• Title/Summary/Keyword: abnormal growth

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Ovulation Rate and Early Embryonic Development of Mouse Atretic Follicular Oocytes Induced by High-dose Gonadotropin (과량의 생식소자극호르몬 처리를 받은 생쥐 폐쇄난포의 배란율과 초기배아 발생률의 변화)

  • 임천규
    • Development and Reproduction
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    • v.1 no.1
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    • pp.67-77
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    • 1997
  • Mammalian ovary consists of various growing stages of follicles. Ovarian follicular growth and differentiation, however, can be distinguished into recruitment, growth, selectiona nd ovulation. while only minute of the selected follicles ovulate their oocytes, all the rest follicles disappear by atresia. this atresia is an important event of which physiological mechanism must be resolved. The present study was carried out to investigate the effects of various doses of pregnant mare's serum gonadotropin (PMSG) on the oocyte quality, ovulation rate, and the early embryonic development in immature mice. Immature mice were administrated with 5, 20, or 40 IU PMSG. At every 12 hour up to 72 hour after treatment, body and ovary weights were measured. Oocytes were flushed from the oviducts under the dissecting microscope and observed under the inverted microscope. Late 2-cell embryos were collected from the mice which were superovulated by the same dosage of PMSG followed by 5 IU hCG 47 hours after PMSG-treatment. The percentage of abnormal oocytes was higher in 20 or 40 IU PMSG-treated animals than 5 IU PMSG-treated ones. Ovulation occured at 12 hours afger PMSG injection in all experimental groups. The percentage of retrieved abnormal oocytes increased in the 20 or 40 IU PMSG-treated goups but not in 5 IU PMSG-treated group. There was no significant difference in the mating rate among the groups [52.6% (10/19), 66.7% (10/15), 44.0% (11/25) : 5, 20, 40 IU group respectively] ; however, ther was a significant (p<0.01) increase of embryo retrieval rates in 5 and 20 IU-treated groups compared with that in 40 IU-treated group [89.2% (239-268), 85.5% (224/262), 40.0% (18/45)]. There was significant (p<0.01) increase of embryo development rates in 5 IU-treated group compared with that in 20 and 40 IU-treated group [231/239(96.7), 179/224(79.9), 77.8(14/18)]. In conclusion, higher doses of PMSG injection increased the occurrence of abnormal oocytes ovulation in immature mice. The most of oocytes collected from 5 or 20 IU-PMSG-treated group has fertilizabioity. But in mice injected iwth higher doses of PMSG, their oocytes exhibit less fertilizability and, even fertilized, all oocytes are not fully capable of development.

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Abnormal Behavior of MOCVD Grown $Al_xIn_{1-x}N$ Observed by Various Material Characterizations

  • Chung, Roy Byung-Kyu;DenBaars, Steven P.;Speck, James S.;Nakamura, Shuji
    • Proceedings of the Materials Research Society of Korea Conference
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    • 2011.10a
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    • pp.14-14
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    • 2011
  • AlInN has been studied extensively over the past few years due to its interesting material properties that are not present in other ternary nitrides. However, basic material study of AlInN has not been reported as much compared to device applications due to the difficulty in the growth. We have performed the material studies from various aspects. A secondary ion mass spectrometry (SIMS) has shown high oxygen content above $1{\times}10^{18}\;cm^{-3}$ with its insensitivity to the growth conditions. While the free carrier concentration observed by the capacitance-voltage (C-V) measurements was about $3{\times}10^{17}\;cm^{-3}$, the activation energy measured by temperature dependent C-V was only about 4 meV. Si doped AlInN (Si level ${\sim}2{\times}10^{18}\;cm^{-3}$) showed almost no carrier freeze-out at carrier density of $1{\times}10^{18}\;cm^{-3}$. More studies were carried out with a transmission electron microscopy, time-resolved photoluminescence and other analytical techniques to understand the results from SIMS and C-V studies. In this report, we will discuss the possible correlations between the abnormal characteristics in AlInN.

