• Natural Product Sciences
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• 제12권1호
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• pp.55-61
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• 2006

A description of simple, isocratic and precise reversed phase HPLC methods is given for simultaneous quantification of pholcodine and ephedrine hydrochloride together with either carbinoxamine maleate or terfenadine in antitussive-antihistaminic oral pharmaceutical formulations. Separations were carried out on X-Terra and symmetry shield C18 column $(250\;{\times}\;4.6\;mm,\;5\;{\mu}m)$. The used isocratic elution systems were either $0.02\;M\;KH_2PO_4-acetonitrile$ in the ratio of 75 : 25 and pH adjusted to 7.70 with orthophosphoric acid or sodium hydroxide, for syrup (method A), or 0.02 octanesulphonic acid sodium salt solution-acetonitrile-acetic acid in the ratio of 75 : 25 : 0.5 for suspension (method B). The elution of both mixtures was achieved with a flow rate of 1 ml/min. Detection was carried out by UV absorbance at wavelengths of 220 and 250 nm for syrup and suspension, respectively. The quantification of the components in synthetic mixtures and actual syrup and suspension were calculated using the internal standard technique with metoclopramide HCl and codeine phosphate as internal standards (IS), respectively. The methods, for both mixtures, were validated and met all the requirements for the quality control analysis recommended by FDA and ICH.

• 한국정밀공학회지
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• 제21권1호
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• pp.116-123
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• 2004

The demand for the stable and comfortable cabin of a high speed passenger ship is increasing. The study on shipboard comfort has been mainly concentrated on the motion control of a whole hull body. In this study, however, a new control system operated by two parallel robots (3RPS, 3SPR) such as the active suspension system of motor vehicle is proposed. The goal of this control is keeping zero velocity of the upper robot (cabin) although the lower robot (ship) is moving by the waves. Jacobian matrix was used to design the controller, From the simulation results, the remarkable reduction of motion of the cabin (upper platform) was observed. The 3SPR parallel robot shows better performance compared to the 3RPS robot.

• 동력기계공학회지
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• 제8권2호
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• pp.53-58
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• 2004

In this paper, the semi active mount featuring Magneto rheological fluid(MR Fluid) is proposed. MR fluid is suspension of micro sized magnetizable particles in a fluid medium, and its apparent viscosity can be varied by the applied strength of magnetic field. When the controllable MR fluid is applied to mechanical devices, the devices provide simple, rapid response interfaces between electronic controls and mechanical systems. The MR fluid is applied in the conventional fluid mount for improving its performance of the mount's isolation effect. A appropriate size of the MR mount is designed and manufactured on the basis of Bingham model of MR fluid. In addition, the field dependent damping forces of MR mount are evaluated with respect to the input frequency variation.

• 한국정밀공학회지
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• 제20권7호
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• pp.91-98
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• 2003

In the field of precision manufacturing demanding high positioning performance, the mechanical friction in positioning device deteriorates the quality of the product and increases the cost of production for positioning devices. Therefore, we propose a contract-free linear actuator using active magnetic bearing. The structure and operating principle of the proposed system are explained, and the magnetic forces are analyzed by magnetic circuit theory to design magnetic bearings and linear actuator. With the derived equation of motion, the stability is identified. Experimental results are presented to show the feasibility.

• 대한전기학회논문지:전력기술부문A
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• 제48권5호
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• pp.593-600
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• 1999

This paper suggests a suboptimal control scheme of an active suspension system with an asymmetric hydraulic cylinder. In this paper a quarter car model including a nonlinear actuator dynamics is used. A feedback linearization technique is applied to obtain a linear model. An LQ regulator is designed with the linear model to keep robustness against sprung mass variation. The gain of the LQ regulator which depends on the damping coefficient of the damper is calculated by using an RBF neural network for real time application. The improvement achieved with our design is illustrated through comparative simulations.

• 한국자동차공학회논문집
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• 제8권2호
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• pp.102-109
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• 2000

This paper deals with an observer-based preview control for semi-active suspensions. An Observer has been designed such that all the state variables and road inputs can be estimated from accelerations. Since the road input to the rear wheels is a delayed version of that to the front wheels, it can be obtained by estimating the road input to the front wheels without preview the estimated values of state and the estimated road input has been investigated. The results show that the observer-based control can provide good performance. The observer-based preview control improves the dynamic behavior of the rear axle and that of pitch motion compared to the LQ optimal control.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2013년도 제45회 하계 정기학술대회 초록집
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• pp.268.1-268.1
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• 2013

Immobilization of conducting nanoparticles on a nanogap comprising two electrodes spaced at a distance comparable to the particle size can be used as a simple and sensitive method of detecting the particles. In this work, we have examined the performance of the nanogap devices in the measurement of metallic nanoparticles, particularly gold nanoparticles (Au NPs). Detection of pM-level Au NPs in an aqueous suspension was quite straightforward irrespective of the existence of non-conducting materials. Speed of detection or the time necessary for the completion of the measurement, however, was strongly dependent upon the immobilization process. Active trapping process was found to be much more efficient and also effective in the detection of nanoparticles than its passive counterpart.

