• The Korean Journal of Physiology and Pharmacology
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• v.19 no.5
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• pp.427-434
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• 2015

Significant evidence supports the role of the vestibular system in the regulation of blood pressure during postural movements. In the present study, the role of the vestibulo-spino-adrenal (VSA) axis in the modulation of blood pressure via the vestibulosympathetic reflex was clarified by immunohistochemical and enzyme immunoassay methods in conscious rats with sinoaortic denervation. Expression of c-Fos protein in the intermediolateral cell column of the middle thoracic spinal regions and blood epinephrine levels were investigated, following microinjection of glutamate receptor agonists or antagonists into the medial vestibular nucleus (MVN) and/or sodium nitroprusside (SNP)-induced hypotension. Both microinjection of glutamate receptor agonists (NMDA and AMPA) into the MVN or rostral ventrolateral medullary nucleus (RVLM) and SNP-induced hypotension led to increased number of c-Fos positive neurons in the intermediolateral cell column of the middle thoracic spinal regions and increased blood epinephrine levels. Pretreatment with microinjection of glutamate receptor antagonists (MK-801 and CNQX) into the MVN or RVLM prevented the increased number of c-Fos positive neurons resulting from SNP-induced hypotension, and reversed the increased blood epinephrine levels. These results indicate that the VSA axis may be a key component of the pathway used by the vestibulosympathetic reflex to maintain blood pressure during postural movements.

• Journal of Ginseng Research
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• v.41 no.4
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• pp.540-547
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• 2017

Background: In general, after Panax ginseng is administered orally, intestinal microbes play a crucial role in its degradation and metabolization process. Studies on the metabolism of P. ginseng by microflora are important for obtaining a better understanding of their biological effects. Methods: In vitro biotransformation of P. ginseng extract by rat intestinal microflora was investigated at $37^{\circ}C$ for 24 h, and the simultaneous determination of the metabolites and metabolic profile of P. ginseng saponins by rat intestinal microflora was achieved using LC-MS/MS. Results: A total of seven ginsenosides were detected in the P. ginseng extract, including ginsenosides Rg1, Re, Rf, Rb1, Rc, Rb2, and Rd. In the transformed P. ginseng samples, considerable amounts of deglycosylated metabolite compound K and Rh1 were detected. In addition, minimal amounts of deglycosylated metabolites (ginsenosides Rg2, F1, F2, Rg3, and protopanaxatriol-type ginsenosides) and untransformed ginsenosides Re, Rg1, and Rd were detected at 24 h. The results indicated that the primary metabolites are compound K and Rh1, and the protopanaxadiol-type ginsenosides were more easily metabolized than protopanaxatriol-type ginsenosides. Conclusion: This is the first report of the identification and quantification of the metabolism and metabolic profile of P. ginseng extract in rat intestinal microflora using LC-MS/MS. The current study provided new insights for studying the metabolism and active metabolites of P. ginseng.

• Proceedings of the Korean Society of Environment and Ecology Conference
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• 2010.04a
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• pp.1-14
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• 2010

• Proceedings of the Korean Magnestics Society Conference
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• 2011.12a
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• pp.155-155
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• 2011

• The Korean Journal of Physiology and Pharmacology
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• v.19 no.2
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• pp.159-165
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• 2015

Input signals originating from baroreceptors and vestibular receptors are integrated in the rostral ventrolateral medulla (RVLM) to maintain blood pressure during postural movement. The contribution of baroreceptors and vestibular receptors in the maintenance of blood pressure following hypotension were quantitatively analyzed by measuring phosphorylated extracellular regulated protein kinase (pERK) expression and glutamate release in the RVLM. The expression of pERK and glutamate release in the RVLM were measured in conscious rats that had undergone bilateral labyrinthectomy (BL) and/or sinoaortic denervation (SAD) following hypotension induced by a sodium nitroprusside (SNP) infusion. The expression of pERK was significantly increased in the RVLM in the control group following SNP infusion, and expression peaked 10 min after SNP infusion. The number of pERK positive neurons increased following SNP infusion in BL, SAD, and BL+SAD groups, although the increase was smaller than seen in the control group. The SAD group showed a relatively higher reduction in pERK expression when compared with the BL group. The level of glutamate release was significantly increased in the RVLM in control, BL, SAD groups following SNP infusion, and this peaked 10 min after SNP infusion. The SAD group showed a relatively higher reduction in glutamate release when compared with the BL group. These results suggest that the baroreceptors are more powerful in pERK expression and glutamate release in the RVLM following hypotension than the vestibular receptors, but the vestibular receptors still have an important role in the RVLM.

