• 제목/요약/키워드: adverse reaction

검색결과 386건 처리시간 0.031초

Cases of Adverse Drug Reaction Monitoring

  • Park, Kyoung-Ho;Son, In-Ja;Park, Byung-Joo
    • 대한약학회:학술대회논문집
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    • 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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    • pp.432-432
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    • 2002
  • Drug used in hospital is allowed marketing through after pharmacological and toxicological tests using various animals and clinical test of human in developing state. But as pre-marketing clinical study take short period with relatively a few of patients and strict selection criteria of people, pediatric, geriatric. pregnancy, liver and kidney patients may be excluded. As the safety of drug isn't completely evaluated before launching. it is important to collect and evaluate drug adverse reaction newly reported by medical practitioners and pharmacists. (omitted)

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증류한약과 상담치료로 호전된 불면증 치험 1례 (A case of distillation Herbal medicine and Counseling on insomnia)

  • 심상민;김태수;고영탁
    • 동의신경정신과학회지
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    • 제17권2호
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    • pp.217-225
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    • 2006
  • The Purpose of this study was to investigate the clinical application of distillation Herbal medicine and Counseling Treatment to the insomnia In this case, a female patient, 40 years old, who had an adverse reaction of a Herbal medicine, complained of insomnia. We treated the patient with distillation Herbal medicine and Counseling. we diagnosed her state Rhosangsimbi(勞傷心脾), so we prescribed distillation Gagamguibi-tang(加減歸脾湯) for patient. In result, the patient's hours of sleep was increased to 6 hours from 1 hour. Conclusionally, Distillation Herbal medicine and Counseling Treatment Could be Effective method to treat the patient of insomnia with an adverse reaction of a Herbal medicine.

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Toxic epidermal necrolysis induced by lamotrigine treatment in a child

  • Yi, Youngsuk;Lee, Jeong Ho;Suh, Eun Sook
    • Clinical and Experimental Pediatrics
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    • 제57권3호
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    • pp.153-156
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    • 2014
  • Toxic epidermal necrolysis is an unpredictable and severe adverse drug reaction. In toxic epidermal necrolysis, epidermal damage appears to result from keratinocyte apoptosis. This condition is triggered by many factors, principally drugs such as antiepileptic medications, antibiotics (particularly sulfonamide), nonsteroidal anti-inflammatory drugs, allopurinol, and nevirapine. Lamotrigine has been reported potentially cause serious cutaneous reactions, and concomitant use of valproic acid with lamotrigine significantly increases this risk. We describe a case of an 11-year-old girl with tic and major depressive disorders who developed toxic epidermal necrolysis after treatment with lamotrigine, and who was diagnosed both clinically and pathologically. Children are more susceptible to lamotrigine-induced rash than adults, and risk of serious rash can be lessened by strict adherence to dosing guidelines. Unfortunately, in our case, the patient was administered a higher dose than the required regimen. Therefore, clinicians should strictly adhere to the dose regimen when using lamotrigine, especially in children.

GINSENG USE AMONG TWO GROUPS IN THE UNITED STATES

  • Siegel Ronald K.
    • 고려인삼학회:학술대회논문집
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    • 고려인삼학회 1980년도 학술대회지
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    • pp.229-236
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    • 1980
  • Tow groups of subjects were studied before, during, and after long-term use of commercial Panax ginseng preparations. Group A (n = 10) consisted of users who also used other psychomotor stimulants including caffeine, while subjects in Group B (n = 8) used no drugs other than ginseng. During 12 weeks of regular ginseng use, users in Group A showed signs of central nervous system stimulation and reported feelings of well-being. Two subjects manifested possible allergic reactions while one developed a ginseng abuse syndrome marked by hypertension, nervousness, sleeplessness, skin eruptions, edema, and morning diarrhea. This syndrome was associated with excessive dosages, concomitant intake of caffeine, and possible allergic reactions. Subjects in Group B reported stimulation and feelings of well-being while showing some signs of nervousness. One subject developed a possible contact urticarial reaction to a ginseng cosmetic. All adverse reaction were transient and disappeared when ginseng use was discontinued. It is suggested that adverse reactions can be prevented by moderate use of standardized ginseng preparations while restricting use of other psychomotor stimulants.

