• Biomolecules & Therapeutics
• /
• v.6 no.2
• /
• pp.171-181
• /
• 1998

DA-3585, a biosynthetic recombinant human erythropoietin has been developed as a treatment for anemia associated with chronic renal failure in Dong-A pharmaceutical Co. Ltd. This study was carried out to assess its acute and subacute toxicities in rabbits. DA-3585 was intravenously administered to rabbits at dose levels of 6250, 12500 or 25000 lU/kg for single dose toxicity study and at dose levels of 100, 500 or 2500 lU/kg/day for 4-week repeated dose toxicity study. In the acute toxicity study, dose up to 25000 lU/kg had no adverse effect on the behavior or body weight gain. Pathological examinations revealed no abnormal gross lesions related to DA-3585. In the subacute toxicity study, all animals survived until termination of treatment. DA-3585 had no influence on clinical signs, food and water intake or on body weight changes. Hematological examination showed increases in the number of RBC, hemoglobin contents and hematocrit values with a dose dependent manner in the animals treated with DA-3585. Histopathological examination revealed erythroid hyperplasia in the bone marrow and extramedullary hematopoiesis in the liver. The changes detected in the hematological and histopathological examination presumably represent exaggerated pharmacological effects of erythropoietin. The NOAEL (no-observed-adverse-effect-level) of DA-3585 was estimated to be 100 lU/kg/ day under this study condition.

• Journal of Veterinary Science
• /
• v.22 no.4
• /
• pp.54.1-54.13
• /
• 2021

Background: Hypoxia causes oxidative stress and affects cardiovascular function and the programming of cardiovascular disease. Melatonin promotes antioxidant enzymes such as superoxide dismutase, glutathione reductase, glutathione peroxidase, and catalase. Objectives: This study aims to investigate the correlation between melatonin and hypoxia induction in cardiomyocytes differentiation. Methods: Mouse embryonic stem cells (mESCs) were induced to myocardial differentiation. To demonstrate the influence of melatonin under hypoxia, mESC was pretreated with melatonin and then cultured in hypoxic condition. The cardiac beating ratio of the mESC-derived cardiomyocytes, mRNA and protein expression levels were investigated. Results: Under hypoxic condition, the mRNA expression of cardiac-lineage markers (Brachyury, Tbx20, and cTn1) and melatonin receptor (Mtnr1a) was reduced. The mRNA expression of cTn1 and the beating ratio of mESCs increased when melatonin was treated simultaneously with hypoxia, compared to when only exposed to hypoxia. Hypoxia-inducible factor (HIF)-1α protein decreased with melatonin treatment under hypoxia, and Mtnr1a mRNA expression increased. When the cells were exposed to hypoxia with melatonin treatment, the protein expressions of phospho-extracellular signal-related kinase (p-ERK) and Bcl-2-associated X proteins (Bax) decreased, however, the levels of phospho-protein kinase B (p-Akt), phosphatidylinositol 3-kinase (PI3K), B-cell lymphoma 2 (Bcl-2) proteins, and antioxidant enzymes including Cu/Zn-SOD, Mn-SOD, and catalase were increased. Competitive melatonin receptor antagonist luzindole blocked the melatonin-induced effects. Conclusions: This study demonstrates that hypoxia inhibits cardiomyocytes differentiation and melatonin partially mitigates the adverse effect of hypoxia in myocardial differentiation by regulating apoptosis and oxidative stress through the p-AKT and PI3K pathway.

• Fashion & Textile Research Journal
• /
• v.19 no.2
• /
• pp.166-179
• /
• 2017

Fashion industry have been emphasizing on eco-friendly business to enhance their public image. Due to the lack of consumers' awareness and experience of eco fashion advertising, this have resulted in adverse outcomes. Therefore, it is required to develop eco fashion advertisement that meets the public interest of Koreans. This study aims to obtain practical implications which can be applied to further eco fashion advertising. The study examines the public opinion towards eco fashion using Twitter as big data analysis and the protracted implication was provided to consumers as consumer vocabulary to see the advertising effect of consumer vocabulary. In addition, this study focuses on the environmental claim types to identify the most effective advertisement in eco fashion. The results are as follow. Associative claim types had a more positive influence on advertising attitude than substantive claim types. Substantive claim types had a more positive influence on brand cognition than associative claim types. In addition, the moderating effects of consumer vocabulary on advertising attitude and brand cognition were supported in substantive claim types. Advertisement attitude shows positive effects to both brand cognition and brand attitude. It has been proved that brand cognition leads to positive influence towards brand attitude and brand attitude eventually increases consumers' urge to buy products. This study has implication when providing a guideline for eco fashion advertisements.

