• Bulletin of the Korean Chemical Society
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• 제35권9호
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• pp.2625-2629
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• 2014

Platelets are anuclear discoid-shaped blood cells with key roles in human body. To understand the mechanisms of their activation process, it is required to have analytical imaging techniques capable of acquiring platelet images under fully hydrated conditions. Herein, for the first time, we demonstrate the capability of synchrotron-based transmission X-ray microscopy (TXM) to study platelets (resting and ADP activated) under hydrated and air-dried conditions. To confirm the biological imaging capability of TXM, fixed platelets were imaged and compared with whole mount electron microscopy (EM) images. TXM provided morphological information with sufficient spatial resolution with simple and quick sample preparation procedure. We also observed temporal changes during the platelet activation, which initially had a discoid shape (0 s), formed pseudopodia (30 s) and generated a network of fibrin (5 min). Our results clearly demonstrate the potential of TXM technique to study fully hydrated biological samples under in situ conditions.

• Investigative Magnetic Resonance Imaging
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• 제4권1호
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• pp.42-51
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• 2000

목적: Projection-type Fast Spin Echo (PFSE) 영상 기법은 일반적인 Fast Spin Echo (FSE) 기법과 비교하여 환자의 움직임과 혈류에 강한 장점이 있는 반면. $T_2$ 대조도(contrast)를 조절하기가 어려운 단점이 있다. 본 연구에서는 PFSE의 대조도를 이론적으로 분석하였고 컴퓨터 모의실험을 통하여 다양한 effective echo time (TE) 을 갖는 일반적인 FSE와 비교, 분석하였다. 또한 인체 실험을 통하여 제안한 PFSE 영상기법으로 움직 임과 혈류에 강인한 $T_2$ 강조 영상을 얻을 수 있음을 보였다. 대상 및 방법: 본 연구에서는 1.OT 전신 MRI 시스템에서 새로운 k-space의 배치를 갖는 PFSE 펠스 시권스를 구현하여, PFSE와 FSE 방식의 $T_2$ 대조도를 컴퓨터 모의설험과 인체 실험을 통하여 비교, 분석하였다. 컴퓨터 모의실험에서는 서로 다른 $T_2$ 값을 갖는 팬텀을 구현하여 다양한 effective TE에 대한 FSE 영상과 PFSE 영상을 재구성하여 대조도를 비교하였다. 인체 설험에서는 multi-slice $T_2$ 강조 두부 영상을 PFSE와 FSE로 얻어 영상기법간의 $T_2$ 대조도를 비교하였다. 결과: 이론적인 분석에서 PFSE의 $T_2$ 대조도는 effective TE가 80-l00ms 정도의 FSE 영상과 등가하게 나타나 $T_2$ 강조 영상을 얻을 수 있을 것으로 판단되었다. 컴퓨터 모의실험에서 PFSE 재구성 영상은 effective TE가 96ms인 FSE 영상과 대조도가 비슷하게 나타났다. 인체 실험에 서도 PFSE 영상은 effective TE가 96ms인 FSE 영상과 비슷하게 나타났으며. PFSE 방법이 FSE 방법에 비하여 움직 엄과 혈류와 관련한 artifact에 강인함을 확인 할 수 었었다. 결론: PFSE 기법은 k-space의 극좌표계에서 서로 다른 각도를 갖는 여러 line틀을 다중 스핀 에코 기법으로 측정하는 방식이다. PFSE기법은 FSE와 비교하여 환자의 움직임과 혈류에 강한 장점이 있는 반면, $T_2$ 대조도를 조절하기가 어려운 단점이 있다. 본 연구에서는 PFSE 방식으로 FSE와 대등한 $T_2$ 대조도 ($T_2$ 강조 영상)를 얻을 수 있음을 이론과 컴퓨터 모의실험 밝히고, 인체 실험을 통하여 확인하였다.

