• Transactions on Electrical and Electronic Materials
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• v.10 no.1
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• pp.5-8
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• 2009

The reliability of multilayer ceramic capacitor with active thin dielectric layer was investigated by highly accelerated life test at various stress condition. The distribution of multilayer ceramic capacitor failure times is plotted as a function of time from Weibull distribution function. According to the test result, voltage acceleration factor is obtained from 2.24 to 2.96. The acceleration by temperature is much higher than other values of active thick dielectric layer. It is clear that median time to failure is affected by the stress voltage for high volumetric efficiency ceramic capacitors with active thin dielectric layer. The degradation under stress of voltage involves electromigration and accumulation of oxygen vacancy at Ni electrode interface of cathode.

• Proceedings of the Korean Society of Machine Tool Engineers Conference
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• 2005.05a
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• pp.401-406
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• 2005

According to the ubiquitous times that is new important topic, the miniature is demanded in the industry at large. The high accuracy and accumulation make the assembly equipment and the production equipment huge from the size of view. The huge equipment brings about the expensive price of the equipment, a low flexibleness and a low productivity. It makes the manufacturing equipment huge that the accuracy only depends on the mechanism stiffness. The position of two assembled parts is transformed with the global coordinate system whose datum is machine coordinate system. The purpose of this research is invention of the module that can adjust one part to the order part automatically. The module that has a function of self adjustment only takes a stiffness in assemble direction and can be moved freely in the other direction so this function makes a self adjustment. The self adjustment module reduces the tact time and also diminishes the inferior goods and makes reconfigurable machine in $\mu-part$ assembly.

• Journal of Genetic Medicine
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• v.19 no.2
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• pp.49-56
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• 2022

Mitophagy, the selective degradation of damaged or surplus mitochondria using core autophagy machinery, plays an essential role in maintaining cellular mitochondrial function. Impaired mitophagy is closely linked to various human diseases, including neurodegenerative diseases, cardiovascular diseases, cancers and kidney disease. Defective mitophagy induces the accumulation of damaged mitochondria and thereby results in a decline in cellular survival and tissue function. Accordingly, enhancement of mitophagy has been proposed as a novel strategy for the treatment of human diseases closely linked to mitochondrial dysfunction. Recent studies showing that the stimulation of mitophagy has a therapeutic effect on several disease models highlight the possibility of disease treatment using mitophagy. The development of mitophagy inducers with toxicity and the identification of molecular mechanisms will enable the clinical application of mitophagy-based treatments.

• Interdisciplinary Bio Central
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• v.5 no.4
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• pp.9.1-9.7
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• 2013

Introduction: Tumor necrosis factor receptor-associated protein 1 (TRAP1) is a mitochondrial heat shock protein (HSP), which belongs to HSP90 family. It plays important roles in regulating mitochondrial integrity, protecting against oxidative stress, and inhibiting cell death. Recent studies suggest that TRAP1 is linked to mitochondria and its metabolism. In this study, we established TRAP1 transgenic mice and performed partial hepatectomy (PH) on wild-type (WT) and TRAP1 transgenic mice to investigate the function of TRAP1 during liver regeneration. Results and Discussion: We found that TRAP1 was highly expressed in liver as well as kidney. In addition, liver regeneration slightly decreased together with increased fatty liver and inflammation at 72 hr after PH in TRAP1 transgenic mice compared with WT control group mice. Concomitantly, we observed decreased levels of p38 protein in TRAP1 transgenic mice compared with WT control group mice. These results suggest that TRAP1 plays a critical role in liver energy balance by regulating lipid accumulation during liver regeneration. Conclusions and Prospects: To our knowledge, we reported, for the first time, that liver regeneration slightly reduced together with increased fat accumulations after PH in TRAP1 transgenic mice compared with WT control group mice. Concomitantly, we observed decreased levels of p38 protein in TRAP1 transgenic mice compared with WT control group mice. Overexpression of TRAP1 might affect liver regeneration via disturbing mitochondrial function leading to fatty liver in vivo.

