• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2000년도 추계학술발표대회 및 bio-venture fair
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• pp.77-80
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• 2000

Various analytical methods such as electron microscopy, quinone analysis, and 16S rDNA sequencing studies were used to investigate the microbial communities and to identify the microorganisms responsible for enhanced biological phosphorus removal (EBPR) in an anaerobic/aerobic sequencing batch reactor (SBR) fed with acetate. Electron photomicrographs showed that oval-shaped microorganisms of about $0.7\;{\sim}\;1\;{\mu}m$ in diameter dominated the microbial sludge. These microorganisms contained polyphosphate granules and glycogen inclusions, which suggests that they are a kind of phosphorus accumulating organism. Quinone and 16S rRNA sequence analyses showed that the members of Proteobacteria beta subclass were the most abundant species, which were affiliated with the Rhodocyclus-likes group. Phylogenetic analysis revealed that the two dominating clones of the beta subclass were most distantly related to Propionivibrio dicarboxylicus DSM 5885 and Rhodocyclus tenuis DSM 109 with about 95% and 96% sequence similarity, respectively. Therefore, it was concluded that the oval-shaped organisms related to the Rhodocyclus-likes group are likely to be responsible for biological phosphorus removal in SBR operation supplied with acetate.

• 기술혁신연구
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• 제7권2호
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• pp.101-118
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• 1999

Factory automation(FA) is a part of technological innovation to make production process more efficient and it also facilitates technological innovation by accumulating the internalization ability of newly imported technology Introduction of FA, however, does not guarantee the increase of production efficiency and high product quality, moreover, the competitiveness of firm. The purpose of this paper is to analyze the relationship between firm's behavioral characteristics during implementation process of FA and organizational performance, and to find out success factors of FA. Results of the case studies for 4 SME's show that financial stability and the fitness between corporate strategy and the purpose of FA are the necessary conditions for successful implementation of FA. But the organizational restructuring for new manufacturing system, openness of all communication channels, and common mind of employees are also needed to achieve the high degree of performance from FA, especially the benefits of qualitative or organizational level.

• BMB Reports
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• 제52권6호
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• pp.360-372
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• 2019

Macrophages play an essential role not only in mediating the first line of defense but also in maintaining tissue homeostasis. In response to extrinsic factors derived from a given tissue, macrophages activate different functional programs to produce polarized macrophage populations responsible for inducing inflammation against microbes, removing cellular debris, and tissue repair. However, accumulating evidence has revealed that macrophage polarization is pivotal in the pathophysiology of metabolic syndromes and cancer, as well as in infectious and autoimmune diseases. Recent advances in transcriptomic and metabolomic studies have highlighted the link between metabolic rewiring of macrophages and their functional plasticity. These findings imply that metabolic adaption to their surrounding microenvironment instructs activation of macrophages with functionally distinct phenotypes, which in turn probably leads to the pathogenesis of a wide spectrum of diseases. In this review, we have introduced emerging concepts in immunometabolism with focus on the impact on functional activation of macrophages. Furthermore, we have discussed the implication of macrophage plasticity on the pathogenesis of metabolic syndromes and cancer, and how the disease microenvironment manipulates macrophage metabolism with regard to the pathophysiology.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.172.1-172.1
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• 2003

3-Monochloro-1 ,2-propanediol (3-MCPD) produced during the acid hydrolysis of vegetable proteins (ex. soybean products) is food-contaminant material detected in acid-hydrolysed soy, bread, water, et al. 3-MCPD is currently being a matter of concern to safety. The nephrotoxicity of 3-MCPD and 3-MCPD metabolites has been reported to result from accumulating of metabolites in kidney tubules and inhibiting of renal metabolism of glucose and lactate. (omitted)

• 한국의류학회지
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• 제45권6호
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• pp.949-964
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• 2021

Accumulation of high-quality data is crucial for AI learning. The goal of using AI in fashion service is to propose of a creative, personalized solution that is close to the know-how of a human operator. These customized solutions require an understanding of fashion products and emotions. Therefore, it is necessary to accumulate data on the attributes of fashion products and fashion emotion. The first step for accumulating fashion data is to standardize the attribute with coherent system. The purpose of this study is to propose a fashion emotional classification system. For this, images of fashion products were collected, and metadata was obtained by allowing consumers to describe their emotions about fashion images freely. An emotional classification system with a hierarchical structure, was then constructed by performing frequency and CONCOR analyses on metadata. A final classification system was proposed by supplementing attribute values with reference to findings from previous studies and SNS data.

