• International Journal of Industrial Entomology and Biomaterials
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• 제30권1호
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• pp.17-25
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• 2015

This study aimed to investigate the effects of silk fibroin on bone metabolism in ovariectomized rats. A total of 30 Sprague-Dawley rats were randomized into sham-operated (SHAM), ovariectomized control (OVX), alendronate (OVX+ALEN, 10 mg/kg body weight/d), low silk fibroin (OVX+SF100, 100 mg/kg body weight/d), and high silk fibroin (OVX+SF300, 300 mg/kg body weight/d) groups. All the rats were fed by gavage for 12 wk. At the end of 12 wk, blood and urine were collected for analysis of bone turnover markers, and bone mineral density (BMD) was measured by micro-computed tomography. The results show that the OVX group (p < 0.05) displayed the highest mean body weight gain. Among the five groups, serum levels of bone alkaline phosphatase (ALP) and urine levels of deoxypyridinoline (DPD) were highest in the OVX group (p < 0.05). Bone ALP levels in the ALEN group were significantly lower than that of the silk-treated groups. On the other hand, DPD levels were not significantly different between the ALEN and silk-fibroin-treated groups (p < 0.05). The trabecular BMD was significantly higher in the ALEN and silk-treated groups compared to the OVX group (p < 0.05). In conclusion, this study showed that silk fibroin has similar effects as alendronate, which is used in osteoporosis medication. Therefore silk fibroin might be a new candidate for the prevention and treatment of osteoporosis in patients.

• 지구물리
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• 제1권1호
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• pp.31-40
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• 1998

양산단층이 통과하는 안강 부근에서 기반암 분포, 지표 근처 단층과 파쇄대 위치 및 규모 등을 밝히기 위하여 중력과 총지자기를 측정하였다. 예상되는 단층의 주향과 거의 직각이 되는 2개 측선을 따라 총 67개 지점에서 15 m 간격으로 중력을 정밀하게 측정하였으며, 총지자기는 동일 측선을 따라 3 m 간격으로 총 296 점에서 측정하였다. 스펙트럼 분석법으로 구한 자기 기반암의 평균 깊이는 형산강을 중심으로 서부와 동부 측선에서 각각 8.5, 10.0 m로 계산되며, 중력 측정값은 형산강 동부가 서부보다 평균 1.71 mGal 이상 크게 나타나서 서부가 동부보다 파쇄 정도가 더욱 심한 것으로 해석된다. 중력 순산모델 연구는 동부 측선의 동쪽 끝에서 210 m 떨어진 지점에 놓인 단층을 경계로 서쪽으로 밀도 2.44 g/cm3, 깊이 70 m의 파쇄대가 발달되어 있으며, 395 m 지점을 중심으로 기반암 상부면이 폭 190 m, 평균 3.5 m 깊이의 소규모 비대칭 지구가 존재할 가능성을 제시한다. 또한 이 지구 위치의 지표 고도는 주위보다 약 44 cm 꺼져 있어서, 이 지구가 그리 오래되지 않은 시기의 단층운동에 의해 형성되었을 가능성이 높은 것으로 해석된다.

• 한국농공학회지
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• 제14권1호
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• pp.2503-2519
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• 1972