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Light Quality during Seed Imbibition Affects Germination and Sprout Growth of Soybean

  • Kang, Jin-Ho;Park, A-Jung;Jeon, Byung-Sam;Yoon, Soo-Young;Lee, Sang-Woo
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.47 no.4
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    • pp.292-296
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    • 2002
  • Soybean seeds were treated with blue, red and far-red lights for 0, 6, 12, and 24 hours during 24-hour imbibition before culture for 6 days. The soybean sprouts raised were classified by their hypocotyl lengths; normal (>4cm), abnormal (<4cm) and non-germination, and their lateral roots, hypocotyl diameters and component dry weights were measured. Red light treatment and dark imbibition reduced the abnormal soybean sprouts more than far-red and blue light treatments, meaning that the former treatments produced more commercial sprouts. The lateral roots were more formed in blue light and dark imbibition than the other light treatments, but were completely blocked by any light treatment lasted during the whole imbibition. Although any light quality treatment did not influence their primary root lengths, blue light one lengthened the hypocotyl more than the others treated during the imbibition, and far-red light enlarged its diameter. Despite this morphological change, component, total or economic yield was not significantly different among the light quality treatments during the imbibition.

The optimal control technology on complex environment in horticulture based on artificial intelligence (인공지능 기반 시설원예 최적 복합 환경 제어 기술)

  • Min, Jae Hong
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2017.10a
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    • pp.756-759
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    • 2017
  • The productivity of cultivated crops in Korea is low compared to the Netherlands, which is an advanced agricultural country. In addition, modernization of facility and complex environmental control technology are needed to overcome poor growth and productivity deterioration caused by shortage of sunshine, abnormal temperature and high temperature due to abnormal climate. On the other hand, domestic facility horticulture complex environmental control is a level of machine automation that can check the internal situation of a green house with a cell phone and remotely operate a sprinkler, heat cover, curtain, ventilator, Therefore, this paper suggests the development of optimum environment control technology for facility horticulture based on the growth model and the cultivation technology knowledge base in order to realize the automation of optimal complex environment control and contribute to improvement of quality and productivity of cultivated crops.

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Effect of Abnormal Grain Growth on Ionic Conductivity in LATP (LATP 내 비정상 입자성장이 이온 전도도에 미치는 영향)

  • Hyungik Choi;Yoonsoo Han
    • Journal of Powder Materials
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    • v.31 no.1
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    • pp.23-29
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    • 2024
  • This study investigates the effect of the microstructure of Li1.3Al0.3Ti1.7(PO4)3 (LATP), a solid electrolyte, on its ionic conductivity. Solid electrolytes, a key component in electrochemical energy storage devices such as batteries, differ from traditional liquid electrolytes by utilizing solid-state ionic conductors. LATP, characterized by its NASICON structure, facilitates rapid lithium-ion movement and exhibits relatively high ionic conductivity, chemical stability, and good electrochemical compatibility. In this study, the microstructure and ionic conductivity of LATP specimens sintered at 850, 900, and 950℃ for various sintering times are analyzed. The results indicate that the changes in the microstructure due to sintering temperature and time significantly affect ionic conductivity. Notably, the specimens sintered at 900℃ for 30 min exhibit high ionic conductivity. This study presents a method to optimize the ionic conductivity of LATP. Additionally, it underscores the need for a deeper understanding of the Li-ion diffusion mechanism and quantitative microstructure analysis.

Single Crystal Growth Behavior in High-Density Nano-Sized Aerosol Deposited Films

  • Lim, Ji-Ho;Kim, Seung-Wook;Kim, Samjung;Kang, Eun-Young;Lee, Min Lyul;Samal, Sneha;Jeong, Dae-Yong
    • Korean Journal of Materials Research
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    • v.31 no.9
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    • pp.488-495
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    • 2021
  • Solid state grain growth (SSCG) is a method of growing large single crystals from seed single crystals by abnormal grain growth in a small-grained matrix. During grain growth, pores are often trapped in the matrix and remain in single crystals. Aerosol deposition (AD) is a method of manufacturing films with almost full density from nano grains by causing high energy collision between substrates and ceramic powders. AD and SSCG are used to grow single crystals with few pores. BaTiO3 films are coated on (100) SrTiO3 seeds by AD. To generate grain growth, BaTiO3 films are heated to 1,300 ℃ and held for 10 h, and entire films are grown as single crystals. The condition of grain growth driving force is ∆Gmax < ∆Gc ≤ ∆Gseed. On the other hand, the condition of grain growth driving force in BaTiO3 AD films heat-treated at 1,100 and 1,200 ℃ is ∆Gc < ∆Gmax, and single crystals are not grown.