• Nuclear Engineering and Technology
• /
• v.26 no.2
• /
• pp.168-178
• /
• 1994

Accident Management involves all measures to prevent core damage and retain the core within the reactor vessel, maintain containment integrity and minimize off-site releases. The accident management approach includes : (1) advanced evaluation of candidate strategies, (2) development of procedures to execute appropriate actions efficiently, and (3) identification and provision for materials, tools, and possible modifications to the plant system that may be needed for such execution. When assessing accident management strategies it effectiveness, adverse effect and its feasibility, including information needs and compatibility with existing procedures, must be considered. The objective of this paper is to introduce analytical tools of decision trees and influence diagrams to develop a framework for modeling and assessing severe accident management strategies. The characteristics associated with these took are presented. Based on decision trees and influence diagrams, the framework is applied to a simple example associated with a single decision.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.17
• /
• pp.7303-7307
• /
• 2014

Objective: To explore the clinical efficacy of gemcitabine concomitant with nedaplatin and drug resistance in the treatment of non-small cell lung cancer (NSCLC) and associated molecular predicators. Materials and Methods: A total of 68 patients diagnosed with NSCLC by histology served as the study objects and were randomly divided into an observation group treated with gemcitabine concomitant with nedaplatin and a control group with cisplatin concomitant with gemcitabine, 34 cases for each group. Short-term and long-term efficacies, adverse responses as well as the expression of nucleotide excision repair cross complementing 1 (ERCC1), ribonucleotide reductase subunit M1 (RRM1) and lung resistance-related protein (LRP) in NSCLC tissues in both groups were assessed. Results: The short-term objective response rate (ORR) and disease control rate (DCR) were 35.3% (12/34) and 76.5% (26/34) in the observation group and 38.2% (13/34) and 85.3% (29/34) in the control group, respectively, the differences not being statistically significant. The time to progression (TTP) in both groups were 1~12 months, while the median TTP was 135 d and 144 d, respectively. Though the survival was slightly higher in the control group, there were no significant differences in TTP and survival time. The rates of decreased hemoglobin, vomiting and nausea as well as renal toxicity were evidently lower in the observation group, while other adverse responses demonstrated no significant difference. The positive expression rates of ERCC1, RRM1 and LRP were 47.1% (16/34), 61.8% (21/34) and 64.7% (22/34) in the observation group, respectively. Compared with negative ERCC1 expression, ORR had decreasing trend and the overall survival time (OS) decreased significantly in patients with positive ERCC1 expression, which were markedly decreased by the positive expressions of RRM1 and LRP. Conclusions: Gemcitabine concomitant with nedaplatin has significant effects in the treatment of NSCLC, with an adverse response rate obviously lower than for cisplatin concomitant with gemcitabine, suggesting that wider use in the clinic is warranted. Additionally, the positive expressions of ERCC1, RRM1 and LRP may increase patient drug resistance, so they can be applied as the chemotherapeutic predicators to guide individualized therapy of NSCLC patients.

• Journal of Animal Science and Technology
• /
• v.65 no.1
• /
• pp.132-148
• /
• 2023

Ruminants are the main contributors to methane (CH₄), a greenhouse gas emitted by livestock, which leads to global warming. In addition, animals experience heat stress (HS) when exposed to high ambient temperatures. Organic trace minerals are commonly used to prevent the adverse effects of HS in ruminants; however, little is known about the role of these minerals in reducing enteric methane emissions. Hence, this study aimed to investigate the influence of dietary organic trace minerals on rumen fermentation characteristics, enteric methane emissions, and the composition of rumen bacteria and methanogens in heat-stressed dairy steers. Holstein (n=3) and Jersey (n=3) steers were kept separately within a 3×3 Latin square design, and the animals were exposed to HS conditions (Temperature-Humidity Index [THI], 82.79 ± 1.10). For each experiment, the treatments included a Control (Con) consisting of only basal total mixed rations (TMR), National Research Council (NRC) recommended mineral supplementation group (NM; TMR + [Se 0.1 ppm + Zn 30 ppm + Cu 10 ppm]/kg dry matter), and higher concentration of mineral supplementation group (HM; basal TMR + [Se 3.5 ppm + Zn 350 ppm + Cu 28 ppm]/kg dry matter). Higher concentrations of trace mineral supplementation had no influence on methane emissions and rumen bacterial and methanogen communities regardless of breed (p > 0.05). Holstein steers had higher ruminal pH and lower total volatile fatty acid (VFA) concentrations than Jersey steers (p < 0.05). Methane production (g/d) and yield (g/kg dry matter intake) were higher in Jersey steers than in Holstein steers (p < 0.05). The relative abundances of Methanosarcina and Methanobrevibacter olleyae were significantly higher in Holstein steers than in Jersey steers (p < 0.05). Overall, dietary organic trace minerals have no influence on enteric methane emissions in heat-stressed dairy steers; however, breed can influence it through selective alteration of the rumen methanogen community.