• The Korean Journal of Physiology and Pharmacology
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• v.1 no.5
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• pp.537-546
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• 1997

It has been postulated that the intracellular taurine is co-transported with $Na^+$down a concentration gradient and prevents the intracellular accumulation of sodium. It is therefore, expected that an elevated level of intracellular taurine prevents the sodium-promoted calcium influx to protect the cellular damages associated with sodium and calcium overload. In the present study, we evaluated the effects of intra- and extracellular taurine on the myocardial $Na^+$and$Ca^{++}$ contents and the cardiac functions in isolated rat hearts which were loaded with sodium by monensin, a $Na^+-ionophore$. Monensin caused a dose-dependent increase in intracellular $Na^+$ accompanied with a subsequent increase in intracellular $Ca^{++}$ and a mechanical dysfunction. In this monensin-treated heart, myocardial taurine content was decreased with a concomittent increase in the release of taurine. The monensin-induced increases in intracellular $Na^+$, $Ca^{++}$ and depression of cardiac function were prevented in the hearts of which taurine content had been increased by high-taurine diet. Conversely, in the hearts of which taurine concentration gradient had been decreased by addition of taurine in the perfusate, the monensin-induced increases in $Na^+$, $Ca^{++}$ and functional depression were accelerated. These results suggest that taurine, depending on the intra-extracellular concentration gradient, can affect intracellular sodium and calcium concentrations, and that an increased intracellular taurine may play a role in protection of myocardial dysfunction associated with the sodium and calcium overload.

• The Korean Journal of Food And Nutrition
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• v.33 no.6
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• pp.614-623
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• 2020

The objective of this study was to produce a nutrient delivery system (NDS) using sialic acid extracted from edible bird's nest (EBN), which improves brain function in patients with Alzheimer's disease and Parkinson's disease, by affinity bead technology (ABT). The inhibitory activity of acetylcholinesterase (AChE) and pyramidal cells in the dentate gyrus of the hippocampus were analyzed to investigate the effect of a sialic acid NDS on Alzheimer's disease. Also, the effect of a sialic acid NDS on Parkinson's disease was evaluated by rota-rod test and pole test in an animal model. Among the groups treated with donepezil, EBN, and sialic acid NDS, the AChE activity was the lowest in the sialic acid NDS-treated group. The results of the hippocampus analysis of the rat model confirmed that the sialic acid NDS inhibited amyloid-beta accumulation depending upon the concentration. Also, the sialic acid NDS group showed more improvement in motor deterioration than the1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced group in both the rota-rod test and pole test. Therefore, the sialic acid NDS had an effect of protecting not only Alzheimer's disease by inhibiting AChE and amyloid-beta accumulation, but Parkinson's disease by preventing neurotoxicity induced by MPTP.

• The Korea Journal of Herbology
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• v.33 no.5
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• pp.1-8
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• 2018

Objectives : The aim of this study is to investigate the preventive effect of Puerariae Flos ethanol extract (PE) on methionin and choline deficient (MCD)-diet-induced Nonalcoholic fatty liver disease (NAFLD) in C57BL/6J mice. Methods : In the in vivo experiments, C57BL/6J mice were divided into 4 groups; Normal group, Control group, MCD+PE 100 group, and MCD+PE 300 group. After 4 weeks, body weight, liver weight, biochemical parameters for liver function test, histological changes, reverse transcription polymerase chain reaction (RT-PCR), and Western blot were assessed. Results : Mice lost body weight with the MCD-diet and the MCD+PE 100 group and MCD+PE 300 groups lost less than the control group, though showed no statistical significance. Liver weights were decreased by the MCD diet, but MCD+PE 300 groups were increased significantly. In the liver function test, all the values were decreased with the MCD-diet, MCD+PE 100 group and MCD+PE 300 groups were increased significance. In histological findings of the livers, MCD-diet induced severe fatty accumulation in the livers, but this fatty change was reduced in the MCD+PE 100 group and MCD+PE 300 groups was inhibited respectively. In lipid accumulation factors (such as SREBP-1c, $C/EBP{\alpha}$, PPAR-${\gamma}$), MCD+PE 100 group and MCD+PE 300 groups showed inhibitory effect on liver lipogenesis by reducing associated gene expressions caused by MCD diet. Conclusions : We were able to know that Puerariae Flos ethanol extract (PE) shown hepatoprotective effects via a decrease on the hepatic lipogenesis factors in the experimental NAFLD Models.

