• Journal of Oriental Neuropsychiatry
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• v.23 no.2
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• pp.99-120
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• 2012

Objectives : The oriental medicine Jangwonhwan, a boiled extract of 12 medicinal herbs/mushrooms, has been prescribed to patients with cognitive dysfunction, as originally described in the Korean medical text, DonguiBogam(amnesia chapter). Recently, a modified formula of Jangwonhwan (LMK02-Jangwonhwan) consisting of seven medicinal plants/mushrooms, was shown to reduce the ${\beta}$-amyloid deposition in the brain of Tg-APPswe/PS1dE9 mouse model for Alzheimer's disease. The toxicity of LMK02-Jangwonhwan was investigated in SD rats, by a daily oral administration for 13 weeks and NOAEL(No observed adverse effect dose), a definite toxic dose and target organ, as well. Methods : Quality control of the tablet form of LMK02-Jangwonhwan was established by estimating the indicative components, Ginsenoside Rg3 of Red Ginseng and Decursin of Angelicagigas Nakai. The toxicity of LMK02-Jangwonhwan was investigated in 6 week old, specific pathogen free (SPF), Sprageu-Dawley rats by oral administration. Each test group consisted of 10 male and 10 female rats. The groups received doses of 500, 1,000 or 2,000 mg/kg/day of test substance for 13 weeks. The clinical signs, death rate, body weight, food consumption, ophthalmic examination, urinalysis, hematological and serum biochemistry, organ weight and pathological changes were examined and compared with those of the control group. Results : The 13-week repeated oral treatment doses didn't result in any specific symptoms or death. There were no significant changes in the rat's weight and food consumption. Further, ophthalmic examination, urinalysis, hematological, serum biochemistry test and organ weight revealed no significant differences. Conclusions : The no-observed-adverse-effect level(NOAEL) of LMK02 for male and female Sprague-Dawley rats was determined as 2,000mg/kg/day and the target organ wasn't confirmed. Because no significant adverse effects were observed, the target organ could not be determined.

• The Korean Journal of Pain
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• v.8 no.2
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• pp.257-265
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• 1995

Patient-Controlled Analgesia (PCA) has been widely used for postoperative pain relief. Meperidine is useful for PCA and has efficient analgesia, rapid onset, and low incidence of adverse effect. To compare the analgesic effect, total dose and hourly dose, side effect and neonatal status of breast feeding with meperidine via intravenous or epidural PCA for 48 hours after Cesarean Section, 40 parturient women undergoing elective Cesarean Section were randomly divided into two groups. Each respective group of 20 parturient women received meperidine via one of the intravenous PCA after general anesthesia with enflurane (IVPCA group) and the epidural PCA after general anesthesia with enflurane (IVPCA group) and the epidural PCA after epidural block with 2% lidocaine 20ml combined with general anesthesia with only $N_2O$ and $O_2$ (EpiPCA group) when they first complained of pain in recovery room. Following the administration of analgesic initial dose, parturient women of IVPCA group were allowed intravenous meperidine 10 mg every 8 minutes when they felt pain. The EpiPCA group received additional bolus dose of meperidine 2 mg and bupivacaine 0.7 mg were administered every 8 minutes as requested the patients with hourly continuous infusion of meperidine 4 mg and bupivacaine 1.4 mg. Data was collected during the 48 hours observation period including visual analog scale (VAS) pain scores, total meperidine dose, hourly dose during 48 hours and each time interval, incidence of adverse effect, satisfaction, and neonatal status with breast feeding. VAS pain scores of analgesic effect in EpiPCA group was significantly lower than in IVPCA group at 2 hours after the initial pain after Cesarean Section. Total dose and hourly dose of meperidine significantly reduced in EpiPCA group. Hourly dose of meperidine at each time interval significantly reduced during first 6 hours and from 12 hours to 24 hours in EpiPCA group. The side effects in IVPCA group were mainly sedation, nausea, and local irritation of skin. And EpiPCA group experienced numbness and itching. The degree of satisfaction of parturient women was 88.2 % in IVPCA group and 85.7 % in EpiPCA group. We did not observe any sedation, abnormal behavior, or seizure like activity in any neonates of breast feeding. From the above results we conclude that epidural PCA was more efficiently analgesic, less sedative, and consumptional, and safer for neonate than intravenous PCA, and could be an alternative method to intravenous PCA.

