• IMMUNE NETWORK
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• v.23 no.1
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• pp.4.1-4.15
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• 2023

Th cells, which orchestrate immune responses to various pathogens, differentiate from naive CD4 T cells into several subsets that stimulate and regulate immune responses against various types of pathogens, as well as a variety of immune-related diseases. Decades of research have revealed that the fate decision processes are controlled by cytokines, cytokine receptor signaling, and master transcription factors that drive the differentiation programs. Since the Th1 and Th2 paradigm was proposed, many subsets have been added to the list. In this review, I will summarize these events, including the fate decision processes, subset functions, transcriptional regulation, metabolic regulation, and plasticity and heterogeneity. I will also introduce current topics of interest.

• Archives of Pharmacal Research
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• v.18 no.6
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• pp.410-414
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• 1995

Adaptive response induced by low dese .gamma.-ray irradiation in human cervical carcinoma cells was examined. Cells were exposured to low dose of .gamma.-ray irradiation in human cervical carcinoma cells was examined. Cells were exposured to low dose of .gamma.-ray (1-cGy) followed by high doses of r-ray irradiation (0,1,2,3,5,7 and 9Gy for chlnogenic assay or 1.5Gy for micronucleus assay) with various time intervals. Survival fractions of cells in both low dose-irradiated and unirrated groups were analyzed by clonogenic assay. Surviva fractions of low dose-irradiated in cell survival was maximum when low and high dose irradiation time interval was 4 hr. Frequencies of micronuclei which is an indicative of chromosome aberration were also enutained from survival fractions analyzed by clonogenic assay, maximum when low and high dose irradiation time interval was 4hr. Frequencies of micronuclei which is an indicative of chromosome aberration were also enumerated in both low dose-irradiated and unirradiated groups. In consiststent with the result obtained from survival fractions analyzed by clonogenic assay, maximum reduction in frquencies of micronuclei was observed when low dose radiation was given 4 hr prior to high response to subsequent high dose .gamma.-ray irradiation in human cervical carcinomal cells. Our data suggest that one of the possible mechanisms of adaptive response induced by low dose rediation is the increase in repair of DNA double strand breaks in low dose radiation-adapted cells.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.34 no.3
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• pp.393-401
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• 2024

Recently, the Internet of Things (IoT) has been widely used in industries and daily life that directly affect human safety, life, and assets. However, IoT devices, which need to meet low-cost, lightweight, and low-power requirements, face a significant problem of shortened battery lifetime due to battery draining attacks and interference. To solve this problem, the 802.11ba standard for the Wake-up Receiver (WuR) has emerged, this feature is playing a crucial role in minimizing energy consumption. However, the WuR protocol did not consider security mechanisms in order to reduce latency and overhead. Therefore, in this study, anAdaptive Power Saving Mechanism (APSM) is proposed for low-power WuR to counter battery draining attacks. APSM can minimize abnormally occurring power consumption by exponentially increasing power-saving time in environments prone to attacks. According to experimental results, the proposed APSM improved energy consumption efficiency by a minimum of 13.77% compared to the traditional Legacy Power Saving Mechanism (LPSM) when attack traffic ratio is 10% or more of the total traffic.

• Journal of Korean Academy of Nursing
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• v.9 no.2
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• pp.49-61
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• 1979

A review of this literature and discussions reveal a development of ideas concerning the elements of nursing models. The elements of a nursing model are the nurses view of the human being, nursing's goal, and nursing activities. It has long been recognized that human beings, at one time or another, require nursing care. Varieties of literature were reviewed in regard to the human being as recipient of nursing care through the theory development in nursing. Florence Nightingale initiated the modern era of nursing and described more clearly man as the recipient of nursing care. She looked at man as responding to the laws of nature whether the person was healthy or sick. Henderson added to Nightingale's concept of man , the recipient of nursing care by emphasizing that man is a whole, complete, and independent being. Her view is further specified by her enumeration of the activities the human being must perform. Johnson has developed a very comprehensive view of man as the recipient of nursing care. Man is a behavioral system which has a tendency to achieve and maintain stability in patterns of functioning. Like Nightingale, Johnson sees that similar patterns occur in both health and illness. Johnson postulates that the whole behavioral system of the human is composed of eight sub-systems: affiliative, achievement, aggressive, dependency, eliminative, ingestive, restorative, sexual. Roger's main contribution to the development of nursing models was her emphasis upon unitary man. She pointed out that man is a unified whole, possessing his own integrity and manifesting characteristics that“are more than and different from the sum of his parts.”Rogers focuses on the life processes of the human and points out that these processes have the following characteristics. Wholeness, openness, unidirectionality, pattern and organization, sentence, and thought. According to Roy, man is a biopsychosocial being in constant interaction with a changing environment. To cope with this changing environment, man has certain innate and acquired mechanisms. Man's ability to respond positively or to adapt, depends upon the degree of the change taking place and the state of the person coping with the change. When she analyzes man as an adaptive organism she further describes man as being composed of four adaptive modes: physiological needs, self-concept, role function, and interdependence. Based on the literary review through the theory development in nursing, general approach by a unified nursing model to a view of the recipient of nursing care may be stated as follows: Man is a unified whole composed of subsystems with a flexible and normal line of defense; his internal regulating mechanisms help him to cope with a changing environment; he functions by the principles of homeodynamics.

