• Natural Product Sciences
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• 제15권4호
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• pp.192-197
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• 2009

Chemical investigation of the aerial parts of Artemisia iwayomogi has afforded five glycoside compounds. Their chemical structures were characterized by spectroscopic methods to be turpinionoside A (1), (Z)-3-hexenyl O-${\alpha}$-arabinopyranosyl-(1${\rightarrow}$6)-O-${\beta}$-D-glucopyranoside (2), (Z)-5'-hydroxyjasmone 5'-O-${\beta}$-Dglucopyranoside (3), (-)-syringaresinol-4-O-${\beta}$-D-glucopyranoside (4), and methyl 3,5-di-O-caffeoyl quinate (5). All of them were isolated for the first time from Artemisia species. The effect of compounds 1 - 5 on the function of osteoblastic MC3T3-E1 cells was examined by checking the cell viability, alkaline phosphatase (ALP) activity, collagen synthesis, and mineralization. Turpinionoside A (1) significantly increased the function of osteoblastic MC3T3-E1 cells. Cell viability, ALP activity, collagen synthesis, and mineralization were increased up to 117.2% (2 ${\mu}M$), 110.7% (0.4 ${\mu}M$), 156.0% (0.4 ${\mu}M$), and 143.0 % (2 ${\mu}M$), respectively.

• Natural Product Sciences
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• 제15권4호
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• pp.234-240
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• 2009

Phytochemical investigation of the MeOH extract of the aerial parts of Bistorta manshuriensis resulted in the isolation of two cerebrosides, two lactams, six phenolic compounds and seven flavonoids. Their chemical structures were characterized by spectroscopic methods to be pinelloside (1), soyacerebroside I (2), pterolactam (3), 5-hydroxypyrrolidine-2-one (4), vanillic acid (5), caffeic acid methyl ester (6), protocatechuic acid (7), caffeic acid (8), 3,5-di-O-caffeoyl quinic acid methyl ester (9), chlorogenic acid methyl ester (10), avicularin (11), afzelin (12), quercetin (13), isoorientin (14), quercetin 3-O-${\beta}$-D-glucoside (15), quercitrin (16), and luteolin (17). The isolated compounds (1 - 4, 7, 12, 14) were isolated for the first time from this plant source and the compounds 1 - 4, 9 and 10 were first reported from the genus Bistorta. Compound 17 exhibited moderate cytotoxicity and compound 6 exhibited weak cytotoxicity against four human cancer cell lines in vitro using an SRB bioassay.

• 약학회지
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• 제49권4호
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• pp.312-316
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• 2005

To develop a new natural antibiotics from Koran plant resources for dealing with the current situation regarding the rapid increase in antibiotic-resistant pathogen, the in vitro inhibitory activities of essential oils from the young leaves of Glehnia littoralis (Umbelliferae) as well as its main constituents were evaluated against susceptible and resistant species of Streptococcus pneumoniae. The essential oil fraction of G. littoralis and its main components, $\alpha-and\;\beta-pinene$, exhibited significant inhibitory activities against the antibiotic-susceptible and resistant strains of S. pneumoniae, with MICs (minimum inhibiting concentrations) ranging from 4.0mg/ml to 16mg/ml. No remarkable differences were shown between the susceptible and resistant strains. Moreover, the disk diffusion test disclosed that these inhibitory activities were dose­dependent. Furthermore, data from the checkerboard titer test with FICIs (fractional inhibiting concentration indices) from 0.15 to 0.28 indicated synergisms between norfloxacin and $\alpha-or\;{\beta}-pinene$ in activity against S. pneumoniae KCCM49629 and S. pneumoniae CCARM4059.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2006년도 Proceedings of ISRS 2006 PORSEC Volume II
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• pp.977-980
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• 2006

Ships and industries damage the delicate coastal ecosystem in many parts of the world by releasing oil or pollutants into rivers, coastal and offshore waters. After a tanker accident the biggest problem is to get a clear idea of the extent of the oil slick and predict the way it will move. For natural and man-made oil spills it is necessary to operate a regular and operational monitoring. In the Mediterranean, North and Baltic seas aircrafts or ships normally carry it out. This is expensive and is constrained by the limited availability of these resources, borders between countries, daylight hours, good weather conditions, etc. Satellite imagery can help greatly identifying probable spills over large areas and then guiding aerial surveys for precise observation of specific locations. The Synthetic Aperture Radar (SAR) instrument, which can collect data almost independently of weather and light conditions, is an excellent tool to monitor and detect oil on water surfaces. SAR is currently on board the ENVISAT, ERS-2 and RADARSAT satellites. The application of this technology to the investigation of oil pollution in the Caspian, Black, Mediterranean, North and Baltic seas is shown.

• 한국약용작물학회지
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• 제3권2호
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• pp.81-83
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• 1995

토양수분함량의 차이가 쥐오줌풀의 지하부생육 및 뿌리의 엑스함량에 미치는 영향을 조사하기 위하여 광룽쥐오줌풀 (Valeriana jauriei var. dasycarpa HARA)을 사용하여 토양수분을 최대용수량의 30, 45, 55, 70, 70 및 90%로 조절하여 pot시험으로 수행하였던 바 얻어진 결과는 다음과 같다. 1. 엽장 및 엽폭은 토양수분함량이 증가 할수록 미미한 증가를 보였으나 엽병장 및 근장은 80%까지 토양수분함량이 증가할수록 직선적인 증가를 보였다. 2. 토양수분함량과 근수량 및 근의 엑스함량간에는 고도의 정의 상관이 인정되었다. 3. 쥐오줌풀의 생육의 최적수분함량은 최대용 수량의 $80{\sim}90%$ 였다.

