• Asian Pacific Journal of Cancer Prevention
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• v.14 no.10
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• pp.6115-6120
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• 2013

Introduction: Some non-small cell lung cancer (NSCLC) tumor cells are insensitive to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) -based therapy. This study was conducted to examine the effect of embelin on the sensitivity of the A549 NSCLC cell line to TRAIL receptor2 (TRAILR2) monoclonal antibodies and to investigate the potential mechanisms. Materials and Methods: A549 cells were treated with embelin, TRAILR2 mAb or a combination of both. Cell viability was measured using ATPlite assay and apoptosis rates were determined by flow cytometry with AnnexinV-FITC and propidium iodide staining, with the expression levels of proteins analyzed by Western blotting. Results: The cell survival rate of separate treatments with 100 ng/ml TRAILR2 antibody or 25 uM embelin were $81.5{\pm}1.57%$ and $61.7{\pm}2.84%$, respectively. Their combined use markedly decreased cell viability in A549 cells to $28.1{\pm}1.97%$ (P<0.05). The general caspase inhibitor Z-VAD-FMK could inhibit the embelin-enhanced sensitivity of A549 cells to TRAILR2 mAb ($75.97{\pm}3.17%$)(P<0.05). Both flow cytometry and cell morphological analysis showed that embelin was able to increase TRAIL-induced apoptosis in A549 cells. Combined treatment with embelin and TRAILR2 mAb augmented the activation of initiator caspases and effector caspase. In addition, A549 cells showed increasing levels of TRAILR2 protein and decreasing levels of Bcl-2, survivin and c-FLIP following the treatment with embelin+TRAILR2 mAb. Conclusions: Embelin could enhance TRAIL-induced apoptosis in A549 cells. The synergistic effect of the combination treatment might be due to modulation of multiple components in the TRAIL receptor-mediated apoptotic signaling pathway, including TRAILR2, XIAP, survivin, Bcl-2 and c-FLIP.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.5 no.3
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• pp.27-45
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• 2010

It is strongly believed that multicast will become one of the most promising services on internet for the next generation. Multicast service can be deployed either on network-layer or application-layer. IP multicast (network-layer multicast) is implemented by network nodes (i.e., routers) and avoids multiple copies of the same datagram on the same link. Despite the conceptual simplicity of IP multicast and its obvious benefits, it has not been widely deployed since there remain many unresolved issues. As an alternative to IP multicast, overlay multicast (application-layer multicast) implements the multicast functionality at end hosts rather than routers. This may require more overall bandwidth than IP multicast because duplicate packets travel the same physical links multiple times, but it provides an inexpensive, deployable method of providing point-to-multipoint group communication. In this paper we develop an efficient method applied greedy algorithm for solving two models of overlay multicast routing protocol that is aimed to construct MDST (Minimum Diameter Spanning Tree : minimum cost path from a source node to all its receivers) and MST (Minimum Spanning Tree : minimum total cost spanning all the members). We also simulate and analyze MDST and MST.

• Geomechanics and Engineering
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• v.14 no.1
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• pp.99-105
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• 2018

Soils are generally classified as fine-grained or coarse-grained depending on the percentage content of the primary constituents. In reality, soils are actually made up of mixed and composite constituents. Soils primarily classified as fine-grained, still consists of a range of coarse particles as secondary constituents in between 0% to 50%. A laboratory scale model test was conducted to investigate the influence of coarse particles on the physical (e.g., density, water content, and void ratio) and mechanical (e.g., quick undrained shear strength) properties of primarily classified fine-grained cohesive soils. Pure kaolinite clay and sand-mixed kaolinite soil (e.g., sand content: 10%, 20%, and 30%) having various water contents (60%, 65%, and 70%) were preconsolidated at different stress levels (0, 13, 17.5, 22 kPa). The quick undrained shear strength properties were determined using the conventional Static Cone Penetration Test (SCPT) method and the new Fall Cone Test (FCT) method. The corresponding void ratios and densities with respect to the quick undrained shear strength were also observed. Correlations of the physical properties and quick undrained shear strengths derived from the SCPT and FCT were also established. Comparison of results showed a significant relationship between the two methods. From the results of FCT and SCPT, there is a decreasing trend of quick undrained shear strength, strength increase ratio ($S_u/P_o$), and void ratio (e) as the sand content is increased. The quick undrained shear strength generally decreases with increased water content. For the same water content, increasing the sand content resulted to a decrease in quick undrained shear strength due to reduced adhesion, and also, resulted to an increase in density. Similarly, it is observed that the change in density is distinctively noticeable at sand content greater than 20%. However, for sand content lower than 10%, there is minimal change in density with respect to water content. In general, the results showed a decrease in quick undrained shear strength for soils with higher amounts of sand content. Therefore, as the soil adhesion is reduced, the cone penetration resistances of the FCT and SCPT reflects internal friction and density of sand in the total shear strength.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.10
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• pp.5257-5261
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• 2012

