• Advances in Traditional Medicine
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• 제2권1호
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• pp.28-35
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• 2002

Toad venom, 'Chan su' in Chinese and 'somso' in Korean, is a well-known traditional oriental medicine obtained from the skin venom gland of the toad. Formulations of toad venom have been widely applied in China, Japan, Korea and other oriental countries for a long time. It is often found in traditional Chinese formulations, such as Jiuxin (or Kyushin in Japan), Yixin, Huoxin, Shexiang baoxin wan, Lu shen wan and Laryngitis pills. According to a pharmaceutical chemistry study, toad venom contains multiple biological active substances, such as bufalin, resibufogenin and cinobufagin. Modern pharmacological studies indicated that toad venom has multiple pharmacological actions, including acting as a cardiotonic, antitumor local anesthetic effects, stimulates the respiratory center, vasopressor action, anti-inflammatory and diuretic effects. Like other medications, toad venom also has certain toxicity and adverse effects, for example, inducing delayed afterdepolarization and triggered arrhythmia. The major chemical constituents, basic pharmacological actions and adverse reactions of toad venom are discussed in this article.

• Journal of Microbiology
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• 제42권4호
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• pp.336-339
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• 2004

The antibacterial actions of two amino acid oxidases, a D-amino acid oxidase from hog kidney and a L-amino acid oxidase from the venom of Agkistrodon halys, were investigated, demonstrating that both enzymes were able to inhibit the growth of both Gram-positive and Gram-negative bacteria, and that hydrogen peroxide, a product of their enzymatic reactions, was the antibacterial factor. However, hydrogen peroxide generated in the enzymatic reactions was not sufficient to explain the degree to which bacterial growth was inhibited. A fluorescence labeling assay showed that both of these two enzymes could bind to the surfaces of bacteria. To the best of our knowledge, this is the first report regarding the antibacterial activity of the D-amino acid oxidases.

• Journal of Yeungnam Medical Science
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• 제27권1호
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• pp.1-7
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• 2010

Having an understanding of the properties of cytokines is essential for the immunologist, the researcher and the medical practitioner who need to understand immunologic diseases and immunological therapeutic approaches. Cytokines are redundant in their actions on target cells and promiscuous in their receptor reactions. (ED note: That is some cool use of English!) Moreover, many cells concomitantly produce several cytokines that have overlapping actions. Here this review provides conceptual framework to understand the intriguing aspects of the cytokine system.

• Journal of Ginseng Research
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• 제20권1호
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• pp.1-6
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• 1996

Effects of Panax ginseng on allergic reactions were studied uslng various in vivo and in vitro experimental models such as 48-hr passive cutaneous anaphylaxis, mediators-induced skin reactions, histamine release from rat peritoneal mast cells, hexosaminidase release from RBL-2H3 cells, and lipoxygenase assay . In all of anti-allergic experiments we conducted, ginseng components (50% ethanol extract or ginseng total saponin or ginsenosides) extracted from Korean red ginseng, did not show significant anti-allergic actions. In 48-hr passive cutaneous anaphylaxis and mediators-induced skin reactions, 50% ethanol extract did not suppress hypersensitivity reactions. Total saponin, 50% ethanol extract, and 8 major ginsenosides did not show inhibitory effects on lipoxygeanse activity. Ginseng total saponin did not inhibit histamine release from rat peritoneal mast cells. All of the ginseng components mentioned above were also tested on RBL-2H3 cells, but none of them inhibited hexosaminidase release from this cell line. These results suggest that Panax ginseng does not have effects on allergic reactions at the level of 50% ethanol extract or total saponin used. All of 8 major saponin components tested ($Rb_1$, $Rb_2$, Rc, Rd, Re, Rf, $Rg_1$, $Rg_2$), did not inhibit lipoxygenase activity and degranulation events.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1995년도 춘계학술대회
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• pp.103-103
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• 1995

There have been several reports regarding the effects of Panax ginseng on allergy reactions. However, they are very sporadic and no systemic yet. To study the effects of Panax ginseng on hypersensitivity, either ginseng total saponin (GTS, 200mg/kg, oral, two hours prior to experiments) or ethanol extract (50 and 200 mg/kg, oral, one week) was administered. Various parameters were employed to assess the anti-allergic actions of Panax ginseng 48hr passive cutaneous anaphylaxis (PCA), skin reactions, histamine release from rat peritoneal mast eel Is, and lipoxygenase activity. In 48hr PCA, and in skin reactions induced by chemical mediators (histamine, serotonin) and mediator releaser (compound 48/80), Panax ginseng did not suppress sensitized immune functions, rather showed tendency to increase the histamine-induced vascular permeabi1ity. Panax ginseng did not inhibit lipoxygenase activity either.

• 대한방사선기술학회지:방사선기술과학
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• 제30권2호
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• pp.89-93
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• 2007

조영제를 사용한 방사선과 검사의 조영제 부작용에 대한 위험성은 잘 알려져 있으며, 조영제의 부작용을 줄이기 위한 연구도 지속적으로 진행되어 왔다. 또한 조영제 부작용에 대한 사전검사를 하더라도 조영제에 의한 치명적 부작용을 예측하기 어렵다. 이러한 조영제 부작용에 대한 법적책임에 대하여 최근에는 의료기관개설자의 책임이 중요시되고 있다. 의료기관은 환자의 건강을 목적으로 하는 조직체이다. 그리고 조직체는 그 구성원에 의한 과실에 책임이 있다. 그러므로 의료기관개설자는 의료서비스에 대해서 기대가능한 모든 노력을 하여야 하며, 불충분 또는 불완전한 조직편성 및 진료조치가 이루어지지 않게 하여야 할 조직의무를 부담한다. 이러한 점에서 의료기관은 방사선조영검사시에 조영제를 주입하는 단계로부터 검사의 완료에 이르기까지 전과정에 충분하고도 완전한 조직편성과 적정한 진료 확보를 위한 제반조치를 취할 책임이 있다. 따라서 환자의 안전과 진료의 적정을 위하여 의료기관이 조직적으로 필요한 조치를 시행하지 않거나 불충분한 경우에는 불법행위법상 의료기관 독자적인 조직책임을 지게 되며, 의료기관의 조직의무위반은 의료기관 자신의 책임이므로 내부관계에서 의료기관종사자 개인에게 구상권을 행사할 수 없다.