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Drug eruption by antihistamine mistaken for chronic urticaria in a child

  • Lee, Gun Moo;Chu, Shou-Yu;Kang, Sung Yeon;Kim, Hyo-Bin;Park, Jin-Sung;Kim, Ja Kyoung
    • Clinical and Experimental Pediatrics
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    • 제62권2호
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    • pp.75-78
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    • 2019
  • Although rare, antihistamines can cause adverse effects, including drug-induced eruptions or anaphylaxis. A 4-year-old child visited the pediatric department of a hospital for skin eruptions after administration of antihistamines, (e.g., ucerax [hydroxyzine] or leptizine [levocetirizine]), for cholinergic rashes; he did not have pruritus. Skin prick, intradermal, and drug provocation tests were performed to determine the relationship between the antihistamines and eruptions. Levocetirizine induced wheals in the skin prick test and a rash in the oral drug provocation test. In contrast, ketotifen induced no reaction in the skin prick test but showed a positive reaction in the oral provocation test. Our case report highlights that children can experience the same types of adverse reactions as seen in adults, and cross-reactivity between various antihistamines can occur.

Simultaneous hypersensitivity reactions to trimethoprim-sulfamethoxazole and amoxicillin-clavulanate in a dog

  • Yunho Jeong ;Yoon-Hwan Kim ;Jin-Ok Ahn;Jin-Young Chung
    • Journal of Veterinary Science
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    • 제24권6호
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    • pp.77.1-77.7
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    • 2023
  • Antibiotics are known to be able to cause hypersensitivity reactions through various mechanisms. We present a case of drug-induced immune thrombocytopenia (DITP) and anaphylactic shock occurring simultaneously in a dog after the administration of two classes of antibiotics, namely trimethoprim-sulfamethoxazole (TMP-SMX) and amoxicillin-clavulanate (AMC). The patient recovered completely from DITP on discontinuation of TMP-SMX and the anaphylactic shock caused by AMC was treated with intensive care. DITP is a rare adverse drug reaction (ADR), and anaphylactic shock is a life-threatening ADR. This is the first case report of a dog manifesting two types of hypersensitivity reactions caused by two antibiotics.

Anaphylactic Shock Caused by the Epidurally-Administered Hyalurinidase

  • Lee, Hae-Kwang;Choi, Eun-Joo;Lee, Pyung-Bok;Nahm, Francis Sahngun
    • The Korean Journal of Pain
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    • 제24권4호
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    • pp.221-225
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    • 2011
  • Hyaluronidase is an enzyme that has temporary and reversible enzymatic effects on the matrix of connective tissue. When added to local anesthetics in pain treatments, it enhances their infiltration and dispersal into tissues. It is widely used in anesthesia for ocular, dental, and plastic surgery. Reports of drug hypersensitivity to hyaluronidase are rare and are usually confined to peribulbar or retrobulbar anesthesia during ophthalmic surgery. However, few reports exist on adverse drug reaction after epidural injection. We have observed two patients experiencing anaphylactic shock caused by hyaluronidase following epidural injection. Most of the patients with a hypersensitivity to hyaluronidase had one previous uneventful injection containing hyaluronidase, implying that sensitization had taken place. However, hypersensitivity occurring at the first administration is possible. A positive skin test can help establish the diagnosis. Although rare, the possibility of an allergic reaction to hyaluronidase should be considered even in patients with no known previous exposure.

