• Clinics in Shoulder and Elbow
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• v.17 no.2
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• pp.64-67
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• 2014

Background: The purpose of this study was to determine whether in patients with rotator cuff tears a correlation exists between molecular changes and clinical parameters such as age, duration of symptom, range of motion, and tear size. Molecular changes of matrix metalloproteinase (MMP) and tissue inhibitor of metalloproteinase (TIMP) were assessed by measuring messenger RNA (mRNA) levels of the two proteins. Methods: The rotator cuff tissue from was obtained from the edge of a torn tendon revealed after debridement by a motorized shaver. Using the sample of rotator cuff tissue, the reverse transcription polymerase chain reaction was performed to quantify MMP-2 and TIMP-2 mRNA expression. To determine whether mRNA levels and the clinical variables, such as age, defect size, range of motion (ROM) of shoulder, and duration of symptoms, show any correlation, Spearman's correlation coefficients were used to test for significant differences. Results: There was an inverse correlation between the mRNA levels of MMP-2 and TIMP-2 from the torn rotator cuff tendons regardless of the clinical variables. However, comparison of mRNA levels versus clinical parameters such as age, defect size, range of motion and duration of symptoms revealed a number of findings. We found a significant correlation between age and mRNA levels of MMP-2 from torn cuffs (r = 0.513, p = 0.021). Further, we found a significant correlation between defect size in the full thickness tears and mRNA levels of MMP-2 (r = 0.454, p = 0.045). Conversely, no significant association between mRNA levels of MMP-2 and ROM or duration of symptom was found. Conclusions: Our results suggest that both MMP-2 and TIMP-2 may be involved in the disease process of rotator cuff tears. Although the level of mRNA expression of MMP-2 and TMP-2 remain constant in torn rotator cuffs irrespective of the clinical variables, their levels may be influenced by age and defect size, which could account to change in tendon degradation and the healing process.

• The korean journal of orthodontics
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• v.42 no.6
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• pp.291-296
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• 2012

Objective: The purposes of this study were to measure the palatal soft tissue thickness at popular placement sites of temporary anchorage devices (TADs) by cone-beam computed tomography (CBCT) and evaluate the age, gender, and positional differences in this parameter. Methods: The study sample consisted of 23 children (10 boys and 13 girls; mean age, $10.87{\pm}1.24$ years; range, 6.7 to 12.6 years) and 27 adults (14 men and 13 women; mean age, $21.35{\pm}1.14$ years; range, 20.0 to 23.8 years). Nine mediolateral and nine anteroposterior intersecting reference lines were drawn on CBCT scans of the 50 subjects, and the resultant measurement areas were designated according to their mediolateral (i.e., lateral, medial, and sutural) and anteroposterior (i.e., anterior, middle, and posterior) positions. Repeated-measures analysis of variance was performed to analyze intragroup and intergroup differences. Results: No significant age and gender differences were found (p = 0.309 and 0.124, respectively). Further, no significant anteroposterior change was observed (p = 0.350). However, the lateral area presented the thickest soft tissue whereas the sutural area had the thinnest soft tissue (p < 0.001). Conclusions: Clinical selection of the placement sites of TADs should be guided by knowledge of the positional variations in the palatal soft tissue thickness in addition to other contributing factors of TAD stability.

• Journal of Korean Foot and Ankle Society
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• v.15 no.1
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• pp.7-12
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• 2011

Purpose: To evaluate the incidence and risk factors of ipsilateral reamputation after lower limb amputation in the patient with diabetic foot lesions. Materials and Methods: Between May 2005 and June 2009, 88 patients who underwent lower limb amputation were analyzed. Group 1 consisted of 73 patients who didn't have a ipsilateral reamputation after lower limb amputation and group 2 consisted of 15 patients who underwent reamputation. We compared several factors between two groups, such as age, gender, BMI, ABI, Wagner classification, wound culture, site of amputation, vascular surgery, the period of diabetes mellitus, chronic renal failure. Results: Fifteen (17%) of 88 patients had a ipsilateral limb reamputation and 13 patients (87%) of them underwent reamputation within 6 months. When we compared the two groups, average age was 59.3 (range, 48-74 years); 62.9(range, 44-78 years). Age was significantly associated with reamputation rate (p=0.02) and no reamputation after initial amputation above ankle joint was found. Other factors did not show statistically difference between both groups. Conclusion: There were no significant difference between diabetic limb amputation and reamputation group in our concerned risk factors except age and amputation level. There should be careful consideration when determine level of amputation in diabetic foot lesions especially in elder patients.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.28 no.4
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• pp.310-317
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• 2002