• Journal of the Korea Institute of Building Construction
• /
• v.18 no.4
• /
• pp.313-319
• /
• 2018

For the entire world, due to the increased risks of explosion and terrorisms, damages on human life and properties have been increased. Regarding this issue, research on high performance fiber reinforced cementitious composite (HPFRCC) with the protecting performance for the building structures or military facilities against explosion or bombing has been increased (important). Among a series of the research, using emulsified refined cooking oil(ERCO) to reduce the autogenous shrinkage may cause some adverse effect on performance of the mixture such as increased viscosity, decreased fluidity, air content, and strength. Hence, in this research, based on the optimum design of HPFRCC induced by previous research, the influence of ERCO adding timing and dosage on autogenous shrinkage and fundamental properties were analyzed. As a result, it was revealed that 0.5% of ERCO should be added right after the mixing is most effective for the quality of HPFRCC such as fluidity, strength development and autogenous shrinkage reducing.

• Journal of Distribution Research
• /
• v.11 no.2
• /
• pp.97-122
• /
• 2006

A common assumption in marketing channel is that assortment benefits consumers. Recent research, however, has suggested that increasing the size of the choice set may have adverse consequences on the consumer choice. This research is to identify several factors that could affect the consumer choice in the context of product assortment. Especially, this research focus on the influence of the number of alternatives on the likelihood of purchase from the choice set. The preference for the no-choice option decreases as the number of alternatives increases. And it becomes higher when a dominating alternatives is present. And familiarity are considered as a factor affecting consumer's preference for a no-choice option. When a dominating alternatives is present, there is a positive and significant interaction between familarity and choice set size. It concludes with a discussion of the implications of the research findings and directions for future research.

• Journal of Nutrition and Health
• /
• v.26 no.2
• /
• pp.145-155
• /
• 1993

A factorial experiment was conducted to determine the influence of phytate(0 or 10g/kg diet) and calcium (Ca)(3 or 10g/kg diet) intakes on Ca, P and Zn metabolism by growing female rats. Food intake and weight were similar for the all groups, however, phytate ingestion for six weeks depressed femur growth. The low Ca plus phytate group showed the lowest Ca content of total femur and this was related to a significant decrease of Ca retention. Phytate intake depressed zinc(Zn) absorption in the first metabolic collection. This inhibitory effect of phytate on Zn absorption was improved in the low Ca plus phytate group after several weeks. Impared Zn absorption however remained in the high Ca plus phytate group which was reflected in the lowest Zn content of femur, phytate intake with high Ca also depressed phosphorous(P) absorption and serum and urinary P. These adverse effects of phytate on Zn and P absorption when the dietary Ca was high could explain reduced femur weight despite the highest concentration of femur Ca(mg/g ash) in this group. Results suggest that phytate can adversely affect not only Ca metabolism but Zn and P utilization. Thus, for the normal bone growth when phytate intake is high, the ingesion of Ca, P, Zn and other minerals should be enhanced.

• Journal of the Korean Society of School Health
• /
• v.31 no.1
• /
• pp.18-28
• /
• 2018

Purpose: The purpose of this study was to investigate the factors that influence ego-resilience among adolescents who have experienced abuse by parents in South Korea. Methods: This correlational study used the 4th year cross-sectional data of the seventh-grade middle school students who participated in the Korean Children and Youth Panel Survey (KCYPS) in fourth grade. Data analysis was performed by using SPSS/WIN 23.0 program, which included descriptive statistics, Pearson's correlations coefficient, and hierarchical regression. Results: The results of the hierarchical regression of model 5 revealed that the quality of peer relations played the most significant role in predicting ego-resilience of abused adolescents, followed by self-identity. Also, self-esteem, the quality of teacher-student relationships, excessive expectations from parents, and community awareness had a significant impact on the variance of self-resilience in abused adolescents. This regression model explained 42% of the variance. Conclusion: This study showed that ego-resilience, an asset and resource to help adolescents overcome adverse effects of abuse, was influenced by social environment as well as individual factors. In addition, social support from peers and teachers had greater influence on ego-resilience than support from family members. Thus, the factors identified in this study need to be considered in programs designed to improve ego-resilience as well as in policies for abused adolescents.