조영제로 유발된 약진(藥疹)환자 치험 1례 (A Clinical Case Report of Contrast-induced drug eruption patient Treated with Traditional Oriental Medicine)

  • 정의민;정종수;윤성우;박재우
    • 대한암한의학회지
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    • 제12권1호
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    • pp.75-82
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    • 2007
  • Drug eruption is a cutaneous reaction caused by various drugs. It is a very common drug induced adverse reaction. Contrast media induced drug eruption is rare. But approximately 10% of people injected with contrast media experience adverse reaction, and drug eruption accounts for more than 40% of all adverse reactions. We report a case of mild drug eruption and its treatment process based on korean traditional medicine. The patient is a 50 years old female diagnosed with functional dyspepsia. The patient had gastric discomfort and alternation between diarrhea and constipation. All symptoms showed nearly complete remission with continued korean traditional medical treatment. The patient had been injected with contrast media for Computed tomography(CT) evaluation of her breast cancer history. Rashes appeared on back and abdomen, and urticaria and pruritus appeared on the patient's finger 1 day after injection. We prescribed Goreisan(TSUMURA CO &, TJ-17) and acupuncture on Quchi(LI11), Zusanli(ST36), Yangxi(LI5), Yanggu(SI5). Consequently, the drug eruption showed remarkable improvement. So the author reports korean traditional medicine is effective complementary treatment for drug eruption.

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완화의료병동 암환자들의 섬망 치료를 위해 사용된 항정신병 약물의 효과 및 안전성 비교 (Efficacy and Safety of Antipsychotics for Delirium Treatment in Cancer Patients Receiving Palliative Care)

  • 오솔;금민정;김재송;손은선;유윤미
    • 한국임상약학회지
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    • 제30권2호
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    • pp.92-101
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    • 2020
  • Background: Delirium is a neuropsychiatric disorder characterized by sudden impairments in consciousness, attention, and perception. The evidence of successful pharmacological interventions for delirium is limited, and medication recommendations for managing delirium are not standardized. This study aimed to provide evidence of antipsychotics for symptomatic treatment of delirium in cancer patients receiving palliative care. Methods: We retrospectively reviewed adult cancer patients in palliative care who received antipsychotic delirium treatment at Severance Hospital between January 2016 and June 2019. The efficacy was evaluated primarily by resolution rates. The resolution of delirium was defined as neurological changes from drowsiness, confusion, stupor, sedation, or agitation to alertness or significant symptomatic improvements described in the medical records. The safety was studied primarily by adverse drug reaction incidence ratios. Results: Of the 63 enrolled patients, 60 patients were included in the statistical analysis and were divided into three groups based on which antipsychotic medication they were prescribed [quetiapine (n=27), haloperidol (n=25) and co-administration of quetiapine and haloperidol (n=8)]. The resolution ratio showed quetiapine to be more effective than haloperidol (p=0.001). No significant differences were seen in adverse drug reaction rates among the three groups (p=0.332). Conclusions: Quetiapine was considered the most effective medication for delirium, with no significant differences in adverse drug reaction rates. Therefore, quetiapine may be considered a first-line medication for treating delirium in cancer patients receiving palliative care. However, further studies comparing more diverse antipsychotics among larger populations are still needed.

구입경로가 다른 두 종류의 육미지황탕을 투여한 흰쥐의 혈액분석연구 (Serum Biochemical Analysis of Rats Administered with Two Types of Yugmijihwangtang Obtained in Different Ways)

  • 전성진;이선동;박해모;최종환;이현우
    • 대한예방한의학회지
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    • 제9권2호
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    • pp.107-123
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    • 2005
  • Traditional herbal medicine is widely used among the Korean people, and other eastern Asian countries employ similar therapies as well. In recent years, due to increasing interest in herbal medicine, many researches have been made on the toxicity and adverse drug reactions of herbal medications. Through private and public media, there have been many opinions that taking herbal medicine is very harmful, especially, to liver and kidney. We face upon evaluation of herbal medication, safe, and efficacy. Furthermore, we need to control quality of herbs. This study aims to verify the evidence that taking herbal medicine will yield equal reaction in 2 lab animal groups (A and B). One frequently prescribed herbal medication, Yugmijihwangtang, was used to test the evaluation of quality on lab animals (SD-Rat). There were no significant differences in body, visceral weight, and serum analysis test results after herbal medication for 1 month. But, AST and ALT scores were raised in 2 subjects in group A (over reference range). It seems to be an adverse drug reaction, and this finding was restricted in group A herbal medicine. These results suggest that we need to qualify herbal plants in Korea, and study which herbs would cause specific reactions in human.

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