• Title/Summary/Keyword: Withdrawal Rate

Search Result 146, Processing Time 0.029 seconds

Development of Bamboo Zephyr Composite and the Physical and Mechanical Properties

  • SUMARDI, Ihak;ALAMSYAH, Eka Mulya;SUHAYA, Yoyo;DUNGANI, Rudi;SULASTININGSIH, Ignasia Maria;PRAMESTIE, Syahdilla Risandra
    • Journal of the Korean Wood Science and Technology
    • /
    • v.50 no.2
    • /
    • pp.134-147
    • /
    • 2022
  • The objective of this study is to determine the effect of fiber direction arrangement and layer composition of hybrid bamboo laminate boards on the physical and mechanical properties. The raw material used was tali bamboo (Gigantochloa apus (J.A. & J.H. Schultes) Kurs) rope in the form of flat sheets (zephyr) and falcata veneer (Paraserianthes falcataria (L) Nielsen). Zephyr bamboo was arranged in three layers using water-based isocyanate polymer (WBPI) with a glue spread rate of 300 g/m2. There were variations in the substitution of the core layer with falcata veneers (hybrid) as much as two layers and using a glue spread rate of 170 g/m2. The laminated bamboo board was cold-pressed at a pressure of 22.2 kgf/cm2 for 1 h, and the physical and mechanical properties were evaluated. The results showed that the arrangement of the fiber direction significantly affected the dimensional stability, modulus of rupture, modulus of elasticity, shear strength, and screw withdrawal strength. However, the composition of the layers had no significant effect on the physical and mechanical properties. The bonding quality of bamboo laminate boards with WBPI was considered to be quite good, as shown by the absence of delamination in all test samples. The bamboo hybrid laminate board can be an alternative based on the physical and mechanical properties that can meet laminated board standards.

Proportion of Non-Medical Opioid Use of Prescription Opioids among Cancer Patients in Korea

  • Se-Il, Go;Jung Hye Kwon;Sung Woo Park;Gyeong-Won Lee;Jung Hun Kang;Eduardo, Bruera
    • Journal of Hospice and Palliative Care
    • /
    • v.26 no.4
    • /
    • pp.185-189
    • /
    • 2023
  • Purpose: Limited research has been conducted on the prevalence of non-medical opioid use (NMOU) in Korean cancer patients who have received prescription opioids (PO). This study aimed to identify the potential proportion of NMOU in cancer patients who had been prescribed opioids in Korea. Methods: A retrospective cohort analysis was conducted on 14,728 patients who underwent cancer-related treatment between January 2009 and December 2019, using electronically collected data from a tertiary hospital in Korea. Information regarding the type and duration of opioid use was gathered. A detailed review of medical charts was carried out, focusing on patients who had been prescribed opioids for over 60 days beyond a 12-month period following the completion of their cancer treatment (long-term PO users). Results: Out of the 5,587 patients who were prescribed PO and followed up for at least 12 months, 13 cases of NMOU were identified, representing 0.23% of the patient population. Among the 204 long-term PO users, the rate was 6.37% (13/204). The most commonly misused opioids were oxycodone and fentanyl. For the group confirmed to have NMOU, the median duration of prescription was 1,327 days in total. Of the 13 patients diagnosed with NMOU, 9 reported withdrawal symptoms, 3 exhibited craving behavior for opioids, and 1 experienced both symptoms. Conclusion: This study found that 0.23% of cancer patients who had been prescribed opioids in Korea demonstrated NMOU. Despite this relatively low rate, careful monitoring is necessary to minimize the risk of NMOU in this population, especially among long-term PO users.

Oestrus Induction, Plasma Steroid Hormone Profiles and Fertility Response after CIDR and eCG Treatment in Acyclic Sahiwal Cows

