• Title/Summary/Keyword: Work hope

Search Result 283, Processing Time 0.027 seconds

Supervised Model for Identifying Differentially Expressed Genes in DNA Microarray Gene Expression Dataset Using Biological Pathway Information

  • Chung, Tae Su;Kim, Keewon;Kim, Ju Han
    • Genomics & Informatics
    • /
    • v.3 no.1
    • /
    • pp.30-34
    • /
    • 2005
  • Microarray technology makes it possible to measure the expressions of tens of thousands of genes simultaneously under various experimental conditions. Identifying differentially expressed genes in each single experimental condition is one of the most common first steps in microarray gene expression data analysis. Reasonable choices of thresholds for determining differentially expressed genes are used for the next-stap-analysis with suitable statistical significances. We present a supervised model for identifying DEGs using pathway information based on the global connectivity structure. Pathway information can be regarded as a collection of biological knowledge, thus we are trying to determine the optimal threshold so that the consequential connectivity structure can be the most compatible with the existing pathway information. The significant feature of our model is that it uses established knowledge as a reference to determine the direction of analyzing microarray dataset. In the most of previous work, only intrinsic information in the miroarray is used for the identifying DEGs. We hope that our proposed method could contribute to construct biologically meaningful structure from microarray datasets.

Determining differentially expressed genes in a microarray expression dataset based on the global connectivity structure of pathway information

  • Chung, Tae-Su;Kim, Kee-Won;Lee, Hye-Won;Kim, Ju-Han
    • Proceedings of the Korean Society for Bioinformatics Conference
    • /
    • 2004.11a
    • /
    • pp.124-130
    • /
    • 2004
  • Microarray expression datasets are incessantly cumulated with the aid of recent technological advances. One of the first steps for analyzing these data under various experimental conditions is determining differentially expressed genes (DEGs) in each condition. Reasonable choices of thresholds for determining differentially expressed genes are used for the next -step-analysis with suitable statistical significances. We present a model for identifying DEGs using pathway information based on the global connectivity structure. Pathway information can be regarded as a collection of biological knowledge, thus we are tying to determine the optimal threshold so that the consequential connectivity structure can be the most compatible with the existing pathway information. The significant feature of our model is that it uses established knowledge as a reference to determine the direction of analyzing microarray dataset. In the most of previous work, only intrinsic information in the miroarray is used for the identifying DEGs. We hope that our proposed method could contribute to construct biologically meaningful network structure from microarray datasets.

  • PDF

Characterization of Fracture Behavior in Repaired Skin/Stiffener Structure with an Inclined Central Crack

  • Chung, Ki-Hyun;Yang, Won-Ho;Heo, Sung-Pil
    • Journal of Mechanical Science and Technology
    • /
    • v.16 no.5
    • /
    • pp.599-608
    • /
    • 2002
  • Finite element analysis for the stress intensity factor (SIF) at the skin/stiffener structure with inclined central crack repaired by composite stiffened panels is developed. A numerical investigation was conducted to characterize the fracture behavior and crack growth behavior at the inclined crack. In order to investigate the crack growth direction, maximum tangential stress (MTS) criterion are used. Also, this paper is to study the performance of the effective bonded composite patch repair of a plate containing an inclined central through-crack. The main objective of this research is the validation of the inclined crack patching design. In this paper, the reduction of stress intensity factors at the crack-tip and prediction of crack growth direction are determined to evaluate the effects of various non-dimensional design parameter including; composite patch thickness and stiffener distance. We report the results of finite element analysis on the stiffener locations and crack slant angles and discuss them in this paper. The research on cracked structure subjected to mixed mode loading is accomplished and concludes that more work using a different approaches is necessary. The authors hope the present study will aid those who are responsible for the repair of damaged aircraft structures and also provide general repair guidelines.

