• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2002.11a
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• pp.196-196
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• 2002

• Proceedings of the Korean Society of Toxicology Conference
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• 2002.11b
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• pp.196-196
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• 2002

p16INK4a tumor suppressor gene transfer in the non-small cell lung cancer cells by transduction of recombinant adenovirus (Ad5CMV-p16) resulted in significant inhibition of cancer cell growth (Anticancer Res., 1998, 18:3257-3261). As a safety concern, we have investigated gene and protein expression after transduction of adenoviral vector (Ad5CMV-p16) in human non-small cell lung cancer (A549) cells by using microarray and 2D gel electrophoresis/ MALDI-TOF.(omitted)

• Nuclear Engineering and Technology
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• v.43 no.2
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• pp.187-194
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• 2011

Korea Nuclear Fuel is developing the X-GEN fuel which shows high performance and robust reliability for the worldwide supply. However, the simplified code systems such as CESEC-III which were developed in 1970s are still used in the current Non-LOCA safety analysis of OPR1000 and APR1400 plants. Therefore, it is essential to secure an advanced safety analysis methodology to make the best use of the merits of X-GEN fuel. To accomplish this purpose, the $\b{i}$ntegrated $\b{s}$afety $\b{a}$nalysis $\b{m}$ethodology (iSAM), is developed by selecting the best-estimate thermal-hydraulic code RETRAN. iSAM possesses remarkable advantages, such as generality, integrity, and designer-friendly features. That is, iSAM can be applied to both OPR1000 and APR1400 plants and uses only one computer code, RETRAN, in the whole scope of the non-LOCA safety analyses. Also the iSAM adopts the unique and automatic initialization and run tool, $\b{a}$utomatic $\b{s}$teady-$\b{s}$tate $\b{i}$nitialization and $\b{s}$afety analysis too l (ASSIST), to enable unhandy designers to use the new design code RETRAN without difficulty. In this paper, a brief overview of the iSAM is given, and the results of applying the iSAM to typical non-LOCA transients being checked during the reload design are reported. The typical non-LOCA transients selected are the single control element assembly withdrawal (SCEAW) accident, the asymmetric steam generator transients (ASGT), the locked rotor (LR) accident, and bank CEA withdrawal (BCEAW) event. Comparison to current licensing results shows a close resemblance; thus, it reveals that the iSAM can be applied to the non-LOCA safety analysis of OPR1000 and APR1400 plants.

• Journal of Radiation Protection and Research
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• v.37 no.3
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• pp.108-115
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• 2012

The Urban Areas Working Group within the EMRAS-2 ($\underline{E}$nvironmental $\underline{M}$odelling for $\underline{RA}$diation $\underline{S}$afety, Phase 2), which has been supported by the IAEA (International Atomic Energy Agency), has designed some types of accidental scenarios to test and improve the capabilities of models used for evaluation of radioactive contamination in urban areas. For the comparison of the results predicted from the different models, the absorbed doses in air were analyzed as a function of time following the accident with consideration of countermeasures to be taken. Two kinds of considerations were performed to find the dependency of the predicted results. One is the 'accidental season', i.e. summer and winter, in which an event of radioactive contamination takes place in a specified urban area. Likewise, the 'rainfall intensity' on the day of an event was also considered with the option of 1) no rain, 2) light rain, and 3) heavy rain. The results predicted using a domestic model of METRO-K have been submitted to the Urban Areas Working Group for the intercomparison with those of other models. In this study, as a part of these results using METRO-K, the countermeasures effectiveness in terms of dose reduction was analyzed and presented for the ground floor of a 24-story business building in a specified urban area. As a result, it was found that the countermeasures effectiveness is distinctly dependent on the rainfall intensity on the day of an event, and season when an event takes place. It is related to the different deposition amount of the radionuclides to the surfaces and different behavior on the surfaces following a deposition, and different effectiveness from countermeasures. In conclusion, a selection of appropriate countermeasures with consideration of various environmental conditions may be important to minimize and optimize the socio-economic costs as well as radiation-induced health detriments.

• Journal of Food Hygiene and Safety
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• v.33 no.4
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• pp.296-305
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• 2018

Spiroxamine, one of fungicides, is used to control powdery mildew in various crops and black yellow sigatoka in bananas. The major strength of spiroxamine is to control powdery mildew in various crops and bananas yellow sigatoka in bananas. The compound has shown a high level of activity, good persistence and crop tolerance. Besides powdery mildew, good control of rust, net blotch and Rhynchosporium diseases been indicated in cereals, together with a complementary activity against Septoria diseases. In 2017, the maximum residue limit (MRL) of spiroxamine established in Korea. According to Ministry of ood and rug afety) regulations, spiroxamine residues defined only parent compound. Thus, a analytical method is needed to estimate the residue level of the parent compound. The objective of this study was to develop and validate analytical method for spiroxamine in representative agricultural commodities. Samples were extracted with acetonitrile and partitioned with dichloromethane to remove the interfering substances. The analyte were quantified and confirmed liquid chromatograph-tandem mass spectrometer (LC-MS/MS) in positive-ion mode using multiple reaction monitoring (MRM). Matrix matched calibration curves were linear over the calibration ranges ($0.0005{\sim}0.1{\mu}g/mL$) for the analyte in blank extract with coefficient of determination ($r^2$) > 0.99. For validation purposes, recovery studies will be carried out at three different concentration levels (LOQ, 10LOQ, and 50LOQ) performing five replicates at each level. The recoveries 70.6~104.6% with relative standard deviations (RSDs) less than 10%. All values were consistent with the criteria ranges in the Codex guidelines (CAC/GL40, 2003) and MFDS guidelines. proposed analytical method be used as an official analytical method in the Republic of Korea.