• 대한한의학회지
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• 제29권4호
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• pp.1-12
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• 2008

Background and Objectives: Sinusitis is a common disease in the otorhinolaryngology field. It is inflammatory change of the mucous membrane which surrounds the sinus. The aim of this study was to investigate the anti-inflammatory effects of the Taklisodok-eum (TSE) extract on the mouse model with acute sinusitis induced by S. pneumoniae. Methods: Thirty six-week-old male BALB/c mice were divided into three groups: the normal group, the group inoculated with S. pneumoniae which caused allergic rhinitis (control group), and the group treated with the TSE extract after it was treated the same as the control group (sample group). Results: $NF-{\kappa}B$ activation was suppressed, and iNOS & COX-2 production were inhibited by TSE in acute sinusitis. Apoptosis was increased by TSE in acute sinusitis. The number of eosinophils in the sample group noticeably decreased when compared to the control group. In the general morphologic change, the increase of damaged respiratory ciliated epithelia & eosinophils' infiltration was lessin the sample group. Goblet cells were maintained in the sample group. MMP-9, HSP-70 and BrdU decreased in the sample group. Apocrine secretion decreased in the sample group. Conclusion: The findings in this study show that TSE reduces acute sinusitis through its anti-inflammatory effects, such as the inhibition of $NF-{\kappa}B$ activity.

• 한방안이비인후피부과학회지
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• 제31권3호
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• pp.1-11
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• 2018

Objectives : The purpose of this study is to analyze the correlation between fine dust(PM10.5, PM2.5) and the number of acute/chronic sinusitis patients. Methods : A simple regression analysis was performed based on the concentration of PM10 and PM2.5 as independent variables and the number of acute/chronic sinusitis patients as dependent variables. Results : As a result of simple regression analysis, if PM10 increases by $1{\mu}g/m^3$, the number of acute sinusitis patients increases by 7,000.291(P<.001, 95%CI :4,951.983-9,048.600). If PM2.5 increases by $1{\mu}g/m^3$, the number of acute sinusitis patients increases by 17,524.476.(P<.001, 95%CI:9,728.725-25,320.228) In addition, PM10 increases by $1{\mu}g/m^3$, the number of acute sinusitis patients increases by 3,163.471 (P<.001, 95% CI:2,268.642-4,058.301). If PM2.5 increases by $1{\mu}g/m^3$, the number of chronic sinusitis patients increases by 8,651.644.(P<.001, 95%CI:5,115.697-12,187.592) Conclusions : Both PM10 and PM2.5 are correlated with changes in the number of sinusitis patients. PM2.5 has effect on the number of patients than PM10. PM10 is the highest correlation in their 50s, PM2.5 in their 60s and 70s.

• Pediatric Infection and Vaccine
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• 제15권2호
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• pp.100-107
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• 2008

Acute otitis media and acute sinusitis are some of the most common antibiotic-prescribed diseases in childhood. Usually, with an accurate diagnosis, a 10-14 day course of antibiotics is recommended to cover common causative agents, including pneumococci. Establishment of management guidelines for these infectious diseases based on further study of the epidemiologic profile, antibiotic resistance, and clinical circumstances in Korea is needed.

• Clinical and Experimental Pediatrics
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• 제57권11호
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• pp.479-483
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• 2014

Purpose: The efficacy of antibiotic therapy for acute sinusitis is controversial. This study aimed to compare the efficacies of amoxicillin with nasal irrigation and nasal irrigation alone for acute sinusitis in children. Methods: This randomized, double-blind, controlled study included 80 children aged 4-15 years with a clinical presentation of acute sinusitis. Patients were randomly assigned to receive either amoxicillin (80 mg/kg/day) in 3 divided doses orally for 14 days with saline nasal irrigation (for 5 days) and 0.25% phenylephrine (for 2 days) or the same treatment without amoxicillin. Clinical improvements in their initial symptoms were assessed on days 3, 14, 21, and 28. Results: On day 3, patients in the amoxicillin with nasal irrigation group showed significant clinical improvement (P=0.001), but there was no significant difference in the degree of improvement between the amoxicillin with nasal irrigation and nasal irrigation alone groups during follow-up (P>0.05). In addition, no significant differences were seen in age, sex, and degree of improvement between groups (P>0.05). Conclusion: High-dose amoxicillin with saline nasal irrigation relieved acute sinusitis symptoms faster and more often than saline nasal irrigation alone. However, antibiotic treatment for acute sinusitis confers only a small therapeutic benefit over nasal irrigation.

• 대한한의학회지
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• 제30권2호
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• pp.133-144
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• 2009

Background and Objectives: Sinusitis, referring to an inflammatory disease that occurs on the mucus membrane inside the sinus, is one of the most common diseases in the otorhinolaryngology area. In oriental clinic, Sunbanghwalmyungeum (SHE) has been used as a primary prescription to treat inflammatory diseases and intumescence and to treat sinusitis. The aim of this study was to investigate the anti-inflammatory and anti-allergic effects of SHE on acute sinusitis induced mice. Materials and Methods: BALB/c mice were divided into three groups: the normal group, the group inoculated with S. pneumoniae which caused them allergic rhinitis (control group), and the group treated with the SHE extract after it was treated the same as the control group (sample group). We investigated the inhibition of Th 2 cell differentiation by SHE and the suppression of NF-${\kappa}B$ activation. Results: NF-${\kappa}B$ activation was suppressed, and iNOS & COX-2 production were inhibited by SHE in acute sinusitis. IL-4 and STAT 6 also appeared to be suppressed. The number of eosinophils in the sample group noticeably decreased when compared to the control group. In the general morphologic change, the increase of damaged respiratory ciliated epithelium & eosinophil's infiltration were decreased in the sample group. Goblet cells were maintained in the sample group. MIP-2 and HSP-70 decreased in the sample group. Apocrine secretion decreased in the sample group. Conclusion: The results suggest that SHE is significantly effective in the treatment of inflammation caused by acute sinusitis through the suppression of NF-${\kappa}B$ activation and the inhibition of Th 2 cell differentiation.

