• Toxicological Research
• /
• 제33권2호
• /
• pp.157-164
• /
• 2017

This study was to evaluate the age-dependent effects of caffeine exposure on the long bones and reproductive organs using male rats. A total of 15 immature male rats and 15 young adult male rats were allocated randomly to three groups: a control group and two groups fed caffeine with 120 and 180 mg/kg/day for 4 weeks. Exposure to caffeine at either dose significantly reduced body weight gain; a proportional reduction in muscle and fat mass in immature animals, whereas a selective reduction in fat mass with relatively preserved muscle mass in young adult animals. The long bones of immature rats exposed to caffeine were significantly shorter and lighter than those of control animals along with decreased bone minerals. However, there was no difference in the length or weight of the long bones in young adult rats exposed to caffeine. Exposure to caffeine reduced the size and absolute weight of the testes significantly in immature animals in comparison to control animals, but not in young adult animals exposed to caffeine. In contrast, the adrenal glands were significantly heavier in caffeine-fed young adult rats in comparison to control animals, but not in caffeine-fed immature rats. Our results clearly show that the negative effects of caffeine on the long bones and testes in rats are different according to the age of the rat at the time of exposure, and might therefore be caused by changes to organ sensitivity and metabolic rate at different developmental stages. Although the long bones and testes are more susceptible to caffeine during puberty, caffeine has negative effects on body fat, bone minerals and the adrenal glands when exposure occurs during young adulthood. There is a need, therefore, to educate the public the potential dangers of caffeine consumption during puberty and young adulthood.

• 한국식품영양과학회지
• /
• 제27권5호
• /
• pp.928-934
• /
• 1998

The purpose of this study was to investigate differences of Ca, Mg and Zn utilization in young and adult rats fed standard diet for 3 weeks. Feed intake and body weight gain in young rats were significantly higher than in adult. There were no significant differences in serum levels of Ca and Zn across age and sex. In liver of young or male groups, Ca and Zn contents were significantly higher than in adult or female. There were no significant differences in tibia contents of Ca and Mg, but Zn content was increased when young or female groups was compared with the other groups. In mineral balances, daily intakes and retentions of Ca, Mg and Zn in young or male groups were significantly higher than those in adult or female. According to this results, it could be suggested that in growth period must be increased dietary intake of Ca, Mg and Zn to compromise the requirement for growth.

• Reproductive and Developmental Biology
• /
• 제37권4호
• /
• pp.247-253
• /
• 2013

Here, we present an approach of blood plasma proteome profiling and their comparisons between the young and the adult pigs as prerequisite for the identification of bio-markers related to the health conditions, growth performance and meat quality. To profile the proteome in porcine plasma, blood samples were collected from 19 young piglets and 20 adult male barrows and the plasma was retrieved. Then, protein profiling was initiated using one and two-dimensional electrophoresis. Proteins were spotted and then identified by MALDI-TOF-TOF and LC-MS-MS. In the results, more than thirty-six and twenty eight protein spots were selected in young piglets and adult pigs, respectively and twenty three proteins were identified. The proteome profile images were compared between those ones using Image Master Version 7.0. The image of expressed proteome showed that most of proteins from plasma of young piglet separated clearly and concentrated in 2DE display compared to ones from adult. Image analysis in detail was carried out to look for the specific proteins related to age progression. It demonstrated that the characteristics of proteome expression could be distinct to their age stages. Further investigations needed to proceed to understand the age dependent change of protein conformation and biological meaning of those differences in proteome expression between young and mature adult pigs.

• 대한치과의사협회지
• /
• 제48권5호
• /
• pp.391-406
• /
• 2010

Orthodontic treatment for middle-aged patients has become more commonplace with various reasons including improved socioeconomic status. Understanding of oral status and treatment modalities of middle-aged patients is mandatory for accurate diagnosis and proper treatment planning. This study investigated 100 consecutive patients aged 40s and 50s and 100 aged 20s who had been examined and diagnosed at the Department of Orthodontics, Chonnam National University Dental Hospital. The results were obtained as follows; 1. Gender distribution showed female outnumbered male patients in young-aged adult patients, but middle-aged patients showed similar male and female distribution. 2. The major concern seeking orthodontic treatment was esthetics not only in young-aged but also in middle-aged adult patients, and a number of middle-aged patients were concerned about oral health as well. 3. Considerable number of middle-aged patients were referred by other dental specialties while young-aged adult patients were more self-motivated for orthodontic treatment. 4. Middle-aged adult patients had more missing teeth and periodontal disease than young-aged adults. 5. The most frequently-observed problem was dental spacing in middle-aged patients while dental crowding in young-aged adult patients. Middle-aged patients showed higher prevalence of deep overbite and overjet while most of young-aged adults presented opposite direction of problem in overbite and overjet. 6. Limited orthodontic treatment was required rather than comprehensive treatment in middle-aged patients, and the most common tooth moving area was anterior part of dentition in case of limited treatment. Need of interdisciplinary therapy with other dental specialties was more common in middle-aged patients. 7. Intervention of specific technique such as invisible TP, passive bracketing, passive wire bonding, and lingual orthodontics was more required in middle-aged patients. Considering that middle-aged patients have different characteristics than young-aged adults, the results of the present study suggest that different treatment modalities are required in middle-aged orthodontic patients in order to manage them properly and efficiently.

