• Asian Pacific Journal of Cancer Prevention
• /
• 제15권13호
• /
• pp.5493-5498
• /
• 2014

Objective: To compare the efficacy of taxane-based regimens in the first line setting retrospectively in Chinese patients with recurrent and/or metastatic esophageal cancer. Methods: We analyzed 102 recurrent and/or metastatic esophageal cancer patients who received taxanes-based regimens in a first-line setting from January 2009 to December 2013. Sixteen (15.7%) patients were administered Nab-PTX based chemotherapy and 86 patients (84.3%) received paclitaxel (PTX) or docetaxel (DTX) based chemotherapy. Patients in the PTX/DTX group could be further divided into TP (71 patients) and TPF (15 patients) groups. Results: The objective response rate (ORR) of all patients was 20.6%, and the disease control rate (DCR) was 67.6%. The median overall survival (OS) was 10.5 months (95% CI 10.1-16.4) and the median progression-free survival (PFS) was 6.04 months (95% CI 5.09-7.91). The DCR was higher in the TPF group than the TP group (93.3% vs. 59.1%; p = 0.015 ). There were no significant differences in ORR, OS, and PFS among Nab-PTX, TPF and TP groups. Conclusions: The three regimens of Nab-PTX based, TP and TPF proved active in a first line setting of Chinese patients with recurrent and/or metastatic esophageal cancer, and should thus be regarded as alternative treatments.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권8호
• /
• pp.3257-3265
• /
• 2015

Background: Radiotherapy is an important treatment of choice for breast cancer patients after breast-conserving surgery, and we compare the feasibility of using dual arc volumetric modulated arc therapy (VMAT2), single arc volumetric modulated arc therapy (VMAT1) and Multi-beam Intensity Modulated Radiotherapy (M-IMRT) on patients after breast-conserving surgery. Materials and Methods: Thirty patients with breast cancer (half right-sided and half left-sided) treated by conservative lumpectomy and requiring whole breast radiotherapy with tumor bed boost were planned with three different radiotherapy techniques: 1) VMAT1; 2) VMAT2; 3) M-IMRT. The distributions for the planning target volume (PTV) and organs at risk (OARs) were compared. Dosimetries for all the techniques were compared. Results: All three techniques satisfied the dose constraint well. VMAT2 showed no obvious difference in the homogeneity index (HI) and conformity index (CI) of the PTV with respect to M-IMRT and VMAT1. VMAT2 clearly improved the treatment efficiency and can also decrease the mean dose and V5Gy of the contralateral lung. The mean dose and maximum dose of the spinal cord and contralateral breast were lower for VMAT2 than the other two techniques. The very low dose distribution (V1Gy) of the contralateral breast also showed great reduction in VMAT2 compared with the other two techniques. For the ipsilateral lung of right-sided breast cancer, the mean dose was decreased significantly in VMAT2 compared with VMAT1 and M-IMRT. The V20Gy and V30Gy of the ipsilateral lung of the left-sided breast cancer for VMAT2 showed obvious reduction compared with the other two techniques. The heart statistics of VMAT2 also decreased considerably compared to VMAT1 and M-IMRT. Conclusions: Compared to the other two techniques, the dual arc volumetric modulated arc therapy technique reduced radiation dose exposure to the organs at risk and maintained a reasonable target dose distribution.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권2호
• /
• pp.819-823
• /
• 2014

Objective: The aim was to evaluate roles of vitamin D3 (VD3) and beta-carotene (BC) in the development of esophageal squamous cell carcinoma (ESCC) in a high-risk area, Huai'an District, Huai'an City, China. Methods: 100 new ESCC diagnosed cases from 2007 to 2008 and 200 residency- age-, and sex-matched healthy controls were recruited. Data were collected from questionnaires, including a food frequency questionnaire (FFQ) to calculate the BC intake, and reversed phase high-performance liquid chromatography (RP-HPLC) was used to measure the serum concentrations of BC and VD3. Odds ratios (OR) and 95% confidence intervals (CI) were calculated in conditional logistic regression models. Results: The average dietary intake of BC was $3322.9{\mu}g$ (2032.4-5734.3) in the case group and $3626.8{\mu}g$ (1961.9-5827.9) in control group per capita per day with no significant difference by Wilcoxon test (p>0.05). However, the levels of VD3 and BC in the case group were significantly lower than in the control group (p<0.05). The OR values of the highest quartile and the lowest quartile of VD3 and BC in serum samples were both 0.13. Conclusion: Our results add to the evidence that high circulating levels of VD3 and BC are associated with a reduced risk of ESCC in this Chinese population.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권24호
• /
• pp.10949-10955
• /
• 2015

