• Title/Summary/Keyword: active agent

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S-Nitrosylation of Sulfhydryl Groups in Albumin by Nitrosating Agents

  • Park, Jeen-Woo
    • Archives of Pharmacal Research
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    • v.16 no.1
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    • pp.1-5
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    • 1993
  • The reaction of sulfhydryl groups in human serum ablumin with bacteriostatic and hypotensive notrosating agents such as sodium nitorprusside and sodium nitrite has been examined. The low reactivity of sodium nitroprusside to sulfhydral groups in albumin has been observed and the sterical inaccessilibility of the agent site which sulfhydryl group resides was implicated. The reaction of sodium nitrite with albumin was highly influenced by pH and little reactivity was observed at physiological pH. On the other hand, the reaction between albumin and S-nitrosoglutatione, an intermediate induced from the reaction of glutathione and nitrosating agents, resulted in the rapid decrease of free sulfhydryl groups in albumin. S-Nitrosylation of the sulfhydryl group by S-nitrosoglutathione and the subsequent production of mixed disulfide is the probable route of modification. In the physiological system, S-nitroso-glutathione may act as an active intermediate in expressing reacivity of nitrosating agents to sulfhydryl groups in albumin.

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A Study on the Hydrolyzed Ginseng Saponin-Quaternary and its Application in Cosmetics (가수분해된 인삼사포닌 4급 암모늄엽과 화장품으로의 응용에 관한 연구)

  • 김영대;김창규;이정남;하병조
    • Journal of Ginseng Research
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    • v.13 no.2
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    • pp.189-197
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    • 1989
  • A new quaternary ammonium compound, hydrolyzed ginseng-saponin quaternary (HGSQ), from Korean ginseng saponin and 2,3-epoxypropyltrimethylammonium chloride has been developed as a conditioning agent in cosmetics. This structure has a hydrophobic group from the aglycone of ginseng saponin which is biologically active and considered to be the most important component of the Korean ginseng. Its properties : surface tension, critical micelle concentration (CMC), eye irritation, sorption onto hair, force reduction(%) and moisture retention effect were studied. Its cationic character allows the molecule to be more substantive than ginseng saponin. HGSQ had good physical properties and was safe. enough as a cosmetic raw material. Also half-head tests of HGSQ-containing shampoo were carried out to compare the conditioning effects in shampoos. HGSQ was an excellent conditioning agent in shampoo..

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The Algorithm Design and Implementation of the Internet Statistics System for using the Robot Agent (로봇에이전트를 이용한 인터넷 주요 통계산출 알고리즘 설계 및 구현)

  • Kim, Weon;Chin, Yong-Ohk;Song, Khwan-Ho
    • Proceedings of the IEEK Conference
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    • 2001.06c
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    • pp.43-46
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    • 2001
  • This thesis proposes the design method of intelligent robot agent system and deals with the implementation of the system which is able to produce key internet statistics. It is believed that the statistics lead to effective investment from internet industry on its development. The system consists of robot agent process module, statistics production module and management module, and has an algorithm that can produce periodically the number of domestic homepages, active domain using .kr or gTLD and intenet hosts. It provides the result of the implementation and performance of the system as well.

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Investigation of the Pharmacological Mechanisms and the R&D of Medical Countermeasures Against Nerve Agent Poisoning (신경작용제 해독제의 약리기전 및 연구개발)

  • Cho, Young
    • Journal of the Korea Institute of Military Science and Technology
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    • v.14 no.5
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    • pp.920-931
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    • 2011
  • Nerve agents are irreversible inhibitors of the cholinesterase enzyme. Exposure causes a progression of toxic signs, including hypersecretions, fasciculations, tremor, convulsions, respiratory distress, epileptiform seizures, brain injuries and death. A combined regimen of prophylaxis and therapy is the most effective medical countermeasure for dealing with the threat of nerve agent poisoning to military personnel. In this paper, the author investigated the updated technologies regarding various pre- and post-treatment drugs for nerve agents detoxification which are under development in several countries including Korea. Some characteristics of active ingredients in the formulations of drugs, their action mechanisms, and effectiveness were analyzed. Additionally, part of experimental data on the transdermal patch studied in ADD using beagle dogs was introduced.

A Study on the Well-being Technique Natural Dyeing with Natural Resources (2) -Effect of Monazite Treatment on the Cotton Fabric with Natural Dyeing using Perilla frutescens var. acuta - (천연물질을 활용한 웰빙기법 천연염색에 관한 연구 (2) -소엽염색 면직물의 모나자이트 처리효과-)

  • Kim, Sang-Yool
    • Fashion & Textile Research Journal
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    • v.12 no.2
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    • pp.240-245
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    • 2010
  • The effects of monazite and fixing agents on cotton fabric dyed with Perilla frutescens var. acuta extract were investigated. The proper monazite treatment concentration, temperature and time were 10%(o.w.b.), $50^{\circ}C$ and 60minutes. By various fixing agent treatment, $FeSO_4$ showed a relatively high K/S value and the order of K/S value decreased as follows, cation surface active agents, soybean and NaCl. And the monazite and $FeSO_4$ fixing agent showed higher anion emissity than those of untreated cotton and other fixing agents. The cotton fabrics showed improved color fastness by monazite and fixing agents treatments with the exception of light fastness. And the cotton fabrics fixed with fixing agents were showed effective bacterial reduction with the exception of NaCl.

