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A RADIOAUTOGRAPHIC STUDY OF POSTNATAL DEVELOPMENT OF THE TONGUE FOLLOWING 5-FLUOROURACIL ADMINSTRATION IN MICE

  • Jang, Sang-Heon
    • The Journal of the Korean dental association
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    • v.14 no.3
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    • pp.297-305
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    • 1976
  • 신생의 Balb/C strain 백서20두를 사용하였고, 실험군과 대조군으로 구분하여 실험군에는 5-fluorouracil의 체중 25 mg/kg씩 2회를 복강내주사하였다. 실험군가 대조군에 모두 희생 2시간전에 체중그람당 5μ Ci의 thymidine-H³ (Specific activity는 9.0 Ci/mM 이상)를 복강내 주사하였다. 각군은 5-fluorouracil 최종 주사후 1, 3, 7, 14, 21일 간격으로 희생시키고, 두부를 4% formalin에 고정하였다. 조직을 0.5M EDTA에 탈회하고 parlodion과 paraplast에 이중 매몰을 하여 Parasagittal serial section 을 10μ의 절편을 만든 후 자기방사용표본을 제작하였다. 그 결과는 다음과 같다. 1. 5-fluorouracil이 백서설의 기저세포층의 핵산합성 및 단백합성에 미치는 영향은 실험초일인 제 1일부터 억제하기 시작하여 (80.9%) 제3일 76.9%이고, 제 7일이 가장 극심하고 (66.2%) 그후부터는 다소회복되기 시작하여 제14일이 92/3%이고, 제21일인 98.9%로서 서의 대조군수치에 접근하였다. 2. 5-fluorouracil은 설유두중 nallate papillae 성장에 가장 억제적 현상을 보였고, 그 다음이 fungiform papillae, filiform papillae의 순위였다. 3. 5-fluorouracil 이 백서설의 기저세포층의 핵산합성을 억제함을 알 수 있고, 아울러 백서설의 조기정상 발육에 영향을 줌울 알 수 있다.

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Study on the Variation of Nighttime Cooling Rate Associated with Urbanization (도시화에 의한 야간 대기 냉각율 변화에 관한 연구)

  • Lee, Soon-Hwan;Park, Myung-Hee;Kim, Hea-Dong
    • Journal of Korean Society for Atmospheric Environment
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    • v.24 no.1
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    • pp.83-90
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    • 2008
  • In order to clarify the urbanization intensity of Daegu Metropolitan and its characteristics, comparative study on the variation of the cooling rate of two different sites was carried out using observation data for 40 years by Korea Meteorological Adminstration. Daegu Metropolitan and Chupungnyung represent well urbanized and rural areas, respectively. In comparison with Chupungnyung, yearly mean temperature at Daegu Metropolitan increases rapidly and especially the differences of minimum temperature increasing rate during 40 years becomes greater. These differences of regional warming are caused by the different urbanization intensity between two sites. And the impact of anthropogenic heat due to urbanization should be stronger in nighttime than in daytime. Sensible heat advection by regional wind during 6 hours from 18 LST contributes to atmospheric cooling. For this reason wind speed is in proportion to cooling rate of atmosphere. However, wind after 24 LST induces the warm air advection and makes decrease the cooling rate in urban area. Although the cooling rates between Daegu Metropolitan and Chupungnyung are some different, the variation tendencies of cooling rate of two site are almost same. Therefore atmospheric cooling rate in nighttime tends to be associated with the intensity of wind speed.

Receptor Specificity of Adenosine Analogs in Terms of Renal Function and Renin Release (Adenosine 유사체의 신장효과에 미치는 Adenosine 차단제의 영향)

  • Yun, Young-Yi;Koh, Gou-Young;Kim, Suhn-Hee;Cho, Kyung-Woo
    • The Korean Journal of Physiology
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    • v.24 no.2
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    • pp.269-280
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    • 1990
  • The purpose of the present experiment was to determine the functional subclassification of renal adenosine receptor fer the hemdynamic, excretory and secretory functions in unanesthetized rabbits. Adenosine antagonist, 8-phenyltheophylline (8-PT) or theophylline, was infused into the left renal artery followed by an infusion of adenosine agonist, cyclohexyladenosine (CHA) or 5'-N-ethylcarboxamidoadenosine (NECA). Intrarenal arterial infusion of CHA or NECA caused decreases in urine volume, glomerular filtration rate, renal plasma flow and excreted amount of electrolytes and renin release in a dose-dependent manner. Dose-response curves in renal function by CHA or NECA was similar and shifted to the right with pretreatment of 8-PT or theophylline. No significant differences in renal response to CHA and NECA in antagonist-treated rabbits were observed. However, the decrease in renin secretion rate was not affected by the adminstration of adenosine antagonists. These results suggest that the renal effect of adenosine receptor agonists appears by way of specific adenosine receptor, but which is not functionally subclassified in the rabbit.

