• Natural Product Sciences
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• v.18 no.4
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• pp.239-243
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• 2012

Mushrooms have a long history of use in traditional medicine, and hundreds of novel constituents in mushrooms with miraculous biological properties have been identified recently. Although diverse effects for medicinal use of mushrooms such as anticancer activity are proven, their reversal activities of drug resistance in cancer cells was rarely reported so far. In the search for novel medicinal use of mushrooms, we tested the multidrug resistance (MDR) reversal activities of diverse mushrooms collected from Korea. Among, the mushroom extracts tested, Cantharellus cibarius (M02) and Russula emetica (M12) revealed MDR reversal activities of paclitaxel in the P-glycoprotein (Pgp)-positive HCT15 and MES-SA/dX5 cancer cells, but not in the Pgp-negative A549 and MES-SA cancer cells. In addition, these mushrooms also enhanced the cytotoxicity of doxorubicin, another well-kwown Pgp-associated anticancer drug against MES-SA/DX5 cells, but not against MES-SA cells. Meanwhile, the cytotoxicity of cisplatin, a well-known Pgp-non-associated anticancer drug, was not affected by the mushrooms all the cells tested. From these results, we suspected that some ingredients of M02 and M12 have Pgp-associated MDR reversal activities.

• The Korean Journal of Quaternary Research
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• v.12 no.1
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• pp.99-109
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• 1998

유성구 장대동 지역의 홀로세 하성퇴적층에서 보존 상태가 양호한 화분, 포자가 풍 부하게 산출되었다. 이들 미화석산출을 근거로하여 두 개의 화부대가 설정되었다. 제 I 화분 대는 낙엽성활엽수의 목본화분이 풍부하게 산출괴며 반면에 초본화분은 상대적으로 빈약한 상태로 산출되는 것이 특징이다. 제 II화분대는 초본화분 중 벼과(재배종)화분이 우점으로 산출되며 소나무속도 비교적 풍부하게 산출되는 반면 낙엽성활엽수의 목본화분은 빈약하게 산출되는 것이 특징이다. 시대설정은 인접한 지역에서 화분분석과 함께 절대연령측정이 수 행된 기존의 연구자료와 비교하여 이루어졌다. 따라서 제 I화분대는 1,500 year B.P 이전 제 II화분대는 1,500 year B.P∼현재를 나타낸다. 제 I화분대에서는 인간간섭의 영향을 받기 전 인 자연식생관계를 나타내지만 제 II화분대에서는 농경과 벌목이 본격적으로 시작된 시기로 나타났다, 기후조건은 제 I화분대 동안은 온난한 온대의 습한 환경이었고, 제 Ii화분대 동안 은 현재와 비슷한 한랭한 온대의 습한 환경이었던 것으로 판단된다, 인간의 정착과 농경생 활의 시기에 대한 해석에 있어서 화분분석자료와 고고학자료가 서로 잘 일치하는 것으로 본 연구에서는 나타났다.

• 한국신재생에너지학회:학술대회논문집
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• 2009.06a
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• pp.565-568
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• 2009

Most of the historic hot springs are artesian wells in Korea. However, many boreholes have been drilled due to the shortage of hot water, and hot water is now being pumped by submersible pump installed at most of hot spring areas. The distribution of boreholes are expected to be related to the geological structure, and the study was carried out to interpret the relationship between two factors. The distributional maps of boreholes were made and the geological structures were interpreted at eight hot spring areas. Some distributions of boreholes have no special direction, and these are not related to the geological structure at Dogo, Suanbo, and Deoksan. The others are consistent with the direction of the geological structure at Goseong, Onyang, Sokcho, Yuseong, and Bugok.