  • Singh, Harpreet;Luthra, R.A.;Khar, S.K.;Nanda, Trilok
    • Asian-Australasian Journal of Animal Sciences
    • /
    • v.19 no.11
    • /
    • pp.1566-1573
    • /
    • 2006
  • The study was conducted on 30 true acyclic Sahiwal cows (15 cows, ${\geq}90$ days postpartum; 15 postpubertal heifers, ${\geq}30$ months of age) and a similar 20 untreated controls (10 cows, 10 heifers). An 'Eazi' breed Controlled Internal Drug Release (CIDR) device (containing 1.38 g progesterone) was inserted intravaginally for 7 days (days 0 to 7) followed by 500 IU eCG i.m. at CIDR removal in all the treated animals. Heifers also received 5 mg oestradiol valerate i.m at CIDR insertion. The reproductive performance of these animals was recorded in terms of oestrus induction response, conception and pregnancy rates. Plasma progesterone ($P_4$) and oestradiol-$17{\beta}$ ($E_2$) profiles of 4 representative animals from each treatment group before, during and after CIDR treatment were also monitored. An oestrus induction response of 100% was observed in treated cows and heifers. The majority of cows (53.3%) and heifers (60%) were induced to oestrus within 24-36 and 36-48 h, respectively after CIDR withdrawal; with mean intervals of $44{\pm}3.18$ and $48{\pm}2.35h$, respectively. The conception rate at induced oestrus was higher in cows (40%) than heifers (20%). The final pregnancy rates after 2 subsequent oestruses were 80 and 60% in cows and heifers, respectively (overall 70% for all treated animals). In comparison, only 10% of control animals (2 cows only, 2/20) showed oestrus and become pregnant (10%) during theentire study period. The pretreatment (day 0) mean plasma P4 levels were statistically (p>0.05) similar in cows and heifers ($0.40{\pm}0.04$ and $0.49{\pm}0.11ng/ml$, respectively). The peak $P_4$ levels were observed on day 1 in cows ($13.94{\pm}1.41ng/ml$) and day 2 in heifers ($19.15{\pm}3.30ng/ml$) with a progressive decline up to the day of CIDR withdrawal ($3.35{\pm}0.92$ and $8.79{\pm}1.71ng/ml$, respectively). Mean $P_4$ levels on day 9 and 10 in cows and heifers did not differ significantly from their respective day 0 values and the lowest values were recorded on day 10 both in cows and heifers ($0.13{\pm}0.03$ and $0.14{\pm}0.02ng/ml$, respectively). Wide variations in individual pretreatment $E_2$ levels were observed both in the cows (range = 4-26, mean = $13.00{\pm}4.65pg/ml$) and heifers (range = 10-14, mean = $11.50{\pm}0.96pg/ml$). Thereafter also, $E_2$ levels in cows showed variation and reached a peak level ($53.50{\pm}2.99pg/ml$) on day 8. In heifers, peak mean $E_2$ level ($111.25{\pm}39.81pg/ml$) was recorded on day 1, followed by a non-significant decline on day 2, a significant fall on day 6 and a non-significant increase on day 9 and 10. However, mean $E_2$ levels on days 7 (p<0.05), 8 and 9 (p<0.01) were significantly higher in cows compared to heifers. The post-CIDR withdrawal mean highest $P_4$ and lowest $E_2$ levels coincided with the period when the majority of animals were induced to oestrus. CIDR and eCG treatment resulted in effective induction of oestrus with satisfactory pregnancy rates in true acyclic Sahiwal cows and heifers.

Assessing Groundwater Vulnerability Using DRASTIC Method and Groundwater Quality in Changwon City (DRASTIC과 지하수 수질에 의한 창원시 지하수 오염취약성 평가)

  • Hamm Se-Yeong;Cheong Jae-Yeol;Kim Moo-Jin;Kim In-Soo;Hwang Han-Seok
    • Economic and Environmental Geology
    • /
    • v.37 no.6 s.169
    • /
    • pp.631-645
    • /
    • 2004
  • This study assesses groundwater vulnerability to contaminants in industrial and residential/commercial areas of the city of Changwon, using DRASTIC technique and groundwater data. The DRASTIC technique was originally applied to situations in which the contamination sources are at the ground surface, and the contaminants flow into the groundwater with infiltration of rainfall. Mostly the industrial area has higher DRASTIC indices than the residential/commercial area. However, a part of the residential/commercial area having much groundwater production and great drawdown is more contaminated in groundwater than other industrial and the residential/commercial areas even if it has lowest DRASTIC indices in the study area. It indicates that groundwater contamination in urban areas can be closely related to excessive pumping resulting in a lowering of the water level. The correlation coefficient between minimum DRASTIC indices and the degree of poor water quality for 10 districts is as low as 0.40. On the other hand, the correlation coefficients between minimum DRASTIC indices and the groundwater discharge rate, and between minimum DRASTIC indices and well distribution density per unit area are 0.70 and 0.87, respectively. Thus, to evaluate the potential of groundwater contamination in urban areas, it is necessary to consider other human-made factors such as groundwater withdrawal rate and well distribution density per unit area as well as the existing seven DRASTIC factors.

