• Archives of Pharmacal Research
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• v.29 no.8
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• pp.657-665
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• 2006

We recently reported that dimethylsphingosine (DMS), a metabolite of sphingolipids, increased intracellular pH and $Ca^{2+}$ concentration in U937 human monocytes. In the present study, we found that dimethylphytosphingosine (DMPH) induced the above responses more robustly than DMS. However, phytosphingosine, monomethylphytosphingosine or trimethylsphingosine showed little or no activity. Synthetic C3 deoxy analogues of sphingosine did show similar activities, with the C16 analogue more so than C18. The following structure-activity relationships were observed between DMS derivatives and the intracellular pH and $Ca^{2+}$ concentrations in U937 monocytes; 1) dimethyl modification is important for the DMS-induced increase of intracellular pH and $Ca^{2+}$, 2) the addition of an OH group on C4 enhances both activities, 3) the deletion of the OH group on C3 has a negligible effect on the activities, and 4) C16 appears to be more effective than C18. We also found that W-7, a calmodulin inhibitor, blocked the DMS-induced pH increase, whereas, KN-62, ML9, and MMPX, specific inhibitors for calmodulin-dependent kinase II, myosin light chain kinase, and $Ca^{2+}$-calmodulin-dependent phosphodiesterase, respectively, did not affect DMS-induced increases of pH in the U937 monocytes.

• Korean Journal of Community Nutrition
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• v.22 no.4
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• pp.347-355
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• 2017

Objectives: Although dietary supplements use in Korea has been rapidly increasing and women are more likely to take dietary supplements more than men, only a few studies have been conducted to investigate factors contributing to gender differences in dietary supplement use in the Korean population. The aim of this study is to evaluate the prevalence of dietary supplement use and also identify gender-specific key factors that contribute to it using the data of the 4th KNHANES. Methods: Subjects were divided into user and non-user groups according to the answer given to the question that asked whether they had used any dietary supplement for more than 2 weeks on a regular basis during the previous year. Factors related to dietary supplement use were examined by general characteristics, health behavior and eating behavior. Results: Prevalence of dietary supplement use was 13.6% for men and 20.6% for women. Users were more likely to be middle-aged, have higher income and education, have a spouse, or reside in dong areas in both men and women. Regarding health behaviors, men with desirable lifestyle behavior were more likely to take dietary supplements, while men who smoked were less likely to take dietary supplements. Regarding disease history, both men and women with a current disease had higher odds of taking supplements. With regard to dietary behavior, frequent eating out and nutrition attitude were associated with higher odds of taking supplements in both men and in women. Conclusions: Health or dietary behavior related factors that were associated with taking supplements differed by gender. These findings can be useful for planning gender-specific dietary education and health programs.

• Tuberculosis and Respiratory Diseases
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• v.48 no.1
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• pp.84-90
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• 2000

The appearance of a tumor in the chest wall is rare compared to that in any other part of the body. It can be classified into benign and malignant types and can be located in the rib, clavicle, sternum, cartilage and soft tissues. Tumors that are metastatic are commonly located in the lung, breast, bone and pleura. But, the soft tissue mass of anterior chest wall is rarely metastasized from a distant organ that is not confined to the thoracic cavity. This and thus has rarely been described. A 68-year-old man was admitted to our hospital with a chief complaint of resting dyspnea. A huge non-tender mass of about $10{\times}15$ cm in size was visible on his left lower anterior chest wall. We pathologically confirmed that the mass was a metastatic renal cell carcinoma of clear cell type by incision biopsy. Through an incision biopsy, the mass was pathologically confirmed as a metastatic renal cell carcinoma of the clear cell type.

• Journal of Radiation Protection and Research
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• v.34 no.4
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• pp.170-175
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• 2009

For the emergency radiation monitoring using gamma spectrometry, we should sufficiently survey the background spectra as environmental samples with systematic nuclide identification method. In this study, we obtained the gamma ray energy spectrum using a HPGe gamma spectrometry system from an air sample. And we identified nuclide of the gamma ray energy peaks in the spectrum using two methods -1) Half life calculation and 2) survey for cascade coincidence summing peaks using nuclear data. As the results, we produced the nuclide identification results for the air sample.

• Research in Community and Public Health Nursing
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• v.17 no.3
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• pp.335-345
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• 2006

Purpose: The Purpose of this study was to develop an exercise program for elder people, and to verify the effects of it. Method: A one-group pretest-posttest experimental design was used. The exercise program was developed by researchers, and applied to 20 elders for 3 times a week for 5 weeks. To evaluate the treatment effects, dependent variables such as subjective health status, cognitive function, ADL, IADL, and depression were measured repeatedly 7 times. One-way Repeated Measures ANOVA was used for analysis. Result: There were significant positive changes in subjective health status, cognitive function, ADL, and depression except IADL during the treatment period. The treatment effects decreased significantly during 1-3 weeks after the treatment period. Conclusion: The exercise program, which had developed by the researchers, enhancing subjective health status, cognitive function, and ADL and decreasing depression of elders. Therefore this program is strongly recommended for geriatric nursing care settings.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.22 no.3
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• pp.371-379
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• 2011

