• 동의생리병리학회지
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• 제25권3호
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• pp.563-572
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• 2011

The purpose of this study was to investigate incidence and related factors of the metabolic syndrome in a Korean medicine hospital. The 716 subjects were analyzed using biochemical data and survey who took medical examination in Daejeon Korean Medicine Hospital for general health check-up. This investigation was conducted from February in 2008 to July in 2010. The metabolic syndrome was diagnosed according to the definition by the NCEP ATP III. The abdominal obesity guidelines for waist circumference applied by the WHO Western Pacific Region, IASO and IOTF: The Asia-Pacific Perspective in 2000. Incidence of metabolic syndrome was 12% (14.6% in men, 8.2% in women). The groups that have two metabolic risk factors were 21.9% in men and 7.5% in women. The incidence increased with ageing. The mean of metabolic syndrome`s triglyceride was in hypertriglyceridemia, and that of their BMI in men was in primary obese and that of their AST, ALT, ${\gamma}$-GTP means were in abnormal liver function. Smokers in men have metabolic syndrome 10 times more than non-smokers in men. Exercisers that do the exercise once or twice a week in women have metabolic syndrome 0.2 times more than non-exerciser in women. Women that have family history of stroke, were associated with metabolic syndrome by $x^2$-test. Men that have family history of hypertension, have metabolic syndrome 4 times more than otherwise men. Men that have family history of diabetes mellitus, have metabolic syndrome 3 times more than otherwise men.

• Toxicological Research
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• 제30권1호
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• pp.39-44
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• 2014

Bisphenol A (BPA) is widely used in the production of polycarbonate plastics, epoxy resins, and food and beverage containers. In the present study, we aimed to investigate the relationship between urinary concentrations of BPA and waist circumference in Korean adults. A total of 1,030 Korean adults (mean age, $44.3{\pm}14.6$ years) were enrolled in the study on the integrated exposure to hazardous materials for safety control, conducted by the Ministry of Food and Drug Safety from 2010 to 2012. Abdominal obesity was defined as having a waist circumference of at least 90 cm and 85 cm for men and women, respectively. The participants were divided into 4 groups according to the urinary BPA concentration quartile. Waist circumference was significantly higher among subjects with a urinary BPA concentration in the highest quartile relative to those in the lowest quartile (p = 0.0071). Linear regression analysis revealed a significant positive association between urinary BPA concentrations and body mass index, body fat, after adjusting for potential confounders. Moreover, subjects with urinary BPA concentrations in the fourth quartile were more likely to be obese compared to those with urinary BPA concentrations in the first quartile (odds ratio, 1.938; 95% CI: 1.314~2.857; p for trend = 0.0106). These findings provide evidence for a positive association between urinary BPA concentration and waist circumference in Korean adults.

• 기본간호학회지
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• 제9권3호
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• pp.412-423
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• 2002

Currently, health promotion is an important issue in health policy for world citizens. Aerobic workout may be one way to attain health promotion. In recent years, there ave been many studies to evaluate the effects of exercise on obese people and various patients. However, there are few studies in which both physiological and psycho-perceptual aspects of health romotion for healthy people have been evaluated. Purpose: This study focused on evaluating the holistic effect of an 8 week aerobic workout for health promotion in young women. Method: This quasi-experimental study was designed as a nonequivalent control group pre-post test study. Forty healthy college women, aged between 20 and 25 volunteered for the study. Twenty women took 30 minutes of exercise a day for five days a week over 8 weeks with Jane Fonda's aerobic workout program. Twenty women participated as controls. The aerobic workout program consisted of warm-up for arms, waist, abdominal, leg, hips, buttocks and cool down exercises. Result: After the eight weeks of aerobic exercise, changes in health related fitness components through the In Body Test, skin fold, circumference of body, Body image, Self concept, Mood and Self-efficacy were compared. The results areas follows ; 1. Following the 8 week aerobic workout, health related body components, and fitness scores, increased significantly (P < 0.05) and skin fold for four sites (right upper arm, scapular, abdomen, supra ilium), and circumference of mid thigh decreased significantly (P<0.05, p<0.005, P<0.001) compared to the control group. 2. Following the 8 week aerobic workout, there was a significant increase in Self-concept and Mood (P<0.005 and 0.001) compared to the control group. Conclusion: According to these results, it is concluded that 8 weeks of aerobic workout have a positive effect on young women's holistic health promotion.