• The Korean Journal of Physiology and Pharmacology
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• v.20 no.1
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• pp.9-14
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• 2016

Adenosine 3',5'-cyclic monophosphate (cAMP) participates in the regulation of numerous cellular functions, including the $Na^+-K^+$-ATPase (sodium pump). Ouabain, used in the treatment of several heart diseases, is known to increase cAMP levels but its effects on the atrium are not understood. The aim of the present study was to examine the effect of ouabain on the regulation of atrial cAMP production and its roles in atrial endothelin-1 (ET-1) secretion in isolated perfused beating rabbit atria. Our results showed that ouabain ($3.0{\mu}mol/L$) significantly increased atrial dynamics and cAMP levels during recovery period. The ouabain-increased atrial dynamics was blocked by KB-R7943 ($3.0{\mu}mol/L$), an inhibitor for reverse mode of $Na^+-Ca^{2+}$ exchangers (NCX), but did not by L-type $Ca^{2+}$ channel blocker nifedipine ($1.0{\mu}mol/L$) or protein kinase A (PKA) selective inhibitor H-89 ($3.0{\mu}mol/L$). Ouabain also enhanced atrial intracellular cAMP production in response to forskolin and theophyline ($100.0{\mu}mol/L$), an inhibitor of phosphodiesterase, potentiated the ouabain-induced increase in cAMP. Ouabain and 8-Bromo-cAMP ($0.5{\mu}mol/L$) markedly increased atrial ET-1 secretion, which was blocked by H-89 and by PD98059 ($30{\mu}mol/L$), an inhibitor of extracellular-signal-regulated kinase (ERK) without changing ouabain-induced atrial dynamics. Our results demonstrated that ouabain increases atrial cAMP levels and promotes atrial ET-1 secretion via the mitogen-activated protein kinase (MAPK)/ERK signaling pathway. These findings may explain the development of cardiac hypertrophy in response to digitalis-like compounds.

• Korean Journal of Child Studies
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• v.27 no.2
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• pp.101-126
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• 2006

In this comparison of the relative effects of children's separation from their parents, socio-emotional adjustment was assessed by emotional and behavioral problems and emotional intelligence. Subjects were 502 elementary school children separated from their parents(162 in Yanbian and 340 in Korea) and their caregivers. Data analysis was by frequency, t-test, and multiple regression controlled by gender and grade in school. Caregivers living with children and their parenting efficacy were significant variables for the development of socio-emotional adjustment in Korean-Chinese children in Yanbian, but reasons for parent-child separation, caregivers' psychological and behavioral characteristics, and SES were significant variables for children in Korea. Implications are that regional differences should be considered in understanding and supporting the development of children's socio-emotional adjustment.

• Research in Community and Public Health Nursing
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• v.24 no.2
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• pp.151-160
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• 2013

Purpose: This study was to investigate depression in Korean-Chinese elder living in the Yanbian Korean Autonomous Prefecture in China. Methods: A cross-sectional community-based survey was conducted using face to face private interviews for elders aged over 59, who have been dwelling in the Yanbian Korean Autonomous Prefecture. The samples consisted of 183 Korean-Chinese and 182 Han-Chinese with the latter as a reference group. Data were collected from August 25 to September 20, 2011 and analyzed with the SPSS 18.0 program. The GDS (Geriatric Depression Scale) was used to measure elderly depression in the subjects. Results: In Korean-Chinese, the rate of depression was higher in those who had lower educational levels, and were economically supported by the government. And those who had depression showed lower scores in Chinese language proficiency, health status, and social supports, and had more chronic diseases. Factors having effects on Korean-Chinese elderly depression included perceived health status and subjective support. Conclusion: According to the results, for preventing the depression of Korean-Chinese, it is necessary to develop health management programs and social support networks, which were easy to approach.

• Journal of the Korean Society of Food Culture
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• v.32 no.3
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• pp.215-226
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• 2017

This study aimed to investigate the perception and preferences related to Korean food according to the ethnicity of university students in Yanbian, China. Korean food was preferred by Korean-Chinese as compared with Chinese students, and Korean-Chinese students preferred Korean food more than Chinese food. Both Korean-Chinese and Chinese preferred Korean food more than traditional Chosun food. More Korean-Chinese than Chinese students had positive perceptions of Korean food, which included foods made with jang, kimchi smell, and healthiness due to diversity. For evaluation of Korean food taste, more Chinese than Korean-Chinese subjects thought Korean food is not greasy and hoped salty taste. Both awareness and preferences related to Korean food were significantly higher in Korean-Chinese than Chinese students. Meat foods (so-galbi, dak-galbi, jang-jorim) were relatively high in terms of preference in both Korean-Chinese and Chinese students. Moreover, Chinese students preferred Korean traditional foods (sujeonggwa, yakgwa, gangjeong). In Korean-Chinese students, Korean representative traditional foods (kimchi, jangajji) and Korean traditional holiday foods (tteokguk, mandu-guk) were relatively low in terms of preference. This study found that the traditional food culture of Korean-Chinese has been maintained in Yanbian, whereas there is a change in the young generation.

• Journal of the Korean Society of Costume
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• v.65 no.7
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• pp.1-18
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• 2015

The purpose of this paper is to compare the body types of Korean-Chinese and Han-Chinese women in their 60's dwelling in Yanbian Korean Autonomous Prefecture. In addition, a survey was conducted to analyze the social and environmental factors that would decide the body types of these two groups of individuals. 1) The comparison of 74 items in physical measurements between the Korean-chinese and Han-chinese showed differences in 36 items. 2) As for the body measurements of women, difference was found between the Han-Chinese and Korean-Chinese in all height items except bust height, circumference, depth, length, and weight. The values of Korean-Chinese were lower than those of Han-Chinese. 3) Cluster analysis shows that Korean- Chinese women appear thinner in regards to common weight, while Han-Chinese women appear to be thicker in regards to with common thinness. 4) Korean-Chinese women dwelling in Yanbian Korean Autonomous Prefecture maintained unique traditional customs and eating habits of Korea and were in constant contact with Korean cultures, which seems to make them care more about body management for health and beauty.