• 제목/요약/키워드: Yonsei University

검색결과 27,432건 처리시간 0.046초

Clinical Implications of Microsatellite Instability in Early Gastric Cancer

  • Kim, Dong Gyu;An, Ji Yeong;Kim, Hyunki;Shin, Su-Jin;Choi, Seohee;Seo, Won Jun;Roh, Chul Kyu;Cho, Minah;Son, Taeil;Kim, Hyoung-Il;Cheong, Jae-Ho;Hyung, Woo Jin;Noh, Sung Hoon;Choi, Yoon Young
    • Journal of Gastric Cancer
    • /
    • 제19권4호
    • /
    • pp.427-437
    • /
    • 2019

  • Purpose: We aimed to evaluate the clinical characteristics of microsatellite instability in early gastric cancer. Materials and Methods: The microsatellite instability status of resected early gastric tumors was evaluated using two mononucleotide repeat markers (BAT25 and BAT26) and three dinucleotide repeat markers (D5S346, D2S123, and D17S250). Tumors with instability in two or more markers were defined as microsatellite instability-high (MSI-H) and others were classified as microsatellite stable (MSS). Results: Overall, 1,156 tumors were included in the analysis, with 85 (7.4%) classified as MSI-H compared with MSS tumors. For MSI-H tumors, there was a significant correlation with the female sex, older age, tumor location in the lower gastric body, intestinal histology, lymphovascular invasion (LVI), and submucosal invasion (P<0.05). There was also a trend toward an association with lymph node (LN) metastasis (P=0.056). In mucosal gastric cancer, there was no significant difference in MSI status in tumors with LN metastasis or tumors with LVI. In submucosal gastric cancer, LVI was more frequently observed in MSI-H than in MSS tumors (38.9% vs. 25.0%, P=0.027), but there was no difference in the presence of LN metastases. The prognosis of MSI-H tumors was similar to that of MSS tumors (log-rank test, P=0.797, the hazard ratio for MSI-H was adjusted by age, sex, pT stage, and the number of metastatic LNs, 0.932; 95% confidence interval, 0.423-2.054; P=0.861). Conclusions: MSI status was not useful in predicting prognosis in early gastric cancer. However, the frequent presence of LVI in early MSI-H gastric cancer may help guide the appropriate treatment for patients, such as endoscopic treatment or limited LN surgical dissection.

  • https://doi.org/10.5230/jgc.2019.19.e38 인용 PDF KSCI

원발성(原發性) 후두(候頭) 임파종(淋巴腫) (Localized Primary Laryngeal Lymphoma Treated by Irradiation)

  • 김귀언;서창옥;김주항;김병수;이광길;김광문;홍원표
    • 대한두경부종양학회지
    • /
    • 제1권1호
    • /
    • pp.81-86
    • /
    • 1985

  • A case of primary laryngeal non-Hodgkin's lymphoma is detailed with a review of the literature, on this rare site of presentation. Histologic findings and radio-therapeutic technique are included with longterm follow-up data. Local radiotherapy is a curative treatment of choice due to longterm NED survival with preservation of voice.

  • PDF