Effects of Participation Environmental UCC Making Program on Elementary School Students' Environmental Literacy (초등학생의 환경 UCC 제작 참여가 환경 소양에 미치는 영향)

  • Kim, Sin-Bae;Nam, Young-Sook
    • Hwankyungkyoyuk
    • /
    • v.22 no.2
    • /
    • pp.107-117
    • /
    • 2009
  • The purpose of this study is to find out the effects of participation environmental UCC(User Created Content) making program on elementary school students' environmental literacy. Through the questionnaires and the analysis of students' outcomes, the effects of environmental literacy in both quality and quantity was verified. By applying computer programs to make environmental UCC to elementary students, helped them increase their environmental knowledge, and got them to recognize the importance of the environment that surrounds them. Students can find a solution to solve environmental problem from their interaction between the environment and themselves. It could also improve students' ability to think positively. From this research, I hope we require to develop possible programs for various kinds of educational activities based on UCC ones, since we already verified the effects of computer programs to make environmental UCC. The programs to make environmental UCC with learners participated is a kind of good model to reflect the learner's need who is a educational user. Or it could be teaching materials to help meet learner's viewpoint. It can also offer learner-oriented and creative learning and which teachers and learners work together to make a good result and that they make a new wave, instead of being teacher-oriented, which teachers force learners to do something. We can have a feeling of achievement through this and we can expect to enhance both our professional ability as a environmental teacher and the quality of lesson.

  • PDF

The understanding of Gwan-Gyeok in "Nangyeong" ("난경(難經)"의 관격(關格) 인식)

  • Jang, Woo-Chang
    • Journal of Korean Medical classics
    • /
    • v.24 no.6
    • /
    • pp.15-28
    • /
    • 2011
  • Gwan-Gyeok(關格) is one of the dangerous conditions that can lead to death and is considered important in clinical practice. However its true concept is unclear and arguments on the subject have been diverse over generations. This kind of confusion is largely due to an insufficient understanding of the study results on Nangyeong(難經). In Nangyeong, Gwan-Gyeok is divided into 'in bowels(在腑)' and 'in viscera(在臟) and distinction is made between 'damaged by heat(傷熱)' and 'damaged by dampness(傷濕) thus establishing a broad outline of differentiation of syndrome(辨證). Moreover, the clinical progress is systematically divided into 3 stages thus providing a very useful viewpoint on diagnostics. A sharp perspective on the pathogenesis is also shown by emphasizing the kidney and Myeongmun(命門) through the comparison between cheok pulse(尺) and chon pulse(寸). This point of view in Nangyeong is truly proposing a permanent standard on the understanding of Gwan-Gyeok. Therefore it is the author's hope that this study will work as a start to look back on the flow of the research on Gwan-Gyeok which has been rather confusing since Sanghallon(傷寒論).

Through continuing education of dental hygienists for the job satisfaction (치과위생사의 계속교육을 통한 직무에 대한 만족도)

  • Yoo, Kyung-Hwa;Lee, Sun-Kyoung;Seong, Jeong-Min
    • Journal of Korean society of Dental Hygiene
    • /
    • v.12 no.4
    • /
    • pp.771-780
    • /
    • 2012
  • Objectives : The purpose of the study was to explorer the extent to which the dental hygienist demand for higher education. Methods : This study was done using the statistical package for social sciences 12.0 (SPSS 12.0) for windows. The results was as followed. Results : Participation continuing education 42.3%, do not attend the continuing education 57.7%. General characteristics of respondents according to education after graduation, in recognition of the existence, winning less than five years if is the most was higher with 42.9%, to 50.5% in the current academic year graduated colleges is the most highly(p<0.05). Through continuing education, improve 'self-regard and identity' $3.12{\pm}.49$ was the highest. General characteristics of subjects with continuing education in accordance with the highest satisfaction of the relevant item 'future work areas hope' has been investigated(p<0.05). Conclusions : Dental hygienists as one of professionals taking responsibility and duties on oral health need to make effort to satisfy. While they show infinite ability, possible as they can and overcome given environment and situation.