Active phased array antenna structure is used for modern multi-function radars. To search targets in high clutter environment, the radar receiver needs high dynamic range performance. Though active phased array antenna structure lead to increase of SNR, the SFDR is not increased. In this paper, high SFDR receiver of X-band active phased array radar was designed and manufactured. One channel digital receiver is connected to 32 T/R modules and one PCB assembly is composed to 2 channel digital receivers with RF part, ADC part, LO distribution part and digital down conversion part. A commercial FIFO board was used for digital receiver measurement about major performance in digital output signal condition. The measured digital receiver gain and SFDR is 33 dB and more than 81 dBc each.

• Journal of Sensor Science and Technology
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• v.22 no.5
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• pp.333-337
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• 2013

This study proposes a simply fabricated micro stator for higher output power than previously reported micro stators. The stator has been fabricated by inserting enamel coil in silicon mold formed by micro etching process. The most merits of the proposed micro stator are the simple fabrication process and high output power. Previously reported micro stators have high resistance because the micro coil is fabricated by relatively thin-film-based deposition process such as sputtering and electroplating. In addition, the previously reported micro coil has many electrical contact points for forming the coil structure. These characteristics of the micro stator can lead to low performance in output power. However, the proposed micro stator adopts commercially available enamel coil without any contact point. Therefore, the enamel coil of the proposed micro stator has low junction resistance due to the good electrical quality compared with the deposited or electroplated metal coil. Power generation tests were performed and the fabricated stator can produce 5.4 mW in 4000 RPM, $1{\Omega}$ and 0.3 mm gap. The proposed micro stator can produce larger output power than the previously reported stator spite of low RPM and the larger gap between the permanent magnet and the stator.

• Journal of Electrical Engineering and Technology
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• v.9 no.3
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• pp.991-996
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• 2014

Power frequency magnetic field is still a critical problem for new construction of overhead power transmission lines in Korea because most people have been concerned about possibly carcinogenic effects of it. Although reference level of power frequency(60Hz) magnetic field has been set to 200uT in ICNIRP guidelines published in 2010, Korean government has no intention of adjusting 83.3uT specified by law in 2006 to this new reference level in consideration of people's concerns for the time being. Regardless of the current regulated magnetic field value, electric utility company has been trying to reduce magnetic field in the residential area in the vicinity of overhead power transmission lines to take into account of public concerns on the long-term effect of magnetic fields. In an effort to reduce magnetic field, engineering side has made considerable efforts to develop passive loop based, cost-effective mitigation technique of power frequency magnetic field more than ten years. In order to verify developed power frequency magnetic field mitigation technique based on passive loop, a horizontal type of passive loop was designed and installed for commercially operating 154kV overhead power transmission line for the first time in Korea. The measurement results before and after the installation of passive loop showed that magnetic field could be reduced to about 20%. The electrical environmental effects such as AN, RI and TVI were assessed before and after the installation of passive loop and these values were complied with the requirements specified by electric utility. It has been confirmed from the field test results that passive loop could be commercially and cost-effectively utilized to mitigate power frequency magnetic field.

• International Journal of Highway Engineering
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• v.12 no.4
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• pp.175-186
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• 2010

When a rigid post is exposed to traffic, it is hazardous not only to head-on impacts but also to side impacts. Clip-type slip base is an effective measure to reduce the severity of head-on impacts and side impacts as well because of its multi-directional release mechanism. Side impact tests were conducted and the results were analysed to demonstrate the hazardousness of a rigid post to a side impact and the crash worthiness of a post having clip-type slip base. For that, side impact test standard was made adapting the NCHRP Report 350, and 820kg-50km/h side impact tests were made for posts of D101.6mm(t=4.2mm) with and without slip base. Additionally, 35km/h side impact to the same post with slip base was conducted to check whether the clip-type slip base release mechanism works properly to the low impact speed. The tests revealed that the rigidly connected post was very hazardous to side impact while the post with the clip-type slip base reduced the impact severity tremendously.

• International Journal of Highway Engineering
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• v.11 no.4
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• pp.107-115
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• 2009

This study was conducted to investigate the effect of the slab thickness on the tensioning design and to determine the optimal slab thickness of the post-tensioned concrete pavement (PTCP). The tensile stresses due to the vehicle and environmental loads were obtained using a finite element analysis model and the tensioning stress was calculated employing an allowable flexural strength. The environmental loads of both the constant temperature gradient and the constant temperature difference between top and bottom of the slab were considered. The tensioning designs for various slab thicknesses were performed considering prestressing losses. The comparison results showed that generally as the thickness increased, the number of tendons became larger. Consequently, the design was not economical for a thicker slab thickness. Even though the number of tendons became smaller with an increase in the thickness under the small environmental load, a thicker PTCP slab was not economical because of a higher cost of concrete than that of steel. Therefore, the slab thickness should be kept in minimum within the construction available thicknesses.