• 대한세포병리학회지
• /
• 제12권1호
• /
• pp.17-23
• /
• 2001

To evaluate the role of sputum and bronchial washing for the diagnosis of lung carcinoma, we studied the sensitivity of both cytologic techniques using the biopsy confirmed cases from 228 patients. Among them, 123 cases were squamous cell carcinomas, 42 cases were adenocarcinomas, 48 cases were small cell carcinomas, one case was large cell carcinoma, and 14 cases were other types of carcinoma including poorly differentiated carcinomas. Three hundreds and ninety two sputa and 173 sputa were obtained in the pre- and post-bronchoscopic periods. Bronchial washing had been taken once in each patient. The overall sensitivity of the sputum cytology was 0.52 and that of the bronchial washing 0.63, while it increased to 0.83 when a combination of both techniques. Squamous cell carcinomas were diagnosed to the great extent in which sensitivities were 0.59 and 0.74, in sputum and bronchial washing, respectively. The post-bronchoscopic sputa showed higher sensitivity (0.44) than pre-bronchoscopic sputa (0.30). The sensitivity on sputa increased from 0.34 to 0.49 when three samples were examined compared to the single examination. The accuracy of cell typing was 94.0% in sputa and 93.8% In bronchial washing. Repeated sputum examination including post-bronchoscopic sputa is warranted to Improve sensitivity and a complementary role of both cytologlc techniques can be postulated by these data.

• 대한세포병리학회지
• /
• 제9권1호
• /
• pp.63-68
• /
• 1998

Fine needle aspiration cytology of "cold" nodules of the thyroid has proved to be of great value in their preoperative diagnosis. Most types of thyroid tumors are readily recognizable from characteristic cellular patterns in the smears of needle aspirates. But follicular neoplasms present some problems because the cytomorphology of the adenomas frequently is same as in carcinoma. For differentiation of benign from malignant follicular neoplasms of the thyroid we tested the usefulness of two objective parameters - nuclear area and perimeter - by morphometry. This study was made on fine needle aspirates from 30 cases with cytologic diagnosis of follicular neoplasm of thyroid. The histologic classification was follicular adenoma in 22 cases and follicular carcinoma in 8 cases. As a reference group we used seven caes with nodular hyperplasia. The smears of aspirates were stained by Papanicolaou method. On each slide 200 randomly selected cells with intact nuclei were measured. The mean value of nuclear area are $25.32{\pm}5.50{\mu}m^2,\;34.08{\pm}7.50{\mu}m^2\;and\;39.97{\pm}6.63{\mu}m^2$ in nodular hyperplasia, follicular adenoma, and follicular carcinoma, respectively. The mean value of perimeter are $19.48{\pm}2.26{\mu}m,\;22.95{\pm}2.65{\mu}m\;and\;24.78{\pm}2.23{\mu}m$ in nodular hyperplasia, follicular adenoma and follicular carcinoma, respectively. The mean nuclear areas and perimeters of cells from follicular adenoma were significantly larger than those from nodular hyperplasia (p<0.05). The mean nuclear areas and perimeters of cells from follicular carcinoma were larger than those from follicular adenoma but the differences are not significant statistically(p>0.05). Therefore, morphometric assessment alone is inadequate to predict malignancy in thyroid aspirates.

• 동의생리병리학회지
• /
• 제18권4호
• /
• pp.943-952
• /
• 2004

We studied on the purpose of comparing the original texts with quotations in edema chapter of Dong- Yi-Bo-Gam. The research mainly depended on compare and consider these original text and quote. In Pyong Yeol Byong chapter of SoMoon, Su Yeol Hyul chapter of SoMoon, Pyong Yin Ki Sang chapter of SoMoon, Ja Jeol Jin Sae chapter of YoungChu, Emperor's Classic of Internal Medicine(黃帝內經;ECIM), We were able to find that some sentences about edema were quoted. Drug arrangement order that construct herb medicine is disposed depends on drug's weight, and all unit was concorded by Jeon and Pun. Quoted words in Emperor's Classic of Internal Medicine(黃帝內經;ECIM) does not perfectly match with original text. However, edema chapter of Dong- Yi-Bo-Gam is identical with original text, because only few words were deleted or inserted.

