• Title/Summary/Keyword: action in pattern

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Mechanism of Action of Anticancer Drug Aziridinylbenzoquinones: Involvement of DT-diaphorase (DNA에 결합하는 항암제의 작용기전)

  • Lee, Chong-Soon-
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1994.11a
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    • pp.147-172
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    • 1994
  • Aziridinylbenzoquinones such as 3, 6-diaziridinyl-1, 4-benzoquinone (DZQ) and its 2, 5-methyl analog (MeDZQ) require bioreductive activation in order to elicit their anticancer activities. To determine the involvement of DTD in the activation of these drugs, we have used a ligation-mediated polymerase chain reaction to map the intracellular alkylation sites in a sing1e copy gene at the nucleotide level. We have performed this analysis in two human colon carcinoma cells, one proficient (HT-29) and one deficient (BE) in DT-diaphorase (DTD) activity. In the DTD proficient HT-29 cell line, DZQ and MeDZQ were found to alkylate both 5'-(A/T)G(C)-3' and 5'-(A/T)A-3' sequences. This is consistent with the nucleotide preferences observed when DZQ and MeDZQ are activated by purified DTD to reactive metabolites capable of alkylating DNA in vitro [Lee, C. -S., Hartley, J. A., Berardini, M. D., Butler, J., Siegel., D., Ross, D., & Gibson, N. W. (1992) Biochemistry, 31: 3019-3025]. Surprisingly in the DTD-deficient BE cell line a pattern of alkylation induced by DZQ and MeDZQ similar to that observed in the DTD-proficient HT-29 cells was observed. This suggests that reductive enzymes other than DTD can be involved in activating DZQ and MeDZQ to DNA reactive species in vivo.

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Experiences in Self-dieting Program of Obese Male College Students (비만 남자대학생의 자가 건강다이어트 프로그램 참여 경험)

  • Kim, Jeong Soo
    • Korean Journal of Adult Nursing
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    • v.25 no.5
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    • pp.504-514
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    • 2013
  • Purpose: This study was to describe the process of healthy dieting and develop a substantive theory that explains lifestyle in obese male college students. Methods: The participants were 11 students who had participated in self-dieting program in a health center. Data were collected with in-depth interviews and analyzed by grounded theory in Strauss and Corbin (1990). Results: Through analyzing process, 36 concepts, 18 subcategories, and nine categories were deduced. In axial coding, casual condition, 'shrinking themselves' and 'oriented to selfish lifestyle', context condition, 'distress in mutual understanding' impacted on phenomenon, 'making health with autonomous living pattern'. Intervening conditions were 'practicing with active measures' and 'growing the willpower' and action-interaction condition, 'devoting realistic plan with positiveness' totally lead to consequence in 'regaining social relationship' and 'pursuing harmonious sound of mind and body'. The periods of process were divided four stages, reflecting self-characteristics, situational copping phase, applying period realistic strategies, and developing phase of social relationship. The core category, 'developing communication competency' incorporated the relationship between and among all categories and explained the process. Conclusion: The findings indicate that self leading health program helped to develop the communication competency. Therefore, we would consider about internalized motives and external incentives in health programs.

Segmental Sensory Nerve Conduction Study in Vibration Exposed Subjects

  • Kim Mi-Jung;Yoon Cheol-In;Choi Hyun-Ju
    • Biomedical Science Letters
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    • v.11 no.2
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    • pp.193-199
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    • 2005
  • The present study was performed to assess peripheral neural involvement by exposure to hand-arm vibration. Segmental sensory nerve conduction in the median and ulnar nerves were measured in shipyard workers exposed to vibration. The subjects were 47 male adults exposed to hand-arm vibration and 7 healthy male controls. The subjects underwent an extensive bilateral neurophysiological examination. Sensory compound nerve action potential (SNAP) of the median and ulnar nerves in palm-finger and wrist-palm segments were measured by antidromic method. And SNAP of the median and ulnar nerves in wrist-proximal finger and wrist-distal finger segments were measured by orthodromic method. Result of sensory nerve conduction study was abnormal in 31 patients $(66\%)$ and normal in 16 patients $(34\%)$ of subjects. The pathological pattern in the hand-arm vibration exposed group was 13 patients $(28\%)$ of carpal tunnel syndrome, 18 patients $(38\%)$ of distal sensory neuropathy, 7 patients $(15\%)$ of multifocal and 1 patient $(2\%)$ of Guyon syndrome. The present study indicates that vibration-induced nerve impairments exist both in the finger-palm and palm-wrist segment of median and ulnar sensory nerves. The results suggest that segmental sensory nerve conduction study would be useful as objective indication of peripheral nerve impairment induced by the hand-arm vibration.

