• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.26 no.12
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• pp.904-908
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• 2013

When an abnormal condition occurs due to a fault current at a consumer location where electricity is supplied through a high-capacity and high-$T_c$ superconducting(HTS) cable, the HTS cable would be damaged if there is no appropriate measure to protect it. Therefore, appropriate measures are needed to protect HTS cables. The fault-current-limiting HTS cable that was suggested in this study performs an ideal transport current function in normal operations and plays a role in limiting a fault current in abnormal operation (i.e., when a fault current is applied). It has a structure that facilitated its self-current-limiting ability through device change and reconfiguration in the existing HTS cable without extra switching equipment. To complete this structure, it is essential to investigate about the selection of the superconducting wire. Therefore, in this paper, HTS wire using two types of different stabilization layer is compared and examined the stability and current limiting properties under the existence of a fault current.

• Interdisciplinary Bio Central
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• v.3 no.1
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• pp.5.1-5.5
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• 2011

Introduction: Many signal transduction pathways mediate cell's behavior by regulating expression level of involved genes. Abnormal behavior indicates loss of regulatory potential of pathways, and this can be attributed to loss of expression regulation of downstream genes. Therefore, function of pathways should be assessed by activity of a pathway itself and relative activity between a pathway and downstream genes, simultaneously. Results and Discussion: In this study, we suggested a new method to assess pathway's function by introducing concept of 'responsiveness'. The responsiveness was defined as a relative activity between a pathway itself and its downstream genes. The expression level of a downstream gene as a function of an upstream pathway activation characterizes disease status. In this aspect, by using the responsiveness we predicted potential progress in cancer development. We applied our method to predict primary and metastatic status of melanoma cancer. The result shows that the responsiveness-based approach achieves better performance than using gene or pathway information alone. The mean of ROC scores in the responsiveness-based approach was 0.90 for GSE7553 data set, increased more than 40% compared to a gene-based method. Moreover, identifying the abnormal regulatory patterns between pathway and its downstream genes provided more biologically interpretable information compared to gene or pathway based approaches.

• Toxicological Research
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• v.3 no.1
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• pp.33-44
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• 1987

A fertility study was carried out in Sprague Daxley rats which have been given the intravenous or intraperitoneal injections of rHuIFN-${\alpha}$A, a commecially available therapeutic agent, at dose levels of $1{\times}10^5$, $4{\times}10^5$ and $1.2{\times}10^6$ I.U/kg/day. Male rats were treated with rHuIFN-${\alpha}$A from 60 days before pairing and until the completion of mating. Femal rats received rHuIFN-${\alpha}$A for 22days prior to mating and up to day of gestation. All pregnant females were sacrificed on day 20 of gestation and all fetuses were examined for abnormalities. Both the male and female animals treated with rHuIFN-${\alpha}$A did not show any abnormal responses. No abnormal signs were seen in reproducibility for the rats treated with rHuIFN-${\alpha}$A. No External, internal and skeletal anomalies attributable to rHuIFN-${\alpha}$A were observed in the fetuses. It was concluded that rHuIFN-${\alpha}A$ had no harmful effect on mating, fertilization, implantation, or embryonic development.

• Childhood Kidney Diseases
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• v.16 no.1
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• pp.9-14
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• 2012

The relationship between central nervous system (CNS) and enuresis has not been sufficiently elucidated despite the presence of several circumstantial evidences. Contrary to common belief, polysomnographic sleep analysis revealed that the disturbance of arousal rather than deep sleep was responsible for enuresis. Subsequent studies confirmed depressed sympathetic tone and retarded brainstem reflex indicating abnormal arousal threshold in enuretics. In accordance with the bladder-brain dialogue, chronic stimulation of bladder may modify the brainstem function elevating arousal threshold. Epidemiological studies have suggested the association between enuresis and various psychosomatic disorders like attention deficit hyperactivity disorder (ADHD), which has shown the abnormal brainstem reflex similar to enuresis. Taken together, CNS is assumed to play a crucial role in the pathogenesis of enuresis. Psychological assessment is vital to understand the psychodynamic effect of enuresis. Studies have shown that the prevalence of psychological problems was higher in enuretic children and externalization of the symptoms was usually found. Several explanations have been brought up regarding the development of enuresis and psychological problems. Enuresis may cause psychological problems and vice versa. Otherwise, both may be associated with other variables, such as socioeconomic status (SES).

• Proceedings of the Korean Nuclear Society Conference
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• 1995.10a
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• pp.185-190
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• 1995

Conventional alarm system has many difficulties in the operator's identifying the plant status during special situations such as design basis accidents. To solve the shortcomings, an on-line alarm annunciator system, called dynamic alarm console (DAC), was developed. In the DAC, a signal is generated as alarm by the use of an adaptive setpoint check strategy based on operating mode, and time delay technique is used not to generate nuisance alarms. After alarm generation, if activated alarm is a level precursor alarm or a consequencial alarm, it would be suppressed, and the residual alarms go through dynamic prioritization which provide the alarms with pertinent priorities to the current operating mode. Dynamic prioritization is achieved by going through the system- and mode-oriented prioritization. The DAC has the alarm hierarchical structure based on the physical and functional importance of alarms. Therefore the operator can perceive alarm impacts on the safety or performance of the plant with the alarm propagation from equipment level to plant functional level. In order to provide the operator with the most possible cause of the event and quick cognition of the plant status even without recognizing the individual alarms, reactor trip status tree (RTST) was developed. The DAC and the RTST have been simulated with on-line data obtained from the full-scope simulator for several abnormal cases. The results indicated that the system can provide the operator with useful and compact information fur the earlier termination and mitigation of an abnormal state.

