• Asian-Australasian Journal of Animal Sciences
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• 제10권2호
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• pp.233-239
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• 1997

A mammary epithelial cell line (MAC-T) established as a model for lactation was utilized to identify and characterize effects of various hormones upon insulin-like growth factor binding protein secretion. Ligand and immunoblot analyses of conditioned media indicated that insulin-like growth factor binding protein-2 was secreted by MAC-T cells. Insulin-like growth factor-I stimulated insulin-like growth factor binding protein-2 secretion in a dose-dependent manner, but prolactin and bovine somatotropin did not alter insulin-like growth factor binding protein-2 secretion. Insulin increased and cortisol decreased insulin-like growth factor binding protein-2 secretion. Effects of insulin-like growth factor-I on insulin-like growth factor binding protein-2 secretion support previous studies using primary cultures of bovine mammary cells and bovine fibroblasts. Effects of cortisol and insulin on insulin-like growth factor binding protein-2 secretion may be explained by changes in protein synthesis. In addition, supraphysiological doses of insulin can cross-react with the insulin-like growth factor-I receptor and stimulate insulin-like growth factor binding protein-2 secretion. MAC-T cells provide a model system to study mechanisms that regulate local insulin-like growth factor-I bioactivity.

• BMB Reports
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• 제38권1호
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• pp.1-8
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• 2005

Transforming growth factor-$\beta$ is a pleiotropic growth factor that has enthralled many investigators for approximately two decades. In addition to many reports that have clarified the basic mechanism of transforming growth factor-$\beta$ signal transduction, numerous laboratories have published on the clinical implication/application of transforming growth factor-$\beta$. To name a few, dysregulation of transforming growth factor-$\beta$ signaling plays a role in carcinogenesis, autoimmunity, angiogenesis, and wound healing. In this report, we will review these clinical implications of transforming growth factor-$\beta$.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2005년도 제36회 하계학술대회 논문집 A
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• pp.480-482
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• 2005

In this paper, utilization of load duration curves is presented for analyzing the effect of load power factor and determining the value of load power factor effectively. In addition, the power factor sensitivity of generation cost and integrated costs including voltage variation penalty cost are used for determining the value of the load power factor from the point of view of voltage regulation and economic investment. It is shown through the application to the KEPCO power system that the load power factor can be enhanced effectively and appropriately using the load duration curve.

• Geomechanics and Engineering
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• 제6권1호
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• pp.17-31
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• 2014

This paper investigates the development of failure surfaces induced by an embankment on soft marine clay deposits and the characteristics of such surfaces through numerical simulations and its comparative study with monitoring results. It is well known that the factor of safety of embankment slopes is closely related to the vertical loading, including the height of the embankment. That is, an increase in the embankment height reduces the factor of safety. However, few studies have examined the relationship between the lateral movement of soft soil beneath the embankment and the factor of safety. In addition, no study has investigated the distribution of the pore pressure coefficient B value along the failure surface. This paper conducts a continuum analysis using finite difference methods to characterize the development of failure surfaces during embankment construction on soft marine clay deposits. The results of the continuum analysis for failure surfaces, stress, displacement, and the factor of safety can be used for the management of embankment construction. In failure mechanism, it has been validated that a large shear displacement causes change of stress and pore pressure along the failure surface. In addition, the pore pressure coefficient B value decreases along the failure surface as the embankment height increases. This means that the rate of change in stress is higher than that in pore pressure.

• 산업기술연구
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• 제19권
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• pp.269-278
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• 1999

When a variety of repeated loads are given, most steel structures failed in much lower level of loads than static failure loads. In addition, bridge always includes the internal defects or discontinuities. from these, fatigue cracks initiates and can lead to sudden failure. Thus, in this study, tensile specimens by the cover plate shapes were used as the test specimens. The fatigue test was performed by constant amplitude fatigue loading and beach mark. From the results of this study, each specimen's fatigue section was observed. in addition, stress intensity factor at crack tip was calculated by using the Green's function which applied to discontinuous section where causing stress concentration. Therefore, the fatigue life of structural detail was investigated by adopting the theories of fracture mechanics. each specimen's crack shape is a semi-elliptical surface crack or center crack sheet, stress gradient correction factor, Fg is the most subjective of all stress intensity correction factors and fatigue life should be predicted by previous proposed function and finite element analysis.