• Biomolecules & Therapeutics
• /
• 제5권2호
• /
• pp.125-132
• /
• 1997

Cisplatin, a platinum-complex, is currently one of the most effective compounds used in the treat-ment of solid tumors. However, its use is limited by severe side effects such as renal toxicity. Our platinum-based drug discovery program is aimed at developing drugs capable of diminishing toxicity and improving selective cytotoxicity. We synthesized new Pt (II) complex analogue containing 1,2-diaminocyclohexane (DACH) as carrier ligand and 1,2-bis (diphenylphosphino) ethane (DPPE) as a leaving group. Furthermore, nitrate was added to improve the solubility. A new series of [Pt(cia-DACH)(DPPE)] . $2NO_3$ (PC) was synthes-ized and characterized by their elemental analysis and by various spectroscopic techniques [infrared (IR), $_{13}$carbon nuclear magnetic resonance (NMR)] .PC demonstrated acceptable and significant antitumor activity against SKOV-3 and OVCAR-3 human ovarian carcinoma cell lines as compared with that of cisplatin. The cytotoxicity of PC in normal cells was found quite less than that of cisplatin using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), ($^3$H)thymidine uptake and glucose consumption tests in rabbit renal proximal tubular cells, human renal cortical cells and tissues. In conclusion, PC is considered to be more selective cytotoxicity toward human ovarian cancer cells than normal human/rabbit kidney cells.

• 한국토양비료학회지
• /
• 제26권4호
• /
• pp.249-252
• /
• 1993

인산(燐酸)을 고농도(高濃度)로 공급하였을 때, 양분의 흡수(吸收) 특히 Zn과 Cu의 흡수를 알기 위하여 온실에서 수경재배(水耕栽培)로 시험을 수행하였다. 공급 인산 수준은 0, 0.2, 0.5, 2.0, 5.0mM의 5수준(水準)이었으며, 개량뽕(Morus alva L.)을 공시품종으로 2.5개월을 재배한 후, 식물체를 수확(收穫)하여 분석(分析)하였다. 건물중(乾物重)은 2.0mM 인산수준까지 계속 증가(增加)한 후 감소(減少)하였다. 잎의 수분함량(水分含量), total-N, P, K, Fe 등은 인산 공급수준과 비례(比例)하여 증가하였다. Total-Zn 함량은 인산수준에 따라 큰 차를 보이지 않았으나, 수용성(水溶性) Zn은 증가하는 반면 Cu는 감소하였다. 인산수준(燐酸水準)의 증가에 따라 $SO_4$와 Cl는 감소하다가 인산 2.0mM 이상에서 현저히 증가하였다. 인산 축적(蓄積) 뽕밭에서의 뽕잎 감소는 Cu의 흡수 저하와 $SO_4$와 Cl의 현저할 흡수(吸收) 증가에서 오는 것으로 추정(推定)되었다.

• 한국물환경학회지
• /
• 제26권5호
• /
• pp.725-731
• /
• 2010

This study was to evaluate the ozone oxidation of dissolved Fe, Mn, $SO{_4}^{2-}$ ions and color in abandoned mining drainage by conducting a bench-scale operation at various reaction times in an ozone reactor. The influent was collected from an abandoned mine drainage (AMD) near the J Mine in Jungsungun, Kangwon Province. The ozone reactor was operated at ozone reaction times of 10, 20 and 30 min with ozone doses of 0.0 and $2.4g\;O_3/hr$. Samples from each effluent from subsequent sand filtration were regularly collected and analyzed for pH, Fe, Mn, Al, Cr, Hg, $SO{_4}^{2-}$, alkalinity, color, ORP, TDS and EC. The effluent concentrations of Fe and Mn from the sand filter were less than 0.1 mg/L, which were below the concentrations on Korean drinking water quality standards (Fe, Mn < 0.30 mg/L). The influent $SO{_4}^{2-}$, concentrations were not noticeably changed during this ozone oxidation. Cr and Hg in the raw wastewater from the abandoned mining drainage were not detected in this study. The experimental result shows that the ozone oxidation of dissolved heavy metals and subsequent sand filtration of metal precipitates are desirable alternative for removing heavy metals in AMD.