• Advances in Traditional Medicine
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• 제6권4호
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• pp.330-335
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• 2006

The present investigation was carried out to determine the efficacy and safety of Abutilon indicum (A. indicum) (Eng: Country Mallow, Fam: Malvaceae) in patients of bronchial asthma. Dried aerial parts of A. indicum were finely powdered and given in the dose of 1 gm tid to 30 patients of either sex in the range of 15 - 80 years with mild to moderate bronchial asthma with or without any concurrent medication. The respiratory functions (FVC, $FEV_{1}$, $FEF_{25-75%}$and MVV) were assessed using a spirometer prior to and after 4 weeks of treatment. Efficacy of the drug in improving clinical symptoms and severity of asthmatic attacks was evaluated by interviewing the patient and by physical and hematological examination at the end of the treatment. 4 weeks treatment with the drug showed statistically significant improvement in various parameters of pulmonary functions in asthmatic subjects. Also significant improvement was observed in clinical symptoms and severity of asthmatic attacks. None of the patient showed any adverse effect with A. indicum. The results of the present study suggest the usefulness of A. indicum in patients with mild to moderate bronchial asthma.

• 한국한의학연구원논문집
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• 제10권1호
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• pp.119-126
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• 2004

For the purpose of developing new anti-HIV agents from natural sources, the extracts of Solanum nigrum L. were tested for their inhibitory effects on HIV-1 replication and its essential enzymes as the reverse transcriptase (RT), protease and ${\alpha}$-glucosidase. In the assay of HIV-1-infected human T-cell line, water extracts inhibited the HIV- 1 -induced cytopathic effects with IC (inhibitory concentration) of 100 ug/ml. Moreover water extracts (100ug/ml) of aerial parts showed strong activity of 32.6% on anti-HIV-1 PR using the activity of the enzyme to cleave an oligopeptide. In the HIV-1 reverse transcriptase inhibition assay, aqueous extract a inhibited 17.4%, but no glucosidase inhibitory activities. We found out this result, for these samples it is possible that the inhibition of the viral replication in vitro is due to the inhibition at least one of PR and RT. It would be of great interest to identify the compounds which are responsible for this inhibition, since all therapeutically useful agent up to date are PR, RT and ${\alpha}$-glucosidase inhibitors.

• 생약학회지
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• 제33권2호통권129호
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• pp.81-84
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• 2002

Three norisoprenoids (2, 4 and 5) were isolated from the aerial parts of Cirsium rhinoceros (Compositae) together with three flavonoids, pectolinarigenin (1), apigenin (3) and cirsimaritin (6). The structures of norisoprenoids were identified as dehydrovomifoliol (2), (+)-loliolide (4) and (-)-epiloliolide (5) on the basis of physico-chemical and spectral evidences. These norisoprenoids were first repoted from Cirsium species.

• Natural Product Sciences
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• 제26권2호
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• pp.151-157
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• 2020

Extensive column chromatography separation of the MeOH extract from the aerial parts of Phyllanthus urinaria afforded seventeen compounds (1 - 17). The structures of the compounds were elucidated by physicochemical and spectroscopic methods to be 5'-β-D-glucopyranosyloxyjasmonic butyl ester (1), (+)-cucurbic acid (2), dendranthemoside B (3), boscialin 4'-O-β-D-glucoside (4), 4,5-dihydroblumenol A (5), (6R,9R)-megastigman-4-ene-9,13-diol (6), (3S,5R,6S,9R)-3,6-dihydroxy-5,6-dihydro-β-ionol (7), (6S,9R)-roseoside (8), mallophenol B (9), icariside B₅ (10), corchoinoside B (11), canangaionoside (12), 5,6-epoxy-3-hydroxy-7-megastigmen-9-one (13), icariside B₂ (14), (7E)-2β,3β-dihydroxy-megastigm-7-en-9-one (15), betulalbuside A (16), and loliolide (17). The compounds 1, and 3 - 16 were isolated for the first time from this plant. The absolute stereochemistry of compound 1 was newly determined. The isolated compounds were tested for cytotoxic activity against four human tumor cell lines in vitro using a Sulforhodamin B bioassay, but all the compounds showed weak cytotoxic activities.

• 한국소음진동공학회논문집
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• 제16권9호
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• pp.926-936
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• 2006

In this study, structural vibration analyses of a smart unmanned aerial vehicle (UAV) have been conducted considering dynamic loads generated by rotating rotor and wakes. The present UAV (TR-S5-03) finite element model is constructed as a full three-dimensional configuration with different fuel conditions and tilting angles for helicopter, transition and airplane flight modes. Practical computational procedure for modal transient response analysis (MTRA) is established using general purpose finite element method (FEM) and computational fluid dynamics (CFD) technique. The dynamic loads generated by rotating blades in the transient and forward flight conditions are calculated by unsteady CFD technique with sliding mesh concept. As the results of present study, transient structural displacements and accelerations are presented in detail. In addition, vibration characteristics of structural parts and installed equipments are investigated for different fuel conditions and tilting angles.