying that the immune response against FMDV showed an age-dependent difference in pigs. In conclusion, within 48 hpi, the 8-week-old piglets responded more rapidly and were more sensitive to FMDV infection than the 35-week-old pigs, which could be associated with the difference in the pathogenesis of FMDV infection among the pigs. These results provide valuable insights into the mechanisms underlying the age-dependent differences in immune response in pigs against FMDV infection.

• Journal of the Ergonomics Society of Korea
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• v.29 no.5
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• pp.819-829
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• 2010

By referring thirty-seven previous studies on manual material handling (MMH), this paper analyzed guidelines and main factors of one-handed tasks. The previous studies concerned main factors of distance, weight, frequency, posture, gender, age, training, direction of force, height of the force exerted, and object shape and size. Based on these factors, the criteria used to understand one-handed tasks were objective measures of maximum strength, reaction force, etc., psychophysical measures of maximum acceptable frequency and weight, etc., and physiological measures of oxygen uptake, heart rate, electromyography, etc. An allowance threshold model regarding quantitative and objective fatigue and workload would be suggested for future research. This study would be expected that it serve to establish and Korean recommendations of one-handed tasks.

• Journal of Korean Institute of Industrial Engineers
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• v.30 no.3
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• pp.250-260
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• 2004

This study considers a linear connected-(r,s)-out-of-(m,n):F lattice system whose components are ordered like the elements of a linear (m,n )-matrix. We assume that all components are in the state 1 (operating) or 0 (failed) and identical and s-independent. The system fails whenever at least one connected (r,s)-submatrix of failed components occurs. The purpose of this paper is to present an optimization scheme that aims at minimizing the expected cost per unit time. To find the optimal threshold of maintenance intervention, we use a genetic algorithm for the cost optimization procedure. The expected cost per unit time is obtained by Monte Carlo simulation. The sensitivity analysis to the different cost parameters has also been made.

• Journal of Korean Society of Rural Planning
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• v.21 no.2
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• pp.1-10
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• 2015

This study consists of an observation of the changes in management and agricultural production of Shinbuk-eup based on the data from the Agricultural, Forestry & Census Report Survey. The following is a short summary and suggestions of the research. First, taking a look at the farming conditions of Shinbuk-eup, it shows that it is extremely polarized into rice paddies and vegetable cropping. Second, using the Tobit model to analyze the factor of determination of farmable lands of the farmers in Shinbuk-eup, the higher the number of family members, the less the hired work, and the more the experience in farming, have larger farmable lands. Meanwhile, the younger the farmer, their land mass is higher, however, after reaching their threshold age, their lands decrease.

• Korean Journal of Acupuncture
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• v.23 no.4
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• pp.101-110
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• 2006

Objectives : The purpose of this study was clinical observation about sensorineural hearing loss compare with acupucture treatment and assessments of prognotic factors. Methods : This study was clinical observation about sensorineural hearing loss cases. for diagnosing in these cases, pure tone audiometry was used. The treatment, acupuncture was used. Results : Three patients(37.5%) remarkably improved, one patient(12.5%), slightly improved, four patients(50%), no change. Conclusions : These results suggest that the prognosis by age and initial hearing threshold was significant. The treatment on sensorineural hearing loss considered that bone condution improved.

• Safety and Health at Work
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• v.6 no.4
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• pp.268-278
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• 2015

Background: This study aimed to assess the whole-body vibration (WBV) exposure among large blast hole drill machine operators with regard to the International Organization for Standardization (ISO) recommended threshold values and its association with machine- and rock-related factors and workers' individual characteristics. Methods: The study population included 28 drill machine operators who had worked in four opencast iron ore mines in eastern India. The study protocol comprised the following: measurements of WBV exposure [frequency weighted root mean square (RMS) acceleration ($m/s^2$)], machine-related data (manufacturer of machine, age of machine, seat height, thickness, and rest height) collected from mine management offices, measurements of rock hardness, uniaxial compressive strength and density, and workers' characteristics via face-to-face interviews. Results: More than 90% of the operators were exposed to a higher level WBV than the ISO upper limit and only 3.6% between the lower and upper limits, mainly in the vertical axis. Bivariate correlations revealed that potential predictors of total WBV exposure were: machine manufacturer (r = 0.453, p = 0.015), age of drill (r = 0.533, p = 0.003), and hardness of rock (r = 0.561, p = 0.002). The stepwise multiple regression model revealed that the potential predictors are age of operator (regression coefficient ${\beta}=-0.052$, standard error SE = 0.023), manufacturer (${\beta}=1.093$, SE = 0.227), rock hardness (${\beta}=0.045$, SE = 0.018), uniaxial compressive strength (${\beta}=0.027$, SE = 0.009), and density (${\beta}=-1.135$, SE = 0.235). Conclusion: Prevention should include using appropriate machines to handle rock hardness, rock uniaxial compressive strength and density, and seat improvement using ergonomic approaches such as including a suspension system.