Liver cancer is one of leading digestive malignancies with high morbidity and mortality. There is an urgent need for the development of novel therapies for this deadly disease. It has been proven that asparagus polysaccharide, one of the most active derivates from the traditional medicine asparagus, possesses notable antitumor properties. However, little is known about the efficacy of asparagus polysaccharide as an adjuvant for liver cancer chemotherapy. Herein, we reported that asparagus polysaccharide and its embolic agent form, asparagus gum, significantly inhibited liver tumor growth with transcatheter arterial chemoembolization (TACE) therapy in an orthotopic hepatocellular carcinoma (HCC) tumor model, while significantly inhibiting angiogenesis and promoting tumor cell apoptosis. Moreover, asparagine gelatinous possessed immunomodulatory functions and showed little toxicity to the host. These results highlight the chemotherapeutic potential of asparagus polysaccharide and warrant a future focus on development as novel chemotherapeutic agent for liver cancer TACE therapy.

• 대한예방한의학회지
• /
• 제1권1호
• /
• pp.59-75
• /
• 1997

After examining the viewpoints of the mental cultivation of The yellow Emperor's Internal Bible(內徑), from the viewpoints of The yellow Emperor's Internal Bible, I studied the principles and methods of the mental cultivation(精神養生) which the Taoism School, the Confusian School and the past physicians proposed. And I studied the methods of mental cultivation of the child, the woman and the old by the differences of ages and sex. At the subject of health preservation(養生學) on the basis of concept of relevant adaptation of man to nature(天人相應思想), the mental cultivation(精神養生) was regard more important than the body cultivation(肉體養生) and it was considered that the success of health preservation depended on the state of mind. the basic principles of the mental cultivation is achivement of the mental internal keeping(精神內守) through the state of peace and tranquility without avarice and wild fancy(恬憺虛無). The ways of mental cultivation of the Taoism School, the Confusian School and the past physicians were in the category of The yellow Emperor's Internal Bible. 4. In the previous Jin dynasty(先秦時代), the important theoretical bases and practices to mental cultivation were made. In the Han dynasty(漢時代), the physicians attached importance to mental treaments. During the time from Sui dynasty to Tang Dynasty(隋唐時代), the mental cultivation was made perfect theoretically. During the Period from Song dynasty to Yuan Dynasty(宋元時代), Many methods of mental cultivation were newly created. During the Ming and the Qing Dynasties(明淸時代), the theory of health preservation and the methods of mental treaments were embodied. 5. Studying the mental cultivation by the differences of ages, the childhood(小兒期) is the spring of life. So the mental cultivation of this period put importance to the cultivation of Sh ng(養生). And the youth(靑年期) is the summer of life. So the mental cultivation of this period pill importance to the cultivation of Ch'ang(養長). And the middle age(中年期) is the autumn of life. So the mental cultivation of this period put imporance to the cultivation of Shou(養收). And the old age(老年期) is the winter of life. So the mental cultivation of this period put importance to the cultivation of Tsang(養藏). Studying the mental cultivation by the differences of sex, the man must do the mental cultivation through the dynamic nature(性情) of Yang(陽) and the woman must do the mental cultivation through the static nature of Yin(陰).

• Parasites, Hosts and Diseases
• /
• 제47권2호
• /
• pp.185-187
• /
• 2009

The prevalence of Enterobius vermicularis infection among preschool children was reported to be low based on a 5-year screening program in Taipei City, Taiwan. The Taipei City government intended to terminate the E. vermicularis screening program among preschool children. Thus, we were entrusted with confirming whether pinworm infections among preschool children in Taipei City had truly declined. From each of 12 administrative districts 2-3 kindergartens were randomly selected for investigation. In total, 4,349 children were examined, of which 2,537 were boys and 1,812 were girls. The cellophane tape adhered to a glass slide was used, and all examinations were done by certified medical technologists. Results indicated that the overall prevalence rate of pinworm infections was 0.62% (27/4,349). Although the infection rate was higher among boys (0.67%, 17/2,537) than in girls (0.55%, 10/1,812), no significant difference was found ($X^2$=0.399, P=0.62). According to the administrative district, the infection rate ranged from no positive cases of E. vermicularis infection in the Xinyi, Zhongzhen, and Wanhua Districts (0%; 0/299, 0/165, and 0/358, respectively), to 0.26% (1/131) in Songshan District, with the highest rate of 1.88% (7/373) in Wenshan District. Because the overall infection rate (0.62%, 27/4,349) in the present study was unchanged compared to that (0.40%, 197/49,541) previously reported in 2005, we propose that regular pinworm screening and treatment programs should be continued in some parts of Taipei City.

