• Title/Summary/Keyword: Yoon Ho

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Collaborative Study for the Establishment of a National Reference Preparation for Erythropoietin

  • Jin, Jae-Ho;Kim, Gi-Hyun;Shin, Won;Shin, Ji-Soon;Choi, Jong-Yoon;Yoon, Sei-Ung;Kim, Min-Sung;Kim, Yang-Woo;Lee, Seung-Woo
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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    • pp.253.2-253.2
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    • 2003

  • National regulatory authority have the duty to ensure that available pharmaceutical products are of the required quality. This is particularly difficult for biotechnological products, the quality of which cannot be established entirely by test on the material in the final container. In general biotechnological products are distinguished from other drugs by being derived from genetically modified microorganism to humans, and frequently have a complex molecular structure. (omitted)

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Determination of a histone deacetylase inhibitor SD-2007 by LC/MS and application to a pharmacokinetic study in rats

  • Shin, Beom-Soo;Yoon, Chi-Ho;Park, Min-Young;Jun, Yoon-Sik
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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    • pp.310.1-310.1
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    • 2003

  • SD-2007 ia an apicidin analogue, possessing a potent histone deacetylase inhibiting activity. A rapid and senstive LC/MS method was developed for the determination of SD-2007 and its major active metabolite. apicidin. in rat serum. SD-2007 and apicidin was extracted by liquid-liquid extraction using methyl t-butyl ether. SD-2007 and apicidin were monitored in a SIM mode at m/z of 679 and 622, respectively. (omitted)

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