Tissue Distribution after dipping administration of Oxytetracycline and Tetracycline in Olive flounder (Paralichthys olivaceus), Rockfish (Sebastes schlegeli), and Red sea bream (Pagrus major) (Oxytetracycline과 Tetracycline의 약욕에 따른 양식어류 (넙치, 조피볼락, 참돔)의 조직내 잔류량의 변화)

  • Lee, Hu-Jang;Kim, Suk;Ha, Ji-Young;Kang, Seok-Jung;Jung, Won-Cheol;Chung, Hee-Sik;Heo, Sung-Hyek;Shin, Yong-Woon;Kim, Kyoung-Won;Kim, Dae-Geun
    • Journal of fish pathology
    • /
    • v.19 no.2
    • /
    • pp.155-164
    • /
    • 2006
  • Tissue distribution and residue depletion of oxytetracycline (OTC) and tetracycline (TC) following dipping administration were evaluated in olive flounder (Paralichthys olivaceus), rockfish (Sebastes schlegeli), and red sea bream (Pagrus major) under field conditions. Fishes were held in floating cages placed in sea water and fed a commercial diet for 15 days to acclimate to a new surrounding. Fishes were dipped in OTC 50 g/ton water for 30min and TC 18 g/ton water for 5 hours. Blood and muscle were sampled from fishes on 0th, 1th, 2th, 3th, and 5th day after administration. After solid-phase extraction, OTC and TC analyses were carried out by HPLC. The recovery rate of OTC in serum and muscle samples was 71-77% and 78-84%, respectively. Also, the recovery rate of TC in serum and muscle samples was 70-79% and 73-78%, respectively. The results of recovery rate were similar to previous studies reported. At the termination of dipping administration of OTC and TC, residue concentration in muscle samples of rockfish was significantly higher than those of olive flounder and red sea bream. At day 5, residue concentrations of all samples were believed to decrease to lower than 0.05 mg/kg, the detection limit. The present study showed that residue concentrations of OTC and TC decreased to below 0.05 mg/kg after treatment 5th day, faster than the established withdrawal period. The tissue reside depletion time of dipping administration of OTC and TC seems to be shorter than those of oral or parenteral administration.

Change of Cerebral Blood Flow during Tilt Tests in Children with Vasovagal Syncope (혈관미주 신경성 실신 소아에서 기립경사 검사 동안에 뇌혈류 변화)

  • Kim, Su Jung;Yom, Hye Won;Hong, Young Mi;Yoo, Jung Hyen;Lee, Sook Hee;Kim, Chong Hee
    • Clinical and Experimental Pediatrics
    • /
    • v.46 no.10
    • /
    • pp.983-988
    • /
    • 2003
  • Purpose : Syncope appears to be common. However, the mechanism of syncope is not clear. Increased vagal activity and withdrawal of sympathetic stimulation cause hypotension, bradycardia and finally loss of consciousness. The purpose of this study was to evaluate changes of cerebral blood flow velocity, blood pressure, and heart rate during tilt test in children with vasovagal syncope. Methods : Sixty four children with a past history of syncope were evaluated. The stand up test was performed for 15 minutes after a rest at supine position for 10 minutes, followed by an $80^{\circ}$ tilt test lasting 45 minutes. If presyncope(lightheadedness, nausea, blurred vision, or sweating) or syncope occurred, the study was discontinued. 12-lead electrocardiography, echocardiography, and electroencephalography were performed. Transcranial Doppler study was performed at the middle cerebral artery with 2 MHz continuous Doppler probe in 10 children with positive tilt test. Systolic, diastolic, mean cerebral blood flow velocity, integral, and pulsatility index were measured with blood pressure, heart rate, and $O_2$ saturation. Results : The positive rate of tilt test was 31.3%(20/64). Systolic, diastolic, and mean cerebral blood flow velocity decreased significantly in absence of hypotension or bradycardia during presyncope. Time velocity integral of cerebral artery also decreased significantly. Conclusion : Decreased cerebral blood flow velocity can predict the presyncope manifestation. Impairment of autoregulation of cerebral blood flow might play an important role in the pathophysiology of vasovagal syncope.

Android Malware Analysis Technology Research Based on Naive Bayes (Naive Bayes 기반 안드로이드 악성코드 분석 기술 연구)

  • Hwang, Jun-ho;Lee, Tae-jin
    • Journal of the Korea Institute of Information Security & Cryptology
    • /
    • v.27 no.5
    • /
    • pp.1087-1097
    • /
    • 2017
  • As the penetration rate of smartphones increases, the number of malicious codes targeting smartphones is increasing. I 360 Security 's smartphone malware statistics show that malicious code increased 437 percent in the first quarter of 2016 compared to the fourth quarter of 2015. In particular, malicious applications, which are the main means of distributing malicious code on smartphones, are aimed at leakage of user information, data destruction, and money withdrawal. Often, it is operated by an API, which is an interface that allows you to control the functions provided by the operating system or programming language. In this paper, we propose a mechanism to detect malicious application based on the similarity of API pattern in normal application and malicious application by learning pattern of API in application derived from static analysis. In addition, we show a technique for improving the detection rate and detection rate for each label derived by using the corresponding mechanism for the sample data. In particular, in the case of the proposed mechanism, it is possible to detect when the API pattern of the new malicious application is similar to the previously learned patterns at a certain level. Future researches of various features of the application and applying them to this mechanism are expected to be able to detect new malicious applications of anti-malware system.