A Study on Color Trend of Domestic Office Furniture Based on the Theory of Color Harmony

  • Kang, Myung-Sun;Baik, Eun
    • Journal of the Korea Furniture Society
    • /
    • v.22 no.3
    • /
    • pp.141-150
    • /
    • 2011
  • This is a study on the status of color scheme of domestic office furniture. In order to pursue the planned and effective usage of color on office furniture, we investigate and analyze the status of used color based on products from four domestic office furniture companies. Once we review the definition and characteristics of office furniture, we theoretically investigate the importance of correct color planning and psychological effect based on the psychological theory as research methods. In addition, objective condition of color analysis is presented by clearly stating the color measurement which is used in this study and the NCS as analysis standards, and status of the usage of color is investigated and analyzed based on representative products from four domestic office furniture companies. Results showed that only five products which are 26.3% out of 19 products from four companies achieved a good balance based on both color harmony theories. We hope that studies to recognize the importance of usage of correct color on the office furniture, to improve the office environment and to increase the efficiency of work will be conducted continuously.

  • PDF

An Empirical Study of IT-based faultlines in Chinese Corporations

  • Huang, Yun-Chu;Kim, Yeong-Real
    • Proceedings of the Korea Society for Industrial Systems Conference
    • /
    • 2008.10b
    • /
    • pp.249-254
    • /
    • 2008
  • Since Lau and Murnighan first introduced the concept of faultlines in 1998, there are many extended studies related to faultlines theory. It is obvious that faultlines theory adds valuable explanations in addition to what numerous previous demographic studies have explored. However, previous research has not been able to fully integrate the characteristics embedded in the workplace environments, and the influence of faultlines in IT industries has yet to be explored. So it is not reasonable and convincing to extend the findings from previous faultlines research to other industries in the global world. In this study, IT related influence is given considerable weight into traditional faultlines theory and the impact of IT-based faultlines is revealed. Our study indicates that IT-based faultlines have negative impact on task conflict, process conflict and relationship conflict, and also have negative impact on individual outcomes such as individual performance and satisfaction. The influence of IT-based faultlines on people s intend to remain in the current organization is found to be insignificant. Our empirical study reconfirmed that faultlines are important indicator in group works and also that faultlines are intimately related to various conflicts and individual outcomes. We hope our research findings would be beneficial to the organizations concerned with effective and efficient group work.

  • PDF

A Study on Effect of Risk Survey Using CATIA V5 Program for Loss Prevention

  • Kim, Tae-Gu;Lee, Sang-Hyun
    • International Journal of Safety
    • /
    • v.5 no.1
    • /
    • pp.5-9
    • /
    • 2006
  • The present study reports on the results of a risk survey of machinery safety at a shoe factory in Qingdao, China. The aim is to decrease industrial accidents and increase worker job satisfaction by searching for a change from a trend analysis and making improvements in problem areas. The first risk survey for machinery safety was carried out in April 2005. Based on the analysis of the survey results, machinery safety devices was installed in the factory by using CATlA V5. Also, we investigated job satisfaction concerning working apparatus and work tool improvement in a questionnaire about the working environment. The second survey of machinery safety was carried out in September 2005. We are in the process of comparing the first survey results with the second survey results in order to analyze decreasing trend in industrial accidents and improvement in job satisfaction. So far the data have shown improved short-term turnover and absenteeism. It means CATIVA V5 and CFR has had positive effect regarding safety in shoe manufacture industry. The survey with CATIVA V5 and CFR will be expanded to other East-Asian countries including Vietnam. The hope is that the present approach could make a significant contribution toward improved safety.

Charging of an Ionic Liquid Droplet in a Dielectric Medium (비전도성 매질 내 이온성 액체 액적의 충전 현상)

  • Im, Do Jin
    • Clean Technology
    • /
    • v.20 no.4
    • /
    • pp.354-358
    • /
    • 2014
  • Ionic liquid (IL) is a salt presents in a liquid form at room temperature. Recently, it attracts huge attention due to its possibilities as a clean solvent, electrolyte, and catalyst. In the present work, the charging behavior of six different ILs were investigated using droplet contact charging phenomenon in a dielectric medium. Basically, the charging of an IL droplet can be explained by a perfect conductor theory. However, there were several different features depending on the species of ions of ILs, which requires rigorous molecular level modeling of charge transport through electrochemical reaction of IL. We hope the present results contribute to build up fundamental understanding of electrochemical charge transport of IL.