• 한국전기전자재료학회논문지
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• 제15권4호
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• pp.356-360
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• 2002

The piezoelectric properties of $0.05Pb(Al_{0.5}Nb_{0.5})O_3-0.95Pb(Zr_{0.52}Ti_{0.48})O_3+0.7wt%Nb_2O_5+o.5wt%MnO_2$ ceramics with the additive of BaCO$_3$were investigated. As the addition of BaCO$_3$increased from 0 to 0.4 wt%, the dielectric constant ($\epsilon^T _{33}$), piezoelectric constant ($d_33$), electromechanical coupling factor ($k_p$), and mechanical quality factor ($Q_m$) increased, while the dielectric loss ($tan\delta$) decreased. The highest piezoelectric and dielectric properties were observed at $1200^{\circ}C$ of the sintered temperature with 0.4 wt% of $BaCO_3$, and the properties of $d_33$, $k_p$, and $Q_m$ were 339 pC/N, 60% and 1754, respectively.

• Design & Manufacturing
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• 제13권2호
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• pp.22-29
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• 2019

This study conducted a research as to condensation heat transfer by using three types of flat micro multi-channel tubes with different processing of micro-fin and number of channels inside the pipes and different sizes of appearances. In addition, identical studies were conducted by using smoothing circular tubes with 5mm external diameter to study heat transfer coefficient. The condensation heat transfer coefficient showed an increase as the vapor quality and mass flux increased. However, each tube shows little differences compared to 400kg/m2s or identical in case the mass flux are 200kg/m2s and 100kg/m2s. The major reason for these factors is increase-decrease of heat transfer area that the flux type of refrigerant is exposed to the coolant's vapor with the effect of channel aspect ratio or micro-fin. In addition, the heat transfer coefficient was unrelated to the heat flux, and shows a rise as the saturation temperature gets lower, an effect that occurs from enhanced density. The physical factor of heat transfer coefficient increased as the channel's aspect ratio decreased. Additionally, the micro pin at the multi-channel type tube is decided as a disadvantageous factor to condensation heat enhancement factor. That is, due to the effect of aspect ratio or micro-fin, the increase-decrease of heat transfer area that the flux type of a refrigerant is exposed to the vapor is an important factor.

• 대한전기학회논문지:전력기술부문A
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• 제54권1호
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• pp.18-24
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• 2005

Various problems such as the increase of the power loss and the voltage instability may often occur in the case of low load power factor. The demand of reactive power increases continuously with the growth of active power and the restructuring of electric power companies makes the comprehensive management of reactive power a troublesome problem, so that the systematic control of load power factor is required. In this paper, the load power factor sensitivity of the generation cost is derived and it is used for determining the locations of reactive power compensation devices effectively and for enhancing the load power factor appropriately. In addition, the voltage variation penalty cost is introduced and the integrated costs including the voltage variation penalty cost are used for determining the value of the load power factor from the point of view of the economic investment and voltage regulation. It is shown through the application to a large-scale power system that the load power factor can be enhanced effectively and appropriately using the load power factor sensitivity and integrated costs.

• Molecules and Cells
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• 제44권5호
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• pp.342-355
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• 2021

The microphthalmia-associated transcription factor family (MiT family) proteins are evolutionarily conserved transcription factors that perform many essential biological functions. In mammals, the MiT family consists of MITF (microphthalmia-associated transcription factor or melanocyte-inducing transcription factor), TFEB (transcription factor EB), TFE3 (transcription factor E3), and TFEC (transcription factor EC). These transcriptional factors belong to the basic helix-loop-helix-leucine zipper (bHLH-LZ) transcription factor family and bind the E-box DNA motifs in the promoter regions of target genes to enhance transcription. The best studied functions of MiT proteins include lysosome biogenesis and autophagy induction. In addition, they modulate cellular metabolism, mitochondria dynamics, and various stress responses. The control of nuclear localization via phosphorylation and dephosphorylation serves as the primary regulatory mechanism for MiT family proteins, and several kinases and phosphatases have been identified to directly determine the transcriptional activities of MiT proteins. In different immune cell types, each MiT family member is shown to play distinct or redundant roles and we expect that there is far more to learn about their functions and regulatory mechanisms in host defense and inflammatory responses.

• Journal of Information Processing Systems
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• 제2권3호
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• pp.178-182
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• 2006

Children exhibit different behaviors, skills, and motivations. The main aim of this research was to investigate children's sensibility factors for icons, and to look for the best typeface for application to Web-Based Instruction (WBI) for e-Learning. Three types of icons were used to assess children's sensibilities toward metaphors: text-image, representational, and spatial mapping. Through the factor analysis, we found that children exhibited more diverse reactions to the text-image and representational types of icons than to the spatial mapping type of icons. Children commonly showedn higher sensibilities to the aesthetic-factor than to the familiarity-factor or the brevity-factor. In addition, we propose a collaborative-typeface system, which recommends the best typeface for children regarding the readability and aesthetic factor in WBI. Based on these results, we venture some suggestions on icon design and typeface selection for e-Learning.