• 유변학
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• 제11권2호
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• pp.112-121
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• 1999

현가장치의 기능은 노면으로부터의 진동이나 충격을 차체와 격리시키며 주행시 차량의 안전성을 확보하는데 있다. 고정된 스프링과 댐퍼의 특성으로는 두 가지 차량 주행특성을 나타내는 차체 가속도와 타이어 동적력을 최소화할 수 없으므로 가변형 댐퍼를 이용한 반능동식 현가장치로서 승차감과 주행 안정성을 동시에 고려하여 성능 지수를 설계하는 LQ(Linear Quadratic)제어 이론을 적용하는 연구가 진행되고 있다. LQ 제어 성능지수의 가중함수는 주파수와 시간에 관계없이 상수로 고정되기 때문에 각 요소에 대한 비중이 모든 상황에서 동일하나 승차감이나 주행 안정성의 평가기준이 모든 주파수에서 동일하지 않으므로 본 연구에서는 자기유변댐퍼를 장착한 1/4차의 반능동형 현가장치를 구성하고 LQ 제어의 문제점을 해결하는 Frequency shaped 최적 제어를 이용하여 특정 주파수 범위에서 차량의 승차감과 주행 안정성을 향상시킨다. Frequency shaped 최적 제어는 가중치가 주파수의 함수인 성능 지수를 통해 제어 규칙을 구하는데, 가중함수의 설계기준을 인간이 가장 민감하게 느끼는 4~8Hz의 주파수에서는 승차감에 두고 차축 고유 진동수 부근에는 주행안전성에 둔다. 모사실험과 실험 결과로부터 Frequency shaped 최적 제어기를 장착한 반능동형 현가장치가 승차감과 주행 안정성을 향상시킬 수 있음을 알 수 있다.

• 생약학회지
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• 제46권3호
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• pp.203-207
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• 2015

This study was performed to examine the antigenic potential of purified bee venom (Apis mellifera L., PBV) collected using bee venom collector. Antigenic potential of PBV was examined by active systemic anaphylaxis (ASA) in guinea pigs. PBV was subcutaneously administered at 0.025 and 0.05 mg/kg and also as a suspension with adjuvant (Freund's complete adjuvant, FCA). Ovalbumin (OVA) as a suspension with adjuvant was used to introduce positive control response. In the weight measurement and clinical observation, experimental groups didn't show any significant changes compared with control group. In the autopsy of body, the abnormalities of lung were detected only in the positive control. In the ASA test, experimental groups didn't show any symptoms of anaphylaxis like piloerection, hyperpnea and staggering gait. These results suggested that PBV didn't have antigenic potential in guinea pig.

• Toxicological Research
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• 제21권3호
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• pp.241-247
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• 2005

HM10760 is a recombinant human erythropoietin that has beer developed as a drug for anemia. In this study, antigenic potential of HM10760 was examined by active systemic anaphylaxis in guinea pigs and passive cutaneous anaphylaxis in a guinea pig-guinea pig system. HM10760 was subcutaneously administered at 0, 2, and $20{\mu}g/kg$ and also as a suspension with adjuvant ($20{\mu}g/kg$ + FCA). Ovalbumin as a suspension with adjuvant was administered to induce positive control responses. In the active systemic anaphylaxis test, no symptoms except rubbing or licking nose and urination that were considered as physiological phenomena were observed at $0{\mu}g/kg$. Four of 5 animals at $2{\mu}g/kg$ and all the 5 animals at $20{\mu}g/kg$ showed cyanosis and lying on side. All animals in the adjuvant mixture group showed relatively mild symptoms such as rubbing or licking nose, urination, and evacuation. In the passive cutaneous anaphylaxis test, 0/5, 3/5, and 5/5 serum samples from the animals immunized with 0, 2, and $20{\mu}g/kg$, respectively, showed positive reactions against HM10760. All 5 sera collected from the animals immunized with an adjuvant mixture contained HM10760-specific antibodies. These results suggest HM10760 have antigenicity in guinea pigs.