• 한국정밀공학회지
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• 제22권12호
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• pp.51-60
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• 2005

This paper describes a robust control scheme for high-speed and long stroke scanning motion of high precision linear motor system consisting of linear motor, air bearing guide and position measurement system using heterodyne interferometer. Nowadays, semiconductor process and inspection of wafer or LCD need high speed and long travel length for their high throughput and extremely small velocity fluctuations or tracking errors. In order to satisfy these conditions, linear motor system are widely used because they have large thrust force and do not need motion conversion mechanisms such as ball screw, rack & pinion or capstan with which the system are burdened. However linear motors have a problem called force ripple. Force ripple deteriorates the tracking performances and makes periodic position errors. So, force ripple must be compensated. To maximize the tracking performance of linear motor system, we propose the control scheme which is composed of a robust control method, Time Delay Controller (TDC) and a feedforward control method, Zero Phase Error Tracking Control (ZPETC) for accurate tracking a given trajectory and an adaptive force ripple compensation (AFC) algorithm fur estimating and compensating force ripple. The adaptive ripple compensation is continuously refined on the basis of tracking error. Computer simulation results based on modeled parameters verify the effectiveness of the proposed control scheme for high-speed, long stroke and high precision scanning motion and show that the proposed control scheme can achieve a sup error tracking performance in comparison to conventional TDC control.

• 정보처리학회논문지:컴퓨터 및 통신 시스템
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• 제2권5호
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• pp.199-202
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• 2013

무선 센서 네트워크에서 클러스터링 방식의 네트워크 수명은 클러스터 헤드 결정 방법에 의해서 영향을 받는다. 대표적인 클러스터링 방식인 LEACH(Low-Energy Adaptive Clustering Hierarchy)의 경우 주기적으로 클러스터 헤드를 선택함으로써 클러스터 재구축으로 인한 에너지 소모가 큰 단점이 있다. 한편 ACAWT(Adaptive Clustering Algorithm via Waiting Timer)는 클러스터 헤드의 잔여 에너지 수준이 하나의 특정 임계치에 도달하면 클러스터를 재구축하는 비주기적인 클러스터 재구축 방식을 사용한다. 본 논문에서는 클러스터를 주기적으로 재구축하지 않고 노드의 잔여 에너지 수준(level)을 여러 단계로 설정한 후 클러스터 헤드의 잔여 에너지 수준이 한 단계 낮아지면 클러스터를 재구축하는 방법을 제안한다. 또한 클러스터 헤드 선정 시 이웃 노드 수와 잔여 에너지 수준을 고려함으로써 클러스터 헤드의 분포를 균일하게 유지시켜 네트워크 수명을 연장시킨다. 본 제안 방식의 성능을 평가하기 위해서 Qualnet 기반의 시뮬레이션을 수행하였으며, ACAWT와 성능을 비교한 결과 제안 방식이 네트워크 수명 측면에서 우월함을 확인하였다.

• 한국정보과학회논문지:데이타베이스
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• 제28권4호
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• pp.742-757
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• 2001

데이타베이스 관리 시스템에서 한계 이상의 로크요청이 발생하는 경우에는 트랜잭션이 철회된 다 최악의 경우에는 트랜잭션들이 연속적으로 철회되어 시스템이 정지된 것과 같이 어느 트랜잭션도 완료 하지 못하는 현상이 발생할 수 있다. 이 문제점을 해결하기 위하여 로크상승을 사용하지만 기존의 로크상 승 방법들은 문제를 완전히 해결하지는 못한다. 본 논문에서는 이 문제를 해결하기 위하여 적응형 로크상승 기법을 제안한다. 먼저 로크상승에 대한 체 계적인 모델과 로크자원의 부족으로인한 트랜잭션 철회의 주 발생 원인인 상승불가능 로크의 개념을 제안 한다 또한 상승불가능 로크의 수를 제어하기 위한 해결책으로 준로크상승, 로크블로킹, 선택적 강제수행의 개념을 제안하고, 이를 적응형 로크상승 기법에 적용한다. 적응형 로크상승 기법은 불필요한 트랜잭션 털 회를 감소시키며 과다한 로크요청 상황에서 시스템의 성능을 단계적으로 저하시키면서 시스템이 정지되는 현상이 발생하지 않음을 보장한다. 적용형 로크상승 기법의 성능을 검중하기 위하여 시뮬레이션을 통한 실험을 수행하였다. 실험결과 적응형 로크상승 기법은 기존의 로크상승 방법을 사용하는 경우에 비하여 트랜잭션의 철회와 평균 응답시간을 크게 줄이고, 단위 시간당 트랜잭션 처리율을 향상시켰다. 특히 동시에 수행할 수 있는 트랜잭션의 수가 15 에서 256배 이상 증가하는 것을 보였다. 본 논문은 모호하게 인식되던 로크자원 관리 측면에서의 로크상승의 역할을 체계적으로 규명하고 상세 한 작동원리를 명확히 했다는 점에서 커다란 의의가 있다. 기존의 로크상승 방법들은 과다한 로크요청이 발생할 때의 문제를 사용자 또는 시스템관리자의 책임으로 처리한다. 반면에 적응형 로크상승 기법은 과다 한 로크요청이 발생할 때의 문제를 자동적으로 조절하므로 사용자의 부담을 크게 감소시킨다. 따라서 최근 에 많은 관심이 모아지고 있는 자체조율(self-tuning)이 가능한 데이타베이스 관리 시스템 개발에 공헌할 것이다

