• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2020년도 추계국제학술대회
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• pp.73-73
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• 2020

Toona sinensis (TS) leaf is known to antinociceptive, antioxidative stress and skin moisturizing effects. Acnes vulgaris is a chronic skin disease with various symptoms including itchiness, pain and interruption of normal skin function. Propionibacterium acnes (P. acnes) is a major factor in the occurrence of inflammatory acnes. This study evaluated the antioxidant and anti-inflammation effects by TS extract from adventitious shoots. TS extract showed anti-inflammatory activities by suppression of pro-inflammation mediators (iNOS and COX-2) in LPS-stimulated RAW264.7 cells. TS extract also has anti-inflammatory activities by inhibiting the secretion of pro-inflammatory cytokines on P. acnes-stimulated HaCaT cells. These effects were regulated by MAPK signaling pathway. Therefore, we suggest that TS extract from adventitious shoots might have applications as a medicine for treating P. acnes-induced skin diseases.

• 한방안이비인후피부과학회지
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• 제11권1호
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• pp.251-268
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• 1998

125 Cases of Acne were treated by Acupuncture and Herb-med treatment during a three months duration from April 1996 to February 1998 in Kyung Hee Univ. Department of Ophthal, Otolaryngology. College of Oriental Medicine. We have observed the cases and the results as follows: 1. The age of average was 24.55 age : 21.91 in males, 24.55 in females. and in these, the gulf between males and females were showed statically significant diference. In the age of onset, averag was 16.96 age and mode was 18 age and male's average was 16.96 age, minimun was 11 age, maximum 40 age and female's average was 20.14 age, minimun was 10 age, maximum 40 age. and these were showed statically significant diference between males and females. 2. In the distribution of season, winter was the most with $37.8\%$ of out patients, the rest was similar to difference of each other. but there was clear difference between males and females. 3. In the duration of history, the average was 5.10 years and male's average was 5.13 years. on the other hand female's was 5.09 years but there is no any significant difference have a resemblance with each other. 4. In blood type, O type was the most with $35.20\%$ and there was in the order of A type was $26.40\%\;B\;type\;was\;23.20\%,\;AB\;type\;was\;15.20\%$ but these were not significant difference by the chi-tend and analysis of variance with total cases, males and females. 5. In select of the preference food, patients of the prefer worm food was $42.40\%\;and\;cool\;food\;was\;38.40\%,\;tepid\;food\;was\;24\%$ but these were no significant difference by the chi-test and ANOVA of each other. 6. the state of pulse classified into 11 type and average was 7.2 times, maximum was 29 times with Hyun Sae, at the same time, the female's average was 6.73 times, maximum was 27 times and male's average was 1.5 times. The result of test with each other, these were showed statically significant difference as compared total cases with males but there were not females ones. 7. In the frequency of the major cause, oversensitiveness was the most with $34.93\%$. secondly there was in order of indigestion $30.82\%$ and menstrual irregularity and menstruation pain $23.28\%$. constipation $10.96\%$ and these showed statically significant difference as compared the females with males on the result of test for difference with each other. 8. In frequency of the symptoms, itching was the most with $31.97\%$ and there was in order of nodule $20.49\%$, pustule $18.85\%,\;papule\;15.58\%,\;flare\;13.12\%$ and also these showed statically significant difference as compared the females with males 9. for the Distribution of acne region, face was the most with $64.06\%$ and there was in order of back $14.29\%,\;upper-chest\;11.69\%,\;neck\;7.79\%$ and there was no significant difference as compared total cases with males and females. 10. Acne applied 30 prescription to 4 weeks and over and 20 weeks and over was $23.3\%$, 30 weeks and over was $16.67\%$ and average of administration duration were 4.2 weeks(male's average 5.78, maximum 96 weeks and female's average 3.85, maximum 23 weeks) maximum was 96 weeks, minimum was 1 week. 11. In the acupuncture treatment, $96.6\%$ applied to acupuncture and average was 5.44 times, maximum 46 times, minimum 1 time(male's average 4.64, female's 5.62) but these were not any significant differeence. 12. for the medication, author made a investigation and comparison between control group with treated group in order to observe for the therapeutic effect during the 1 month and 2, 3. From these results, we can see that acne was improved by the oriental treatment. in the 1 month, average of control group was 13.24 and treated group was 11.78. these showed statically significant decrease in P<0.02 as compared the treated group with control group. In the 2 months, average of control group was 13.43 and treated group was 9.03. these showed statically significant decrease in P<0.003 as compared the treated group with control group. In the 3 months, average of control group was 13.78 and treated group was 8.06. these showed statically significant decrease in P<0.008 as compared the treated group with control group.