• Biomolecules & Therapeutics
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• v.5 no.2
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• pp.202-210
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• 1997

Protective effect of DA-9601, an extract of Artemisia Herb, against ethanol-induced gastric mucosal injury was evaluated in rats. In the prophylactic study, DA-9601 exhibited total protection (99.4%) against absolute ethanol-induced gastropathy, And the protective effect of DA-9601 lasted up to 2 hours, which was longer than those of other contemporary mucoprotectants. In the treatment study, DA-9601 significantly facilitated the healing of 70% ethanol-induced mucosal damage, which was superior to cetraxate, a commonly used anti-ulcer drug. The mechanisms of mucoprotection of DA-9601 were also assessed. DA-9601 increased the release of prostaglandin E$_2$ from murine neutrophils in a dose-dependent manner in vitro. The cytoprotective effect of DA-9601 against ethanol-induced mucosal damage was significantly diminished by the concommitant injection of N$\omega$-nitro-L-arginine methyl ester (L-NAME, 5 mg/kg, i.v.), a non-specific nitric oxide (NO) synthase inhibitor, while it was not affected by preinjection of indomethacin (5 mg/kg, s.c.), a prostaglandins-depletor. And it was found that DA-9601 significantly enhanced adaptive cytoprotective action of 10% ethanol against absolute ethanol (56.9$\pm$6.5 vs 23.0$\pm$3.3 mm$^2$, p<0.05, mean$\pm$SEM), though its exact underlying mechanism remains to be clarified. The present fin[lings demonstrate that DA-9601 exerts gastroprotecticv actions for the stomach against ethanol through several different underlying mechanisms, in which prostanglandins and NO are involved. In conclusion, the results obtained suggest that DA-9601 can be useful both in prevention and treatment of ethanol-induced gastric damage.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.5 no.5
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• pp.941-950
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• 2001

In this paper, we present the integrated network architecture for supporting mobile IP in third generation mobile communication networks, and propose the end-to-end QoS control mechanisms of DiffServ and QoS control functions of each network element in the proposed network. First, the QoS supporting schemes of IMT-2000 are described. Second, the necessities of integrating the networks are discussed and the integrated architecture are proposed. Third, the mapping between wireless channels and DiffServ classes are presented. Finally, the end-to-end QoS control mechanisms are proposed. We also analyze the link level protocols with QoS provisioning for mobile multimedia assuming that the system support voice and data traffic simultaneously. In case of data traffic, the delay and throughput of SREJ ARQ and Type-1 Hybrid ARQ scheme are compared, and In case of voice traffic, the packet loss rate of BCH coding is analyzed according to the varying data traffic loads. The results indicate that the adaptive link level protocols are efficient to meet the QoS requirements while the complexities are increased.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.39B no.2
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• pp.114-122
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• 2014

Beacon transmission is one of the fundamental mechanisms in vehicular ad hoc networks. Variety services including context awareness can be embodied by exchanging beacons in each vehicle. In this paper, we propose dual beacon transmission instead of traditional single beacon transmission for beaconing mechanism. dual beacon transmission divides beacon into two functions and operates two beaconing process independently. We verified the superiority of dual beacon transmission by comparing beacon packet delivery ratio with single beacon transmission. In conclusion, dual beacon transmission can reduce channel load and have both wider communication range and effective context awareness. In addition, implementing dual beacon transmission has less complexity and appliable with conventional adaptive beaconing schemes.