• Journal of Microbiology and Biotechnology
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• 제27권4호
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• pp.709-717
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• 2017

Mucosal tissues are the initial site through which most pathogens invade. As such, vaccines and adjuvants that modulate mucosal immune functions have emerged as important agents for disease prevention. Herein, we investigated the immunomodulatory mechanisms of the B subunit of Escherichia coli heat-labile enterotoxin type IIa ($LT-IIa-B_5$), a potent non-toxic mucosal adjuvant. Alternations in gene expression in response to $LT-IIa-B_5$ were identified using a genome-wide transcriptional microarray that focused on dendritic cells (DC), a type of cell that broadly orchestrates adaptive and innate immune responses. We found that $LT-IIa-B_5$ enhanced the homing capacity of DC into the lymph nodes and selectively regulated transcription of pro-inflammatory cytokines, chemokines, and cytokine receptors. These data are consistent with a model in which directional activation and differentiation of immune cells by $LT-IIa-B_5$ serve as a critical mechanism whereby this potent adjuvant amplifies mucosal immunity to co-administered antigens.

• Journal of Dairy Science and Biotechnology
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• 제33권4호
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• pp.231-235
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• 2015

The beneficial effects of probiotics on human health have been extensively studied. Strains of Lactobacillus and Bifidobacterium have gained considerable attention, as they are major groups of probiotic bacteria that improve gastrointestinal health. Recently, probiotics have been found to have positive effects on obesity and type 2 diabetes mellitus (T2D) that go beyond the improvement of gut health. Probiotics can alter the secretion of substances such as leptin and adiponectin from white adipose tissue via certain mechanisms. Additionally, probiotics can modulate the adaptive immune system against low-grade inflammation caused by obesity. The potential role of probiotics in the treatment of T2D has garnered interest because of increasing evidence of the anti-diabetic effect of probiotics. In this review, we discuss the results of in vivo studies that have examined the use of probiotics to prevent obesity and T2D, while primarily focusing on the studies that explore the cellular and molecular mechanisms underlying the activity of promising probiotic strains. The conclusions of this review could be of help to researchers who are investigating the effects of probiotics on obesity or T2D, and to patients with these diseases.

• Journal of Dairy Science and Biotechnology
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• 제32권1호
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• pp.1-6
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• 2014

Probiotics have been extensively studied for their beneficial effects on human health. In particular, Lactobacillus and Bifidobacterium strains have gained considerable attention as major groups of probiotic bacteria that improve gastrointestinal health. However, emerging evidence suggests that probiotics offer benefits beyond those observed in the gut recent studies suggest that probiotics and/or their components exert favorable effects on alcoholic liver disease (ALD) pathogenesis such as decreasing intestinal permeability, inhibiting pathogenic bacteria growth, increasing the activity of alcohol metabolism enzymes, modulating the adaptive immune system, and suppressing fatty acid synthesis genes. In this review, we discuss the results of in vivo and in vitro studies that have examined the use of probiotics to prevent ALD, primarily focusing on those that explore the cellular and molecular mechanisms underlying the activities of promising probiotic strains. The evidence presented in this review could help in screening for probiotic strains that have protective effects in ALD patients and in further elucidating the mechanisms of their actions.