We have examined 20 tongue-tie patients who had been operated the lingual frenectomy in Dept. of Oral & Maxillofacial surgery, Pusan National University for the effect of the lingual frenectomy on the tongue motion and speech, and divided patients into groups by age. Each group was separated as follows ; the age of 5-6, 7-9, 10-12, 13-15, and 16-18. We measured the frenal lengh, the range of tongue motion and evaluated the speech pre- and postoperatively. The preoperative patient groups have larger tongue tips and smaller lingual frenums than normal ones. In the preoperative patient group, there was significant obstacle of the protrusive and superior movement of the tongue. The exception was the laterotrusive movement on both sides. There was the lower value of the Picture Consonant Articulation Test(PCAT) in the preoperative 5 to 6 year-old group compared with normal group. In other age groups, there was no significant difference. The range of postoperative PCAT in all age groups has become as similiar as that of normal group. The 5 to 6 year-old group which had significant difference in PCAT was improved in PCAT. In conclusion, we propose that the PCAT as well as anatomical tongue size and functional tongue movement is the basis of the indication of lingual frenectomy and the 5-6 year-old is the optimal time of the lingual frenectomy for improvement of the tongue movement and the speech.

• The Korean Journal of Community Living Science
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• v.15 no.2
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• pp.55-64
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• 2004

The purpose of this study was to examine the differences in skin temperature and thermal comfort of participants in a $19^\circ{C}$ room (the recommended room temperature in the winter) depending on age, sex and clothing weight. Subjects were divided into four groups (6 young males, 5 young females, 6 old males, 6 old females) and experimental trials consisted of three conditions: wearing underwear in a $19^\circ{C}$ room (19CUW), without underwear in a $19^\circ{C}$ room (19C), and without underwear in a $24^\circ{C}$ room (24C). The results indicated the following: 1) There were no significant differences in mean skin temperature based on age or sex, and the mean skin temperatures of the four groups were in the range of 32.4∼$34.0^\circ{C}$. 2) In the 19C condition, the skin temperatures of the hands and feet of old females were higher than those of the other three groups. 3) In terms of perceived thermal comfort, young females showed a tendency to feel the most uncomfortable. Both old and young groups agreed that the 24C condition was the most comfortable. 4) Relational coefficients between thermal comfort and skin temperatures were higher in the young group than in the old group. Furthermore, the perceived thermal comfort had a stronger relationship with mean skin temperatures than with local skin temperatures. 5) The mean skin temperatures of subjects who indicated they were 'comfortable' were in the range of 31∼$36^\circ{C}$ regardless of age or sex.

• Journal of forensic and investigative science
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• v.3 no.1
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• pp.50-59
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• 2008

The purpose of this study was to figure out clinical characteristics in young and adult acute myocardial infarction patients come to emergency room. One hundred fifty four acute myocardial infarction cases were collected and analized from January 2003 to April 2006, especially focused on below the age 50. The results of the study were summarized as follows. The results were proportion up disease occur to women disease rate as men after 50 age and acute myocardial infarction occur to spring and winter most of all. Research for this patients coronary artery condition in cardiac angiography room and coronary artery condition is left anterior descending portion was obstruction and stenosis most of all at that time in emergency room. HDL-cholesterol was not normal range of this patients. About 57.9% patients downward normal range but total cholesterol was very variant condition. Investigated chest X-ray of this patients and result in upward 75% patients was C-T ratio 50% upward condition. And it was shown result from this patients 94. 7% was obesity condition and family history showed mother or father got hypertension or diabete mellitus patients but 42. 7% patients not family history. This patients not going to direct emergency room after via local medical center result in badly condition up. Have got outcomes of youth and adults age patient of acute myocardial infarction come to emergency room. Government and administration have to support advertising this results about acute myocardial infarction condition of nation people. We need to preservation and preventing this disease but if this disease occurrence, to the utmost directly and speedly emergency room for fast therapy.