Morphological and Anatomical Evaluation of Grafted Pinus merkusii

  • Susilowati, Arida;Iswanto, Apri Heri;Wahyudi, Imam;Supriyanto, Supriyanto;Siregar, Iskandar Z
    • Journal of the Korean Wood Science and Technology
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    • v.44 no.6
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    • pp.903-912
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    • 2016
  • Morphological and anatomical evaluation of grafted P. merkusii have been undertaken to obtain the information about compatible and incompatible symptoms of 18 years old grafts based on morphological observation and microscopic analysis. Samples of compatible and incompatible grafts were obtained from previous research conducted by the Silviculture Departement Team in 1994. Result showed that compatible grafts have normal stem form and secondary growth (diameter growth), but some abnormality symptoms like undulated pattern of annual growth rings, phloem thickening and abnormality resin ducts in inner and middle parts of the union area occurred. Incompatible ones showed abnormality of the stem form, cortex-bark necrosis and swelling in the union area. Microscopic observation showed abnormality of all parts of the union, undulated pattern of annual growth rings, phloem thickening, abnormal resin ducts, low numbers and discontinuity of vascular elements in the union area.

A FRACTIONAL-ORDER TUMOR GROWTH INHIBITION MODEL IN PKPD

  • Byun, Jong Hyuk;Jung, Il Hyo
    • East Asian mathematical journal
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    • v.36 no.1
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    • pp.81-90
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    • 2020
  • Many compartment models assume a kinetically homogeneous amount of materials that have well-stirred compartments. However, based on observations from such processes, they have been heuristically fitted by exponential or gamma distributions even though biological media are inhomogeneous in real environments. Fractional differential equations using a specific kernel in Pharmacokinetic/Pharmacodynamic (PKPD) model are recently introduced to account for abnormal drug disposition. We discuss a tumor growth inhibition (TGI) model using fractional-order derivative from it. This represents a tumor growth delay by cytotoxic agents and additionally show variations in the equilibrium points by the change of fractional order. The result indicates that the equilibrium depends on the tumor size as well as a change of the fractional order. We find that the smaller the fractional order, the smaller the equilibrium value. However, a difference of them is the number of concavities and this indicates that TGI over time profile for fitting or prediction should be determined properly either fractional order or tumor sizes according to the number of concavities shown in experimental data.

Effect of Plant Growth Regulators on Plant Regeneration Through Somatic Embryogenesis of Medicago sativa L.

  • Kim, Young-Sook;Kim, Mi-Young;Yang, Moon-Sik
    • Journal of Plant Biotechnology
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    • v.6 no.2
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    • pp.87-90
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    • 2004
  • An efficient plant regeneration system in alfalfa (Medicago sativa L.) through somatic embryogenesis was established. Embryogenic callus was obtained by culture of hypocotyl segments on MS medium with 0.02mg $L^{-1}$ IAA and 1.0mg $L^{-1}$ zeatin after 45 days of culture. Embryogenic calli were converted to the somatic embryos when transferred to either MS medium without plant growth regulators (PGRs) or MS medium containing various cytokinin (BA, kinetin and zeatin). Most of the somatic embryos were developed into plantlets on MS medium supplemented with 0.1 mg $L^{-1}$ kinetin. Also, secondary embryos appeared on the surface of primary embryo but they showed abnormal growth. Regenerated plantlets were transplanted to pots containing vermiculite and perlite for further analysis.

Acute Toxicity of Recombinant Human Epidermal Growth factor, DWP-401 in Mice (Recombinant Human Epidermal Growth Factor, DWP-401에 대한 마우스에서의 급성독성)

  • 김효정;서경원;오미현;선우유신;유영효;문병우
    • Biomolecules & Therapeutics
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    • v.2 no.1
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    • pp.77-81
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    • 1994
  • The acute toxicity of recombinant human epidermal growth factor, DWP-401 was evaluated in ICR mice of both sexes. Six groups of mice were administered orally or subcutaneously with 0, 0.125, 0.25, 0.5, 1 and 2 mg/kg of DWP-401. Abnormal clinical signs related to the compound were not observed, and no deaths occurred. Gross findings of necropsy revealed no evidence of specific toxicity related to DWP-401. LD$_{50}$ values for both male and female mice were evaluated to be over 2 mg/kg, which is approximately 2, 000 fold of presumed clinical dose.e.

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