• BMB Reports
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• 제42권4호
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• pp.212-216
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• 2009

The short in vivo half-life of GLP-1 prevents it from being used clinically. This short half-life occurs because GLP-1 is rapidly degraded by dipeptidyl peptidases such as DPP-IV. To overcome this obstacle, a GLP-1/Fc was constructed and evaluated to determine if it was degraded by DPP-IV and in serum. When the degradation of GLP-1/Fc by human DPP-IV and rabbit serum was compared with that of GLP-1 it was found to be reduced by approximately 5- and 4-fold, respectively. Furthermore, GLP-1/Fc showed a potent activity for human GLP-1 receptor activation ($EC_{50}$ approximately 6 nM). Taken together, these results indicate that GLP-1/Fc may have an extended half-life in vivo that occurs as a result of inhibition of degradation by human DPP-IV. Due to the extended half life, GLP-1/Fc may be useful for clinical treatments.

• 한국의류산업학회지
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• 제12권6호
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• pp.837-842
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• 2010

This study examines the dyeability, light fastness, washing fastness, and antibacterial activity of chitosan and nano silver composite knit fabrics dyed with extracted solution from Chrysanthemum Indicum Linn. The results show that ${\Delta}E$ values of chitosan and nano silver composite knit fabrics were higher than cotton 100% knit fabrics in dyed condition with extracted solution from Chrysanthemum Indicum Linn, and mordant treatments influenced the chrominance change. Chrysanthemum indicum Linn confirmed that this could be a polygenetic colors. ${\Delta}E$ values of post-mordant treatments knit fabrics were higher than pre-mordant treatments knit fabrics in dyed condition with extracted solution from Chrysanthemum Indicum Linn., and mordant treatments method influenced the chrominance change. The dyeability of chitosan and nano silver composite knit fabrics was increased by mordant treatment. The fastness of the chitosan and nano silver composite knit fabrics was better than cotton 100% knit fabrics. In the result of antibacterial activity, the bacterial reduction rate of chitosan and nano silver composite knit fabrics was 99.9% to Staphylococcus aureus and Klebsiella pneumoniae.

• 한국작물학회지
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• 제42권4호
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• pp.429-434
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• 1997

산형과에 속하는 약용작물의 특성은 분열과로서 두 개의 종자가 형성되고 유관(油管)과 주병 혹은 동병이 현저하게 특이한 모양을 나타내고 있어서 산형과 작물분류 뿐만 아니라 더 나아가서 종자의 특성이 식물분류에 이용되고 있다. 종자의 형태는 장방형, 타원형 그리고 난형이며 종피색은 옅은 노란색에서부터 흑갈색까지 다양하다. 종자의 길이는 2∼7mm 그리고 폭이 2∼5mm이다. 이 중에서 가장 작은 종자인 시호는 그 천립중이 1.7g이고 가장 큰 종자인 당귀는 3.9g이다.

• 대한세포병리학회지
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• 제11권1호
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• pp.47-52
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• 2000

Diffuse sclerosing papillary carcinoma(DSPC), a variant of papillary carcinoma of the thyroid, is characterized by diffuse involvement of one or both thyroid lobes, and histologic features such as prominent sclerosis, intense lymphocytic infiltrate, numerous psammoma bodies, and squamous metaplasia together with the characteristic cytoarchitectural pattern of classical papillary carcinoma. We experienced a case of fine needle aspiration cytologic(FNAC) findings of DSPC, which was confirmed by histologic examination of the thyroidectomy specimens. The patient was 26 years old female who presented with diffuse firm enlargement of the thyroid gland with enlargement of many cervical lymph nodes. FNAC smears showed numerous psammoma bodies, many lymphocytes, metaplastic squamous cells, absence of stringy colloid, and epithelial cells showing classical features of papillary carcinoma, such as nuclear grooves, intranuclear unclusions, and ground glass chromatin pattern.

• 동의신경정신과학회지
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• 제19권3호
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• pp.245-254
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• 2008

This study was designed to evaluate the effects of an Schultz's autogens traning and herbal medicine with various scales on symptoms of UL-syndrom(鬱證). We treated UL-syndrom(鬱證) with Schultz's autogens traning, including herbal medicine and we evaluated the clinical progress of the patient using BDI. After treatment about 2-month, the chief complaint and most of symptoms were subsided and improved. BDI score were decreased 32 to 10. This study suggests that Schultz's auto gens traning and herbal medicine is significantly effective in the treatment of UL-syndrom(鬱證).

