• 한국영양학회:학술대회논문집
• /
• 한국영양학회 2003년도 추계학술대회 및 정기총회
• /
• pp.100-100
• /
• 2003

• 대한약학회:학술대회논문집
• /
• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
• /
• pp.107.1-107.1
• /
• 2002

• 대한본초학회지
• /
• 제31권5호
• /
• pp.99-106
• /
• 2016

Objectives : Salvianolic acid B (SAB) is an active ingredient in Salvia miltiorrhiza frequently used for cardiovascular and cerebrovascular diseases. The present study investigated the antioxidant effects of SAB on the skeletal muscle and the brain tissue of rats following exhaustive exercise.Methods : The rats were treated with oral administration of SAB (30 mg/kg) daily for 5 days prior to the exhaustive exercise. The exhaustive exercise was performed as swimming for 150 min with 5% body weight attached to the tail on the 5th day. The antioxidant effects of SAB was evaluated by measuring the superoxide generation in the gastrocnemius and the 4-HNE expression in the hippocampal tissue. In addition, c-Fos-expressing cells in the brain tissue was observed using immunohistochemistry.Results : Histological features and muscle fiber type composition were not different between the SAB group and the exhaustive exercise group. SAB significantly reduced the upregulation of superoxide generation in the muscle tissue. SAB significantly reduced the increase of c-Fos-expressing cells in the cerebral cortex, paraventricular thalamic nucleus, dorsomedial hypothalamic nucleus, the CA1, CA3, and DG regions of hippocampus. SAB significantly reduced the upregulation of 4-HNE expression in the CA1 and DG regions of hippocampus caused by the exhaustive exercise.Conclusions : The results suggest that SAB exerts antioxidative effect against oxidative stress in the skeletal muscle and the brain tissue following exhaustive exercise, while SAB may has an anti-stress effect on stress responses in the brain.

• 대한본초학회지
• /
• 제31권6호
• /
• pp.73-81
• /
• 2016

Objectives : $18{\beta}$-Glycyrrhetinic acid (18betaGA) is an metabolite of glycyrrhizin in Glycyrrhiza (licorice). The present study investigated anti-inflammatory and anti-apoptosis effect of 18betaGA on the brain tissue of lipopolysaccharide (LPS)-treated C57BL/6 mice. Methods : 18betaGA was administered orally with low (30 mg/kg) and high (100 mg/kg) doses for 3 days prior to LPS (3 mg/kg) injection. Pro-inflammatory cytokines mRNA including tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$), interleukin (IL)-$1{\beta}$, IL-6, and inflammatory enzyme cyclooxygenase-2 (COX-2) mRNA were measured in the cerebral cortex, hippocampus, and hypothalamus tissue using real-time polymerase chain reaction at 24 h after the LPS injection. Histological changes of Cornu ammonis area 1 (CA1) neurons, Bax, Bcl-2, and caspase-3 expression in the hippocampus was also evaluated by immunohistochemistry and Western blotting method. Results : 18betaGA significantly attenuated the up-regulation of TNF-${\alpha}$, IL-$1{\beta}$, IL-6 mRNA, and COX-2 mRNA expression in the brain tissues induced by the LPS injection. 18betaGA also significantly attenuated the reductions of the thickness of CA1 and the number of CA1 neurons. The up-regulation of Bax protein expression in the hippocampal tissue by the LPS injection was significantly attenuated, while the ratio of Bcl-2/Bax expression was increased by 18betaGA treatment. 18betaGA also significantly attenuated the up-regulation of Bax and caspase-3 expression in the CA1 of the hippocampus. Conclusion : This results indicate that 18betaGA has anti-inflammatory and anti-apoptosis effect under neuroinflammation induced by the LPS injection and suggest that 18betaGA may be a beneficial drug for various brain diseases accompanied with the brain tissue inflammation.

• 한국환경과학회지
• /
• 제20권4호
• /
• pp.483-491
• /
• 2011

Harvesting of marshfire glasswort (Salicornia europaea) by local people has been increased recently since this plant was known for a well-being food. Even though some harvesting sites are facing high risk of environmental pollution, Salicornia europaea is still harvested on a large scale. Therefore, to investigate safety of Salicornia europaea as a food resource, salt marsh environment, potential harvestable biomass, element and heavy metal accumulations in Salicornia europaea has been studied in three salt marshes, west-coast of Korea. Salicornia europaea showed 150 - 230$g/m^2/yr$ harvestable biomass. Biomass and nitrogen contents of Salicornia europaea were closely related to soil nitrogen and carbon concentrations. Average Na, Zn, Fe, Cr accumulations in Salicornia europaea were 41479, 18, 297, 1.5 (mg/kg), indicating valuable trace element contents. However, average heavy metal accumulations such as As, Cd, Cu, Pb, Hg accumulations were 1.5, 7.1, 4.2, 1.5, 0.1 (mg/kg), which were even or higher than national standards (0.5, 0.5, 2, 2, 0.1) of salts. These results imply that harvesting and eating of Salicornia europaea in west-coast research sites would be harmful because the contents would be much higher if it is calculated as only considering salts and minerals. Therefore, harvesting of Salicornia europaea from some salt marsh in west-coast of Korea should be done cautiously.

