• Tuberculosis and Respiratory Diseases
• /
• v.70 no.6
• /
• pp.490-497
• /
• 2011

Background: It is difficult but important to differentiate between bacterial and viral infections, especially for respiratory infections. Hence, there is an ongoing need for sensitive and specific markers of bacterial infections. We investigated novel biomarkers for discriminating community acquired bacterial pneumonia from 2009 H1N1 influenza A infections. Methods: This was a prospective, observational study of patients with community acquired bacterial pneumonia, 2009 H1N1 Influenza A infection, and healthy controls. Serum samples were obtained on the initial visit to the hospital and stored at $-80^{\circ}C$. We evaluated CRP (C-reactive protein), PCT (procalcitonin), LBP (lipopolysaccharide-binding protein) and copeptin. These analytes were all evaluated retrospectively except CRP. Receiver operating characteristic curve (ROC) analyses were performed on the resulting data. Results: Enrolled patients included 27 with community acquired bacterial pneumonia, 20 with 2009 H1N1 Influenza A infection, and 26 who were healthy controls. In an ROC analysis for discriminating community acquired bacterial pneumonia from 2009 H1N1 influenza A infection, areas under the curve (AUCs) were 0.799 for CRP (95% Confidence interval [CI], 0.664~0.934), 0.753 for PCT (95% CI, 0.613~0.892) and 0.684 for LBP (95% CI, 0.531~0.837). Copeptin was not different among the three groups. Conclusion: These findings suggest that serum CRP, PCT and LBP can assist physicians in discriminating community acquired bacterial pneumonia from 2009 H1N1 influenza A infection.

• Journal of Digital Contents Society
• /
• v.13 no.3
• /
• pp.421-429
• /
• 2012

Lately, the number of interventional radiology is increased by the extension of procedure in medical radiation, and radiation exposure may be appeared differently by interventional radiologists, it is caused increase of radiation dose for radiation worker, patient, and radiologists. This study has done a comparative analysis characteristic of radiation exposure for five radiologists who executed interventional cardiology for 303 patients in S university hospital of Gyeong-Buk from Nov. 1, 2011 to Jan. 31, 2011. The average exposure time of five radiologists was 697.95sec. The average of cumulative DAP(exp) for patients was $52,730mGycm^2$ and the average of total DAP for patients was $104,875.14mGycm^2$. The average of frames for image was 855.52 frames in acquired images, and the average of frames for images was 802.2 frames in exposure images. They were statistically significant differences (p<0.05). Exposure time, cumulative DAP(fluro), cumulative DAP(exp), total DAP, acquired image, and exposure image were high correlation except cumulative DAP(exp), and acquired runs in x-ray exposure characteristics of machine. Exposure time was a great influence on radiologist. It signified that the more exposure time lead to the more radiation dose for radiologist. Radiation dose is related to ability, experience, difficulty, and precision of procedures in interventional procedure. The number of angiography and exposure time is difficult to control by radiologists. Therefore, it is in need of reasonable system which was evaluated the real dose of medical teams in interventional proceedings. We think that self education and training are required to reduce radiation dose for radiologists and radiation workers.

• Tuberculosis and Respiratory Diseases
• /
• v.58 no.6
• /
• pp.607-613
• /
• 2005

Background : Early death is an important problem associated with the management of community-acquired pneumonia. However, there is little information on the risk factors associated with it. The aim of this study was to identify the factors associated with early death in community-acquired pneumonia patients. Methods : From January 1999 to July 2004, 1,487 adult patients with community-acquired pneumonia who were admitted to the pulmonary department via emergency center were examined. Early death was defined as those who died within 2 days of hospitalization. The clinical and laboratory aspects of the patients who died early (n = 30) were compared with those of an age and gender matched control population (n = 60). Results : In the early death group, respiratory rate, heart rate, and blood urea nitrogen (BUN) were significant higher (p < 0.05 for all), while the arterial pH, systolic pressure, and $PaO_2$ were significant lower (p < 0.05 for all) than the control. The independent factor significantly associated with early death was tachypnea (OR, 7.049). Conclusion : The importance of an early clinical assessment in emergency center with community-acquired pneumonia needs to be emphasized in order to recognize patients at risk of early death.

