• 제목/요약/키워드: Yu Il-Sun

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Suppressive Effects of a Truncated Inhibitor K562 Protein-Derived Peptide on Two Pro-inflammatory Cytokines, IL-17 and TNF-α

  • Hwang, Jong Tae;Yu, Ji Won;Nam, Hee Jin;Song, Sun Kwang;Sung, Woo Yong;Kim, Yongae;Cho, Jang-Hee
    • Journal of Microbiology and Biotechnology
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    • 제30권12호
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    • pp.1810-1818
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    • 2020

  • Inhibitor K562 (IK) protein was first isolated from the culture medium of K562 cells, a leukemia cell line, and is an inhibitory regulator of interferon-γ-induced major histocompatibility complex class II expression. Recently, exogenous truncated IK (tIK) protein showed potential as a therapeutic agent for inflammation-related diseases. In this study, we designed a novel putative anti-inflammatory peptide derived from tIK protein based on homology modeling of the human interleukin-10 (hIL-10) structure, and investigated whether the peptide exerted inhibitory effects against pro-inflammatory cytokines such as IL-17 and tumor necrosis factor-α (TNF-α). The peptide contains key residues involved in binding hIL-10 to the IL-10 receptor, and exerted strong inhibitory effects on IL-17 (43.8%) and TNF-α (50.7%). In addition, we used circular dichroism spectroscopy to confirm that the peptide is usually present in a random coil configuration in aqueous solution. In terms of toxicity, the peptide was found to be biologically safe. The mechanisms by which the short peptide derived from human tIK protein exerts inhibitory effects against IL-17 and TNF-α should be explored further. We also evaluated the feasibility of using this novel peptide in skincare products.

  • https://doi.org/10.4014/jmb.2004.04062 인용 PDF KSCI

조선(朝鮮) 전(前)·중기(中期)의 소갈(消渴) 인식에 관한 연구 - 「의방류취(醫方類聚)」 및 「동의보감(東醫寶鑑)」을 중심으로 - (A Study of the Perception of SoGal in the early through mid Chosun Dynasty - centering on UiBangYuChi and DongUiBoGam -)

  • 조선영;차웅석;김남일
    • 한국의사학회지
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    • 제18권2호
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    • pp.229-244
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    • 2005

  • In order to find out how SoGal was perceived in the Korean medical history and under what logic it was treated, the SoGal section of UiBangYuChi and DongUiBoGam were compared and examined. Through this process, the following could concluded. First of all, in UiBangYuChi's SoGal Section, mainly the fire/heat theory was adopted. In DongUiBoGam's SoGal Section, the lack of Bodily Liquids and Blood theory was selected. Secondly, in DongUiBoGam's SoGal Section, it went beyond UiBangYuChi's perspective of viewing all thirst caused by fire/heat as SoGal, and perceived SoGal as a state of thirst reached for the lack of Bodily Liquids and Blood. Lastly, UiBangYuChi's SoGal Section accepts the fire/heat theory, and heavily restricts the use of BuJa in PalMi, while DongUiBoGam's SoGal Section elucidates the use of BuJa when needed.

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