• 한국수산과학회지
• /
• 제49권1호
• /
• pp.13-19
• /
• 2016

A total of 423 shellfish (Oysters, Crassostrea gigas; short-necked clams, Ruditapes philippinarum and corb shells, Cyclina sinensis) were collected from the west coast of Korea, from which 277 Escherichia coli strains were isolated. The antimicrobial susceptibility patterns of isolated strains were analyzed for 22 antimicrobial agents used in Korea for clinical or veterinary therapy. The resistance of E. coli isolates to ampicillin (37.2%) was highest, followed by cephalothin (21.7%), cefazolin (19.9%), trimethoprim (15.2%). Antimicrobial resistance was present in 56.7% of E. coli isolates against at least one antimicrobial agent. Of 277 isolates, 44 (15.9%) were resistant to multiple antimicrobial agents.

• 수산해양기술연구
• /
• 제47권4호
• /
• pp.338-343
• /
• 2011

To obtain the effective sampling estuarine fauna by a passive net in the West Sea of Korea occurring strong tide, catch were collected by bag nets with various sampling trials off Ganghwa Island in November 2009. We compared the difference of community structures (on spring tide vs. neap tide, total sample vs. subsample and 4 nets vs. 1 net) with each species composition as a sampling unit by the Pearson chi-square test. Number of individual at the spring tide was more abundant than that at the neap tide (p<0.0001) although number of species at the spring tide was not significantly different with that at the neap tide (p=0.174). Both number of species (p=0.138) and number of individual (p=0.096) were not significantly different between total sample and random subsample. Number of species was not significantly different between the subsample by 1 net and the subsample by 4 nets (p=0.515), but number of individual was a little different on both samples (p=0.024). In conclusion, we suggest the subsample by 1 net at spring tide as the effective sampling estuarine fauna by a passive net in the West Sea occurring strong tide.

• 대한한의학원전학회지
• /
• 제23권4호
• /
• pp.39-62
• /
• 2010

Background : I investigated clinical research methodology of Traditional Korean Medicine(TKM) for treatment of lung cancer with Evidence Based Medicine(EBM) approach. Methods : I conducted the internet search of National Central Library, the National Assembly Library, Korea Education & Research Information Service, Korea Institute of Science and Technology Information for Korean theses and papers, and MEDLINE for the outside articles. Conclusion : In addition to outcomes of clinical trial, abundant clinician's experience and patients' preference are also considered. Pragmatic trials and quasi-experimental trials are better than clinical trials to plan clinical design of TKM for lung cancer and appropriate endpoints includes overall survival, disease-free survival, patient reporting outcome.

• 수산해양교육연구
• /
• 제25권4호
• /
• pp.991-997
• /
• 2013

Distribution and occurrence of swimming crab, Portunus trituberculatus larvae were investigated in the mid-western coast of Korea in the Yellow Sea. P. trituberculatus larvae were collected in July and August from 2010 to 2012. Bongo net with 303 mesh was deployed once with a double oblique tow. Zoea I (ZI) densities were highest in all sampling months. Then densities of later larval stages decreased dramatically. In general, larval densities at the stations in northern parts and coastal areas were higher than those at the southern and offshore area. Because egg bearing seasons of P. trituberculatus in the study area are between April and August, larval densities, particularly, of ZI may be underestimated. Considering higher densities of ZI and lower ones of later stages, larvae may be transported to growing area and returned to the parental populations. Larval densities and sea surface temperature were not correlated.

• 한국수산과학회지
• /
• 제53권5호
• /
• pp.761-772
• /
• 2020

In order to study about species composition and community structure of fish in the coastal water off Boryeong were investigated from January 2018 to December 2019. A total of 10,863 individuals of 87 species of 44 families were collected. The dominant species were Liparis tanakai accounted for 19.8 percent of the total with Amblychaeturichthys hexanema and Collichthys niveatus accounted for 12.4 percent and 11.0 percent of the total number. A cluster analysis based on the Bray-Curtis similarity revealed that the fish community divided into two groups, According to season. The fish species that appeared summer and autumn were mainly migratory, while the fish species that appeared in spring and winter were mainly resident species. Fish caught by stow net had a high percentage of immature fish. It presented that coastal water off Boryeong is located an important spawning and nursery for fisheries resource.