• 대한한방내과학회지
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• 제33권2호
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• pp.180-187
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• 2012

Objectives : The aim of this study was to investigate weight gain effects of the Sungjangjeungbo-tang (Ch$\acute{e}$ngzh$\check{a}$ngz$\bar{e}$ngb$\check{u}$-tang) on thin Korean preschool children. Methods : Sungjangjeungbo-tang is composed of 9 herbs for treating indigestion. We analyzed 119 preschool children who visited Kim Kijoon Oriental Clinic BOM from Jan. 1, 2006 to Aug. 31, 2011 with three criteria: 1) 2~5yrs of age and BMI < 50th percentile on the baseline visit; 2) the child had taken the Sungjangjeungbo-tang for 1~3 month(s); and 3) the clinic had records of both height and weight on the baseline and at least once over 1~3 month(s). Results : Sungjangjeungbo-tang significantly improved BMI percentile in all groups. The changes in BMI percentile variations were larger in the 3 months group than in other groups, but not significantly. Gender, age and BMI on the baseline had no significant effects on the effectiveness of Sungjangjeungbo-tang. Conclusions : Sungjangjeungbo-tang positively affected on weight gain in thin Korean preschool children within 1~3 month(s) of treatment. However, additional studies on functional dyspepsia or the change of energy intake were needed to know the factors related to weight gains.

• Archives of Plastic Surgery
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• 제41권1호
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• pp.40-44
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• 2014

Background Chloral hydrate (CH) is the primary agent most commonly used for pediatric sedation prior to diagnostic, therapeutic procedures. In the management of pediatric facial laceration, the initial dose of CH has to balance the need for adequate sedation against the need to minimize sedative complications. Methods A retrospective review of medical records of 834 children who visited our emergency room for facial lacerations from August 2010 to September 2012 was conducted. They were divided into six groups on the basis of the initial dose of CH administered. Further, each group was compared with the standard group (70 to ${\leq}80mg/kg$) with respect to sedation success, augmentation dose, failed sedation, time to procedure, and time of stay. Results With respect to the complication rate, only group 1 (range, 40 to ${\leq}50mg/kg$) showed a significantly lower complication rate. In the case of all the other variables considered, there were no significant differences among any of the groups. Conclusions An initial CH dose of $48{\pm}2mg/kg$ does not negatively affect the success rate of sedation or the need for additional sedative during the primary closure of facial lacerations in pediatric patients. Further, lower doses reduce the incidences of adverse effects and do not delay procedure readiness. Therefore, $48{\pm}2mg/kg$ of CH can be considered the optimal initial dose for pediatric sedation.

• Asian Pacific Journal of Cancer Prevention
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• 제15권18호
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• pp.7665-7671
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• 2014

Objectives: The association between body mass index (BMI) and ovarian cancer risk is unclear and requires further investigation. The present meta-analysis was conducted to assess the effect of overweight and obesity on ovarian cancer risk in the premenopausal and postmenopausal periods. Data sources: Major electronic databases were searched until February 2014 including Medline and Scopus. Reference lists and relevant conference databases were searched and the authors were contacted for additional unpublished references. Review Methods: All cohort and case-control studies addressing the effect of BMI on ovarian cancer were included, irrespective of publication date and language. The effect measure of choice was risk ratio (RR) for cohort studies and odds ratio (OR) for case-control studies. The results were reported using a random effects model with 95% confidence intervals (CIs). Results: Of 3,776 retrieved studies, 19 were ultimately analyzed including 10 cohort studies involving 29,237,219 person-years and 9 case-control studies involving 96,965 people. The results of both cohort and case-control studies showed being overweight and obesity increased the risk of ovarian cancer compared to women with normal weight during both premenopausal and postmenopausal periods: RR=1.08 (95%CI: 0.97, 1.19) and OR=1.26 (95%CI: 0.97, 1.63) for overweight and RR=1.27 (95%CI: 1.16, 1.38) and OR=1.26 (95%CI: 1.06, 1.50) for obesity. Conclusions: There is sufficient evidence that an increase in BMI can increase the risk of ovarian cancer regardless of the menopausal status, mimicking a dose-response relationship although the association is not very strong.