• 한국식품영양학회지
• /
• 제28권2호
• /
• pp.247-252
• /
• 2015

본 연구에서는 Allium 속 식물인 달래, 대파, 양파의 물 추출물에 존재하는 항산화 활성과 tyrosinase 및 elastase 저해 효과를 확인하여 화장품 자원으로 이용 가능성을 확인하고자 하였다. DPPH 라디칼 소거능의 실험에 사용한 식물 물 추출물의 $IC_{50}$은 양파($IC_{50}=19.81mg/mL$) < 달래($IC_{50}=21.50mg/mL$) < 대파($IC_{50}=137.87mg/mL$) 순으로 높았다. 그리고 ABTS 라디칼 소거능의 경우에도 양파($IC_{50}=7.67mg/mL$) < 달래($IC_{50}=8.17mg/mL$) < 대파($IC_{50}=11.88mg/mL$) 순으로 DPPH 라디칼 소거능의 결과와 일치하였다. 그리고 달래 물 추출물의 총 폴리페놀 함량을 측정한 결과, 달래 물 추출물(43.03 mg/g)이 가장 높았으며, 그 다음으로 양파(38.27 mg/g), 대파(30.01 mg/g) 순이었다. Tyrosinase의 저해 효과를 측정한 결과, 대파 물 추출물($IC_{50}=36.95mg/mL$) < 양파($IC_{50}=37.31mg/mL$) < 달래($IC_{50}=51.97mg/mL$) 순으로 대파 물 추출물이 가장 높은 저해 활성을 나타냈다. 다음, elastase의 저해 효과를 측정한 결과, 달래 물 추출물($IC_{50}=298.37$ < 대파 $IC_{50}=323.75mg/mL$) < 양파($IC_{50}=367.21mg/mL$) 순으로 달래 물 추출물이 가장 높은 저해 활성을 나타냈다. 마지막으로 가열처리에 의하여 DPPH 라디칼 소거능과 tyrosinase 저해 활성이 일반 실험군보다 더 우수하게 나타났는데, elastase 저해 활성 실험에서는 반대로 가열 처리한 실험군이 일반 실험군보다 현저한 차이로 낮게 나타났다.

• Asian-Australasian Journal of Animal Sciences
• /
• 제32권2호
• /
• pp.217-223
• /
• 2019

Objective: An experiment was conducted to investigate the effects of feed intake restriction during late pregnancy on the function, anti-oxidation capability and acute phase protein synthesis of ovine liver. Methods: Eighteen time-mated ewes with singleton fetuses were allocated to three groups: restricted group 1 (RG1, 0.18 MJ ME/kg $W^{0.75}$ d, n = 6), restricted group 2 (RG2, 0.33 MJ ME/kg $W^{0.75}$ d), n = 6) and a control group (CG, ad libitum, 0.67 MJ ME/kg $W^{0.75}$ d, n = 6). The feed restriction period was from 90 days to 140 days of pregnancy. Results: The ewe's body weight, liver weights, water, and protein content of liver in the restricted groups were reduced compared with the CG group (p<0.05), but the liver fat contents in the RG1 group were higher than those of the CG group (p<0.05). The increased hepatic collagen fibers and reticular fibers were observed in the restricted groups with the reduction of energy intake. The concentrations of nonesterified free fatty acids in the RG1 and RG2 groups were higher than those of the CG group with the reduction of energy intake (p<0.05), but there were decreased concentrations of lipoprotein lipase and hepatic lipase in both restricted groups compared with the CG group (p<0.05). In addition, the increased concentrations of ${\beta}$-hydroxybutyric acid, triglycerides, malondialdehyde, total antioxidant capacity and activities of superoxide dismutase activity and catalase were found in the RG1 group, and the concentrations of cholinesterase in the RG1 group were reduced compared with the CG group (p<0.05). For the concentrations of acute phase proteins, the C-reactive protein (CRP) in the RG1 group were reduced compared with the CG group, but there were no differences in haptoglobin relative to the controls (p>0.05). Conclusion: The fat accumulation, increased hepatic fibrosis, antioxidant imbalance and modified synthesis of acute phase proteins were induced in ewe's liver by maternal malnutrition during late pregnancy, which were detrimental for liver function to accommodate pregnancy.