• 한국의류학회지
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• 제15권4호
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• pp.393-403
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• 1991

The purpose of this study were to explain the difference in body dimensions and body shape between the early in the twenties and the late in the twenties and to get information clothing construction. Subject were 483 Korean males, which were extracted from men's physique investigation on June to August in 1989, consisted of 149 aged $19\~24$ and $25\~29$. T-test and factor analysis were applied to 52 measurement items and 58 indices. The Result of the study were as follow; 1. As regards $19\~24$ aged group, they were taller their waistband level was higher than the late in the twenties. Upper arm and thigh were thick in comparison with trunk. As the difference between shoulder and waist in dimension was great, they showed reverse triangular silhouette. As regard $25\~29$ aged group, their body from variation between individual was greater than that of 19~24 aged group and they were obese on mainly waist and abdominal parts. For that reason, waist band level became low and their shoulder and hip looked slim relatively that reason, waist band level became low and their shoulder and hip look slim relatively to bust and waist parts. 2. Between $19\~24$ aged and $25\~29$ aged groups, as each had charicteristic body from, there was the difference in factor structure. 3. The change of men's body from with age in their twenties was obeseness on the whole body but the increasing rate of upper arm and thigh girth was less than that of trunk girth.

• International Journal of Industrial Entomology and Biomaterials
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• 제14권2호
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• pp.121-126
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• 2007

Obesity is a major risk factor for cardiovascular disease. In our case study using animal models for disease states such as obesity or hypertension, we found that, Isaria sinclairii remarkably reduced body weight and ameliorated metabolic abnormalities in Zucker and SHR rats. Genetically obese (fa/fa) Zucker rats were one animal model chosen for this study. Four groups of rats received a standard diet and were treated orally with the following test samples daily for 8 weeks: saline (negative control), ethanol extracts of I. sinclairii, hot water extract of I. sinclairii, or $Xenical^{(R)}$ (30 mg/kg, positive control). Mild reductions (6.3%) in body weight gain were observed in the groups treated with the hot water extract of I. sinclairii compared to the control after 8 weeks. Interestingly, organ weight was greatly reduced by this Dongchunghacho (I. sinclairii), in parallel with the mild reductions in body weight gain and reductions in abdominal fat (adipose tissue). Also observed was a 4.1 % decrease in the ratio of heart weight/body weight compared to the control group. As a hypertensive animal model, SHR (spontaneously hypertensive rat) and WKY (Wistar Kyoto) rats were also administered these extracts for one month. Treatment with the hot water extract of I. sinclairii caused greater reductions in body weight gain for the SHR group (10.9%) compared to the WKY group's (5.2%). Based on these results, I. sinclairii extracts contain selective action for anti-obesity activity, naturally occurring candidate for regulation of body weight increase, as demonstrated in the present study.

• Nutrition Research and Practice
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• 제13권2호
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• pp.159-168
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• 2019

BACKGROUND/OBJECTIVES: Over the past few decades, Malaysia has been experiencing an increased prevalence of overweight and obesity that threatens the health of Malaysians. Poor dietary intake is one of the major contributors to the development of obesity and many non-communicable diseases. The dietary intakes of adults in Malaysia were assessed to determine the association between the dietary intake variables and the body mass index (BMI) and waist circumference (WC) measurements. This study examined whether the dietary intake achieved the recommended nutritional guidelines and compared the intakes between both sexes. SUBJECTS/METHODS: The height, weight, and WC of four-hundred-and-ninety adults (n = 490) in Malaysia were measured using standard procedures. The three-day 24-hour dietary recalls were conducted on 422 out of the 490 adults and their dietary intakes were evaluated in detail. The selected dietary intake variables were used to determine the associations with the obesity indicators. RESULTS: Among the participants, 52.8% were overweight or obese. After data analysis, the mean energy intake was 1,550 kcal/day, in which male participants had a significantly higher energy and macronutrients intake than females. Protein consumption and its percentage of energy contribution exceeded the recommended range. The consumption of fruits, vegetables, and milk and milk products were lower than the recommended number of servings for a healthy diet. The male participants consumed significantly more servings of carbohydrate-based foods, meat, and fats, oils, and sweets than females. Among the selected dietary intake variables, only the carbohydrate intake was negatively associated with the BMI (Estimate b = -0.008) and WC measurements (Estimate b = -0.019) after adjusting for covariates. CONCLUSIONS: This study evaluated the dietary intakes of a sample of Malaysian adults and its association with the obesity indicators. The results highlight the need for improvements and modifications of the dietary intake of Malaysians to reduce the overweight and obesity rates.

• 대한의생명과학회지
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• 제25권3호
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• pp.227-236
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• 2019

In this study, the anti-oxidant, anti-inflammatory, and anti-obesity activities of an ethanol extracts of Ulmus divididiana var. japonica (UDE) were investigated in vitro and in vivo. UDE anti-oxidant activity was evaluated with an Electron Spin Resonance (ESR) spectrometer, which measured 1, 1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging activity. Cell viabilities were estimated using 3-[4,5-Dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide (MTT) assay. LPS-stimulated BV-2 microglia were used to study the production of nitric oxide (NO). Cells stimulated with LPS produce more NO than normal control cells. However, cells treated with the UDE decreased this production in a concentration dependent manner (100, 250, 500, $1,000{\mu}g/mL$). Also, we investigated the anti-obese activity of UDE in SD rats. The SD rats were randomly divided into five groups: 10% low fat diet (N), 45% high fat diet (H), 45% high fat diet + garcinia extracts 200 mg/kg/day (HG200), high fat diet + UDE 200 mg/kg/day (HU200), high fat diet + UDE 400 mg/kg/day (HU400). UDE was found to lower whole body and abdominal and epididymal adipose tissue weights and lowered plasma levels of triglyceride (TG), compared to those in H group. Histological analyses of the liver and fat tissues of rat treated with UDE revealed significantly decreased number of lipid droplets and decreased size of adipocytes compared to the H group. These results suggest that UDE might be used to develop potent anti-oxidant, anti-inflammatory, and anti-obesity agents, and may be useful as ingredients for related new functional raw materials.