Background: High incidence of breast cancer and its fatal effect has reached an alarming stage across the globe, including the third world countries. Many factors have been reported to be associated with the development of breast cancer but detailed structural and functional information is missing. CA 15-3 is one of the known potential tumor marker of breast cancer; however little is known about structure and functional site of this protein. Present study aims to investigate the functional role of CA 15-3 in breast cancer, especially in development and metastasis. Material and Methods: Hundred female breast cancer patients confirmed by histopathological reports were included in the study. Their physiological characters were recorded in a performa. Enzyme linked immunosorbent assay (ELISA) technique was used to estimate serum CA 15-3 level. Immunohistochemistry was done for estrogen (ER), progesterone (PR) and Her2/neu receptors expression. Results: The study revealed the details of physiological characteristics of female breast cancer. Mean age was $37.72{\pm}5.99$ and $55.05{\pm}7.28$ years and serum CA 15-3 (MUC1) level was $60.47{\pm}8.59$ and $63.17{\pm}4.58$ U/ml in pre and post-menopause respectively, and both groups of women had sedentary life style. Their receptor status especially of progesterone, estrogen and HER-2/neu were positive in 50% of premenopausal women and 65% of postmenopausal women. Conclusion: There are multiple physiological factors promoting breast cancer. High serum CA 15-3 level and hormonal imbalance of ER, PR and Her2/neu appears to be the main cause of breast cancer. It may be possible that the functional sites of these proteins may be altered which may increase the chances of metastasis in breast cancer.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.1
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• pp.232-239
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• 2020

The purpose of this study was to identify the effect of stress and sense of coherence on health behavior compliance in patients with stroke. The subjects were 124 outpatients with stroke at a general hospital in Ulsan from May to July, 2019. The data were analyzed using descriptive statistics, t-test, one-way ANOVA, Scheffé test, Pearson's correlation coefficient and hierarchical multiple regression analysis by using SPSS 25.0. In the results, the health behavior compliance showed a significantly positive correlation with sense of coherence(r=.71, p<.001) and a negative correlation with stress(r=-.53, p<.001). The predictors of model 1 were gender(t=4.07, p<.001), education level(t=4.18, p<.001), and monthly income(t=-2.34, p=.021) and the statistical power was 39.6%. The predictors of model 2 were gender(t=4.65, p<.001), education level(t=43.24, p<.001), and sense of coherence(t=4.33, p<.001) and the statistical power was 60.4%. Thus, a nursing intervention program which is focused on a sense of coherence could promote health behavior compliance in patients with stroke.

• Journal of Korean Society of Forest Science
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• v.86 no.3
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• pp.311-318
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• 1997

Chemical properties of soil(N, P, K, Ca, Na, Mg, CEC, and pH) were studied after annual additions of $NH_4NO_3$(336kg/ha N), treble superphosphate(112kg/ha P), and KCl(224kg/ha K) fertilizers in a willow(Salix spp.) bioenergy plantation. Soil samples were collected from November through December 1992 from previously established the fertilized and non-fertilized willow plantation at Tully, New York, U.S.A. in 1987. Total fertilizer additions from 1987 through 1991 were 1,680kg/ha N and 560kg/ha P and 1.120kg/ha K. Fertilization with N, P, and K resulted in no difference in total soil N content between the fertilized and non-fertilized plots, increased soil P and K, decreased base cations ($Ca^{2+}$ and $Mg^{2+}$) and soil pH, and increased soil pH with soil depth. Strong positive correlations of soil carbon to soil N, Ca, Mg, and CEC were noted. Soil C/N ratio in the study plots ranged from 9.6 to 11.2 for all treatment combinations. Significant differences in soil P, K, Ca, and pH between the fertilized and non-fertilized plots indicate that fertilization had changed chemical properties of soil in this fertilizer trial.