• 한국철학논집
• /
• 제52호
• /
• pp.157-183
• /
• 2017

근대는 서구 문명이 보편으로 자리잡은 시기였지만, 유학적 자산에 대한 근대적 성찰은 한국적 근대, 주체적 주체를 물을 수 있는 토대가 되었다. 박은식은 양명학적 사상 전환과 진아론을 통해 근대적 맥락에서 유학문명을 재건하였다. 특히 진아론은 주체의 역사성을 강조했던 신채호의 '아(我)'와 함께 이성적 주체란 보편타자에 매몰되지 않은 한국 근대 주체를 정립했다는 측면에서 매우 중요한 철학적 진전이었다. 타자화된 주체성으로는 보편타자의 폭력성을 넘어서 제국주의침략을 극복하고 새로운 삶을 전망할 수 없었기 때문이다. 자강기에는 서구 근대문명 수용이 불가피하다고 인식되었고 박은식 역시 신학(新學) 및 그 정수인 물질학(物質學[과학(科學)])의 필요성을 인정하였다. 그러나 박은식은 신학 수용이 곧 유학의 전면적 부정으로 귀결되어서는 안 된다고 보았다. 그는 유학을 기존의 성리학적 메커니즘에서 벗어나, 양지(良知)를 사상적 기축으로 근대사회에서 유학본지를 구현하고자 하였다. 그는 유학이 평등시대를 구현해야 한다고 전제하고, 유학이념을 실현할 주체로서 민중 혹은 무문자(無文者)를 제시하였다. 무문자는 성리학적 구습에 얽매이지 않고 양지를 그대로 발현할 수 있다는 점에서 진아(眞我)이기도 하였다. 진아는 개인적 영욕화복을 계교하지 않고 시비판단과 실천을 능동적으로 할 수 있는 근대주체였으며, 한국 독립은 물론 세계 평화를 구현할 주축이기도 하였다. 지금 우리는 탈식민주의적 관점에서 전근대 및 근대적 유산을 새롭게 성찰할 필요가 있는데, 박은식의 진아론을 통해 이 두 가지 문제에 대한 실마리를 얻을 수 있다. 진아는 서구적 보편성에 대응할 유학적 보편성[인(仁), 양지(良知)]과 함께 민족적 주체성[자가정신(自家精神)] 및 문화적 정체성[국혼(國魂)]을 담지한 근대적 주체였다. 그러나 진아는 이성적 주체와 달리 타자에 대한 배제와 차별의 원리는 아니었다는 점에서 근대적 경계를 향유하면서도 근대 너머를 지향했다고 하겠다. 또 하나는 유럽중심주의적 근대 인식의 '밖'을 사유하는 전략 중의 하나로써 유학적 자산을 재음미하는 것이다. 특히 박은식이 유학을 민중 중심의 평등시대 평화이념으로 체계화한 것은 시사하는 바가 크다.

• 동양고전연구
• /
• 제59호
• /
• pp.387-404
• /
• 2015

중국의 육조 시기에는 대부분의 사상가들이 인간의 육체와 영혼의 관계에 대하여 언급하였는데, 이러한 시기가 바로 중국 철학사에 있어서 육체와 영혼의 관계를 가장 집중적으로 논의한 시기라고 할 수 있다. 당시에 회자 되었던 인간의 육체와 영혼의 관계에 대한 논의는 그 시기를 살아가던 사상가들에 있어서 논쟁의 핵심 주제였다고 할 수 있다. 당시의 사상가들 가운데 일부는 불교에서 주장하는 생사윤회의 영향을 받아서 '영혼은 소멸되지 않는다'고 하는 관념을 형성했으며, 다른 사상가들은 '영혼은 소멸된다'라고 하여 불교의 입장과는 반대되는 의견을 제시하였다. 이러한 육체와 영혼의 관계에 대한 논쟁은 결국은 '영혼은 소멸되는가? 소멸되지 않는가?'라고 하는 논쟁으로 발전하게 된다. 이러한 육조 시기는 분열과 동란의 시대로서, 어지러운 세태 속에서 자연히 귀신관념이 일세를 풍미했던 시대이기도 했다고 말할 수 있다. 귀신관념에 대한 사상이 세상에 유행하게 되자 덩달아 사람들은 육체와 영혼의 관계에 대하여 관심을 갖게 되었다. 또한 당시 사상가들은 육체와 영혼 둘의 관계에 대한 사고를 확대시켜나가서 점진적으로 당시의 시대적 담론으로 자리를 잡게 만든다. 이와 같은 시대적 분위기속에서 당시의 사람들은 육체와 영혼의 관계에 대하여 매우 광범위하게 사고를 진행해 나갔다고 볼 수 있으며, 또한 당시에 벌어졌던 '신멸론'과 '신불멸론'의 논쟁은 육체와 영혼의 관계 문제에 대한 논의로까지 확산되어가는 추세를 보여주고 있다. 본문에서는 이와 같은 육체와 영혼의 관계 문제에 대하여 양진시기의 육체와 영혼의 관계 문제 및 남북조시기의 육체와 영혼의 관계 문제를 중심으로 개략적인 차원에서 검토를 진행해보도록 하겠다.