• 성인간호학회지
• /
• 제19권2호
• /
• pp.248-259
• /
• 2007

Purpose: The purpose of this study was to explore the experiences of young adults with hypertension, using phenomenology in order to describe the essence of such experiences and to understand them from the patients' point of view. Methods: Participants in this study were 4 hypertension patients with ages ranging from 20 to 35 years old, living in Seoul city. Data were collected from in-depth interviews done from October to November in 2005. Colazzi method(1978) was used to analyze the data. Results: The 12 themes were extracted in this study ; 'Discovery by accident', 'Denial of the diagnosis', 'A disease unworthy of the young men', 'Guilty feeling toward their parents', 'Fear of death', 'Unconvinced reason', 'Worry about the future', 'Attribute all symptoms to the disease', 'Will of not life-long medication', 'Concern for fertility problem', 'Not convinced with current treatment method', 'Becoming unimportant'. Conclusion: The results of this study show that the young adult with hypertension will be in a high risk group of non compliance, so helpful program for them should be developed and the nurses need to pay more attention to the psychosocial aspect of nursing.

• PNF and Movement
• /
• 제19권3호
• /
• pp.435-440
• /
• 2021

Purpose: The purpose of this study is to investigate the effects of older adult's head-turn gait on gait parameters by comparing with head oriented forward gait and to provide criteria for their risk of falling compared to young adult. Methods: The subjects were 19 young adults in their 20s and 18 older adults in their 60s or above residing in Daegu or Gyeongsangbuk-do. To evaluate their gait parameters, spatiotemporal gait parameters were measured using a gait analysis tool (Legsys, BioSensics, USA) under two conditions: 1) walking while keeping one's eyes forward and 2) walking while turning the head. The measurement for each test was performed after one practice session, and the mean value of three measurements was analyzed. The collected data were statistically processed using a two-way analysis of variance (ANOVA) to compare any differences in gait parameters between the two groups under the two conditions. The statistical significance level was set at α=0.05. Results: According to the comparison of gait parameters in young adult and older adult between the head oriented forward gait and head-turn gait, statistically significant differences were observed in two parameters: stride length according to the height ratio and stride speed obtained by dividing the stride length according to the height ratio by time (p<0.05). Conclusion: The results of this study indicate that the head-turn gait causes greater differences in stride length and speed among older adult than in young adult and therefore can act as a cause of falling.

• BMB Reports
• /
• 제52권4호
• /
• pp.259-264
• /
• 2019

Social requirements are needed for living in an aging society and individual longevity. Among them, improved health and medical cares, appropriate for an aging society are strongly demanded. Human cord blood-derived plasma (hUCP) has recently emerged for its unique anti-aging effects. In this study, we investigated brain rejuvenation, particularly olfactory function, that could be achieved by a systemic administration of young blood and its underlying mechanisms. Older than 24-month-old mice were used as an aged group and administered with intravenous injection of hUCP repetitively, eight times. Anti-aging effect of hUCP on olfactory function was evaluated by buried food finding test. To investigate the mode of action of hUCP, brain, serum and spleen of mice were collected for further ex vivo analyses. Systemic injection of hUCP improved aging-associated olfactory deficits, reducing time for finding food. In the brain, although an infiltration of activated microglia and its expression of cathepsin S remarkably decreased, significant changes of proinflammatory factors were not detected. Conversely, peripheral immune balance distinctly switched from predominance of Type 1 helper T (Th1) cells to alternative regulatory T cells (Tregs). These findings indicate that systemic administration of hUCP attenuates age-related neuroinflammation and subsequent olfactory dysfunction by modulating peripheral immune balance toward Treg cells, suggesting another therapeutic function and mechanism of hUCP administration.