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Effect of Gonadotropin-releasing Hormone Administration in Repeat-breeder Hanwoo (저수태 한우에 대한 성선자극 호르몬 방출호르몬 투여 효과)

  • 임석기;우재석;윤상보;전기준
    • Journal of Embryo Transfer
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    • v.12 no.1
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    • pp.117-122
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    • 1997
  • The objective of this study was to enhance the pregnancy rate of repeat-breeder Hanwoo with gonadotropin-releasing hormone(Gn-RH) at the time, dose and site of administration.The results obtained were summaried as fallows:1.Ovulation time and pregnancy rate following GnRH administration time was 46.0, 27.4, 42.0 and 43.2hr and 33.3, 57.1, 37.5 and 40.0% at non-treatment, estus, 1st A' and 2nd Al treatment, respectively.2. Ovulation in repeat-breeder was induced 100% within 24hr with GnRH administration at the time of estrus.3. Ovulation time and pregnancy rate following GnRH adminstration dose and site was 25.2, 32.6, 17.6 and 27.6hr, and 28.6, 42.9, 75.0 and 66.7% at 50$\mu$g+IU, 50$\mu$g+IM, 100$\mu$g+IU and 100$\mu$g+IM treatments, respectively. It is concluded that GnRH administration for repeat-breeder was enhanced the pregnancy rate when treated with 100$\mu$g intrauterine at the time of estrus.

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Estimation on the Power Spectral Densities of Daily Instantaneous Maximum Fluctuation Wind Velocity (변동풍속의 파워 스펙트럴 밀도에 관한 평가)

  • Oh, Jong Seop
    • Journal of Korean Society of Disaster and Security
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    • v.10 no.2
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    • pp.21-28
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    • 2017
  • Wind turbulence data is required for engineering calculations of gust speeds, mean and fluctuating loading. Spectral densities are required as input data for methods used in assessing dynamic response. This study is concerned with the estimation of daily instantaneous maximum wind velocity in the meteorological major cities (selected each 6 points) during the yearly 1987-2016.12.1. The purpose of this paper is to present the power spectral densities of the daily instantaneous maximum wind velocity. In the processes of analysis, used observations data obtained at Korea Meteorological Adminstration(KMA), it is assumed as a random processes. From the analysis results, in the paper estimated power spectral densities function(Blunt model) shows a very closed with von Karman and Solari's spectrum models.

Detection and Distribution of Apple scar skin viroid-Korean Strain (ASSVd-K) from Apples Cultivated in Korea

  • Lee, Jai-Youl;Kwon, Mi-Jo;Hwang, Seung-Lark;Lee, Sung-Joon;Lee, Dong-Hyuk
    • The Plant Pathology Journal
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    • v.18 no.6
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    • pp.342-344
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    • 2002
  • Apple scar skin viroid (ASSVd) has been one of the most destructive diseases in Korean apple orchards. Symptoms of the scar skin viroid disease were detected in various apple cultivars, namely, Sansa, Fuji, Chukwang, Miki-Life, Hongro, and Songbongeum cultivated in the southern part of Korea. The RNA molecules were extracted from the apples bearing dapple apple symptoms with the application of CF-11 RNA extraction method. The purified RNAs were used for the synthesis of cDNA with RT-PCR. The PCR products were cloned and sequenced. The viroid RNA molecules from the six different cultivars bearing the dapple symptos showed the same nucleotide sequences as that of the Korean strain of ASSVd(ASSVd-K). ASSVd-K was detected from apple orchards in Kunwi, Sangju, Uiseong, Yeong-yang, Andong, and Youngduk in Gyeongbuk Province in 2001, and in Muju in Jeonbuk Province in 2002. As the viroid disease could be propagated vegetatively, it can be widely transmitted gradually in Korea.