• Nuclear Medicine and Molecular Imaging
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• 제42권1호
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• pp.81-81
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• 2008

A 69-year old male with cholangiocellular carcinoma (CCC) was assigned to our department for whole body PET/CT scan. $^{18}F$-FDG PET/CT images showed an intense hypermetabolic lobulating mass(SUVmax = 8.7 / size : 11.4 mm) in the right hepatic lobe with multiple metastatic lung nodules. We made three dimensional volume rendering fusion images by using advantage workstation 4.3 (GE health care) which provide quick anatomic overview and improve the planning process significantly.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1995년도 추계학술대회
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• pp.167-170
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• 1995

An frequency modulated (FM) DANTE pulse sequence generates a quadratic phase toward the transverse of image by an FM RF pulse. In the image of a serious susceptibility effect, the phase due to the difference of the susceptibility in the pixel occurs susceptibility error which arise signal loss. But the signal loss due to the susceptibility effect in the pixel is reduced when the quadratic phase adds in the pixel. In this paper, we have generated a quadratic function toward the transverse (X-Y) using FM DANTE sequence and the susceptibility effect is reduced in the gradient echo (GE) imaging. Computer simulation and experimental results is obtained by using a whole-body KAIS 2.0T NMR system.

• Journal of Korean Neurosurgical Society
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• 제44권6호
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• pp.401-404
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• 2008

Primary intracranial squamous cell carcinoma is extremely rare, with most cases arising from a preexisting benign epidermoid cyst. We report a rare case of primary intracranial squamous cell carcinoma in the brain stem with a cerebellopontine angle (CPA) epidermoid cyst. A 72-year-old female suffered from progressive left hemiparesis, difficulty in swallowing, and right hemifacial numbness. Diffusion-weighted magnetic resonance imaging revealed a high signal intensity (SI) lesion in the CPA region and an intra-axially ring-enhanced cystic mass in the right brain stem with low SI. Whole-body positron emission tomography showed no evidence of metastatic disease. The histological findings revealed a typical epidermoid cyst in the CPA region and a squamous cell carcinoma in the brain stem. We speculate that the squamous cell carcinoma may have been developed due to a chronic inflammatory response by the adjacent epidermoid cyst. The patient underwent a surgical resection and radiotherapy. After 12 months, she had no evidence of recurrence.

• 천문학회지
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• 제29권spc1호
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• pp.77-78
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• 1996

We perfom a large project for complex study of Blue Compact Galaxies (BCGs) with strong star formation, which includes optical spectroscopy, BVR CCD photometry and HI 21 cm radio survey. The most interesting galaxies are studied also with HST and VLA. In the frame of this project we began the study of H$\alpha$ morphology of BCGs with 6-m telescope. We present and discuss here the results for the first 6 galaxies. We found the noticeable variety of forms for H$\alpha$ morphology comparing to broad band images: from very compact HII region in very center of stellar body (Mark 996, possible dwarf post-merger, old galaxy experiencing strong star formation burst), to very extended gas emission encompassing the whole area traced by stars (SBS 0335-052, the most probable young galaxy in formation).

• Journal of Korean Neurosurgical Society
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• 제51권3호
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• pp.141-143
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• 2012

The authors describe a case of choriocarcinoma that metastasized to the cerebral cortex, vertebral body, and intramedullary spinal cord. A 21-year-old woman presented with sudden headache, vomiting and a visual field defect. Brain computed tomography and magnetic resonance examinations revealed an intracranial hemorrhage in the left temporo-parietal lobe and two enhancing nodules in the left temporal and right frontal lobe. After several days, the size of the hemorrhage increased, and a new hemorrhage was identified in the right frontal lobe. The hematoma and enhancing mass in the left temporo-parietal lobe were surgically removed. Choriocarcinoma was diagnosed after histological examination. At 6 days after the operation, her consciousness had worsened and she was in a state of stupor. The size of the hematoma in the right frontal lobe was enlarged. We performed an emergency operation to remove the hematoma and enhancing mass. Her mental status recovered slowly. Two months thereafter, she complained of paraplegia with sensory loss below the nipples. Whole spine magnetic resonance imaging revealed a well-enhancing mass in the thoracic intramedullary spinal cord and L2 vertebral body. Despite chemotherapy and radiotherapy, the patient died 13 months after the diagnosis.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2001년도 춘계학술대회 논문집 전기기기 및 에너지변환시스템부문
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• pp.22-25
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• 2001

The research results on the superconducting magnet for whole body MRI are presented. The magnet consists of main coil with 6 solenoid coils, shielding coil with 2 solenoid coils and 6 sets of cryogenic shim coil. The ferromagnetic shim assembly is installed on the inside wall of the room temperature bore for shimming inhomogeneous field components generated due to manufacturing tolerances, installation misalignments and external ferromagnetic materials near the magnet. Also, the magnet is enclosed with the horizontal type cryostat with 80cm room temperature bore to keep the magnet under the operating temperature. The magnetic field distributions within the imaging volume were measured by the NMR field mapping system. Through the test, the central field of magnet was 1.5 Tesla and the field homogeneity of 9.3 ppm has been obtained on 40cm DSV(the diameter of spherical volume) and using this magnet, comparatively good images for human body, fruits and water phantoms have been achieved.

