• 말소리와 음성과학
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• 제1권4호
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• pp.203-207
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• 2009

Electrically evoked compound action potentials (ECAP) have originated from the distal end of the auditory nerve. ECAP are characterized as the difference between the clearly large trough (N) and the following positive peak (P). N-wave occurs around $200-400\;{\mu}s$ after stimulus onset and P-wave at around $400-800\;{\mu}s$. Contrary to expectations, positive peaked ECAP (pp-ECAP) was dominated by a relatively large-amplitude positive following negative peak. pp-ECAP can be recorded from the sites on or near the surgically exposed nerve trunk in animal models and/or in cases of monophasic stimulation. This study will provide the causes of the appearance of pp-ECAP in cases of cochlear implant recipients using imaging studies and medical records and statistically analysis between N-P and P-N on the amplitude input-output function (amp-I/O) for the prediction of the possibilities of clinical tools. Thirteen children participated in the study and received a Cochlear CI-24RE (CA). ECAP was recorded using auto-NRT (Cochlear Ltd., Australia) at four to five weeks post surgery. pp-ECAP was measured from 36 electrodes and typical ECAP from 220 electrodes. There was no abnormality in the imaging study and operation finding in patients with typical ECAP. pp-ECAP was found at the inner ear anormaly and ossification in imaging study and gel-state inner ear fluid was observed in the operation finding. The amplitude of pp-ECAP increased depending on current intensities, but amp-I/O increase more gradually than in the case of typical ECAP (p=0.003). pp-ECAP is antidromic potential which can record from the inner ear anormaly and ossified cochlear. Amp-I/O also depends on current intensity as well typical ECAP. These results provide a useful tool for audiological evaluation for the spiral ganglion cell status to the value of pp-ECAP.

• 한방안이비인후피부과학회지
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• 제20권3호
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• pp.82-97
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• 2007

Objective : Cortex of Ulmi pumilae(CUP) has been used to treat several diseases including boil, swelling, and scabies etc. Recently, CUP was known to have wrinkle care and whitening actions. But, It's exact mechanisms are unclear. Methods : The present study was designed to investigate effects of CUP on Human HaCaT keratinocyte and malignant melanoma cells such as SK-MEL-2 and B16F10 in terms of cell viabilities, proliferations, DPPH free radical scavenging activities, oxygen free radical productions and inhibitory action on elastase activities. Results : CUP accelerated proliferation of HaCaT keratinocytes in the lower concentration. CUP also prevented cell death of HaCaT induced by Hydrogen peroxide, which products oxygen free radicals. On the contrary, CUP did not affect proliferations of SK-MEL-2 or B16F10. Futhermore, CUP showed inhibitory action against SK-MEL-2 proliferation at the concentration of $500{\mu}g/m{\ell}$ In addition, CUP was shown to have DPPH free radical scavenging activities and also have inhibitory effects on elastase activities too. On the fluorescent examinations, the present author knows that CUP elevated production levels of oxygen free radicals in malignant melanoma cell, SK-MEL-2. Conclusions : These results suggest that CUP has possibilities of usage for functional cosmetics which have wrinkle care and whitening activities and related mechanisms are involved in inhibition of elastase action and acceleration of oxidative stress in melanoma cell.

• Food Science and Biotechnology
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• 제18권4호
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• pp.833-841
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• 2009

Monoterpenes, in special limonene and its derivatives, are well studied in the literature due to their several properties. They are well recognized as major components of essential oils; some of them, are important industry residues, and others present some important biological activities. In this review, the biotransformation of the inexpensive limonene into flavor compounds was briefly reviewed and the main pathways for limonene biotransformation are presented. Furthermore, some important biological properties of these compounds were also considered, like bactericidal activity, induction of immune response, and role in disease prevention, with a little emphasis on some possibilities related to the mechanisms of anticancer action.

• 만화애니메이션 연구
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• 통권6호
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• pp.193-220
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• 2002

The world being made by computers showing great expanses and complex and various expression provides not simply communication places but also a new civilization and a new creative world. Among these, 3D computer graphics, 3D animation and virtual reality technology wore sublimated as a new culture and a new genre of art by joining graphic design and computer engineering. In this study, I tried to make a diagnosis of possibilities, limits and differences of expression in the area of virtual reality computer graphics animation as a comparison between camera action, angle of actual still camera and film camera and virtual software for 3D computer graphics software - Maya, XSI, Softimage3D.

• 한국초등과학교육학회지:초등과학교육
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• 제24권5호특별호
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• pp.602-611
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• 2005

The 'Mobile Science Lab' is a public program designed to bring teenagers to be engaged in the activities of science and technology. In this study, we attended to elementary school students' participating actions in the program and intended to understand their enjoyment of science from sociocultural and practical perspectives. By drawing on case materials culled from our database, we articulated the features of the enjoyable science activities in the form of two major claims. First, students had rich opportunities to communicate emotionality, which therefore grounds emerging actions on the positive emotional valence. Second, ongoing actions opened up new action possibilities not only to the actors themselves, but also to other community members. The results of this study constitute theoretical frameworks for understanding enjoyment without dichotomizing emotion and cognition, and thereby contribute to designing enjoyable activities of learning science.