• Pediatric Infection and Vaccine
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• 제29권2호
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• pp.96-104
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• 2022

Chronic recurrent multifocal osteomyelitis (CRMO)는 소아에서 호발하는 비감염성 염증성 골질환으로 염증성장질환, 건선, 베게너 육아종, SAPHO 증후군 등의 다른 자가 면역 질환이 병발하기도 한다. 13세 중앙아시아 인종의 남자환자가 18개월 동안 반복되는 하지 관절 통증과 연조직 염증 증상을 주소로 내원하여 CRMO로 진단 하 비스테로이드성소염제 치료를 시작하였다. 5개월 간 약물 복용하였으나 근골격계 증상 악화, 새롭게 발생한 위장관 증상에 대해 CRMO에 크론병이 병발한 것으로 진단되었으며, 이에 대해 infliximab을 투여하였다. 본 증례에서는 크론병이 병발한 CRMO 환자에서 비스테로이드성 소염제 치료에 실패한 후 infliximab을 이용하여 효과적으로 치료된 증례를 보고하는 바이다.

• Nutrition Research and Practice
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• 제7권3호
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• pp.172-177
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• 2013

Benign prostatic hyperplasia (BPH) is one of the most common diseases among elderly men. As the old-age population is increasing recently, it is to our interest to observe the growing BPH within them. In BPH, the dihydrotestosterone (DHT) acts as promotes prostate growth. It inhibits enzyme $5{\alpha}$-reductase that is involved in the conversion of testosterone to the DHT activity which reduces the excessive prostate growth. Through experiments, the effects of Phellius linteus water extract performed on the BPH rats were induced by testosterone treatments. For 12 weeks, Sprague-Dawley rats were treated with testosterone for the induction of BPH. Rats were divided into four experimental groups: the not treated group (N), the testosterone injection and D.W treatment group (TN), the testosterone injection and Phellinus linteus treatment group (TP) and testosterone injection and finasteride treatment group (TF). Prostate weight, volume and weight ratio in the TP group and the TF group were significantly lower than the TN group. Testosterone and DHT levels in the TN group were significantly higher than that of the N group. And the TP group was significantly decreased than that of the TN group. While prostates of control rats revealed severe acinar gland atrophy and stromal proliferation; the TP and TF groups showed trophic symptoms and were lined by flattened epithelial cells, thus, the stromal proliferation is relatively low as compared to the TN group. These suggest that Phellinus linteus water extracts may be an useful remedy for treating the benign prostatic hyperplasia.

• 한방안이비인후피부과학회지
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• 제9권1호
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• pp.166-172
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• 1996

The alopecia is classified to Alopecia areata, Telogen effluvium, Anagen effluvium and Androgenetic alopecia. The exact cause of alopecia is not known, but a inherent and immunologic anc psychosomatic and endocrinic factors are suspected. We analysed clinical study in 77 patients, who had visited to the Dept. of Dermatology, Hospital of Oriental Medicine, Kyung Hee University to treat alopecia from June, 1994 to March, 1995. The results were summarized as follows; 1. In the series of 77 patients, $52\%\;were\;male\;and\;48\%$ were female. The peak incidence of age group was 20 to 29 ($55\%$). 2. The peak incidence of age group at on set was 20 to 29 ($49\%$). 3. The most frequent feature was insomnia ($25\%$). Frequent appeared signs and symptoms in descending order were head itching, head scale, fatigue and dizziness. 4. The personal history of patient were seborrheic dermatitis ($17\%$), atopic dermatitis, disorder of thyroid gland and acne in descending order. 5. The patients with family history occupied $25\%$. 6. Shineung Yangjin Dan was most used in treatments as $36\%$.