• Proceedings of the Korean Geotechical Society Conference
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• 2010.09a
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• pp.445-456
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• 2010

Massive underground excavation can be carried out recently due to the technical development of the excavation for retaining wall. Feed-back analysis using field measurement results is recommended to secure the stability of the construction because calculated values at stages of the design and the construction are uncertain. Reinforcement plan should be established based on the result of it. This study deals with the underground excavation site, which is under construction and is close to structure(subway) at downtown area. The result of feed-back analysis on the measurement data of displacement at multi-soil layers was reflected to make a plan for safe construction. This case study can be useful information for contingency plan on abnormal displacement which can be occurred at similar underground excavation.

• Journal of Power System Engineering
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• v.7 no.2
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• pp.29-35
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• 2003

The monitoring and diagnostics of the rotating machinery have been received considerable attention for many years. The objectives are to classify the machinery condition and to find out the cause of abnormal condition. This paper describes a classification method of diagnosing the small reciprocating compressor for refrigerators using the artificial neural network and the wavelet transform. In order to extract salient features, the wavelet transform are used from primary noise signals. Since the wavelet transform decomposes raw time-waveform signals into two respective parts in the time space and frequency domain, more and better features can be obtained easier than time-waveform analysis. In the training phase for classification, self-organizing feature map(SOFM) and learning vector quantization(LVQ) are applied, and the accuracies of them ate compared with each other. This paper is focused on the development of an advanced signal classifier to automatize the vibration signal pattern recognition. This method is verified by small reciprocating compressors, for refrigerator and normal and abnormal conditions are classified with high flexibility and reliability.

• Asian-Australasian Journal of Animal Sciences
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• v.13 no.11
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• pp.1514-1517
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• 2000

In chicken, exogenous genes introduced into germinal crescent region (GCR) of the early developmental stage, where primordial germ cells (PGCs) were concentrated, were successfully transferred to the gonads via PGCs. The foreign genes were also confirmed to be successfully incorporated into F1 and F2 generations. We tried to incorporate the exogenous genes into PGCs by lipofection, then the DNA mixture was injected into GCR at stage 3-5 or 9-11 of embryonic development (Hamburger and Hamilton, 1951). The manipulated eggs were incubated, and hatched chicks were reared until sexual maturation. F1 generation was obtained from the DNA-treated chicken (DNA-chicken) mated with normal birds. Furthermore, F2 generation was also obtained from the F1 chicken mated with normal birds. The transfer of introduced foreign genes were confirmed by marker gene detection methods and PCR analysis in the hatched chicks, F1 and F2 generations. However, in our experiments, DNA-chickens showed abnormal characteristics such as low egg production rate, abnormal appearance and decreased number of spermatozoa. In the case of F1 chicken, low egg production and the deterioration of sperm capacity for insemination in male chicken were observed.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.23
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• pp.10067-10070
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• 2015

Background: Unopposed estrogen has a central role in development of endometrial benign, premalignant and malignant lesions. The aim of this study was to evaluate the anti-estrogenic effect of metformin on endometrial histology in comparison with progesterone. Materials and Methods: A total of 43 patients who were referred to our center for abnormal uterine bleeding and had a histologic diagnosis were disordered proliferative endometrium or simple endometrial hyperplasia were included and randomly distributed in two groups treated with metformin (500mg Bid) or megestrol (40mg daily), respectively, for three months. After this period the patients were evaluated by another endometrial biopsy to assess the impact of the two drugs in restoring normal endometrial histology. Results: Our findings revealed that metformin could induce endometrial atrophy in 21 out of 22 patients (95.5%) while this positive response was achieved in only 13 out of 21 patients (61.9%) in the megstrol group. In addition two low grade endometrial carcinomas in the metformin group responded very well. Conclusions: We conclude that metformin could be used as an effective antiestrogenic agent in control of abnormal endometrial proliferative disorders.

• Proceedings of the Botanical Society of Korea Conference
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• 1993.07a
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• pp.1-36
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• 1993

It is possible to regenerate plants from calli, single cells and protoplasts of numerous species via organogenasis or embryogenesis in cell and tissue culture systems. Also such regeneration of plants can directly occur from cells of explants. However certain plant species has not been yet provided cultures suitable for plant regeneration from cells or tissues. For example, we have to confirm the regenerability of plant from cells before preparing transformed cells for application. Even more, it is very important to notice that regenerated plants in cell and tissue cultures often show structural abnormality. The mojority of those plants is functionally disordered and eventually cases degenerated. One of such examples is vitreous plants which are manifested mainly in the leaves and manifesteds to a lesser extent in the stems and roots. Regenerants in suspension cultures show more frequent vitrification than on gelled media so that relative humidity and water potential are the key factors involved in abnormal morphogenesis in vitro. The other is that somatic embryos formed in media containing BAP or high concentration of sucrose show frequently cotyledon aberrancy such as polycotyledon and born type cotyledon. The embryos with aberrant cotyledon of Codonopsis lanceolata could not germinate or regenerate into plants in many cases. In contrast, the polycotyledon embryos of Aralia cordata germinated in higher percentage than two cotyledonary embryos, but horn type cotyledonary embryos rarely germinated. The major cause of poor germination is the abnormal development of plumule apex meristem.