• 대한치과교정학회지
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• 제19권3호
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• pp.79-86
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• 1989

The wires for initial alignment purposes require a combination of excellent strength, excellent springiness, and a long rang of action. The variables in selecting appropriate arches for alignment are the arch wire material, its diameter, and the distance between attachments. The principle that there should be 0.02 inch clearance for initial wires means that an .016 diameter wire is the largest that should be considered for initial alignment in the .018 slot system. The three major possibilities for alignment arches are multistranded steel wires, nickel-titanium wires, and single-stranded steel wires with loops. The excellent choice for initial alignment in .018 bracket is .014 steel wire with loops.

• International Journal of Railway
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• 제3권1호
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• pp.1-6
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• 2010

The steel plate-girder bridges with concrete gravity piers have possibilities of overturning by lateral inertial force which can be reproduced by sudden earthquake attack. This paper explores an overturning mechanism of existing concrete gravity pier onto the sandy soil in the event of lateral push-over load by in-situ experimental observation. The in-situ push-over experiment for pier with earth anchors between spread footing and rock beds exhibits a reasonable enhancement of ductility against overturning. In unanchored system, a flexural crack at cold joint of concrete pier is not developed because of the over-turning of the pier. This leads a global instability (rotation) of pier-footing system with relatively low stresses in pier itself. While a lateral load is persistently increased in anchored system, the successive flexural cracking failure at cold joint is observed even after the local shear failure of soil due to redistribution of stress equilibrium between soil and pier structure as long as a tensile action of anchor cable is active.

• International Journal of Internet, Broadcasting and Communication
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• 제16권2호
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• pp.68-74
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• 2024

This thesis explores the embodiment of a performer and a character/role specifically by examining what the term character is associated with and implies in a sense of the performer's bodily training through which what happens to their body. First of all, this research begins to investigate the relationship between a performer and a character centred on the performer's bodily experience through training and/or studio work. From a perspective of a performer, the concept and practical approach of a character itself essentially includes and signifies all the given circumstance of a specific play which has to be acknowledged then inhabited through the performer's body. That is, the internal structure of the text parallels with articulating and developing the spine of a specific character which take place as the substance leads the performer's body to an organic action and/or that of way corresponding to what the character needs and wants to obtain through a series of moment on stage. Here, we argue that the purposeful action as a process and result of applying/inhabiting the substance enhances the performer's body as the whole being participates in the given environment within which his/her body can also work or function by means of the integrated oneness. Second, in a manner of the most fundamental level, both the ethic of acting and the central task of a performer remind us the significance of allowing therefore experiencing subtle bodily movement, namely, responses to stimulus from in/outside of his/her body either visible or invisible on the one hand. At the same time, such a journey of self-discovery empowers the performer to explore new potential possibilities on the other. Finally, as the research finding suggests that these practical insights are necessarily need to be acknowledged as a point of the departure through which the quality of a performer's body is also cultivated by means of the changeable wholeness in order to being on stage.

• 대한약리학회지
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• 제18권1호
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• pp.1-10
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• 1982

중추의 ${\beta}-adrenoceptor$가 신장기능의 조절에 있어서 어떠한 역할을 하고 있는지를 알고자, 가토의 측뇌실내에 isoproterenol 및 propranolol을 투여하여 신장기능의 변동을 관찰하였다. Isoproterenol은 $5{\sim}50{\mu}g/kg$ i.c.v.의 범위에서 항이뇨작용을 나타냈으나 이는 주로 전신혈압하강에 따르는 신혈류 및 사구체여과율의 감소에 기인하며 세뇨관에서의 Na 재흡수억제효과는 음폐된 것으로 추론되었다. Propranolol $(500\;{\mu}g/kg\;i.c.v.)$은 신장기능에 현저한 변동을 초래하지 아니하였으나, propranolol후에 isoproterenol을 투여하면 전신혈압하강은 현저히 약화됨과 동시에, Na, K 배설의 증가와 신혈류의 증가, 그리고 뇨량증가경향이 관찰되었다. 즉, prapranolol에 의하여 isoproterenol의 강압작용은 영향을 받으나 신장작용은 영향받지 아니하고 현저하게 표현되었다. 본연구의 결과는, 중추의 ${\beta}-adrenoceptor$도 ${\alpha}-receptor$보다는 약하지만 신장기능의 조절에 있어서 어떤 역할을 하고 있음을 시사하였다.

• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2001년도 제2회 생물정보학 국제심포지엄
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• pp.139-149
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• 2001

Since 1990, the National Cancer Institute(NCI) has screened more than 60.000 compounds against a panel of 60 human cancer cell lines. The 50-percent growth-inhibitory concentration (GI$_{50}$) values encode unexpectedly rich, detailed information on mechanisms of drug action and drug resistance. Each compound's pattern is like a fingerprint, essentially unique among the many billions of distinguishable possibilities. These activity patterns are being used in conjunction with molecular structural features of the tested agents to explore the NCI's database of more than 460, 000 compounds, and they are providing insight into potential target molecules and modulators of activity in the 60 cell lines. For example, the information is being used to search for candidate anticancer drugs that are not dependent on intact p53 suppressor gene function for their activity. It remains to be seen how effective this information-intensive strategy will be at generating new clinically active agents.s.