• 순환기질환의공학회:학술대회논문집
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• 2002.11a
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• pp.3-18
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• 2002

Hemorheology plays an important role in atherosclerosis. Hemorheologic properties of blood include whole blood viscosity, plasma viscosity, hemaocrit, RBC deformability and aggregation, and fibrinogen concentration in plasma. Blood flow is determine by three parameters (pressure, lumen diameter, and whole blood viscosity), whole blood viscosity is one of the key physiological variables. However, the significance of whole blood viscosity has not yet not been fully appreciated. Whole blood viscosity has a unique property, non-Newtonian shear-thinning characteristics, which is primarily due to the presence of RBCs. Hence, RBC deformability and aggregation directly affect the magnitude of blood viscosity, and any factors or diseases affecting RBC characteristics influence blood viscosity. Therefore, on can see that whole blood viscosity is the causal mechanism by which traditional risk factors such as hypertension, hyperlipidemia, smoking, exercise, obesity, age, and gender are related to atherogenesis. In this regard, we included whole blood viscosity in the three key determinants of injurious pulsatile flow that results in mechanical injury and protective adaptation in the arterial system. Because whole blood viscosity is a potential predictor of cardiovascular diseases, it should be measured in routine cardiovascular profiles. Incorporating whole blood viscosity measurements into a standard clinical protocol could improve our ability to identify patients at risk for cardiovascular disease and its complications.

• Korea-Australia Rheology Journal
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• v.16 no.2
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• pp.85-90
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• 2004

The present study investigated the deformability of red blood cells (RBC) and its effect on whole blood viscosity using a laser-diffraction slit-rheometer (LDSR). The LDSR has been recently developed with significant advances in laser-diffractometry design, operation and data analysis. While shear stress levels in a slit flow are continuously decreasing, both the deformation of red blood cells and the shear stress were simultaneously measured. Additionally, the viscosity of whole blood was measured using the LDSR. The present study found that the whole blood viscosity is strongly dependent on the RBC deformability. The less deformable the RBCs are, the higher the blood viscosity is.

• The Journal of Korean Medicine
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• v.16 no.1 s.29
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• pp.351-369
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• 1995

In order to investigate the effect of Qingbaozhuyutang(淸胞逐瘀湯), Bee Veenom on 'Blood Stasis Pattern', here We regard Thrombosis and Elevated Blood viscosity as Blood Stasis Pattern. rats were injected Endotoxin into the caudal vein to make experimental thrombosis model(control group), and at sample group, rats were orally administrated solid extract of Qingbaozhuyutang(淸胞逐瘀湯) 0.5g/200g or were injected Apitoxin 1mg/Kg into the abdominal region(sample group), and then we observed platelet, fibrinogen, prothrombin time and FDP level. Another group were injected HA into the muscular rump to make experimental elevated blood viscosity instead of Endotoxin. Thereafter we measured whole blood viscosity and plasma viscosity. The results were summarized as follows. 1. Platelets were increased significantly in sample I compared with the control group. 2. Fibrinogen levels were increased significantly in sample I compared with the control group. 3. Prothrombin times were shortened significantly in sample II and sample III compared with the control group. 4. FDP levels were decreased significantly in sample II and sample III compared with the control group. 5. Whole blood viscosity and plasma viscosity were decreased significantly in all shear rates compared with the control group. According to the above results, it is considered that Qingbaozhuyutang(淸胞逐瘀湯) has significant effects on platelets, fibrinogens, prothrombin times, FDP levels, whole blood viscosity and plasma viscosities, therefore it seems to be applicable to disease related to 'Blood Stasis Pattern' through the thrombosis and elevated blood viscosity. But, Veenom has a little effect. the mechanism concerned for the effects is to be investigated in future.

• Journal of Mechanical Science and Technology
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• v.18 no.6
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• pp.1036-1041
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• 2004

A newly designed pressure-scanning slit viscometer is developed to combine an optical device without refraction while measuring blood viscosity over a range of shear rates. The capillary tube in a previously designed capillary viscometer was replaced with a transparent slit, which is affordable to mount optical measurement of flowing blood cells. Using a pressure transducer, we measured the change of pressure in a collecting chamber with respect to the time, p(t), from which the viscosity and shear rate were mathematically calculated. For water, standard oil and whole blood, excellent agreement was found between the results from the pressure-scanning slit viscometer and those from a commercially available rotating viscometer. This new viscometer overcomes the drawbacks of the previously designed capillary viscometer in the measuring whole blood viscosity. First, the pressure-scanning slit viscometer can combine an optical instrument such as a microscope. Second, this design is low cost and simple (i.e., ease of operation, no moving parts, and disposable).

• Journal of Veterinary Clinics
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• v.35 no.3
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• pp.77-82
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• 2018

The aim of this study was to measure whole blood viscosity (WBV) and then to establish its reference values and identify correlation between WBV and hematology or serum chemistry in beagle. The experiment was made up of 82 healthy beagle dogs. Jugular vein blood samples (10 ml) were collected. WBV (cP) measured within 4 hours after collection by U-shaped scanning capillary-tube viscometer ($BVD-PRO1^{(R)}$) which is capable of measuring yield stress and viscosity of whole blood continuously over a wide range of shear rates from $1s^{-1}$ to $1000s^{-1}$ is new type of capillary tube viscometer and calculates viscosity using Casson fluid model. Measured values of WBV, Complete blood cell count, serum chemistry were analyzed by RM-ANOVA test. Mean diastolic and systolic WBV (cP) were $29.032{\pm}6.137$ and $4.528{\pm}0.865$. Bodyweight (BW), Red blood cell count (RBC), Hemoglobin (HGB), Hematocrit (HCT), Alkaline phosphatase (ALP), Cholestetol (CHOL), Total protein (TP), Globulin, Chloride (Cl), Fibrinogen, were statistically correlated with WBV over whole range of shear rates (p < 0.05). This study newly evaluated reference values of WBV by U-shaped viscometer in beagle. Correlation between WBV and BW, RBC, HGB, HCT, ALP, CHOL, TP, Globulin, Cl, Fibrinogen was presented.