• Journal of Korea Water Resources Association
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• v.55 no.9
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• pp.701-705
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• 2022

Reliable drought inflow scenarios are required to plan reservoirs in response to the present severe drought-like conditions. However, the previously developed method for generating drought inflows, the K-water cumulative difference method (KCM), is considered inadequate owing to its potential for negative inflow, reversal phenomena, and overestimation. Nevertheless, the occurrence of these aspects has not been theoretically analyzed. Hence, this study employed the quantile function and frequency factor for log-normal and Gumbel distributions to quantify the contributing factors of these limitations. Consequently, it was found that the negative inflows are generated when the difference in the location parameters, during the accumulation process, exceeds that of the scale parameters. In addition, as the standard deviation decrease during the accumulation process, the reversal phenomena, and inflated values prevailed.

• Journal of Navigation and Port Research
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• v.31 no.3 s.119
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• pp.205-212
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• 2007

Due to the construction of Incheon Grand Bridge, there is driven a necessity for rearranging the function of Inner Port with the development of Outer South Port. In this paper, I'd like to simulate the port operation levels of Lock Gate in Inner Port with estimating the traffic volumes of 2011 and 2015, which will reveal the Demurrage Cost and the Accumulation Cost of Freight in Inner Port. Finally I will evaluate the economic movement effects of the container ship's calling from Inner port to South Port/Outer South Port from 2011 to 2015. The results are as followings ; (1) The average utilization of Lock Gates are reduced by $7\sim8$ percentage point. (2) The mean queueing value are saved by 25 percentage point. (3) The Demurrage Cost and the Accumulation Cost of Freight except Lock Gate charges and the Benefit of Routeing Reduction are saved about 800 million Won annually.

• Korean Journal of Organic Agriculture
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• v.8 no.1
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• pp.111-129
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• 1999

In order to get some basic data to check the environmental sound function against soil and water pollution and the safe vegetable production by korean organic farming where an internationally recognized basic concepts of soil fertility management for organic farming is not practiced and only applying the organic fertilizer to maintain the soil fertility, the chemical characteristics of soils and $NO_{3}^{-}$ content of chinese cabbage and lettuce cultivated by the conventional farming, greenhouse cultivation and organic farming were investigated. The highest value of $NO_{3}^{-}$-N in 0~30cm subsoil among the three different farming systems was found in the subsoil of organic farming and it was 3.6 and 6.6 times higher than those of conventional farming in chinese cabbage and lettuce respectively. $P_2O_5$ accumulation in the rhizosphere by organic farming also showed the highest value. The accumulation of $NO_{3}^{-}$-N and $P_2O_5$ in organic farming soil were similar or even more higher to those of greenhouse cultivation. The $NO_{3}^{-}$ accumulation in the vegetable by organic farming reached 3224ppm for chinese cabbage and 2543ppm for lettuce, and it were 4.7 and 6.4 times higher than those by conventional farming. It was concluded that there is urgently necessary to introduce the main concepts of soil fertility management of the Basic Standard of IFOAM, EU regulation and FAO/WHO Codex Alimentarius on organic agriculture(draft) into korean organic agriculture for the operation of environmental sound system and the production of sate vegetable in terms of $NO_{3}^{-}$ content.