• 미국학
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• 제43권2호
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• pp.111-136
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• 2020

This paper aims to reveal how the fundamental assumptions informing race and gender issues in contemporary society have remained relatively unchanged by examining how such issues pervade Octavia Butler's Kindred. By exploring the protagonist of the novel, Dana's actions in her present (1976 Los Angeles) and the antebellum past in addition to her maternal ancestor, Alice's actions, a clear picture of contemporary and antebellum views of race and gender is provided. Particularly interesting are the reactions of the characters to Dana's and Alice's interracial relationships and the circumstances on the Weylin plantation. By juxtaposing the two times, a deeper commentary on the lack of fundamental change in the present treatment of such issues is then revealed. Furthermore, a potential path to addressing this lack of change is suggested by Butler through Dana and Kevin's successful interracial relationship.

• 한국정보통신학회논문지
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• 제11권6호
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• pp.1062-1068
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• 2007

유비쿼터스게임을 디자인하고 개발하기 위하여 현실세계과 가상세계와의 자연스럽고 다양한 상호작용이 필요하다. 이는 물리적인측면 뿐 아니라 상황변화에 알맞은 대응 감지기술을 필요로한다. 이를 위하여 가상세계와의 유저인터페이스 모델을 정의하고 이를 구현하기 위하여 텍타일감지 시스템을 제작하였다. 텍타일 데이터는 외부환경에 민감하므로 신호처리방법을 사용하여 잡음을 제거하고 유저인터페이스를 위한 데이터 형태로 외부입력을 분석 추론하였다. 이는 일반적인 게임에서 사용하는 마우스나 키보드에 따른 입력과 전혀 다른 형태의 입력으로 유비쿼터스 환경에서의 플레이어의 상황대응에 대한 중요한 정보를 제공하여준다. 구현한 시스템을 통하여 가상공간상에 존재하는 공에 작용한 힘을 3차원적으로 분석하여 힘의 위치, 크기, 분포, 방향 등을 분석하는 방법을 제시 해보았으며 이 같은 실세계 정보 분석을 통하여 가상공간상에서 3차원적인 자연스러운 반작용이 가능하도록 하는 가능성을 보였다. 이 같은 방법들은 유비쿼터스 게임의 상호작용 개발을 위한 기초자료로 사용될 수 있다.

• Asian Journal for Public Opinion Research
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• 제8권3호
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• pp.265-296
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• 2020

Macao, a special administrative region of China, has been able to maintain the records of zero deaths and keep confirmed cases under 50 since the outbreak of COVID-19 for more than half a year as of July 2020, despite being the world's most densely populated city. The current paper utilizes the dialogic public relations theory to analyze the situation using both literature review on how the various government actions and strategies during the pandemic were corresponding to the theory, and a quantitative random digital dialing (RDD) telephone survey, with a sample of 502 Macao residents aged 18 or above, to study the public reactions towards the government pandemic prevention actions. Survey results show a high level of public satisfaction towards epidemic prevention performance, as well as some forms of collaborative information redissemination behavior in social media platforms. Literature review and analysis from dialogic theory found that spirit of mutual equality, collaboration with local community, immediacy of presence in crisis time, engagements with stakeholders through maximum media channels and networks, supportiveness to public with both useful information and practical social support like subsidy program, as well as commitment to transparent and genuine communication, are all the dialogic communications strategies that describe what the Macao government has done in the crisis of COVID-19. The dialogic strategies that could be learned from the Macao government may be used as a reference for similar urbanized and densely populated cities in other territories.

• 한방안이비인후피부과학회지
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• 제15권2호
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• pp.33-52
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• 2002

The effects of Arctii fructus extract on allegenic inflammation were investigated using in vivo and in vitro test models. Firstly, the cytotoxicity of Arctii fructus extract was validated using MTT assay. As a result, Arctii fructus extract showed no cytotoxic potential, while SDS, a positive control, revealed strong cytotoxic effect. In LLNA assay, Arctii fructus extract showed no skin allergenicity. Next, the anti-allergic actions of Arctii fructus extract were evaluated using rodent experimental models. The oral, intraperitoneal and intradermal administration of Arctii fructus extract significantly inhibited the compound 48／80-induced vascular permeability documented by Evans blue extravasation. In addition, Arctii fructus extract showed potent inhibitory effect on passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) IgE when orally administered. In an in vitro study, Arctii fructus extract revealed to possess inhibitory potential on the compound 48／80-induced histamine release from rat peritoneal mast cells. Moreover, Arctii fructus extract inhibited the IL-4 and TNF-${\alpha}$ mRNA induction by PMA and A23187 in human leukemia mast cells, HMC-1. Finally, it revealed that Arctii fructus extract significantly suppressed histamin-provoked antigenic inflammation reactions in human prick test. Taken together, these results suggest that anti-allergic action of Arctii fructus extract may be due to the inhibition of histamine release and cytokine gene expression in the mast cells.