• Asian-Australasian Journal of Animal Sciences
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• v.20 no.3
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• pp.412-417
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• 2007

An experiment was conducted to determine the distribution of nitrogen-15 in tissues of laying hens receiving different levels of $^{15}N$-CCC in diets. Twenty brown laying hens were divided into four groups and randomly assigned into one of four dietary treatment groups consisting of 0, 5, 50 and 100 ppm $^{15}N$-CCC inclusion. The hens were individually fed with the $^{15}N$-CCC diets in battery cages for 11 days and then all hens restored to feeding on the control diet for 7 days. After eleven days, eight hens were slaughtered, and the others were slaughtered seven days after $^{15}N$-CCC diets withdrawal. Samples of blood, liver, heart and meat were collected and their $^{15}N$ contents were determined. The ${\delta}^{15}N$ excess (${\delta}^{15}N$-ex) and atom percentage excess in $^{15}N$ were calculated. The ${\delta}^{15}N$-ex and atom percentage excess $^{15}N$ increased significantly (p<0.05) with increasing levels of $^{15}N$-CCC in diets in all tissues after feeding $^{15}N$-CCC diets for eleven days. The highest concentration of ${\delta}^{15}N$-ex and atom percentage excess $^{15}N$ were detected in blood, followed in order by liver, heart and thigh meat. The concentrations reduced significantly (p<0.05) after $^{15}N$-CCC diets were withdrawn. Comparison between treatment groups showed that ${\delta}^{15}N$-ex and atom percentage excess $^{15}N$ were still higher in hens that had been fed diets with higher levels of $^{15}N$-CCC. This study showed that nitrogen-15 was distributed in blood, liver, heart and meat of laying hens.

• Journal of Oral Medicine and Pain
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• v.21 no.2
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• pp.305-315
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• 1996

This study was performed to investigate the changes of head posture according to natural standing or sitting posture. Twenty seven healthy dental students without any signs and symptoms of temporomandibular disorders participated in this study. Cervical resting posture (CRP) of the head in sagittal plane was measured by Cervical-Range-of-Motion $^\textregistered$(CROM, U.S.A.) and lateral cephalograph was taken in natural posture. The items related to angle in cephalograph were the angles of cranial and cervical inclination to true vertical line(VER/NSL, VER/AML), the angles of cervical inclination to nasion-sella line(CVT/NSL, OPT/NSL), the angles of comical inclination to horizontal line(CVT/HOR, OPT/HOR), the angle of cervical lordosis(CVT/OPT). The items related to line measurement were the distance from subocciput to Cl(Dl), Cl to C2(D2), C2 to C3(D3), C3 to C4(D4), the upper(PNS to posterior pharyngeal wall) and the lower(tongue base to posterior pharyngeal wall) pharyngeal space, the distance from nation to mention(Na-Me), and the radius of comical curvature from the first comical vertebra(Cl ) to the fifth cervical vertebra(C5). The data were analyzed with SAS/STAT program. The obtained results were as follows : 1. Most items related to angular measurement showed significant difference between in standing and sitting posture. The angles of CRP, CVT/NSL, OPT/NSL, CVT/HOR, OPT/HOR, and CVT/OPT were high in sitting posture, but the angles of VER/NSL, VER/NSL were low in sitting posture. 2. In vertebral distance, only the distance between C3 and C4 was differed by the posture, which decreased in sitting posture. In sitting posture, the distance from nasion to menton(Na-Me) was longer, but the radius was shorter than in standing posture. 3. Correlationship in angular measurements was almost same in both postures. Ceervical resting posture(CRP) was correlated with VER/NSL, VER\ulcornerNSL was correlated with CRP, CVT/NSL, and OPT/NSL, VER/AML was correlated with CVT/HOR, OPT/HOR, CVT/OPT, and the angle of cervical lordosis(CVT/OPT) was correlated with the radius. 4. Correlationship in linear measurement was observed only in among D3, D4, and radius. And the Na-Me was not correlated with any other items. From this results, The author concluded that the head posture in sitting was mote backward extended than in standing.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.27 no.3
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• pp.221-230
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• 2001