• 한국인터넷방송통신학회논문지
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• 제14권1호
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• pp.211-217
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• 2014

스마트폰이 주도하는 스마트 혁명은 우리의 일상생활 전반의 패러다임을 변화시키고 있다. 이러한 스마트 혁명은 우리에게 많은 편리성을 제공하고 있지만 반면에 역기능도 나타나고 있다. 특히 미래의 주인공인 청소년들의 과도한 스마트 기기 사용으로 인한 부작용의 우려가 커지고 있다. 본 연구에서는 청소년의 스마트 기기 사용 시간과 스포츠 활동 시간 등이 청소년의 감성지능에 어떠한 영향을 주는지에 대해 실증적으로 분석하였다. 회귀분석 결과 스마트 기기 사용 시간이 감성 지능에 부(-)의 관계로 유의한 영향을 미치는 것으로 나타났으며 스포츠 활동 시간도 감성 지능에 정(+)의 관계로 유의한 영향을 미치는 것으로 나타났다. 추가적인 분석으로 독서량도 감성 지능에 정(+)의 관계로 유의한 영향을 미친다는 결론을 얻었다. 이 연구를 통해 전통적인 활동, 즉 스포츠 활동이나 독서는 청소년의 감성 지능 발전에 도움이 되는 반면, 스마트 기기의 사용은 청소년의 감성 지능 발전에 저해 요인이 된다는 결론을 얻었다.

• Clinical and Experimental Pediatrics
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• 제46권1호
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• pp.86-90
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• 2003

Alagille 증후군은 간내 담도 형성 부전으로 인한 만성 담즙 정체, 말초 폐동맥 협착, 골격 이상, 눈의 이상, 특징적인 얼굴 모양 등을 주요 증상으로 하는 상염색체 우성 유전 질환으로 말초 폐동맥 협착 이외에도 여러 말초 혈관 병변들이 동반된다. 관련된 유전자로 20번 염색체 위에 존재하는 JAG1이 발견되었고, 이 유전자의 결손으로 인한 Notch 신호전달체계의 결함이 혈관형성에 영향을 미친다고 생각되고 있다. Alagille 증후군에서 만성 뇌동맥 폐색질환인 moyamoya병이 발생한 예들이 보고된 바 있는데, Alagille 증후군의 혈관병증의 또 다른 한 발현으로 이해되어야 할 것이다. 저자들은 생후 2개월에 Alagille 증후군을 진단받고 추적 관찰 중에 갑자기 편측 마비가 발생하여 뇌혈관 조영술을 통해 moyamoya병을 진단받은 25개월 여아를 경험하였기에 이를 보고하는 바이다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제43권6호
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• pp.407-414
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• 2017

Objectives: The study was designed to evaluate the efficacy of performing a second, repeat anterior maxillary distraction (AMD) to treat residual cleft maxillary hypoplasia. Materials and Methods: Five patients between the ages of 12 to 15 years with a history of AMD and with residual cleft maxillary hypoplasia were included in the study. Inclusion was irrespective of gender, type of cleft lip and palate, and the amount of advancement needed. Repeat AMD was executed in these patients 4 to 5 years after the primary AMD procedure to correct the cleft maxillary hypoplasia that had developed since the initial procedure. Orthopantomogram (OPG) and lateral cephalograms were taken for evaluation preoperatively, immediately after distraction, after consolidation, and one year postoperatively. The data obtained was tabulated and a Mann Whitney U-test was used for statistical comparisons. Results: At the time of presentation, a residual maxillary hypoplasia was observed with a well maintained distraction gap on the OPG which ruled out the occurrence of a relapse. Favorable movement of the segments without any resistance was seen in all patients. Mean maxillary advancement of 10.56 mm was achieved at repeat AMD. Statistically significant increases in midfacial length, SNA angle, and nasion perpendicular to point A distance was achieved (P=0.012, P=0.011, and P=0.012, respectively). Good profile was achieved for all patients. Minimal transient complications, for example anterior open bite and bleeding episodes, were managed. Conclusion: Addressing the problem of cleft maxillary hypoplasia at an early age (12-15 years) is beneficial for the child. Residual hypoplasia may develop in some patients, which may require additional corrective procedures. The results of our study show that AMD can be repeated when residual deformity develops with the previous procedure having no negative impact on the results of the repeat procedure.

• 한국정보과학회논문지:컴퓨팅의 실제 및 레터
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• 제8권6호
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• pp.630-638
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• 2002

리눅스 기반의 임베디드 시스템에서 동작하는 응용 프로그램의 디버깅은 타겟 시스템의 제한된 자원으로 인하여 대부분 원격으로 이루어진다. 리눅스 기반의 시스템에서 동작하는 gdb는 원격에서 또는 로컬에서 디버깅 중인 프로세스가 fork 시스템 콜 호출 시 새로이 생성된 프로세스를 디버깅할 수 있도록 지원하지 않는다. 이에 따라, 리눅스 환경에서 동작하는 gdb와 gdbserver를 사용해서 단일 프로세스 구조를 갖는 옹용 프로그램을 원격 또는 로컬 디버깅할 수는 있으나 다중 프로세스 구조의 옹용 프로그램을 원격으로 디버깅할 수는 없다. 또한 로컬에서 gdb를 사용하여 다중 프로세스 구조의 응용 프로그램을 디버깅할 수는 있지만 이를 위해서는 개발자비 부가적인 코딩이 필요하다. 본 논문에서는 리눅스 커널의 변경 없이 라이브러리 래핑(wrapping) 방법을 이용하여 원격 시스템에서 동작하는 다중 프로세스 구조의 응용 프로그램을 gdb와 gdbserver를 사용하여 디버깅하는 방법을 제시한다.