• Investigative Magnetic Resonance Imaging
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• 제7권1호
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• pp.12-21
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• 2003

목적 : 기존의 일반적인 스펙트로미터보다 향상된 성능을 가진 새로운 스펙트로미터를 설계 및 제작하였다. 대상 및 방법 : 초당 10억번의 부동 연산 능력을 갖춘 TMS320C6701 DSP를 이용하여 연속적으로 변하는 복잡한 경사자계파형을 실시간으로 계산하여 출력할 수 있고, 선택 단면을 interactive하게 조절할 수 있는 스펙트로미터를 설계, 제작하였다. 설계된 스펙트로미터는 DSP 기반의 디지털 제어부와 파형을 만들고 변조 및 복조를 수행하는 아날로그부로 구성되어 있다 RF 신호의 변조 및 복조는 디지털 기술을 사용하여 정밀도와 안정성을 높였다. 고속 병렬영상을 위하여 하나의 측정 보드당 4채널까지 측정할 수 있도록 하였고, 고속 DSP를 이용하여 빠른 재구성이 가능하도록 하였다. 결과 : 제작된 스펙트로미터를 1.5 테슬라 전신자기공명영상 시스템에 장착하여 다양한 방법으로 성능을 시험하였다. 디지털 변조/복조 방식에서 요하는 정밀한 위상 제어를 확인할 수 있었고, phase array 코일 영상을 통하여 다중 채널 측정시스템의 성능을 검증할 수 있었다. 개발된 스펙트로미터를 기존의 상품화된 스펙트로미터와 비교해 볼때 보다 정밀한 위상 제어가 가능한 것으로 나타났다. 결론 : Interactive하게 영상의 단면을 선택하고, 실시간 계산에 의한 파형출력은 나선주사 심장영상과 같은 첨단의 영상기법에 요구되는 스펙트로미터의 기능이다 또한 다채널 측정시스템도 병렬영상을 위한 필수적인 기능이다. 본 논문에서는 초당 10억번의 부동소수점 연산이 가능한 TMS320C6701 디지털신호처리기를 사용하여 이러한 기능들을 가진 스펙트로미터를 설계, 제작하였다. 디지털 방식의 변조/복조 기술을 채택하여 정밀한 위상제어가 가능하였다. 개발된 스펙트로미터를 FSE, GE, angiography 등 다양한 영상방법에 적용하여 성능을 확인하였으며, 기존의 제품보다 뛰어난 화질의 영상을 얻을 수 있었다.

• 대한의용생체공학회:의공학회지
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• 제37권1호
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• pp.7-14
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• 2016

Radiopharmaceutical agents for positron emission tomography (PET), such as $^{18}F$-FDG and $^{68}Ga$, have been used not only for whole-body PET imaging but also for intraoperative radionuclide-guided surgery due to their quantitative and sensitive imaging characteristics. Current intraoperative probes detect gamma or beta particles, but not both of them. Gamma probes have low sensitivities since a collimator has to be used to reduce backgrounds. Positron probes have a high tumor-to-background ratio, but they have a 1-2 mm depth limitation from the body surface. Most of current intraoperative probes produce only audible sounds proportional to count rates without providing tumor images. This research aims to detect both positrons and annihilation photons from $^{18}F$ using plastic scintillators and a GAGG scintillation crystal attached to silicon photomultiplier (SiPM). The depth-of-interaction (DOI) along the plastic scintillator can be used to obtain the 2-D images of tumors near the body surface. The front and rear part of the intraoperative probe consists of $4{\times}1$ plastic scintillators ($2.9{\times}2.0{\times}12.0mm^3$) for positron detection and a Ce:GAGG scintillation crystal ($12.0{\times}12.0{\times}9.0mm^3$) for annihilation photon detection, respectively. The DOI resolution of $4.4{\pm}1.6mm$ along the plastic scintillator was obtained by using the 3M enhanced specular reflector (ESR) with rectangular holes between the plastic scintillators, which showed the feasibility of a 2-D image pixel size of $2.9{\times}4.4mm^2$ (X-direction ${\times}$ Y-direction).