• Journal of KSNVE
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• v.11 no.1
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• pp.82-88
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• 2001

In a transmission or geared rotor system a coupled phenomenon of lateral and torsional vibrations may occur due to the gear meshing effect. Particularly, in high speed or low vibration and low noise applications of geared rotor systems a coupled rotordynamic analysis is required to precisely predict their dynamic characteristics. In this paper a generalized finite element model of a gear pair element is developed, which actively couples the lateral and torsional vibrations due to the gear meshing effect. In the modeling the generalized forces due to the transmission error. geometrical eccentricities. and unbalances in the gear system are also considered. Then. using the developed gear pair element model a coupled unforced rotordynamic analysis is performed with a prototype 800 RT turbo-chiller rotor-bearing system having a hull-pinion speed increasing gear. Results show that the torsional vibration characteristics experience some changes due to the gear meshing and lateral dynamic coupling effect, but that they have no adverse effect and the lateral ones have no practical changes in an operating speed range.

• Structural Engineering and Mechanics
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• v.76 no.2
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• pp.175-191
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• 2020

In this study, the effect of Nano silica (SiO2) on the buckling strength of the glass fiber reinforced laminates containing the machining process causes holes were investigated. The tests have been applied on two status milled and non-milled. To promote the mechanical behavior of the fiber-reinforced glass epoxy-based composites, Nano sio2 was added to the matrix to improve and gradation. Nano sio2 is chosen because of flexibility and high mechanical features; the effect of Nanoparticles on surface serenity has been studied. Thus the effect of Nanoparticles on crack growth and machining process and delamination caused by machining has been studied. We can also imply that many machining factors are essential: feed rate, thrust force, and spindle speed. Also, feed rate and spindle speed were studied in constant values, that the thrust forces were studied as the main factor caused residual stress. Moreover, entrance forces were measured by local calibrated load cells on machining devices. The results showed that the buckling load of milled laminates had been increased by about 50% with adding 2 wt% of silica in comparison with the neat damaged laminates while adding more contents caused adverse effects. Also, with a comparison of two milling tools, the cylindrical radius-end tool had less destructive effects on specimens.

• Coupled systems mechanics
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• v.5 no.4
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• pp.285-304
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• 2016

The effects of large rotations and p-delta on the dynamic response of a structure subjected to seismic loading and local uplift of its foundation were analyzed in this work. The structure was modeled by an equivalent flexible mat mounted on a rigid foundation that is supported either by a Winkler soil type or a rigid soil. The equations of motion of the system were derived by taking into account the equilibrium of the coupled foundation-mat system where the structure was idealized as a single-degree-of-freedom. The obtained nonlinear coupled system of ordinary differential equations was integrated by using an adequate numerical scheme. A parametric study was performed then in order to evaluate the maximum response of the system as function of the intensity of the earthquake, the slenderness of the structure, the ratio of the mass of the foundation to the mass of the structure. Three cases were considered: (i) local uplift of foundation under large rotation with the p-delta effect, (ii) local uplift of foundation under large rotation without including the p-delta effect, (iii) local uplift of foundation under small rotation. It was found that, in the considered ranges of parameters and for moderate earthquakes, assuming small rotation of foundation under seismic loading can yield more adverse structural response, while the p-delta effect has almost no effect.