Operation rule curve for supplying urban instream flow from reservoir (도시 하천유지유량 공급의 저수지 운영 방법)

  • Noh, Jae-Kyoung;Lee, Jae-Nam
    • Korean Journal of Agricultural Science
    • /
    • v.38 no.1
    • /
    • pp.163-172
    • /
    • 2011
  • To provide the operation rule curve for suppling instream flow to urban stream from reservoir, the Soho reservoir with watershed area of 7.4 $km^2$ and total water storage of 2.58 $Mm^3$ was planned at the headwaters of the Daejeoncheon. Daily streamflow was simulated and using the simulated streamflow and desired instream flow, the operation rule curve by Senga method was drawn and evaluated through reservoir operation. Senga method is derived by accumulating the differences between streamflow and desired instream flow adversely. Water storages were simulated on a daily basis to supply urban instream flow from Soho reservoir, but the amount of supplying instream flow to urban stream was not nearly increased comparing with that of normal operation that does not used the rule curve. Thereafter the new simulation-based operation rule curve was derived and applied to supply instream flow from Soho reservoir. In normal operation, the amount of instream flow was shown to 15,000 $m^3$/d, but it was increased to 27,700 $m^3$/d in withdrawal limited operation using the new derived rule curve, in which the applicability of this rule curve was proved. Also comparing with the flow duration curves at station just before urban Daejeoncheon stream without and with upstream Soho reservoir, the 95th flow was decreased from 1.64 mm/d to 1.51 mm/d, and the 355th flow was increased from 0.17 mm/d to 0.30 mm/d. Monthly streamflows during October to March were increased from 10.6~24.1 mm to 24.1~34.0 mm with the increasing rate of 141~227%.

Performance test and factor analysis on the performance of shutoff units with the research reactor (연구용 원자로의 정지봉 장치 성능에 미치는 인자 분석과 성능 시험)

  • Kim, Kyoung-Rean;Kim, Seoug-Beom;Ko, Jae-Myoung;Moon, Gyoon-Young;Park, Jong-Ho
    • The KSFM Journal of Fluid Machinery
    • /
    • v.10 no.2 s.41
    • /
    • pp.41-45
    • /
    • 2007
  • The shutoff unit was designed to provide rapid insertion of neutron absorbing material into the reactor core to shutdown the reactor quickly and also to withdraw the absorber slowly to avoid a log-rate trip. Four shutoff units were installed on the HANARO reactor but the half-core test facility was equipped with one shutoff unit. The reactor trip or shutdown is accomplished by four shutoff units by insertion of the shutoff rods. The shutoff rod(SOR) is actuated by a directly linked hydraulic cylinder on the reactor chimney, which is pressurized by a hydraulic pump. The rod is released to drop by gravity, when triplicate solenoid valves are de-energized to vent the cylinder. The hydraulic pump, pipe and air supply system are provided to be similar with the HANARO reactor. The shutoff rod drops for 647mm stroke within 1.13 seconds to shut down the reactor and it is slowly inserted to the full down position, 700mm, with a damping. We have conducted the drop test of the shutoff rod in order to show the performance and the structural integrity of operating system of the shutoff unit. The present paper deals with the 647mm drop time and the withdrawal time according to variation of the pool water temperature, the water level and the core flow.

Application of a Lateral Flow Immunoassay to Determine Ampicillin Residues in Muscle Tissue of Olive Flounder (Paralichthys olivaceus)

  • Cha, Chun Nam;Yu, Eun-Ah;Shin, Min Jung;Park, Eun Kee;Choi, Hyunju;Kim, Suk;Lee, Hu Jang
    • Journal of Food Hygiene and Safety
    • /
    • v.28 no.3
    • /
    • pp.213-216
    • /
    • 2013
  • Antibiotic Detection Kit (Combination I), a lateral flow immunoassay (LFIA) developed for the detection of antibiotic residues in milk, was utilized for the analysis of antibiotic residues in the muscle tissue of olive flounder. After 60-min treatment by dipping in water dosed with ampicillin (200-g/ton water), the residue depletion of ampicillin was investigated in 25 cultured olive flounder (Paralichthys olivaceus). Muscles of fish were sampled on the 1st, 2nd, 3rd, 4th and 5th day after drug treatment. The concentration of ampicillin in the muscle was determined by LFIA. The absorbance ratio of the sample to the control blank (Bs/Bo) was employed as an index to determine the muscle residues in olive flounder. To investigate the recovery rate, standard solutions were added to muscle samples to give final concentrations in the muscle of 4 and 8 ng/ml. The recovery rates of all spiked samples were > 96% of the spiked value. Ampicillin was detected in the muscle of fish treated with the drug until the 2nd day of the withdrawal period. The present study showed that the LFIA can be easily adopted to predict ampicillin residues in tissue of farmed fishes.