• 한국의류학회지
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• 제43권2호
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• pp.184-203
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• 2019

This study examines the multilateral characteristics of elderly body shapes by applying body measurement items and obesity indices (BMI, WHR, WHtR, WC, and flatness). The subjects were 397 males, 378 females aged 70-85 from the $6^{th}$ Size Korea and 132 males, 212 females aged 60-69, 596 males, 650 females aged 20-29 from the $7^{th}$ Size Korea. In order to examine the body size differences among age groups, age was divided into 7 groups (20-24, 25-29, 60-64, 65-69, 70-74, 75-79, and 80-85). Both elderly males and females showed lower values of height and weight than those in their 20s. However, abdominal obesity indices (WHR and WHtR) showed higher values in the elderly than those of their 20s; in addition, they showed larger mean values as age increased. The chest and arm circumference tended to decrease in elderly males as age increased; however, elderly females tended to decrease in thigh and calf circumference size. There were gender differences in body changing due to aging. Obesity frequency was significantly higher in the elderly than in the 20s. The study represents basic data for product design for the elderly.

• Journal of Microbiology and Biotechnology
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• 제31권7호
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• pp.1011-1021
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• 2021

The root bark of Ulmus davidiana var. japonica (Japanese elm) is used in Korea and other East Asian countries as a traditional herbal remedy to treat a variety of inflammatory diseases and ailments such as edema, gastric cancer and mastitis. For this study, we investigated the lipid metabolism and anti-obesity efficacy of ethyl alcohol extract of Ulmus davidiana var. japonica root bark (UDE). First, HPLC was performed to quantify the level of (+)-catechin, the active ingredient of UDE. In the following experiments, cultured 3T3-L1 pre-adipocytes and high-fat diet (HFD)-fed murine model were studied for anti-obesity efficacy by testing the lipid metabolism effects of UDE and (+)-catechin. In the test using 3T3-L1 pre-adipocytes, treatment with UDE inhibited adipocyte differentiation and significantly reduced the production of adipogenic genes and transcription factors PPARγ, C/EBPα and SREBP-1c. HFD-fed, obese mice were administered with UDE (200 mg/kg per day) and (+)-catechin (30 mg/kg per day) by oral gavage for 4 weeks. Weight gain, epididymal and abdominal adipose tissue mass were significantly reduced, and a change in adipocyte size was observed in the UDE and (+)-catechin treatment groups compared to the untreated control group (^***p < 0.001). Significantly lower total cholesterol and triglyceride levels were detected in UDE-treated HFD mice compared to the control, revealing the efficacy of UDE. In addition, it was found that lipid accumulation in hepatocytes was also significantly reduced after administration of UDE. These results suggest that UDE has significant anti-obesity and lipid metabolism effects through inhibition of adipocyte differentiation and adipogenesis.

• 대한임상검사과학회지
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• 제52권4호
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• pp.327-334
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• 2020

본 연구는 대한민국 비만 성인에서 대사증후군과 대사증후군 구성요소의 증가와 인슐린저항성(homeostasis model assessment of insulin resistance, HOMA-IR) 및 베타세포기능(homeostasis model assessment of beta cell function, HOMA-B)의 관련성을 조사하였다. 본 연구는 2010년 국민건강영양조사 자료(2010 Korean National Health and Nutrition Examination Survey, KNHANES V-1)의 20세 이상 성인 1,860명을 대상으로 실시하였다. 본 연구의 주요한 결과는 다음과 같다. 첫째, 대사증후군(P<0.001) 및 대사증후군 구성요소의 증가(P<0.001)는 HOMA-IR의 증가와 관련이 있었다. 둘째, 증가된 혈압군(P<0.001)과 증가된 혈당군(P<0.001)의 HOMA-B는 정상군보다 낮았고, 복부비만군(P=0.003)과 감소된 저밀도 콜레스테롤군(P=0.030)의 HOMA-B는 정상군보다 높았다. 그럼에도 불구하고 대사증후군 및 대사증후군 구성요소의 증가에 따라 HOMA-B은 감소하였다. 결론적으로, 대한민국 비만 성인에서 대사증후군 및 대사증후군 구성요소의 증가에 따라 인슐린저항성은 증가하였고 베타세포기능은 감소하였다.