• Clinical and Experimental Pediatrics
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• 제50권4호
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• pp.323-327
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• 2007

Although most clinicians now agree that sinusitis can afflict children of all ages, appropriate diagnosis remain controversial. Sinusitis is one of the most challenging diagnoses for a clinician, because there is a lack of validated diagnostic criteria for acute rhinosinusitis. Symptoms generally include nasal congestion, purulent nasal discharge, and cough .The physical examination is often unsuccessful in confirming the diagnosis. If purulent discharge is seen oozing from the middle meatus, the diagnosis of acute rhinosinusitis is almost certain. Purulent drainage may also be seen in the posterior pharynx and accompanied by halitosis. Absence of light by transillumination may indicate acute rhinosinusitis. Imaging studies are not necessary to confirm the diagnosis of sinusitis in children younger than 6 years and should be used sparingly in children older than 6 years. Sinus radiographs still have several advantages over CT scanning including the relatively low cost and the ability to obtain films without the use of sedation in younger children. Positive findings of sinusitis on plain film include air-fluid levels, complete opacification, or mucosal thickening greater then 4 mm. The CT scan however, is significantly more sensitive then plain films in detecting these abnormalities. Although recovery of bacteria from a sinus aspiration is considered reference standard for diagnosis in pediatric rhinosinusitis, its routine used by pediatricians is not practical and therefore is not recommended.

• Clinical and Experimental Pediatrics
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• 제50권4호
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• pp.328-334
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• 2007

Sinusitis is a common medical problem in children. The prevalence of penicillin-resistant S. pneumoniae infection has been increased during the last decade. The medical management is based on the choice of antimicrobial agents. This article reviews current literatures on the management of acute bacterial sinusitis and chronic sinusitis, with an emphasis on penicillin-resistant S. pneumoniae infection. This article also explores the potential pathophysiologic mechanisms of chronic sinusitis.

• Pediatric Infection and Vaccine
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• 제22권3호
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• pp.201-205
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• 2015

급성 상악동염의 원인으로는 급성 상기도 감염이 가장 흔하며 함치성 낭종 등의 치성원인에 의한 경우는 상악동염의 10-12%를 차지한다. 함치성 낭종은 주로 치과에서 우연한 방사선학적 검사에 의해 발견되며 소아에서는 드물게 보고되고 있다. 함치성 낭종이 과잉치와 동반되었을 때 주위 상악골의 파괴와 치근의 흡수를 야기하거나 침범된 치아의 변위를 유발할 수 있으므로, 조기 진단과 적절한 치료가 중요하다. 본 증례에서 콧물과 코막힘으로 부비동염으로 진단받았던 9세 남자 환아가 2개월 뒤 좌측안면부 연부조직염으로 내원하여 시행한 방사선학적 검사에서 좌측 상악동에 과잉치와 동반된 함기성 낭종이 관찰되었으며, 치료로 외과적 절제술을 시행하였다. 저자들은 소아에서 부비동염의 원인으로 과잉치를 동반한 감염된 함치성 낭종을 경험하였으며, 부비동염의 진단과 치료에 있어 항생제 치료로 호전되지 않거나 증상이 지속될 시 단순 상기도감염 합병증 외에 다른 질환의 감별을 고려할 것을 당부하는 바이다.

• Pediatric Infection and Vaccine
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• 제27권1호
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• pp.62-68
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• 2020

급성 세균성 부비동염은 소아에서 흔하게 발생하는 질환 중 하나로, 바이러스성 상기도 감염 후 5-13%에서 동반하는 것으로 알려져 있다. 접형동에 국한된 부비동염이 발생할 확률은 모든 부비동염의 3% 미만이나 접형동의 구조적 특성상 주위 조직으로 감염이 전파되면 치명적일 수 있다. 비피막형 인플루엔자균(non-typeable Haemophilus influenzae[NTHi])은 급성 세균성 부비동염의 흔한 원인균이나 정상면역인 환아에서 균혈증으로 파급되는 경우는 매우 드물다. 저자들은 특별한 기저질환이 없는 소아가 발열과 두통으로 내원하여 균혈증을 동반한 NTHi에 의한 편측 접형동에 국한된 부비동염이 확인되어 항생제 및 수술적 치료로 호전된 예를 경험하여 보고하는 바이다.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제35권1호
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• pp.60-65
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• 2013

The maxillary floor sinus augmentation is considered as a safe and predictable procedure to ensure optimal implant placement. However, this procedure may have a variety of intra-surgical or post-surgical complications, also the major drawback of the procedure is deemed maxillary sinusitis. This case is a very unusual delayed occurrence of acute maxillary sinusitis after simultaneous maxillary sinus augmentation, using xenograft and implant placement. This report describes a serious complication of the maxillary sinus augmentation.