Prediction of Chemical and Physical Properties by Climatic Factors in Flue-cured Tobacco (기상요인에 의한 황색종 잎담배의 이화학적 특성 예측)

  • Jeong, Kee-Taeg;Cho, Soo-Heon;Bock, Jin-Young;Lee, Joung-Ryoul
    • Journal of the Korean Society of Tobacco Science
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    • v.29 no.1
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    • pp.1-7
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    • 2007
  • This study was conducted in order to predict the chemical and physical properties by climatic factors during the growing season of flue-cured tobacco as soon as possible. The data of eight chemical and five physical properties were collected from "Analysis of physical and chemical properties on farm leaf tobacco" conducted at KT&G Central Research Institute from 1987 through 2006. Data of climatic factors from April to July in 10 districts were collected from Korea Meteorological Adminstration. Except for yellowness(b), all probabilities of linear regression equations between the climatic factors(X) and the average contents of twelve grades(whole plant) for chemical and physical properties(Y) were significant($P{\leq}0.05$). The predicable probabilities within ${\pm}20%$ range of difference were 100% in ether extract content, in nicotine content, and in filling value, 90% in total nitrogen content, and 70% in total sugar content. These results suggest that the regression equations may be useful to predict the average content of twelve grades for eight chemical and four physical properties by climatic factors during the growing season of flue-cured tobacco at the beginning of August.

Prediction of Chemical and Physical Properties by Climatic Factors in Burley Tobacco (기상요인에 의한 버어리종 잎담배의 이화학적 특성 예측)

  • Jeong, Kee-Taeg;Cho, Soo-Heon;Bock, Jin-Young;Lee, Joung-Ryoul
    • Journal of the Korean Society of Tobacco Science
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    • v.29 no.1
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    • pp.8-13
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    • 2007
  • This study was conducted in order to predict the chemical and physical properties by climatic factors during the growing season of burley tobacco as soon as possible. The data of six chemical and five physical properties were collected from "Analysis of chemical and physical properties on farm leaf tobacco" conducted at KT&G Central Research Institute from 1987 to 2006. Data of climatic factors from April to July in 6 districts were collected from Korea Meteorological Adminstration. Except for total nitrogen, total nitrogen/nicotine and yellowness(b), all probabilities of linear regression equations between the climatic factors(X) and the average contents of twelve grades(whole plant) for chemical and physical properties(Y) were significant($P{\leq}0.05$). The predicable probabilities within ${\pm}20%$ range of difference were 100% in ether extract content, 95% in nicotine content, and 90% in filling value. These results suggest that the regression equations may be useful to predict the average content of twelve grades for four chemical and four physical properties by climatic factors during the growing season of burley tobacco at the beginning of August.

A Study to Assess the Reliability and Improvement of the Instrument of Pattern Identification for Jing Ji and Zheng Chong (경계정충 변증도구 신뢰도 평가 및 개선방안 연구)

  • Choi, Woo-Chang;Lee, Hun-Soo;Seo, Bok Nam;Kang, Wee-Chang;Jung, In-Chul
    • Journal of Oriental Neuropsychiatry
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    • v.25 no.4
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    • pp.371-382
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    • 2014
  • Objectives: The purpose of this study is to examine the test-retest reliability and to suggest methods to enhance reliability. Methods: Participants consisted of 145 patients with generalized anxiety disorder who were diagnosed by the Structured Clinical Interview for DSM-IV Axis I Disorders. Participants were tested twice within one week. Results: The test-retest reliability of the Instrument of Pattern Identification for Jing Ji and Zheng Chong was examined in 145 patients and it was calculated as 0.3919. Internal Reliability of each part was calculated as 0.320~0.502. Reliability and concordance rate of symptoms are presented in the table. Frequency of symptoms and correlation between weight and frequency are also presented in the table. Conclusions: Based on these results, we have modified the Instrument of Pattern Identification for Jing Ji and Zheng Chong.

Study on Jong-jun Lee's Medical Records in Sinsuntaeeuljagumdan ("신선태을자금단(神仙太乙紫金丹)"에 수록된 이종준(李宗準) 의안(醫案)에 대한 연구)

  • Kim, Jae-Eun;Choi, Dall-Yeong;Jeong, Han-Sol;Shin, Hyun-Jong;Shin, Sang-Woo;Ha, Ki-Tae
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.25 no.2
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    • pp.155-162
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    • 2011
  • Sinsuntaeeuljagumdan is a medical book written by Jong-jun Lee, who was an government official in Yonsan-gun period in Chosun dynasty. This book has importance in medical history, as it was the first privately published medical book in early Choson dynasty, and written by an bureaucratic gentry, not by a professional doctor. Three versions of this book remain, among which Sungam version is printed and closest to the original, while Kyoto version is facsimile manuscript of the Sungam version. The contents of the book can be divided into three subsections, i.e. constituents and making instructions, applicable symptoms and adminstration directions, and medical records and episodes. The medical records, of these three sections, are total 8 cases, with a great value as the first ever medical record in korean history.