• Herbal Formula Science
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• v.25 no.4
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• pp.437-447
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• 2017

Objective : Zhang zhi-cong insisted the theory related to the 'Six-meridian qi transformation', and Zhen xiu-yuan inherited that theory understanding six-meridian disease of "Shang-Han-Lun". This emphasizes that the disease of 'three yin and three yang' in "Shang-Han-Lun" is a disease caused by Six-meridian qi transformation, not a lesion of meridian itself. He said, "If you do not know brightly in the 'Tip, Root and Middle qi', you can not read the "Shang-Han-Lun"." Therefore, in this paper, we examine the interpretation of the "Shang-Han-Lun"by using the theory of 'five circuits and six qi'. Method : First, extract sentences related to 'Tip, Root and Middle qi' from the sentences of "Shang-Han-Lun" Second, the sentence is interpreted through the Zhen xiu-yuan's "Sang han lun qian zhu". Third, the meaning of the sentence is examined and summarized. Result : Zhen xiu-yuan proposed a clear and systematic theory that can understand the meaning of Six-meridian in "Shang-Han-Lun", by utilizing the discipline that 'Tip, Root and Middle qi' Conclusion : The change of 'Tip, Root and Middle qi' is a very central theory that explains the properties of 'Yin and Yang' and mutual correspondence among Korean medicine theories. It also provides basic directions for understanding the changing patterns of disease.

• Journal of Microbiology and Biotechnology
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• v.29 no.1
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• pp.141-150
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• 2019

The spatial landmark protein Bud8 plays a crucial role in bipolar budding in the budding yeast Saccharomyces cerevisiae. The unconventional yeast Yarrowia lipolytica can also bud in a bipolar pattern, but is evolutionarily distant from S. cerevisiae. It encodes the protein YALI0F12738p, which shares the highest amino acid sequence homology with S. cerevisiae Bud8, sharing a conserved transmembrane domain at the C-terminus. Therefore, we named it YlBud8. Deletion of YlBud8 in Y. lipolytica causes cellular separation defects, resulting in budded cells remaining linked with one another as cell chains or multiple buds from a single cell, which suggests that YlBud8 may play an important role in cell separation, which is distinct from the function of Bud8 in S. cerevisiae. We also show that the YlBud8-GFP fusion protein is located at the cell membrane and enriched in the bud cortex, which would be consistent with a role in the regulation of cell separation. The coiled-coil domain at the N-terminus of YlBud8 is important to the correct localization and function of YlBud8, as truncated proteins that do not contain the coiled-coil domain cannot rescue the defects observed in $Ylbud8{\Delta}$. This finding suggests that a new signaling pathway controlled by YlBud8 via regulation of cell separation may exist in Y. lipolytica.

• The Journal of Korean Philosophical History
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• no.53
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• pp.63-100
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• 2017

In this article, I researched Nam Dae-nyeon's(1887~1958) thought of Neo-confucian theories, interpretation of confucian canons, and evaluation of historical figures. First, from the side of Neo-confucian theories, he asserted that Qi(氣) had behaviors and Li(理) had not. About his teacher Jeon Wu's(田愚) theories, he thought that those were in tradition of Confucius(孔子) and Mencius(孟子), but not emphasized presidence of mind. And he criticized the theory of mind was Li(理). Second, from the side of interpretation of Confucian canons, Nam Dae-nyeon's study centered on Four Books(四書). This showed he was in tradition of Neo-confucianism. Through this studies he emphasized the importance of Confucian Ren(仁) and Filial piety(孝), self-consciousness as gentry(士). Third, from the side of evaluation of historical figures, Nam Dae-nyeon evaluated many Chinese and Korean scholars, for example, Qu Yuan(屈原), Lu Zhong-lian(魯仲連), Zhen De-xiu(眞德秀), Lu Long-qi((陸?其), Zhang Lu-xiang (張履祥) of China, and Jeong Mong-ju(鄭夢周), Zho Kwang-jo(趙光祖), Yi Hwang(李滉), Yi Yi(李珥), Jeon Wu(田愚) of Korea. And his criteria for evaluation of historical figures was fidelity and insight.