• Proceedings of the Korean Radioactive Waste Society Conference
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• 2004.02a
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• pp.51-59
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• 2004

The geological research as a part of HLW disposal program in Korea is carried out to provide necessary data for the establishment of the reference repository system in term of design and safety assessment in the crystalline rock terrains. Six deep boreholes were drilled to obtain hydrogeological and hydrochemical data from Jurassic granites in the Yuseong area, Korea. The core observation, televiewer logging and hydraulic testing were carried out during and after drilling and multi-packer system were installed in the boreholes of 500m depth for hydraulic and hydrochemical monitoring including environmental isotopes. The integration of hydrogeochemical and hydrodynamic data would be built greater confidence for the understanding of groundwater system in fractured rock mass. This geoscientific program could be possible to suggest a general guideline to develop the reference disposal concept of high-level radioactive waste in Korea.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2018.05a
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• pp.383-386
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• 2018

Interesting and focused learners are attracting more and more interesting and efficient learning methods. Research on game-based learning that converges information and communication technology in accordance with this trend is being attempted. I want to take advantage of the characteristics of the game that enhance the concentration. However, if you play a game, you may get less exercise. Therefore, in this paper, we have designed and implemented a system that improves fitness and improves the performance by using Dance Dance Revolution (DDR) to fuse games and sports.

• Tunnel and Underground Space
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• v.12 no.3
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• pp.198-209
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• 2002

To assess deep geological environment for the research and development of hish-level radioactive waste disposal, six boreholes of 3" in diameter were installed in two granitic areas. An areal extent of the rock block scale in the study sites was estimated by the lineament analysis from satellite images and shaded relief maps. The characterization of fracture system developed in rock block scale was carried out based on the acoustic televiewer logging in deep boreholes. In the Yuseong site, the granite rock mass was divided into the upper and lower zones at around -160m based on the probabilistic distribution characteristics of the geometric parameters such as orientation, fracture frequency, spacing and aperture size. Since the groundwater flow is dependent on the fracture system in a fractured rock mass, the correlation of the fracture frequency and cumulative aperture size to the hydraulic conductivity was also discussed.

• Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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• 2006.04a
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• pp.360-364
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• 2006

물수지 분석을 통해서 유역의 수문순화 체계를 이해하기 위해서는 무엇보다 필요한 인자가 증발산량이다. 장기간에 걸쳐 연구유역에서 수소와 산소 동위원소를 이용하여 증발산량을 산정하였다. 물 분자를 이루는 이상적인 추적자인 수소와 산소 강우를 풍수기($4{\sim}10$월)와 갈수기(11월$\sim$3월)로 나누어 수소와 산소 동위원소 조성을 강수량 가중 평균치를 구하고 이 값을 지하수의 수소와 산소 동위원소 조성 값과 비교하여 증발산량을 산정한 것이다. 이러한 시도는 증발산량의 산정이 단순한 경험식이나 열전도 가정식이 아닌 실측했다는데 의의가 있다.

• Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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• 2005.04a
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• pp.352-358
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• 2005

This study aims to separate hydrograph into baseflow and event water to calculate baseflow rate during a rainfall in small catchments, Yuseong, Daejeon, The hydrograph of stream during a period with no excess rainfall will decay. The discharge is composed entirely of groundwater contributions. During the period, the Cl concentration of the stream water can be regarded as being in equilibrium with that of the groundwater. Using Cl as a conservative tracer, two-component hydrograph separations were performed from end point of the period to next end point. The required data were obtained by monitoring of the surface water table, along with discharge rate of stream. Cl concentration of rainfall, surface water were measured and recorded. Hydrograph separation, a mixing model using chemical tracer is applied to chemical hydrograph separation technique. These results show that baseflow rates are 31.6% of rainfall in the catchments during study period.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.35 no.4
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• pp.219-226
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• 2012

Recently real-estate investment business is standing out as a new plan for creation of source of income. In this paper, we suggested appropriate real-estate investment strategy through the reconstruct case study of existing one-storied building. That is, we showed the efficient process of decision and propel to reconstruct and the key points for lease business and post management after building completion. Also, we analyzed the rate of return of commercial building investment in order to find its optimum dealing time. Therefore the results of this paper are expected to be a help to old ages and persons laying plans for a similar business.

• Korean Journal of Veterinary Service
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• v.31 no.1
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• pp.31-35
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• 2008

In order to investigate the seroprevalence of Salmonella Pullorum in boilers reared in Daejeon area, 509 samples were collected from 10 boiler farms randomly selected from 38. The survey was carried out during 6 months from April to October in 2007. Out of 509 chickens, 35 (6.9%) were seropositive and average titer was $2^{4.8}$. The seroprevalence by district was 5.5% (5/90) in Dong-gu, 4.1 % (4/96) in Seo-gu, 7.9% (24/303) in Yuseong-gu, 10.0% (2/20) in Daedeok-gu.