• IMMUNE NETWORK
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• 제19권1호
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• pp.4.1-4.16
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• 2019

Long noncoding RNAs (lncRNAs) are non-protein coding RNAs of more than 200 nucleotides in length. Despite the term "noncoding", lncRNAs have been reported to be involved in gene expression. Accumulating evidence suggests that lncRNAs play crucial roles in the regulation of immune system and the development of autoimmunity. lncRNAs are expressed in various immune cells including T lymphocytes, B lymphocytes, macrophages, neutrophils, dendritic cells, and NK cells, and are also involved in the differentiation and activation of these immune cells. Here, we review recent studies on the role of lncRNAs in immune regulation and the differential expression of lncRNAs in various autoimmune diseases.

• Korean Journal of Radiology
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• 제20권1호
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• pp.134-147
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• 2019

Gadolinium-based contrast agents (GBCAs) are commonly used for enhancement in MR imaging and have long been considered safe when administered at recommended doses. However, since the report that nephrogenic systemic fibrosis is linked to the use of GBCAs in subjects with severe renal diseases, accumulating evidence has suggested that GBCAs are not cleared entirely from our bodies; some GBCAs are deposited in our tissues, including the brain. GBCA deposition in the brain is mostly linked to the specific chelate structure of the GBCA: linear GBCAs were responsible for brain deposition in almost all reported studies. This review aimed to summarize the current knowledge about GBCA brain deposition and discuss its clinical implications.

• 한국수학교육학회지시리즈A:수학교육
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• 제62권4호
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• pp.473-490
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• 2023

국내외 선행연구들에서는 교수실험을 통하여 학생들의 연속적인 변화에 대한 추론 방식에 대한 정보를 축적해가고 있다. 이들 연구에서는 연속적인 변화를 매끄러운 추론과 덩어리 추론을 하는 학생들이 교수실험에서 함께 수학적 결과물을 구성해가는 장면들을 다루고 있는데, 이들의 결과를 보다 세밀하게 분석하기 위해서는 특정 방식으로 연속적인 변화를 추론하는 학생이 이전 선행 연구들에서의 과제들에 대하여 어떠한 결과물을 구성해가는지 확인할 필요가 있다. 이러한 연구의 필요에 따라, 연구자는 덩어리 추론을 하는 것으로 확인된 고등학교 1학년 학생 한 명을 대상으로 총 14차시의 교수실험을 진행하였다. 본 연구에서는 덩어리 추론을 하는 학생이 '이전 선행연구에서 연속적인 변화에 대한 추론 방식이 다양한 학생들이 구성하였던 수학적 결과물'과 유사한 산출물을 구성해가는 장면을 관찰할 수 있었다. 특히 본 연구에 참여한 학생에게서 '시간-거리함수에서 시간-속력함수를 구성하는 일관된 구성 방식'이 관찰되었으며, 이러한 학생의 독특한 구성 방식에 대한 정보가 후속 연구에 도움이 될 것이라 기대하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권6호
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• pp.2575-2580
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• 2015

Cancer is a multifaceted and genomically complex disease and rapidly accumulating high impact research is deepening our understanding related to the mechanisms underlying cancer development, progression and resistance to therapeutics. Increasingly it is being realized that genetic/epigenetic mutations, inactivation of tumor suppressor genes, overexpression of oncogenes, deregulation of intracellular signaling cascades and loss of apoptosis are some of the extensively studied aspects. Confluence of information suggested that rapidly developing resistance to therapeutics is adding another layer of complexity and overwhelmingly increasing preclinical studies are identifying different natural agents with efficacy and minimal off-target effects. We partition this multi-component review into citrus fruits and their bioactive ingredients mediating rebalancing of pro- and anti-apoptotic proteins to induce apoptosis in resistant cancer cells. We also discuss how oncogenic protein networks are targeted in cancer cells and how these findings may be verified in preclinical studies.

• 한국경영과학회지
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• 제39권2호
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• pp.1-19
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• 2014

Recently, one of the core keywords in information technology (IT) as well as areas such as business management is big data. Big data is a term that includes technology, personnel, and organization required to gather/manage/analyze collection of data sets so large and complex that it becomes difficult to manage and analyze using traditional tools. The military has been accumulating data for a long period due to the organization's characteristic in placing emphasis on reporting and records. Considering such characteristic of the military, this study verifies the possibility of improving the performance of the military organization through use of big data and furthermore, create scientific development of operation, strategy, and support environment. For this purpose, the study organizes general status and case studies related to big data, traces back examples of data utilization by Korean's national defense sector through US military data collection and case studies, and proposes the possibility of using and applying big data in the national defense sector.