• The Journal of Internal Korean Medicine
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• v.16 no.1
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• pp.181-196
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• 1995

The present experiments were designed to investigate the effects of BangPoongSan on the cardiovascular system in the experimental Animals. And thus the change of blood pressure, auricular blood flow, artery contraction, death rate, platelet aggregation repression, plasma coagulation factor activity, plasma antithrombin activity, whole blood viscosity and plasma viscosity were studied. The result were summarized as the followings: 1. BangPoongSan dropped the blood pressure in the spontaneous hypertensive rat. 2. The drug increased the auricular blood flow in rabbit. 3. The drug relaxed the artery contraction by pretreated norepinephrine in white rat. 4. The drug inhibited the death rate of mouse which was led to thromboembolism by serotonin and collagen. 5. The drug inhibited the platelet aggregation in rat. 6. The drug prolonged the prothrombin time and activated partial thromboplastin time on the test of plasma coagulation factor activity in rat, but was not valuable. 7. The drug presented the antithrombin activity in rat. 8. The drug reduced the whole blood viscosity and plasma viscosity in rat, but the latter was not valuable. According to the results, Bangpoongsan increased the blood flow and dropped the blood pressure by dilatation of blood vessel smooth muscle. And the drug presented the antithrombin acivity, inhibited the platelet aggregation and reduced blood viscosity. Therefore these effects are assumed to improve the cardiovascular circulation disorder and prevent thrombosis.

• Journal of Mechanical Science and Technology
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• v.16 no.12
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• pp.1719-1724
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• 2002

A previously designed capillary viscometer with measuring differential pressure was modified to measure the viscosity of non-Newtonian fluids including unadulterated blood continuously over numerous shear rates in a single measurement. Because of unavoidable experimental noise and a limited number of data, the previous capillary viscometer experienced an inaccuracy and could not directly determine a viscosity without an iterative calculation. However, in the present measurement there are numerous data available near the point of interest so that the numeric value of the derivative, d(In Q)/d(In Q$\sub$w/), is no longer sensitive to the method of differentiation. In addition, relatively low and wide shear rate viscosity measurements were possible because of the present precision pressure-scanning method with respect to time. For aqueous polymer solutions, excellent agreement was found between the results from the pressure-scanning capillary viscometer and those from a commercially available rotating viscometer. In addition, the pressure-scanning capillary viscometer measured the viscosity of unadulterated whole blood without adding any anticoagulants.

• The Journal of Internal Korean Medicine
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• v.10 no.1
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• pp.137-155
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• 1989

In order investigate the effect of Boyanghwanotang (BT) on thrombosis, Sprague-Dawley rats injected endotoxin into the caudal vein were oral administrated solid extract of BT-182. 4mg/200g (Sample A) and 364.8mg/200g (Sample B), and then observed Platelet, fibrinogen, prothrombin time and FDP. Another group injected hydrocortisone acetate into the muscular rump were adopted to observe the effect of BT on elevated blood Viscosity, administrated Sample A and Sample B, thereafter measured body weight, body temperature, whole blood viscosity, plasma viscosity, hematocrit, RBC, WBC, hemoglobin, glucose, albumin, total protein, triglyceride, cholesterol and prothrombin time. 1. Platelet was increased significantly in Sample B compared with the control group. 2. Fibrinogen of the trial groups compared with the control group was increased, and revealed a significance in Sample B. 3. Prothrombin time was decreased significantly in the trial groups compared with the control group. 4. FDP was decreased in the trial groups compared with the control group. 5. Body weight was increased significantly in Sample B after 7 days, body temperature revealed a significance in the trial groups after 5 days. 6. Whole blood viscosity and plasma viscosity of lower shear rates, both were highly decreased in the trial groupn than the control group. 7. The increase of WBC and decrease of hematocrit, RBC and hemoglobin was showed in the trial groups, and Sample B revealed a significance on the increase of WBC and decrease of RBC. 8. The increase of prothrombin time and decrease of glucose, albumin, total protein, triglyceride and cholesterol was showed in the trial group, and Sample B revealed a Significance on the increase of prothrombin time and decrease of albumin, total protein and triglyceride. 9. As compare with Sample A and Sample B, generally Sample B was highly Significant. According to the above results, it was considered that Boyanghwanotang may be the curative effects for thrombosis and elevated blood viscosity.

• 한국전산유체공학회:학술대회논문집
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• 2010.05a
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• pp.224-227
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• 2010

In the present study, the characteristics of blood flow inside a carotid artery numerically investigated with shear rate specific blood viscosity. To simulate the blood flow with a patient-specific arterial geometry, the geometry of a carotid artery was constructed from 2D rain MRA data. The measured data of blood flow velocity at the common carotid artery were used as boundary conditions of the simulation. For the blood rheology data to be used in the simulation, the patient specific blood viscosity over the whole ranges of shear rate was obtained using $BioVisco^{TM}$. From the numerical results of the blood flow in the carotid artery, the increase of blood viscosity and the decrease of wall shear stress could be found in the carotid bifurcated region, more specifically at the post-plaque dilated region. These characteristics of blood viscosity and wall shear stress can be used more precisely and efficiently to predict the region vulnerable to plaque growht or thrombosis on top of the plaque.

• 순환기질환의공학회:학술대회논문집
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• 2003.11a
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• pp.42-43
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• 2003