• Journal of Computing Science and Engineering
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• 제7권3호
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• pp.187-197
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• 2013

Security has long been a challenging problem in wireless networks, mainly due to its broadcast nature of communication. This opens up simple yet effective measures to thwart useful communications between legitimate radios. Spread spectrum technologies, such as direct sequence spread spectrum (DSSS), have been developed as effective countermeasures against, for example, jamming attacks. This paper surveys previous research on securing a DSSS channel even further, using physical layer attributes-keyless DSSS mechanisms, and watermarked DSSS (WDSSS) schemes. The former has been motivated by the fact that it is still an open question to establish and share the secret spread sequence between the transmitter and the receiver without being noticed by adversaries. The basic idea of the latter is to exploit the redundancy inherent in DSSS's spreading process to embed watermark information. It can be considered a counter measure (authentication) for an intelligent attacker who obtains the spread sequence to generate fake messages. This paper also presents and evaluates an adaptive DSSS scheme that takes both jam resistance and communication efficiency into account.

• The Plant Pathology Journal
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• 제35권6호
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• pp.684-691
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• 2019

Evolution of adaptive mechanisms to abiotic stress is essential for plant growth and development. Plants adapt to stress conditions by activating the abscisic acid (ABA) signaling pathway. It has been suggested that the ABA receptor, clade A protein phosphatase, SnRK2 type kinase, and SLAC1 anion channel are important components of the ABA signaling pathway. In this study, we report that the shaker type potassium (K⁺) channel, GORK, modulates plant responses to ABA and abiotic stresses. Our results indicate that the full length of PP2CA is needed to interact with the GORK C-terminal region. We identified a loss of function allele in gork that displayed ABA-hyposensitive phenotype. gork and pp2ca mutants showed opposite responses to ABA in seed germination and seedling growth. Additionally, gork mutant was tolerant to the NaCl and mannitol treatments, whereas pp2ca mutant was sensitive to the NaCl and mannitol treatments. Thus, our results indicate that GORK enhances the sensitivity to ABA and negatively regulates the mechanisms involved in high salinity and osmotic stresses via PP2CA-mediated signals.

• Journal of Dairy Science and Biotechnology
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• 제28권2호
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• pp.25-30
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• 2010

For centuries, probiotics have been known to promote health and prevent diseases. In recent times, modulation of diseases related to the immune function by probiotics has been recognized as very important to the health of the host's gut. Inflammatory bowel diseases (IBDs) are the most frequently studied diseases in which probiotic administration has been tested as a potential therapy. Various in vitro and in vivo studies have been performed. The studies discussed in this review suggest several mechanisms: probiotics could modulate the gut microflora by competing with disease-causing pathogenic bacteria and could directly regulate the mucosal immune system, which activates the innate and adaptive immune systems. In addition, human clinical trials have shown alleviation of disease symptoms of ulcerative colitis (UC), Crohn's disease, etc. This study aimed to understand the molecular mechanisms underlying immune modulation by probiotics and review studies on the functional aspect of IBD alleviation by probiotics. With more scientific studies confirming the effect of probiotics, this therapy holds promise for use in alternative medicine and/or pharmaceutical preparations, given the long history of safe consumption of probiotics.

• Journal of Communications and Networks
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• 제15권4호
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• pp.422-429
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• 2013

Advances in wireless sensor network (WSN) technology have enabled small and low-cost sensors with the capability of sensing various types of physical and environmental conditions, data processing, and wireless communication. In the WSN, the sensor nodes have a limited transmission range and their processing and storage capabilities as well as their energy resources are limited. A triple umpiring system has already been proved for its better performance in WSNs. The clustering technique is effective in prolonging the lifetime of the WSN. In this study, we have modified the ad-hoc on demand distance vector routing by incorporating signal-to-noise ratio (SNR) based dynamic clustering. The proposed scheme, which is an efficient and secure routing protocol for wireless sensor networks through SNR-based dynamic clustering (ESRPSDC) mechanisms, can partition the nodes into clusters and select the cluster head (CH) among the nodes based on the energy, and non CH nodes join with a specific CH based on the SNR values. Error recovery has been implemented during the inter-cluster routing in order to avoid end-to-end error recovery. Security has been achieved by isolating the malicious nodes using sink-based routing pattern analysis. Extensive investigation studies using a global mobile simulator have shown that this hybrid ESRP significantly improves the energy efficiency and packet reception rate as compared with the SNR unaware routing algorithms such as the low energy aware adaptive clustering hierarchy and power efficient gathering in sensor information systems.