Design of Intelligent Intrusion Detection System Based on Distributed Intrusion Detecting Agents : DABIDS (분산 임칩 탐지 에이전트를 기반으로 한 지능형 침입탐지시스템 설계)

  • Lee, Jong-Seong;Chae, Su-Hwan
    • The Transactions of the Korea Information Processing Society
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    • v.6 no.5
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    • pp.1332-1341
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    • 1999
  • Rapid expansion of network and increment of computer system access cause computer security to be an important issue. Hence, the researches in intrusion detection system(IDS)are active to reduce the risk from hackers. Considering IDS, we propose a new IDS model(DABIDS : Distributed Agent Based Intelligent intrusion Detection System) based on distributed intrusion detecting agents. The DABIDS dynamically collects intrusion behavior knowledge from each agents when some doubtable behaviors of users are detected and make new agents codes using intrusion scenario data base, and broadcast the detector codes to the distributed intrusion detecting agent of all node. This DABIDS can efficiently solve the problem to reduce the overhead for training detecting agent for intrusion behavior patterns.

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Adopting EVA Knowledge to Agent-Based Intelligent ERP Development (경제적부가가치 지식을 채택한 에이전트 기반의 지능형 ERP 개발)

  • Kwon, O-Byung;Jung, Jin-Hong
    • Asia pacific journal of information systems
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    • v.9 no.4
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    • pp.41-67
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    • 1999
  • ERP is now one of the prevailing applications for integrated information systems, So far, the conventional ERPs lack how to manage knowledge of making decisions, that is one of the important goal of ERP. This gives a motivation on adding decision support capabilities to the ERPs: active advice for business analysis, evaluation and control. In this paper, we proposed an agent-based intelligent ERP that is operated on the Internet. In special, knowledge of economic value added (EVA) is explicitly acquired as a set of data, models and methodologies, A new knowledge representation format, MIF, is suggested to show the communication mechanism between agents, The agent-based knowledge processing is adopted to deliver intelligence on the Internet.

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Design of Parallel Migration Method of Mobile Agents Using an Object Replication (객체 복제를 통한 이동 에이전트의 병렬 이주 방식 설계)

  • Kim, Kwang-Jong;Lee, Yon-Sik
    • The KIPS Transactions:PartD
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    • v.11D no.2
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    • pp.351-360
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    • 2004
  • Most mobile agents are migrated to many mobile agent systems by the sequential node migration method. However. in this case, if some problems such as host's fault or obstacle etc. happened, mobile agent falls infinity walt or orphan states. Therefore, it is difficult to get an expectation effect as use of other distribution technologies because the required time for networking between nodes increases. And so, many researches have been performed to solve this problems. However, most of methods decide node migration based on passive routing table or detour hosts which have some problems. Actually, the researches for reducing the total required time for networking are insufficient yet. In this paper, to reduce the required time for networking of mobile agent we design an active routing table based on the information of implemented objects which are registered in the meta-table of naming agent. And also, for user's keyword, we propose an replication model that replicates many agent object according to the information and number of object references corresponding to meta-table. Replicated objects are migrated to mobile agent systems in parallel and it provides minimized required time for networking.

Quantification of an active ingredient in tablets by NIR transmission measurements

  • Niemoller, Andreas;Schmidt, Angela;Weis, Aaron;Weiler, Helmut
    • Proceedings of the Korean Society of Near Infrared Spectroscopy Conference
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    • 2001.06a
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    • pp.4114-4114
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    • 2001
  • For the quality control of tablets several parameters have to be checked. The most important one is the content of an active ingredient which has to match a narrow range around the designated content. The only useful measurement mode is transmission which provides information of the complete tablet. A measurement in diffuse reflectance would register only the surface which is useless especially in case of a coated tablet. In this work tablets for a clinical study (placebo/verum studies) with very low concentrations of the active ingredient were measured. The concentration range was 0 to 6 mg with a total weight of the tablets of 105 mg, leading to a highest concentration of the active component of 5.7% by weight. Especially the spectroscopic distinction between the placebo and the low dosage forms with 0.25 and 0.5 mg active agent requires an extraordinarily accurate sampling technique. Using the VECTOR 22/N-T in transmission mode allows the collection of the information from the complete tablets. A quantitative PLS-model with transmission spectra from the tablets described above shows that the active substance can be predicted with a RMSECV (root mean square error of cross validation) of 0.04% absolute for this special application. The results are compared with those of measurements in diffuse reflectance using different accessories.

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