• Journal of Preventive Medicine and Public Health
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• 제29권4호
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• pp.785-799
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• 1996

절삭유의 사용과 피부질환의 관계를 알아보기 위하여 한 자동차공장의 엔진 및 구동부서 근로자 1,004명을 대상으로 피부 이상 증세에 대한 기초설문조사를 실시하여 응답을 해준 근로자 667명을 대상으로 분석 및 피부과적 검진을 실시하였다. 또한 절삭유의 노출 정도를 알기 위한 방법으로 공기 중 오일 미스트를 측정하였다. 이 조사의 결과를 요약하면 다음과 같다. 1. 공기 중 오일미스트는 3개 부서로 나누어서 측정 하였는데, 전체 52건의 측정건수 중에서 8시간가중 평균 기준치인 $5mg/m^3$을 넘는 건수는 9건(17.3%)이었고, 로그정규분포상에서 95% 신뢰한계의 전체 상한치는 기준치 미만이었다. 2. 조사한 부서는 엔진가공부(258명), 가솔린 엔진조립부(210명), 디젤엔진조립부(96명), 구동부 가공반(86명), 구동부 조립반(17명)의 5개 부서였으며, 조사한 667명의 평균 나이는 34.5세였고, 근무연수의 중앙값은 7년 7개월이었다. 3. 이들 부서 중 엔진가공부와 구동부 가공반(A군)은 절삭유를 공정상 많이 사용하는 부서로 근로자 344명 중 298명 (86.6%)이 한 가지 이상의 절삭유를 사용하고 있는 반면, 가솔린엔진 조립부, 디젤엔진 조립부, 구동부 조립반의 근로자 323명(B군) 중에는 31명 (9.1%)만이 절삭유를 사용하고 있었다. 4. 피부 이상 증세의 경험자 227명 중 213명에 대하여 피부과전문의의 진찰을 시행하였는데, 이중에 172명이 검진당시 증세를 호소했는데, 1인당 평균 호소증세 건수가 1.5건 정도였다. 가장 많은 증세는 가려움증(32.5%), 구진(21.6%), 인설(15.7%), 소수포(12.5%), 반점(9.4%)의 순서였다. 5. 검진을 받은 근로자 231명 중 정상소견이나 뚜렷한 병변이 없는 사람으로 분류된 경우는 53명이었고, 나머지 160명에서 피부과적 질환이 발견되었다. 가장 많은 것은 접촉 피부염으로 전체 질환자 중 92명 (57.5%)을 차지하였고, 이들 중에는 여드름이나 낭포염 등 기타 다른 피부질환을 동반한 경우가 23명 (25%) 이었다. 기타 낭포염, 여드름만 있는 경우도 각각 9명(5.6%), 8명(5.0%)이었으며 , 각질화와 색소 이상도 1명 씩 발견되었다. 기타의 수부 습진은 비특이성 수부습진으로 분류되었는데 이들은 47명이었다. 6.피부질환이 있다고 진단받은 160명에서 발견된 피부과적 이상부위는 1인당 1.3부위였다. 이상이 발견된 부위는 손바닥(27.6%), 손가락과 손톱(22.7%), 상박부(16.0%), 손등(11.8%), 손가락 사이(10.3%)의 순이었고, 이들 수부 및 상박부위의 이상이 전체 이상의 약 88.7%였다. 7. 전체 피부질환의 유병상태는 각 부서별로 차이가 많았는데, 특히 접촉 피부염의 경우 엔진가공부는 1,000명당 213명, 가솔린엔진 조립부는 1,000명당 29명, 디젤엔진 조립부는 1,000명당 73명이었고, 구동부 가공반은 1,000명당 267명, 구동부 조립반은 1,000명당 59명으로 부서별로 차이가 매우 켰다. 이러한 경향은 절삭유 사용에 따라서 특히 수용성 절삭유만 사용하는 군과 두 종류의 절삭유를 모두 사용하는 근로자에서 마찬가지로 높게 관찰되었다. 8. 감별진단이 필요하다고 판단된 접촉 피부염 환자 49명은 첩포 검사를 시행하였다. 첩포 검사 결과, 기본 표준시료에 양성이 나타난사람이 12명, 기본표준시료와 오일시료에 모두 양성이 나타난 사람 3명, 그리고 오일 시료에만 양성이 나타난 사람 3명이 있었고, 기본 표준시료와 유기용제시료에 양성이 나타난 사람, 유기용제 시료에만 양성이 나타난 사람이 각각 1명 있었다. 9. 전체 피부질환의 유무에 대하여, 근로자의 나이와 근무기간의 영향을 통제한 후 근로자들이 사용하는 절삭유의 종류에 따른 위험도를 알아보기 위하여 다변량 분석을 하였다. 분석결과 절삭유를 전혀 사용하지 않는 군과 비수용성 절삭유만을 사용하는 군과는 유의한 차이가 없었으며 수용성 절삭유만 사용하는 사람은 $1.4\sim3.3$배(교차비의 95%신뢰한계), 두 종류의 절삭유를 모두 사용하는 사람은 $1.9\sim4.1$배 정도로 위험도가 높았다. 10. 알레르기성 접촉 피부염을 종속변수로 같은 분석을 했을 때도 결과는 같았으나, 수용성 절삭유만 사용하는 군이 $2.7\sim9.7$배, 두 종류를 모두 사용하는 군에서는 $3.7\sim12.6$배 정도로 위험도가 증가한 것을 관찰할 수 있었다.