• BMB Reports
• /
• v.51 no.12
• /
• pp.660-665
• /
• 2018

Human epidermal growth factor receptor 2 (HER2) inhibitors, such as trastuzumab and lapatinib are used to treat HER2-positive breast and gastric cancers. However, as with other targeted therapies, intrinsic or acquired resistance to HER2 inhibitors presents unresolved therapeutic problems for HER2-positive gastric cancer. The present study describes investigations with AUY922, a heat shock protein 90 (HSP90) inhibitor, in primary lapatinib-resistant (ESO26 and OE33) and lapatinib-sensitive gastric cancer cells (OE19, N87, and SNU-216) harboring HER2 amplification/over-expression. In order to investigate whether AUY922 could overcome intrinsic and acquired resistance to HER2 inhibitors in HER2-positive gastric cancer, we generated lapatinib-resistant gastric cancer cell lines (OE19/LR and N87/LR) by continuous exposure to lapatinib in vitro. We found that activation of HER2 and protein kinase B (AKT) were key factors in inducing intrinsic and acquired lapatinib-resistant gastric cancer cell lines, and that AUY922 effectively suppressed activation of both HER2 and AKT in acquired lapatinib-resistant gastric cancer cell lines. In conclusion, AUY922 showed a synergistic anti-cancer effect with lapatinib and sensitized gastric cancer cells with intrinsic resistance to lapatinib. Dual inhibition of the HSP90 and HER2 signaling pathways could represent a potent therapeutic strategy to treat HER2-positive gastric cancer with intrinsic and acquired resistance to lapatinib.

• 한국연소학회:학술대회논문집
• /
• 2014.11a
• /
• pp.141-142
• /
• 2014

This numerical study was carried out to optimize dual fuel combustion on natural gas-diesel in static chamber. Spray experiments conducted under conditions of premixed methan 0%, 5% and 10%. In the results, penetration decreases when premixed methane is increasing. Constants of numerical models were acquired from results of spray experiments to enhance accuracy of numerical study. And dual fuel engine simulation was implemented by using AVL-FIRE with acquired constants.

• Journal of the Korean Society of Manufacturing Technology Engineers
• /
• v.8 no.5
• /
• pp.20-24
• /
• 1999

Grinding System is very difficult to examine closely wear phenomenon or dynamic characterastic because it is very complex and different from a general cutting system, Considering automatization and precision it is very important to examine closely grinding system. In this study grinding wheel surface is acquired by using computer vision system in order to explain wear and loading phenomenon. We investigate the relationship between wear and Fourier spectrum of acquired image and observe the entropy variation in the process of manufacturing.

• Journal of Chest Surgery
• /
• v.20 no.2
• /
• pp.270-280
• /
• 1987

One hundred thirteen cases of open heart surgery were performed in the department of thoracic and cardiovascular surgery of Inha General Hospital from April 1986 to April 1987. There were 73 cases of congenital heart disease and 40 cases of acquired valvular heart disease, including one redo case respectively. The technique of deep hypothermia with circulatory arrest was used widespreadly for infants and small children, and early extubation was performed as possible in the great number of all cases. There were three operative deaths [2.7%], all in congenital cases, and three follow-up deaths, all in acquired cases.

• Proceedings of the KIEE Conference
• /
• 1999.07b
• /
• pp.749-751
• /
• 1999

We acquired operating data in an existing steam turbine power plant using analog control system to investigate operation characteristics. We analyzed a load control logic to develop a digital turbine control system. The load control logic is constituted of load target, load reference, loading rate, load limit and admission mode transfer of valve. The result of this paper is utilized to implement a digital turbine control system.

• Proceedings of the Korean Society of Marine Engineers Conference
• /
• 2005.11a
• /
• pp.148-149
• /
• 2005

In this study, among the precision decline main causes of sounding, I suggested the characteristics of sounding data acquired by echo sounder with increasing of turbidity For this, I acquired sounding data by inputting turbidity inducer artificially in artificial water tank. And then achieved regression analysis. Conclusion are as following : Sounding Capabilities can be divided into three ranges according to the turbidity : normal range, critical range and the range where data can not be obtained by an echo sounder

• Proceedings of the IEEK Conference
• /
• 2003.07e
• /
• pp.1763-1766
• /
• 2003

This paper proposes a non-contact color inspection system for plasma display panel (PDP). The red, green, and blue test pattern images are acquired by using the area color CCD camera at the various distance from the PDP. The RGB values are obtained from the region of interest (ROI) which are extracted by applying the image processing to the test pattern image. Finally, the CIE xy and u'v' chromaticity coordinates of the test pattern images according to the distance are acquired from the RGB color coordinates.