• 한국수정란이식학회지
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• 제24권1호
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• pp.1-14
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• 2009

Ovarian cancer is a significant cause of cancer-related death in women, but the main biological causes remain open questions. Hormonal factors have been considered to be an important determinant causing ovarian cancer. Recent studies have shown that gonadotropin-releasing hormone (GnRH)-I and its analogs have clinically therapeutic value in the treatment of ovarian cancer. In addition, numerous studies have shown that the potential of GnRH-II in normal reproductive system or reproductive disorder. GnRH-I receptors have been detected in approximately 80% of ovarian cancer biopsy specimens as well as normal ovarian epithelial cells and immortalized ovarian surface epithelium cells. GnRH-II receptors have also been found to be more widely expressed than GnRH-I receptors in mammals, suggesting that GnRH receptors may have additional functions in reproductive system including ovarian cancer. The signal transduction pathway following the binding of GnRH to GnRH receptor has been extensively studied. The activation of protein kinase A/C (PKA/PKC) pathway is involved in the GnRH-I induced anti-proliferative effect in ovarian cancer cells. In addition, GnRH-I induced mitogen-activated protein kinase (MAPK) activation plays a role in anti-proliferative effect and apoptosis in ovarian cancer cells and the activation of transcriptional factors related to cellular responses. However, the role of GnRH-I and II receptors, there are discrepancies between previous reports. In this review, the role of GnRH in ovarian cancer and the mechanisms to induce anti-proliferation were evaluated.

• 한국정보통신학회논문지
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• 제20권10호
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• pp.1994-2000
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• 2016

개인의 위치를 확인할 수 있는 기술은 위치기반제어, 개인화된 광고 등 다양한 응용분야에서 요구된다. 미아발생 방지나 현장 학습을 위한 지원, 사용자의 위치에 따른 적절한 Push 이벤트 등 그 응용분야는 무궁무진하다. 기존의 많은 연구들이 위치 확인의 정확도에 비중을 두고 연구되어, 별도의 장비를 장착하거나 시설물에 특정 장치를 해야 하는 등의 제약 조건이 있었던 것과 달리 본 논문에서 제안한 알고리즘은 대부분의 사용자가 갖고 있는 스마트폰의 기본 사양만으로 위치 추적을 수행하는 것을 목적으로 하였다. 스마트 폰에 의해 수집 가능한 GPS와 WiFi RSS, 가속도계 센서 데이터를 파티클 필터를 적용하여 센서 융합을 실행하여 위치를 확인하는 알고리즘을 설계 구현하였고, 실험 결과, 사용자의 위치 확인 정확도가 다른 비교 알고리즘에 비해 우수한 성능을 보여, 해당 알고리즘의 실제 환경 사용 가능성을 확인할 수 있었다.

• Safety and Health at Work
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• 제8권1호
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• pp.77-83
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• 2017

Background: In contemporary China, most parents are dual-earner couples and there is only one child in the family. We aimed to examine the associations of parents' work stress with suicidal ideation among the corresponding adolescent. We further hypothesized that low parental support experienced by adolescents may mediate the associations. Methods: Cross-sectional data from school students and their working parents were used, with 907 families from Kunming City, China. Stress at work was measured by the effort-reward imbalance questionnaire. Perceived parental support was assessed by an item on parental empathy and their willingness to communicate with the adolescent. Suicidal ideation was considered positive if students reported thoughts about suicide every month or more frequently during the previous 6 months. Logistic regression was used to examine the associations. Results: We observed that parents' work stress was positively associated with low parental support, which was in turn associated with adolescent suicidal ideation. The odds ratio for parents' work stress and adolescent suicidal ideation was 2.91 (95% confidence interval: 1.53-5.53), and this association was markedly attenuated to 2.24 (95% confidence interval: 1.15-4.36) after additional adjustment for parental support. Notably, mothers' work stress levels exerted stronger effects on children's suicidal ideation than those of fathers. Conclusion: Parents' work stress (particularly mother's work stress) was strongly associated with adolescent's suicidal ideation, and the association was partially mediated by low parental support. These results need to be replicated and extended in prospective investigations within and beyond China, in order to explore potential causal pathways as a basis of preventive action.