• Journal of Korean Neurosurgical Society
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• 제30권11호
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• pp.1320-1323
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• 2001

SAPHO syndrome is an acronym for an increasingly recognized syndrome of synovitis, acne, pustulosis, hyperostosis, and osteitis. Most of the previously reported case are from Japan and Europe. The authors report a case of SAPHO syndrome in Korean female who presented with extrasternal neurologic symptoms. A 60-year-old female with thoracic and right chest wall pain presented with the sternocostoclavicular hyperostosis, and recurrent aseptic osteitis. Previously, she had hystrectomy and thyroidectomy due to uterine malignancy 25 years ago. Also, she started to take medications for palm and sole pustulosis 7 days prior to admission. Through evaluation of clinical, radiological, serological studies, studies was done along with bone needle biopsy for the biological reassessment. The hyperostosis was found in the pedicles of thoracic 8, 9, 10 vertebrae and sternoclavicular joint. Radio-isotope bone scan showed an accumulation of tracer in thoracic vertebra. The bone biopsy from these site showed increased osseous turnover, thickening of trabeculae accompanied by mild acculuation of granulation tissue and round cell infiltration, compatible with mild chronic inflammation with marrow fibrosis. The patient showed good response to conservative management. The authors report a case of SAPHO syndrome with thoracic radiculopathy. It is considered that SAPHO syndrome is related to spondyloarthropathy, and appears to have benign disease process with good prognosis.

