• 한방안이비인후피부과학회지
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• 제21권1호
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• pp.83-95
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• 2008

Objectives : Younggamgangmisinhayin-tang is clinically used for the treatment of the aller -gic rhinitis. The aim of this study is to investigate the effects of Younggamgangmisinhayin -tang on allergic rhinitis. Methods : The thirty rats were divided into three groups : control group, AR(allergic rhinitis eliciated) group, YT(Younggamgangmisinhayin-tang treated after allergic rhinitis elicitation) group. To induce allergic rhinitis in AR group, YT group rats were sensitized intraperitoneally with 0.1% ovalbumin(OVA) solution 3 times at intervals of 1 week. Then intranasal sensitization was performed by diffusing 0.1% ovalbumin(OVA) solution 3 times at intervals of 2 days. After that time rats in YT group were oral administration treated by Younggamgangmisinhayin-tang for 7days. The change of the amounts of esinophil, PAS, ZO-1, MIP-2, COX-2, IL-4 were observed in each group. Th 2 skewed condition in EL4 cell was induced by using PMA and OPl. Younggamgangmisinhayin-tang was added into EL4 cell by density. And then IL-4 mRNA was observed. Results : In esinophil study YT group was proved significant inhibitary effect. In PAS and ZO-1 YT group were preserved well. In MIP-2, COX-2 study YT group was proved significant inhibitary effect. In IL-4 and IL-4 mRNA study YT group was proved significant inhibitary effect. Conclusion :According to the above results, it is considered that Younggamgangmisinha- yin-tang has inhibitory effects on the allergic rhinitis rat models.