• 동의신경정신과학회지
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• 제19권3호
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• pp.255-264
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• 2008

The purpose of this study is to identify the effect on a patient with bulimia nervosa-purging type and depression according to the oriental medical treatment and cognitive-behavioral therapy. In this case, a 28 year-old female patient had a binge eating and reward behaviors for 2 years. This patient was treated with acupunture therapy, Soyo-san for 5 months after cognitive-behavioral therapy for 12 sessions(2 times a week). The result of this research showed that bulimia nervosa with depression was improved by our treatment.

• 한국정밀공학회지
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• 제26권8호
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• pp.47-54
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• 2009

In this study, a simple and effective method was proposed to minimize electrolytic corrosion on the workpiece during ED-drilling using water as a working fluid. The adhesion of a cover plate onto the surface of the workpiece was greatly effective for suppressing electrolytic corrosion during ED-drilling. The experiment revealed that the adhesion of the cover plate prevented corrosion without causing significant changes in machining characteristics. Using the machining method proposed in this paper, electrolytic-corrosion-free holes can be machined without change in the machinery system. By using corrosion-free hole as a start hole for wire EDM, a lead frame die with high quality was fabricated successfully.

• 한국강구조학회 논문집
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• 제10권4호통권37호
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• pp.701-708
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• 1998

최근 2등급(DB18)으로 설계된 국도상의 일부 교량들은 교통량 수송능력 향상을 위해 외부후긴장 방법을 적용하여 보강하는 방법이 사용되고 있으나, 그러한 보강 작업의 대부분은 실험 및 해석적 검증없이 사용되고 있다. 본 논문에서는 DB18로 설계된 단순 합성보에 외부 후긴장을 적용하여 보강효과 및 거동을 실험적으로 연구하였으며 실험 결과로부터 외부 후긴장은 극한 및 항복에 대한 강성을 증가시키며 인장파괴 모드로 설계된 구조물의 인장보강에 특히 효과적임을 알 수 있었다.

• Mycobiology
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• 제31권1호
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• pp.32-35
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• 2003

Restriction enzyme-mediated integration(REMI) was used to transform uracil auxotrophs of Pleurotus ostreatus to prototrophy. When protoplasts of Pleurotus ostreatus were treated by the reaction mixture containing 10 units of BamHI, the frequency of REMI was about 64 transformants per 1 ${\mu}g$ of DNA. This efficiency was increased by 14.2 times compared with that of the conventional PEG transformation. The optimal condition for REMI of P. ostreatus was achieved when 1 ${\mu}g$ of linearized pTRura3-2 DNA was added into $1{\times}10^7$ protoplasts along with 10 units BamHI. Southern blot analysis revealed that about 50% of transformants examined were caused by REMI event and 30% carried single copy insertion at the genome. This suggested that the REMI method might be a useful tool for efficient transformation and tagging mutagenesis of P. ostreatus.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2011년도 제42회 하계학술대회
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• pp.1918-1919
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• 2011

상체 지원 외골격 로봇은 크게 인간의 근력을 보조하는 형태와 인간의 근력을 증강하는 형태가 있다. 여기서는 인간의 근력을 증강하는 외골격 로봇을 중심으로 기술하고자 한다. 이러한 외골격 로봇은 팔의 EMG (Electromyograph;근전도) 신호를 측정하는 방법보다는 손의 힘을 직접 감지하는 방법을 통한 팔꿈치와 어깨의 엑추에이터를 구동하는 방식을 취하는 경향이 있다. 본 논문에서도 후자의 방식을 이용하여 손에 작용하는 힘을 분석하여 외골격 로봇을 움직이는 방식을 취하였다. 손의 힘 중에서도 인간을 중심으로 볼 때 위방향과 전진방향의 힘을 분석하기 위하여 2개의 F/T(Force/Torque) 센서를 사용하였으며 팔을 벌리는 동작은 엑추에이터 없이 자유롭게 동작이 가능하도록 설계하였다. 이러한 위방향 및 전진방향 힘의 크기를 팔꿈치와 어깨의 엑추에이터의 동작으로 바꾸어 인간의 동작을 도울 수 있고 힘을 증폭할 수 있는 외골격 로봇을 설계 제작하였다. F/T 센서는 손의 힘을 전기적 신호로 바꾸어주는 로드셀로 이루어지며 손의 힘을 최대한 잘 반영하기 위한 구조를 고안하였다. F/T 센서의 전기신호는 증폭기를 거쳐서 잡음을 제거한 후에 A/D 변환하여 processor에서 처리되어진다.