• 한국산학기술학회논문지
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• 제17권12호
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• pp.701-707
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• 2016

본 연구는 지루성 두피염 발생빈도가 높은 것으로 알려진 30~50대 남성 150명을 대상으로 생활 습관과 샴푸 습관이 지루성 두피에 어떠한 영향을 미치는지 알아보고자 하였다. 그 결과 지루성 두피의 주요 원인과 관련이 있다고 알려진 두피 가려움증과 과다 유분, 두피 뾰루지, 두피 붉은 증상에 대하여 샴푸 시기와 잦은 피로감은 모든 증상에서 통계적으로 유의한 영향을 미치는 것으로 조사되었으며(p<0.01), 샴푸 시기, 잦은 피로감, 규칙적인 출 퇴근, 스트레스 민감, 헤어스타일 제품사용 유 무와 같은 생활과 샴푸 습관은 지루성 두피에 영향을 미치는 것으로 확인되었다. 연구 결과를 통해 사무직 군무 종사자들의 생활과 샴푸 습관이 지루성 두피의 발생원인과 통계적으로 유의한 것으로 확인 되었으며, 특히 샴푸 습관과 샴푸의 불완전한 세정 및 모발 건조에 의한 습진이 지루성 두피 발생의 일차적인 원인이 되고, 불규칙적인 출 퇴근과 잦은 피로감, 만성 스트레스가 지루성 두피의 이차적 악화 원인이 되고 있음을 알 수 있었다.

• Clinical and Experimental Reproductive Medicine
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• 제21권3호
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• pp.227-232
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• 1994

In order to define the clinical characteristics of Korean women with polycystic ovary syndrome, clinical symptoms, biochemical features and ultrasonographic findings were determined in ninety PCO patients. Frequency of clinical manifestations were as follows:acne 42%, overweight 31 %, oily skin 14 %, hirsutism 10%. Relatively low frequencies of hirsutism is recognized in patients with Korean PCO syndrome. Mean(${\pm}$S.E.) of each hormone was:testosterone 1.18${\pm}$1.07ng/ml, LH 21.47${\pm}$${\pm}$2.6mIU/ml, FSH 7.26${\pm}$2.67mIU/ml, LH/FSH ratio 2.94${\pm}$1.29, prolactin 25.48${\pm}$46.33ng/ml, DHEA-S 333.78${\pm}$309.60ng/dl, 17-0HP 1.72${\pm}$1.74ng/ml. Mean 17-OHP after ACTH stimulation test was 5.07${\pm}$12.01ng/ml. Ultrasonographically measured mean ovarian volume were $11.02{\pm}5.92cm^3$ in right and $9.23{\pm}5.64cm^3$ in left and small sized multiple subcapsular follicular cysts were noted in 43 patients (47.9%) with PCO syndrome.

• 정보처리학회논문지:소프트웨어 및 데이터공학
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• 제9권9호
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• pp.259-266
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• 2020

본 논문에서는 온라인 고객 리뷰를 활용하여 건강 보조제, 화장품 등 현재의 상태를 개선하기 위해 사용되는 제품을 대상으로 그 효과를 알아보기 위한 제품 효과 분석 기법을 제시하였다. 제안하는 제품 효과 분석 기법은 블로그 포스팅에 존재하는 광고를 자동 제거하고, 효과 분석을 위한 증상, 효과, 증가, 및 감소로 이루어진 단어 사전을 구축하며, 제안하는 알고리즘을 통해 제품의 효과를 측정한다. 제품 효과 분석 기법을 검증하기 위해 정답 레이블이 존재하는 네이버 쇼핑 리뷰 데이터셋을 대상으로 성능평가를 실시하였으며, 전통적인 긍부정 사전과 RNN 모델과 성능을 비교하였다. 실험 결과, 본 논문에서 제안하는 효과 분석 기법이 다른 두가지 방법보다 정확도가 뛰어남을 보여주었다. 또한, 아토피 피부염, 여드름 치료제에 제안하는 기법을 적용하여 소셜 미디어에 나타난 효과적인 치료법을 소개하였다. 본 논문에서 제시한 알고리즘은 블로그를 포함한 여러 매체의 리뷰로부터 제품의 효과를 점수화할 수 있으므로 다양한 제품군과 소셜 미디어에 적용될 수 있을 것으로 보인다.