• 토지주택연구
• /
• 제6권4호
• /
• pp.231-237
• /
• 2015

본 연구는 다변화 되는 건설환경에서 모듈러 주택에 대한 관심이 높아지고 있어 모듈러 목업 주택을 대상으로 신축시 실내공기질 현황을 측정하였다. 붙박이 가구가 미설치된 세대(101호)와 붙박이 가구가 설치된 세대(102호), 2세대를 대상으로 시간경과에 따라 3차 측정을 실시하였다. 1차는 마감 및 붙박이 가구 설치 직후 측정하였으며 2차는 베이크아웃 실시 이후, 3차는 약 2.5개월(77일) 이후 측정하였다. 측정결과 1차 측정시 붙박이 가구 설치세대가 오염물질 방출농도가 높았으나 톨루엔의 경우를 제외하고 모두 권고기준 이하로 나타났다. 3차 측정시에는 톨루엔과 스티렌을 제외하고 두세대가 유사한 방출량으로 나타났으며 두세대 모두 미미한 수준으로 방출량이 낮아졌다. 이는 측정세대 모듈이 적어($14.7m^2$) 베이크아웃 및 환기에 의한 영향이 크게 나타난 것으로 판단되며 이를 통해 오염물질이 외부로 방출되어 저감된 것으로 판단된다. 일반 공동주택의 입주시점을 고려한다면 모듈러 주택의 경우도 모두 실내공기질 권고기준 이하로 나타날 것으로 판단되며, 가구에 의한 영향은 톨루엔이 가장 큰 영향을 받는 것으로 나타났다. 향후에는 모듈조합을 통해 중형 이상 규모 모듈러 주택에 있어서 가구설치 여부에 따른 상관관계를 살펴 볼 필요성이 있을 것으로 판단된다.

• 토지주택연구
• /
• 제6권4호
• /
• pp.215-220
• /
• 2015

본 연구는 공동주택에 적용되고 있는 환기장치를 선정하고 환기장치의 에너지특성 분석과 에너지저감을 목적으로 시뮬레이션 프로그램 (ECO2)을 이용하여 환기장치 별 에너지성능평가를 수행하였으며, 아래와 같이 결과를 도출하였다. 공동주택을 대상으로 환기장치 별 에너지 효율등급평가 기준에 따른 소비량을 수행하고자 하였다. 또한 단지별 에너지소비량과 비교 검토 결과를 통하여 현재 우리나라에서 공동주택에 적용하고 있는 환기장치별 에너지 소비량 실태를 파악하였다. 중부지방의 84type, 한 개동을 대상으로 시뮬레이션한 결과, 자연환기장치의 등급용 1차에너지소요량 값은 $159.9kWh/m^2yr$, 전열교환환기장치 $161kWh/m^2yr$, 바닥환기장치 $179.7kWh/m^2yr$로 계산 되었다. 위 시뮬레이션 결과를 공동주택의 실제 현장자료로 검증하였으며, 환기장치별 에너지소요량에 대한 비율로 비교해본 결과, 전열교환환기방식이 자연환기방식에 비해 -1~6% 적은 값을 보였으며, 바닥배관환기방식이 자연환기방식에 비해 약 10~20% 더 많은 1차에너지소요량이 나타났다. 환기장치의 팬동력과 열회수효율에 따라 에너지소요량의 난방과 환기 값이 변화하며, 향후 기계환기장치의 효율화 및 최적화가 필요하다고 판단된다.

• 한국재료학회지
• /
• 제14권9호
• /
• pp.676-681
• /
• 2004

In-situ observation in SBM on the microfracture behavior of coating layer was performed for GA steel sheets that have various Fe contents and thickness of coating layer. In case of cross sectional side of coating layer that was in a tensile stress state during bending, fine perpendicular crack pre-induced during galvannealing grew and propagated rapidly toward the coating surface with the increase of strain. And then it grew and propagated along the ${\Gamma}/Fe$ matrix interface, and combined with the nearest another perpendicular crack. Consequently, flaking occurred. The more Fe content and thickness of coating layer increased, the more average crack interval and flaking resistivity increased. Exfoliation was little observed at coating surface in a tensile stress state.

• 한국광학회지
• /
• 제21권5호
• /
• pp.185-189
• /
• 2010

본 논문에서는 단일 주파수를 가지는 파장 가변 어븀 첨가 광섬유 링 레이저를 제안하고 실험적으로 구현하였다. 레이저 공진기에 포화 흡수체로서 어븀 첨가 광섬유를 삽입하여 좁은 선폭의 단일 편광모드를 가지고 단일 주파수로 발진하는 광섬유 레이저를 구현하였다. 대칭적 구부림 기술을 이용하여 레이저의 발진파장을 넓게 가변할 수 있으며, 양방향 구부림에 의한 인장력과 수축력을 광섬유 격자 내에 유도하여 약 5 nm 이상의 파장 변환이 가능한 레이저를 구현하였다. 광섬유 레이저는 약 400 mW의 펌프파워를 인가하여 1540.72 nm의 중심파장에서 -1.85 dBm의 출력파워를 가지고 발진하였고, 약 60 dB 이상의 소광비를 보였다. 약 5 nm 이상의 파장범위에서 거의 동일한 출력파워를 유지하며 안정적으로 파장 변환이 가능하였다.