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A Study on the Territoriality in Open Space for Community Activation - Focused on the Case of Apartment in Gwang-ju - (커뮤니티 활성화를 위한 오픈스페이스 영역성 사례연구 - 광주광역시 아파트를 중심으로 -)

  • Lee, Ha-Yeon;Moon, Jeong-Min
    • Journal of the Korean housing association
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    • v.27 no.6
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    • pp.1-8
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    • 2016
  • This study is focusing on Territoriality which is supposed to be one of the most important elements to activate open spaces in apartment communities. Case analysis with onsite visit is selected as the research method of this study targeting 6 apartment complexes in Bukgu and Gwangsangu, Gwangju city which accommodate over 500 households up to 800 households, which show high occupancy ratio and which were built after 2006 to minimize the physical environment variable. The result of this study is concluded as follows. First, we need the elements which can induce various action and the use of floor surface in color, pattern, and material should be considered in the stance of pedestrian for easy recognition of Territoriality change. Second, To secure the view, we should consider to plant shrubs or to plant trees wider apart. In most cases, enclosure is secured by using trees of Vertical Boundary for safety and comfort, but overuse in some cases make residents feel fear of enclosed spaces and insecurity. Third, Various and harmonious design elements can be recommended to increase aesthetic impression, to induce positive response for design, and to be used consistently. Finally, Unique space using notable landmark or design elements should be considered.

Optimal management of multi-airport opening non-real time network system

  • Wang, Zhanwei;Heo, Hui-Yeong
    • 한국항공운항학회:학술대회논문집
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    • 2016.05a
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    • pp.269-275
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    • 2016
  • This paper considers the arrival, airport and departure capacity as a whole, through which, the network effect between airports is fully emphasized, the flight action is coordinated, and the flight demand pattern is reasonably assigned. The optimization problem of flight queues in multi-airport is studied in detail; the mathematical model of multi-airport opening non-real time flow management in terminal area is established, and related problems such as the parameters, the simplification and the solving of the model are discussed in detail to some extent. Appropriate decision making variables are taken to make the multi-airport network system linear 0-1 integer programming model, thus, the solving of the model is available and the central flow management is realized. The heuristic implicit enumeration presented in this paper can effectively solve this kind of problems. Through the simulation of some airports network system, we not only validate the algorithm presented in this paper, but also give a deep analysis of the results, which would produce reference for later practicable use. The simulation proves that this algorithm offers a good way to settle the problem of multi-airport flight queue optimization in air traffic management automation system in terminal area.

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Alyssin and Iberin in Cruciferous Vegetables Exert Anticancer Activity in HepG2 by Increasing Intracellular Reactive Oxygen Species and Tubulin Depolymerization

  • Pocasap, Piman;Weerapreeyakul, Natthida;Thumanu, Kanjana
    • Biomolecules & Therapeutics
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    • v.27 no.6
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    • pp.540-552
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    • 2019
  • To determine the chemopreventive potential of alyssin and iberin, the in vitro anticancer activities and molecular targets of isothiocyanates (ITCs) were measured and compared to sulforaphane in hepatocellular carcinoma cell HepG2. The SR-FTIR spectra observed a similar pattern vis-a-vis the biomolecular alteration amongst the ITCs-treated cells suggesting a similar mode of action. All of the ITCs in this study cause cancer cell death through both apoptosis and necrosis in concentration dependent manner ($20-80{\mu}M$). We found no interactions of any of the ITCs studied with DNA. Notwithstanding, all of the ITCs studied increased intracellular reactive oxygen species (ROS) and suppressed tubulin polymerization, which led to cell-cycle arrest in the S and $G_2/M$ phase. Alyssin possessed the most potent anticancer ability; possibly due to its ability to increase intracellular ROS rather than tubulin depolymerization. Nevertheless, the structural influence of alkyl chain length on anticancer capabilities of ITCs remains inconclusive. The results of this study indicate an optional, potent ITC (viz., alyssin) because of its underlying mechanisms against hepatic cancer. As a consequence, further selection and development of effective chemotherapeutic ITCs is recommended.