• Journal of Audiology & Otology
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• v.24 no.3
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• pp.133-139
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• 2020

Background and Objectives: The Gaps-In-Noise (GIN) test is a clinically effective measure of the integrity of the central auditory nervous system. The GIN procedure can be applied to a pediatric population above 7 years of age. The present study conducted the GIN test to compare the abilities of auditory temporal resolution among typically developing children, children with speech sound disorder (SSD), and children with cognitive difficulty (CD). Subjects and Methods: Children aged 8 to 11 years-(total n=30) participated in this study. There were 10 children in each of the following three groups: typically developing children, children with SSD, and children with CD. The Urimal Test of Articulation and Phonology was conducted as a clinical assessment of the children's articulation and phonology. The Korean version of the Wechsler Intelligence Scale for Children-III (K-WISC-III) was administered as a screening test for general cognitive function. According to the procedure of Musiek, the pre-recorded stimuli of the GIN test were presented at 50 dB SL. The results were scored by the approximated threshold and the overall percent correct score (%). Results: All the typically developing children had normal auditory temporal resolution based on the clinical cutoff criteria of the GIN test. The children with SSD or CD had significantly reduced gap detection performance compared to age-matched typically developing children. The children's intelligence score measured by the K-WISC-III test explained 37% of the variance in the percent-correct score. Conclusions: Children with SSD or CD exhibited poorer ability to resolve rapid temporal acoustic cues over time compared to the age-matched typically developing children. The ability to detect a brief temporal gap embedded in a stimulus may be related to the general cognitive ability or phonological processing.

• Biomolecules & Therapeutics
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• v.30 no.6
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• pp.562-569
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• 2022

Etretinate, an acitretin metabolite, has a long retention duration in adipose tissues with a teratogenic potential. FDA advises a contraceptive period of at least three years after discontinuing acitretin. However, the effect of accumulated etretinate in adipose tissues on fetus is unknown. Although the teratogenic threshold for serum concentration of etretinate has been presented as higher than 2 ng/mL, that of acitretin is unknown. To examine factors affecting body retention of acitretin and etretinate, effects of acitretin dosage, acitretin-taking duration, elapsed time after stopping acitretin, age, sex, concomitant alcohol consumption, and foods and supplements rich in vitamin A intake on serum concentrations of acitretin and etretinate were analyzed in 14 acitretin-taken patients and 58 controls without taking acitretin or etretinate. Serum concentrations of acitretin, but not etretinate, tended to be inversely related to the discontinuation duration. They were also related to old age. Different from a published result that alcohol consumption could promote the metabolism of acitretin into etretinate, alcohol intake did not affect serum concentrations of etretinate. Unexpectedly, more frequent intake of vitamin A or provitamin A-rich food and supplements was associated with higher serum acitretin, whereas less frequent intake of vitamin A or provitamin A-rich food and supplements was associated with higher serum levels of etretinate in acitretin-taken patients. Despite preliminary data, inter-individual variations in serum retention of etretinate suggest the necessity of further research before applying the same guidelines to everyone to minimize unnecessary contraception.

• Korean Journal of Audiology
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• v.24 no.3
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• pp.133-139
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• 2020

Background and Objectives: The Gaps-In-Noise (GIN) test is a clinically effective measure of the integrity of the central auditory nervous system. The GIN procedure can be applied to a pediatric population above 7 years of age. The present study conducted the GIN test to compare the abilities of auditory temporal resolution among typically developing children, children with speech sound disorder (SSD), and children with cognitive difficulty (CD). Subjects and Methods: Children aged 8 to 11 years-(total n=30) participated in this study. There were 10 children in each of the following three groups: typically developing children, children with SSD, and children with CD. The Urimal Test of Articulation and Phonology was conducted as a clinical assessment of the children's articulation and phonology. The Korean version of the Wechsler Intelligence Scale for Children-III (K-WISC-III) was administered as a screening test for general cognitive function. According to the procedure of Musiek, the pre-recorded stimuli of the GIN test were presented at 50 dB SL. The results were scored by the approximated threshold and the overall percent correct score (%). Results: All the typically developing children had normal auditory temporal resolution based on the clinical cutoff criteria of the GIN test. The children with SSD or CD had significantly reduced gap detection performance compared to age-matched typically developing children. The children's intelligence score measured by the K-WISC-III test explained 37% of the variance in the percent-correct score. Conclusions: Children with SSD or CD exhibited poorer ability to resolve rapid temporal acoustic cues over time compared to the age-matched typically developing children. The ability to detect a brief temporal gap embedded in a stimulus may be related to the general cognitive ability or phonological processing.