• Title/Summary/Keyword: Yonsei University

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Rectal balloon for the immobilization of the prostate internal motion (전립선 내부 움직임 고정용 직장풍선)

  • Cho, Sam-Ju;Cho, Jae-Ho;Lee, Sang-Kyoo;Chu, Sung-Sil;Bak, Jin-Ho;Lee, Se-Byong;Jeong, Kyoung-Keun;Lee, Chang-Geol;Suh, Chang-Ok
    • Proceedings of the Korean Society of Medical Physics Conference
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    • 2004.11a
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    • pp.136-139
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    • 2004

  • In this study, we used the rectal balloon to overcome the dose limit of the radiation therapy in the prostate cancer. Using the rectal balloon, we could minimize the planning target volume (PTV) by minimizing the internal motion of prostate and increased the gap between the rectum wall and the high dose region. To this purpose, we analyzed the position reproducibility of rectal balloon during the patient setup. Moreover, we studied the clinical feasibility of rectal balloon by performing the IMRT plan.

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Berberine Inhibits the Production of Lysophosphatidylcholine-induced Reactive Oxygen Species and the ERK1/2 Pathway in Vascular Smooth Muscle Cells

  • Cho, Bong Jun;Im, Eun Kyoung;Kwon, Jun Hye;Lee, Kyung-Hye;Shin, Hye-Jin;Oh, Jaewon;Kang, Seok-Min;Chung, Ji Hyung;Jang, Yangsoo
    • Molecules and Cells
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    • v.20 no.3
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    • pp.429-434
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    • 2005

  • Lysophosphatidylcholine (lysoPC) induces vascular smooth muscle cell (VSMC) proliferation and migration, which has been proposed to initiate the intimal thickening in coronary atherosclerotic lesions. Berberine is an alkaloid in Berberis aquifolium and many other plants. Recently, it has been shown to have beneficial effects on the cardiovascular system, such as anti-hyperglycemic and cholesterol-lowering activity. In this study, we investigated its effects on lysoPC-induced VSMC proliferation and migration. Berberine inhibited lysoPC-induced DNA synthesis and cell proliferation in VSMCs, as well as migration of the lysoPC-stimulated VSMCs. It also inhibited the activation of extracellular signal-regulated kinases (ERKs) and reduced transcription factor AP-1 activity and the lysoPC-induced increases in intracellular reactive oxygen species (ROS). These results indicate that the inhibitory effects of berberine on lysoPC-stimulated VSMC proliferation and migration are attributable to inhibition of ROS generation and hence of activation of the ERK1/2 pathway. This suggests that berberine has potential in the prevention of atherosclerosis and restenosis.

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Image-guided Stereotactic Neurosurgery: Practices and Pitfalls

  • Jung, Na Young;Kim, Minsoo;Kim, Young Goo;Jung, Hyun Ho;Chang, Jin Woo;Park, Yong Gou;Chang, Won Seok
    • Journal of International Society for Simulation Surgery
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    • v.2 no.2
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    • pp.58-63
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    • 2015

  • Image-guided neurosurgery (IGN) is a technique for localizing objects of surgical interest within the brain. In the past, its main use was placement of electrodes; however, the advent of computed tomography has led to a rebirth of IGN. Advances in computing techniques and neuroimaging tools allow improved surgical planning and intraoperative information. IGN influences many neurosurgical fields including neuro-oncology, functional disease, and radiosurgery. As development continues, several problems remain to be solved. This article provides a general overview of IGN with a brief discussion of future directions.

  • https://doi.org/10.18204/JISSiS.2015.2.2.058 인용 PDF KSCI