• The Journal of Internal Korean Medicine
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• v.27 no.2
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• pp.471-479
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• 2006

Backgrounds & Objectives: Banhasasimtang granule(BHSST) has been used for the treatment of functional dyspepsia regarded as one of the gastric dysmotility disease. but its mechanisms of action are not well known yet: So we investigated the effects of BHSST on gastric emptying and its mechanisms of action in rats. Methods: Gastric emptying was measured by glass beads(1mm in diameter) expelled from the stomach for 60 min after administration of normal saline(NS) or BHSST 31mg/kg or 93mg/kg in rats. And by the same method gastric emptying was measured after administration of NS or BHSST 93mg/kg in rats treated with atropine sulfate(1mg/kg, s.c.), quinpirol HCI(0.3mg/kg, i.p.), NAME(NG-nitro-L-arginine methyl ester, 75mg/kg, s.c.) or cisplatin(10mg/kg, i.p.) to make delayed gastric emptying. Results: BHSST 93mg/kg improved gastric emptying more than NS or BHSST 31mg/kg(p=0.016). Under the delayed gastric emptying, BHSST 93mg/kg improved gastric emptying in the group treated with NAME$(5.00{\pm}3.101\;vs\;9.00{\pm}3.51,\;p\;=0.046)$, but aggravated it With atropine sulfate$(5.71{\pm}3.45\;vs\;2.57{\pm}1.62,\;p\;=0.050)$ and cisplatin$(12.7{\pm}2.29\;vs\;8.57{\pm}5.06,\;p\;=0.072)$. Conclusions: BHSST improves the gastric emptying through cholinergic and 5-hydroxytryptamine 3 receptors. Especially it is effective to improve gastric emptying delayed by NAME. So we expect that it would be effective in functional dyspepsia with impaired reservoir functions such as gastric adaptive relaxation.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.21 no.3
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• pp.713-720
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• 1996

In recent, the demand of mobile communication system is increasing rapidly. However, since wireless resources is limitted, the protocol to utilize wireless resource efficiently is needed. Up to now, Slotted CDMA_ALOHA(S_CDMA_ALOHA) and Mini-Slotted CDMA_ALOHA(MS_CDMA_ALOHA) methods are proposed as a CDMA_ALOHA mechanism, and it is turned out that MS_CDMA_ALOHA offers betterperformance than S_CDMA_ALOHA mechanism. Also, IS-95 multiple access mechanism has been proposed as common air interface(CAI) protocol of CDMA digital cellular system. However, in former study, the performance evaluations were made without considertion of chnnel characteristics of wireless communication environment. In this paper, a new access mechanism for improring the performance in the DS/CDMA digital cellular environment is suggested. This mechanism is adaptive to the channel condition and based on the conventional MS_CDMA_ALOHA mechanism. Also, the performance of new access mechanism is compared with that of conventional mechanisms, through computer simulation. According tot h simulation results, it is shown that the proposed NA_CDMA_ALOHA(Noise-Adaptation CDMA_ALOHA) mechanism offers better performance than conventional three CDMA_ALOHA mechanisms in view of mean delay time and system throughput characteristics. This phenomenon is due to the fast that NA_CDMA_ALOHA mechanism controls the access attempts efficiently based on the channel condition in heavy traffic environments.

• The Transactions of the Korea Information Processing Society
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• v.4 no.9
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• pp.2366-2377
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• 1997

An Adaptive Usage Parameter Control(UPC) mechanism using a Variable Token Pool(VTP) which is kind of preventive traffic control in the Asynchronous Transfer Mode(ATM) networks is described. The VTP mechanism can monitor violations of the average bit rate and burst duration as well as peak bit rate for the ON-OFF type traffic. The VTP can vary the token pool size by monitoring burst duration and silence duration for a long term. It also improves the sensitivity against the violation of burst duration and average bit rate and enables to response for the violating traffic situation quickly. The variable token pool size is varied in step size by every burst duration and silence duration. Two important parameters for controlling token pool size are Down_size and Up_size. We compare the performance of LB and JW mechanism with the proposed VTP mechanism by computer simulations. We have known that the proposed method is more effective than the previous mechanisms. It is shown that the cell loss rate of the VTP quite depends on the value of Down_size and Up_size. The two parameters should be decided as a propr value according to traffic situations.