This study was performed to evaluate hard tissue cephalometric norms for Korean adults which can be implemented in surgical orthodontic treatment planning using selected horizontal reference plane especially for Koreans (Male: $SN-7.5^{\circ}$, Female: $SN-9.0^{\circ}$) and a simplified analytical method. 70 males and 70 females consisting of freshmen of Yonsei University from 1996 to 1997 and students from the Dental College of Yonsei University were chosen according to clinical examination and cephalometric analysis. The samples had normal profiles, normal anteroposterior skeletal relationship(ANB angle of $0^{\circ}$ to $4^{\circ}$ and Wits appraisal of -4.0mm to 0mm), and Class I molar and canine relationship. They had no missing or supernumerary teeth and had no experience of orthodontic or prosthetic treatment. After the selection of 23 landmarks and the construction of horizontal and vertical reference lines, 22 skeletal and 12 dental measurements were taken. These consisted of vertical and horizontal linear measurements and angular measurements. The results were as follows. 1. Mean and standard deviation of the measurements were calculated for males and females. 2. Most of the skeletal vertical measurements, and maxillary and mandibular length were bigger in males than females. Whereas anterior facial height ratio(N-ANS/ANS-Me) as well as maxillary and mandibular antero-posterior position in relation to the vertical reference line(N-perpendicular) showed no signigicant difference between sexes. 3. Maxillary and mandibular dental antero-posterior position in relation to the vertical reference line(N-perpendicular) showed no significant difference between sexes. 4. The upper incisor show(U1-Stms) was $2.1{\pm}1.7mm$ in males and $3.3{\pm}1.7mm$ in females. In this study, hard tissue cephalometric norms of Korean adults for orthognathic surgery were obtained.

• Proceedings of the Korea Society of Costume Conference
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• 2001.08a
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• pp.11-13
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• 2001

For those unfamiliar with the shoe world, Pinet (1817-1897) was a contemporary of Worth, the great Parisian couturier. So I look at the glamour shoes and the world of haute couture, and indeed the development of the named designer. That is a concept we are all familiar with now. So it is not easy to comprehend the lack of names for the exquisite work before 1850. Straightway I have to say that the number of noted shoe designers is far fewer than famous dress designers, but I will introduce you to some of them, against the background of contemporary shoe fashions. Franc;ois Pinet was born in the provinces (probably Touraine) in 1817, two years after the end of the Napoleonic Wars. His father, an ex-soldier, settled to shoemaking, a comparatively clean and quiet trade. It had a tradition of literacy, interest in politics, and was known as the gentle craft, which attracted intelligent people. We should presume father would be helped by the family. It was usual for a child to begin by the age of 5-6, tying knots, sweeping up, running errands and gradually learning the job. His mother died 1827, and father 1830 when he was 13, and at the time when exports of French shoes were flooding world markets. He went to live with a master shoemaker, was not well treated, and three years later set out on the tour-de- France. He worked with masters in Tours and Nantes, where he was received as Compagnon Cordonnier Bottier du Devoir as Tourangeau-Ia rose dAmour (a name to prove most appropriate). He went on to Bordeaux, where at 19 he became president of the local branch. In 1841 he went to Paris, and in 1848, revolution year, as delegate for his corporation, he managed to persuade them not to go on strike. By now the shoemakers either ran or worked for huge warehouses, and boots had replaced shoes as the main fashion. In 1855 Pinet at the age of 38 set up his own factory, as the first machines (for sewing just the uppers) were appearing. In 1863 he moved to new ateliers and shop at Rue ParadisPoissoniere 44, employing 120 people on the premises and 700 outworkers. The English Womans Domestic Magazine in 1867 records changes in the boots: the soles are now wider, so that it is no longer necessary to walk on the uppers. There is interest in eastern Europe, the Polonaise boots with rosette of cord and tassels and Bottines Hongroises withtwo rows of buttons, much ornamented. It comments on short dresses, and recommends that the chaussure should correspond to the rest of the toilet. This could already be seen in Pinets boots: tassels and superb flower embroidery on the higher bootleg, which he showed in the Paris Exposition that year. I think his more slender and elegant Pinet heel was also patented then or 1868. I found little evidence for colour-matching: an English fashion plate of 1860 shows emerald green boots with a violetcoloured dress.