• Transactions of the Korean Society of Automotive Engineers
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• v.5 no.3
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• pp.137-146
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• 1997

Spray characteristics of high pressure injectors for diesel engines have been experimentally studied with special emphasis on the effect of swirl. A constant volume chamber was rotated in order to generate a continuous swirl having the flow field of a solid body rotation, resulting in the linear dependance of the swirl number on the rotating speed of the chamber. Emulsified fuel is injected into the chamber and the developing process of fuel sprays is visualized. The fuel spray developing process in D.I. diesel engine was investigated by this liquid injection technique. The effect of swirl on the spray tip penetration is quantified through modelling. Results show that the spray tip penetration is qualitatively different for low and high pressure injections. For high pressure injection case, a good agreement is achieved between the experimental results and the modeling accounting the effect of swirl. For low pressure injection, a reasonable agreement is obtained. It is found that excessive swirl may cause adverse effect on spray dispersion during the initial combustion period since the spray can not be impinged on chamber wall.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.36 no.4
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• pp.145-155
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• 2023

Objectives : The aim of this study is to review the effect of acupuncture/moxibustion on vitiligo. Methods : Using 5 databases(Pubmed, EMBASE, Cochrane Library, RISS, OASIS) clinical studies about effect of acupuncture/moxibustion on vitiligo were searched. Only randomized controlled trials(RCTs) were selected to analyze. Results : Total 235 studies were searched. After screening those studies 5 studies were selected from china and Iran. 3 studies used effective rate to measure the effect of acupuncture for vitiligo. 1 study used Vitiligo Area Scoring Index(VASI) and 1 study assessed 4 grade of repigmentation to prove acupuncture's effect on vitiligo. All studies showed repigmentation in acupuncture/moxibustion group. Adverse effects reported in the five studies were temporary erythema, itching, and dryness. Conclusions : These findings suggest that acupuncture and moxibustion can be considered a safe treatment for vitiligo. However, due to the small number of RCTs conducted on acupuncture and moxibustion for vitiligo, more RCTs should be conducted to confirm the effectiveness of acupuncture and moxibustion for vitiligo.

• Journal of Applied Reliability
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• v.7 no.4
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• pp.173-181
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• 2007

Out door exposure to daylight and weather climate conditions can cause adverse effect on the properties of automotive plastic materials. The effects of sunlight exposure, especially ultra violet (UV) radiation, can break down the chemical bonds in a polymeric material. This degradation process is called photo-degradation and ultimately leads to color changes, cracking, chalking, the loss of physical properties and deterioration of other properties. To explore the effect of sunlight exposure on the automotive materials, this study investigated photo-oxidation degree and surface property change of molding parts by analytical methods. For the further study, accelerated weathering test methods are proposed, which can correlate with out door weathering, to predict long term performance of automotive plastic materials.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.22 no.3
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• pp.244-252
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• 2012

Recently, the speed of a train has been increased. So the trains are being exposed to wind more severely than before. Because of the operation of high speed trains and lightweight of the train, risks of train derailment have being increased. In this study, aerodynamic effects of a newly designed high speed train, HEMU-400x, are evaluated. For aerodynamic effect evaluation, analysis method is selected by examining the safety standards for high speed train. The condition of aerodynamic effects is selected by adverse effect conditions. In order to calculate $C_s$ coefficients, numerical analysis is conducted. Using $C_s$ coefficients, the side force is calculated. Through dynamics analysis, derailment and wheel unloading are obtained. Using these results, derailment evaluation is performed.

• Proceedings of the KIEE Conference
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• 2011.07a
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• pp.256-257
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• 2011

The development for Eco-friendly cars has been expanded as the concern about environmental pollution and a rise in gas prices. The Electric Vehicle(EV) and Plug in Hybrid Electric Vehicle(PHEV) are generally connected on distribution power systems to charge the traction batteries. The growing number of EV/PHEVs could have a effect on distribution power systems and result in overload of power utilities and power quality problems. In order to reduce the adverse effect on distribution power systems, the influence of electric vehicle loads should be evaluated. In this paper, the influence of electric vehicle loads is evaluated by using OpenDSS(Open Source Distribution System Simulator) according to the penetration rate of electric vehicle.