• Journal of Nutrition and Health
• /
• 제19권4호
• /
• pp.255-265
• /
• 1986

This study was designed to investigate the effect of age on the lipid metabolism in the rats fed different diets. In experiment A male Wistar rats of 5 weeks of age and of 32 weeks of age were divided into low fat diet groups and high fat-cholesterol groups. The rats were sacrificed 1 week, 2 weeks and 4 weeks after experiment begins. Also after 4 weeks. the rats in low and high fat diet groups were tube-fed 500mg of choelsterol and were sacrified 3 days later. In experiment b, male Wistar rats of 4 weeks of age and of 6 months of age were divided into 2 groups of butter and cron oil groups. And then eachgroup were divided into 2 subgroups ; meal feeding and nibbling groups . Each diet was fed for 4 weeks. In experiment A, age of the rats and experimental diets did not affect the serum cholesterol and triglycerides concentrations were higher in rats fed high fat cholesterol diet than in those fed low-fat or high -fat diets, but age of the animals had no effect on liver lipid content. The weight and cholesterol content of epidymal fat pad, however were higher in adult rats than in young ones regardless of the diets fed. When the rats were challenged with 500mg cholesterol, the rates of increase in serum and hepatic cholesterol level were higher in adult rats compared to young rats regardless of the diets . On the other hand, the rate of increase of small intestinal cholesterol content was lower in adult rats than in young rats. In experiment B, serum cholesterol and triglyceride content were relatively higher in young rats than adult ones. Stored body lipid was higher in adult rats, as judged by epididymal fat pad weight and total carcass lipid. Meal frequency and the kinds of fat in the diet did not affect the serum choelstero concentration . The serum triglyceride levels. however, was higher in butter fed rats thancron oil fed ones. The cholesterol content of live rand epididymal fat pad was lower in butter fed groups than corn oil groups for both young and adult rats, but there was no difference in liver triglycerides livel.

• Toxicological Research
• /
• 제5권1호
• /
• pp.17-25
• /
• 1989

Chronic adminstraction of morphine to adult male rats has long been known to lower hepatic cytochrome p-450 content and its dependent mixed-function oxidase activity. Following the treatment of adult male rats with morphine, pethidine pentazocine and codeine and also by concomitant adminstration of naloxone activities of microsomal electron transfer in the adult male rats were examined. In present study, the acute treatment of mature male rats with a dose of narcotic drugs higher than that used chronically also reduces their hepatic cytochrome p-450.

• 한국비블리아학회지
• /
• 제34권4호
• /
• pp.303-329
• /
• 2023

본 연구는 국내 문헌정보학과 대학에서 수행되는 어린이청소년 문학 교육의 현황을 알아보고 개선 방안을 제시하기 위해 문헌정보학과의 학부와 대학원에 개설된 어린이청소년 문학 관련 교과목의 현황을 파악하고, 국내 대학 문헌정보학과에서 어린이청소년 문학 관련 교과목을 강의한 경험이 있는 교수자들을 대상으로 심층 면담과 설문조사를 진행하였다. 연구 결과에 따르면, 국내 문헌정보학과 대학 학부 과정에서는 평균 1.7개의 어린이청소년 문학 관련 교과목이 개설되어 있는데, 개설 과목이 1개 이하인 학교가 전체 대학의 36%이며, 학부와 대학원 모두 개설 과목이 대체로 '독서지도론'에 편중되어 있었다. 설문 응답자 29명 중 자신이 담당하는 어린이청소년 문학 관련 교과목에서 '어린이청소년 문학'에 관한 내용을 가르친다고 응답한 이는 24명(83%) 이었다. 교수자들이 수업에서 가장 많은 시간을 할애하는 장르는 그림책이었으며, 적은 시간을 할애하는 장르는 SF, 판타지, 만화 등 다양했다. 상대적으로 소홀한 장르가 있을 수밖에 없는 가장 큰 이유는 수업 시간이 부족하다는 것이었다. 부족한 수업 시간은 어린이청소년 문학을 가르치며 느끼는 가장 큰 어려움으로 지적되기도 했다. 설문 응답자 중에는 스스로 어린이청소년 문학에 대한 이해 역량을 갖고 있으면서도 어린이청소년 문학의 전문가가 아니라고 생각하는 이들이 일부 존재했는데, 면담 대상자들은 어린이청소년 문학과 관련한 문헌정보학 전공자의 강점을 스스로 인정하지 못하는 분위기를 안타까워했다. 면담 대상자 모두와 일부 설문 응답자들은 문헌정보학과에서의 어린이청소년 문학 교육이 현장 중심이어야 한다고 주장했다. 교수자들은 토론, 스토리텔링 실습, 리뷰 작성 등 다양한 교수 방법을 활용하여 학생들이 졸업 후 실제 도서관에서 어린이청소년 서비스를 제공할 때 도움이 되는 지식을 습득할 수 있게 하기 위해 노력하고 있었다.