A study on the influence of Self-Leadership to Technology Innovation: Mediate Effect of Emotional Intelligence (셀프리더십이 기술혁신에 미치는 영향에 관한 연구 - 감성지능의 매개효과 -)

  • Lee, Sun-Kyu;Lee, Da-Jung;Bae, Jung-Mi;Lee, Seung-Woo
    • Journal of Digital Convergence
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    • v.9 no.6
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    • pp.277-293
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    • 2011
  • This study aims to mediating effects of Emotional Intelligence on the relationships between Self-Leadership. Additionally, this study is to examine the impact of Self-leadership(behavior-focused strategies, natural reward strategies and constructive thought pattern strategies) to Technology Innovation. Hypotheses were tested by surveying 420 employees at Gumi Industrial Complex. The findings are as follows: First, all factors of Self-leadership had a significant positive effect on Technology Innovation. Second, four factors of Emotional Intelligence had a significant positive mediating effect on Technology Innovation except behavior- focused strategies of Self-Leadership. It is indicated a need for action in organization's self-leadership and it is also shown reliable criterion to effective organizational management of success in Technology Innovation.

A Study on Identification Keys of Araliae Continentalis Radix and its Adulterants : Focused on External·Internal Morphology and Pattern Analysis (독활(獨活)과 그 위품의 감별기준 연구 : 외·내부형태 및 이화학패턴을 중심으로)

  • Yoon, Jee-Hyun;Ju, Young-Sung
    • The Korea Journal of Herbology
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    • v.33 no.2
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    • pp.29-43
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    • 2018
  • Objectives : Araliae Continentalis Radix(AC) is a medicinal herb belonging to the drug efficacy group treating musculoskeletal disorders(MSD) with anti-inflammatory, analgesic and antipyretic action. However, due to morphologic and onomastic similarity, adulterants(Angelicae Pubescentis Radix: AP, Gypsophilae Oldhamianae Radix: GO, Levistici Officinalis Radix: LO) have been included or replaced the standard. Methods : Multilateral methods were carried out on the identification of AC and its adulterants. Macroscopic and microscopic characteristics were observed by using stereoscope and microscope. For the comparison of chromatogram pattern, standard compounds were analyzed simultaneously using high performance liquid chromatography. Results : 1. The macroscopic identification of original plants was determined by the phyllotaxis type, the inflorescence type, the leaf margin and the color of flowers. The macroscopic identification of herbal materials was examined by oil spots, the cambium, heteromorphic vascular bundles, and the pholem. 2. For the microscopic identification, the fact whether its xylem ray is proliferated or not was first determined. Then medicinal herbs were secondly divided by cellular inclusions, fiber bundles, the distribution of secretary canals and the shape of cambium. 3. AC and its adulterants showed different chromatographic fingerprints. AC was containing continentalic acid and kaurenoic acid. AP was containing osthole and columbianadin. LO was containing osthole and falcarindiol. None of the compounds were found in GO. Conclusions : This recent identification keys of might be helpful to discriminate the pharmacopoeia standard and its adulterants for the right usage in clinics.

Community development and parasite control (지역사회개발(地域社會開發)과 기생충(寄生虫))