• Clinical and Experimental Pediatrics
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• v.58 no.3
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• pp.102-107
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• 2015

Purpose: Human parechovirus (HPeV) and enterovirus (EV) are causative agents of a sepsis-like illness in neonates and of infections of the central nervous system in young children. The objectives of this study were to assess the prevalence of HPeV3 and EV infection in young children with a sepsis-like illness or with meningitis in Jinju, Korea. Methods: Cerebrospinal fluid (CSF) samples were collected from 267 patients (age range, 1 day to 5 years) and assessed for HPeV and EV by performing reverse transcription polymerase chain reaction assay. Amplification products of the VP3/VP1 region of HPeV and of the VP1 region of EV were sequenced to identify the virus type. Results: HPeV and EV were detected in 3.4% and 7.5% of the total CSF samples assessed, respectively. The age distribution of EV-positive patients (median age, 1.4 months) had a significantly broader range than that of HPeV-positive patients (median age, 7.8 months). The peak seasons for HPeV and EV infection were spring and summer, respectively. The clinical symptoms for HPeV and EV infection were similar, and fever was the most common symptom. Pleocytosis was detected in 22.2% of HPeV-positive patients and 35.5% of EV-positive patients. The VP3/VP1 gene sequence of the nine Korean strains clustered most closely with the Japanese strain (AB759202). Conclusion: The data indicate that HPeV infection is predominant in young infants (<6 months) and that meningitis without pleocytosis was caused by both HPeV and EV infection in children.

• Journal of Preventive Medicine and Public Health
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• v.53 no.5
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• pp.371-380
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• 2020

Objectives: This study investigated the effects of socio-demographic factors on the decreasing trend in the sex ratio at birth from 1997 to 2017 in Korea. Methods: Data from 10 349 602 live births registered with Statistics Korea from 1997 to 2017 were analyzed. The secondary sex ratio (SSR), defined as the ratio of male to female live births, during the study period (1997-1999 [phase I], 2000-2002 [phase II], 2003-2005 [phase III], 2006-2008 [phase IV], 2009-2011 [phase V], 2012-2014 [phase VI], and 2015-2017 [phase VII]) was calculated according to selected socio-demographic factors, such as parental age, education, occupation, and birth order. Logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals for a male birth after adjusting for potential confounders. Results: The SSR gradually decreased from 1.10 (in 1998-2000 and 2002) to 1.05 (in 2013-2016). While a decreasing trend in the SSR was not noted among first births, male-biased sex ratios were prominent among third and higher-order births, for which the highest SSR was 1.46 in 1998. Higher birth order was significantly associated with an excess of male births in phases I-VI (≥third vs. first, OR range, 1.03 to 1.35). Advanced maternal age was significantly associated with an excess of female births in phases II, III, and V (≥40 vs. 20-24 years, OR range, 0.92 to 0.95). Conclusions: This study demonstrated that advanced maternal age and reduction of the artificially-biased SSR among third and higher-order births may partially explain the decreasing trend in the SSR from 1997 to 2017 in Korea.

• Journal of The Korean Society of Integrative Medicine
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• v.2 no.1
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• pp.51-62
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• 2014

Purpose : The purpose of this work was to ascertain the effects of cervical traction on the pain, the range of motion and the quality of sleep of the older women with the tension headache. Method : 25 subjects between ages 66 and 82 who agreed on this experiment and diagnosed with tension headache participated in this study. All subjects were treated with air-pressure cervical traction while 20 minutes a day, 3 times per week, for 4 weeks. The effects of air-pressure cervical traction were evaluated by PSQI(Pittsburgh sleep quality index), a pain last a day, VAS, and four ROMs. In order to investigate the effect of age on the treatment, subjects were divided into two groups, of less and of over than age 75. The measured data were analyzed by using one-way repeated ANOVA and two-way repeated ANOVA. Result : 1) The group of less than age 75 showed the significant improvements in all measurement variables, PSQI, a pain last a day, VAS and four ROMs. 2) The group of over than age 75 showed the significant improvements in all measurement variables excluding the flexion ROM of cervical. 3) No significant differences between two groups were showed in all measurement variables, but the interaction effect between group and period was significant in only VAS. Conclusion : From the results of this study, a cervical traction intervention using an air-pressure cervical traction proved to be effective on the reduction of tension headache and the improvement of the quality of sleep.

• Journal of Korean Society of Forest Science
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• v.22 no.1
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• pp.67-70
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• 1974

Experiments were carried out to find the difference of resin canal numbers by tree age and topophysis of crown of black pine needles, and the results were summarized as follows. 1. The average numbers of resin canal by tree age were increased from the age of 5 years were not difference between 10 and thereafter years significantly. 2. In this observation, the range of resin canal number was 2 to 9. 3. The numbers by the topophysis of crown did not show significant differences but the individual trees showed significant variations in the canal number in younger trees.