  • Rim, Han-Jong
    • Journal of agricultural medicine and community health
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    • v.1 no.1
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    • pp.10-21
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    • 1976
  • The traditional application of night soil to vegetable gardens and rice paddies results in a most wide spread condition of parasitism, with a variety of helminths found in Korea. In addition to the above fact, the peculiar habit of the consumption of raw vegetables, fish, crustaceans and mammals provides a means of infestations of helminths. During the last sixty years numerous reports were found on the prevalence of helminths amongst the Korean population in different parts of the country, and it was generally recognized that ascariasis, hookworm disease, filariasis, clonorchiasis and paragonimiasis constitute the important helminthic disease in Korea. In practical measures of parasite control activities the main measures are summarized as mass-treatment, night-soil disposal and transmission control. Among the three, the mass-treatment has been commonly applied, however, no reduction of transmission has been obtained by treatment of a population. Therefore, the ultimate eradication of parasites will depend upon the application of comprehensive environmental sanitation measures. The basic environmental measures will be concerned with (a) the safe disposal of human excreta, (b) the provision of adequate and safe water supplies in such a way as to promote a higher standard of personal hygiene in the population, and (c) the prevention of food contamination by faecal material. Additional environmental measures will deal with the improvement of housing and housing hygiene and with general community development. Community development means social and cultural as well as economic development. The control measures on the parasitic endemic diseases, such as clonorchiasis and paragonimiasis are the good examples for community health development in Korea. The control of Clonorchis and Paragonimus infections are theoretically very simple, as the infection can only invade the human body by way of encysted metacercaria which are taken into the body when eating passive intermediate hosts(fishes, crabs and crayfishes). Although prophylactic measures in the case of the infections deal with above merely consist the fishes in cooking or submerging in hot water before eating them, it is exceedingly difficult to carry out such simple measures in face of century old traditions, to which the relatively primitive population clings with great tenacity. There is no one universally applicable method of control. The choice of methods must be dictated by the nature of the environment. the habit and custom of the people. the pattern of transmission and the resources of the country. There must exist a well organized public health infrastructure. Since a control programme is of necessity on a longterm basis and continuity in its implementation is essential. An investigation should be made on the prevalence of the diseases and its relationships to irrigation engineering, freshwater ecology, agricultural methods, hydro-electric schemes, and the development of communities in affected areas. In conclusion, however. the control of clonorchiasis and paragonimiasis in Korea is not an impossible task. A combination of efforts with major emphasis on health education and mass chemotherapy coupled with governmental aid in enforcing legislative public health measures could reduce the diseases. Health education in particular attempts following four things: (a) It supplies a person with enough general knowledge about a disease to make the preventive measures. (b) It makes a person feel sufficiently about the importance of his own health to make him alter his behavior and adopt these preventive measure. (c) It makes him concerned for the health others. (d) It tries to make him feel so strongly about the first three that be supports and even initiates preventive action by the community. Educational efforts should be directed primarily toward school children because it is during the early years that most persons become infected, and also because children are less entrenched in their food habits so that, the educational process should be involved at various levels in successive changes of knowledge, attitude, beha viour, habit and custom of their lives. The most parasitic endemic diseases are related to community diseases. In caring for a sick community. the first stage is to gather epidemiological data, the next is to make inferences from it-to make the community diagnosis. The third is to prescribe community treatment or community health action part of a community health action programme. The community health action is the sum of the steps decided upon to remedy the critical features revealed by the community diagnosis. Action takes various forms; health education is the most important.

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Electrophysiologic Pattern of Facial Muscles in Bell's Palsy (얼굴마비에서 얼굴근육의 전기생리학적 양상)

  • Lee, Sang-Soo;Shin, Dong-Ick
    • Annals of Clinical Neurophysiology
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    • v.6 no.2
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    • pp.75-79
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    • 2004
  • Backgrounds: Electrodiagnostic tests have been developed to estimate the degree of facial nerve injury during the acute phase. Side-to-side amplitude comparison with the affected side expressed as a percentage of the nonaffected side has been one of the most valuable electrophysiologic methods of assessing facial nerve functioning. This study was designed to know whether there is any difference in the side-to-side comparison of amplitudes and terminal latencies of the compound muscle action potentials (CMAP) of the facial muscles in the patients with Bell's palsy. Methods: Electroneurographic recordings with surface electrodes on the frontalis, orbicularis oculi, nasalis, and orbicularis oris muscles were made within 2 weeks post-onset (mean, day 7) in 39 patients. Results: Of the 39 Bell's palsy patients, 38 patients (97.4%) recovered satisfactorily within 6 months. The amplitude of CMAP in all patients was not reduced to 10% or less of that of the contralateral healthy muscle. The correlation of amplitude change between four facial muscles was relatively strong, but the correlation of latency change was weak. When the electroneurographic values were compared in the four muscle groups, the general linear models procedure did not show any significant difference for CMAP amplitude and latency changes (p=0.62-0.63). Conclusions: This study did not show any significant clinical advantage of electroneurographic recordings in more than one facial muscle at the early stage of Bell's palsy.

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