The studies were carried out to find the cause and the quantitative evaluation of sea dike materials loss which is occured during the period of construction works for the tideland reclamation projects on the west coast of Korea. Major subjects to studies were to establish the typical relationships between the tidal flow and the movement of dike materials, the tidal-flow and the erosion, the dike materials and the ratio of material movement(losses), construction methods and the ratio of materials movement (losses). Based on the above subjects, the studies were made for the purpose of obtain the following informations; (1) Collecting and evaluaing the data of dike material losses due to foundation settlement, from designed existing dikes on the west coast. (2) By the field investigation at A-San Sea Dike, Pyong Taek Project, the Comparison would be made by the relationships between the tide velocity and the movement of dike foundation under the natural conditions and the period of construction so that find out the relationship between the dike materials of foundation situation and settlements. With regard to the dike construction works, it is so difficult to calculate the exact quantity of material losses due to the foundation settlements. The major factors that affect the settlement losses of the dike materials are: (1) Topographical variation (2) Swepting the sectional area of dike by the tide velocity. (3) Dumping riprap to the outerside of dike during the period of construction works. (4) Sectional area losses by the cause of occurence of the new tide channels. (5) material losses by the heavy storms. (6) Consolidation settlement by the foundation weakness. (7) Material losses by the earth materials by tide flow. Most hi호 material losses were occured by the Consolidation settlement due to the foundation weakness, the maximum tide velocities due to decrease the cross sectional area of the gaps and erosion of foundation due to the range of tide, Inner and outerside of dike, or dike material loses due to the tide flow. Final conclusion would be obtained by the continuous measurement of consolidation settlement at the stage of final clusure of the dike. (It is scheduled to close on the end of 1972) However, intermediate conclusion can be introduced as follows: (1) The estimation of material(losses) during the period of construction works for the existing sea-dikes up to date were only empirical. The material losses at the general closure for design was estimated at 10% of the riprap, 20% of the earth materials, and 20% of the riprap, 40% of the earth materials at the final closure of the dike. The final closure estimated double quantity to the general closure, but it is still doubt. (2) The ratio of consolidation settlements was found smaller than the calculated quantity. It can be foreseen that settlement speeds is higher thom the calculated speeds. (3) The movement of dike foundation under the natural conditions were not so depends on the geological conditions of the foundation. (4) When the tide velocities was estimated 100 at the normal tide, it was estimated 125 at the high tide and 55 at the low tide. The tide velocities at the low tide shows apparently lower than the high tide and the higher velocities at the deep water depth.

• 한국연극학
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• 제40호
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• pp.5-27
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• 2010

The Korean Mask-Dance Theatre has been developed closely related to Korean Shaman rituals. As many scholars noticed, the performers of the Mask-Dance Theatre were closely related to the Shaman family. In addition, there are mask-dance performances in actual shaman rituals. and are the representative performances among them. This essay intends to compare these two mask-dance performances in the shaman rituals to the similar performance of Old Grandpa and Grandma episode in the regional Mask-Dance Theatre. This study would bring us further in proving the close relation between the shaman ritual and the Mask-Dance Theatre. is one episode, Keori, in the shaman ritual of 'Baeyeonsin-kut' and 'Taedong-kut' in the mid-west seashore area. 'Taedong-kut' is the village shaman ritual for fertility and prosperity, while 'Baeyeonsin-kut' is a private shaman ritual for a large catch of the ship. is held in the later part of the whole shaman ritual since the later part tend to be more for entertainment than actual ritual. The story of is very similar that of in Pongsan Mask-Dance Theatre of the mid-west region. In addition, some of their dialogues are very similar. Only the later part is different. These similarities indicate that the Mask-Dance Theatre, which came into being in later period than the shaman ritual, has likely taken the story motif of the shaman ritual. is also a performance in the shaman ritual of east coasts. is more elaborate and recreational than of the west coasts. is also performed near the end of the ritual, and sometimes it is not performed at all. This indicates that has little ritual meaning left. When we compare it with the regional Mask-Dance Theatres such as Keosung Okwangdae, Tongyong Okwangdae, and Suyong Yaryu, the structure and the story lines are also very similar. It is a question why only the motif of the Grandpa and Grandma isfound both in the shaman ritual and the Mask-Dance Theatre. Many other motifs of other episodes in the Mask-Dance Theatre are not found in the shaman rituals. It seems that the Grandpa and Grandma motif is related to the ur-belief in fertility. In other words, this motif seems to be originated from the old belief in the fertility couple of Chonha Taechanggun and Jiha Yeochanggun. The shaman ritual for fertility first picked up this motif, and then the mask-dance theatre also adapted this motif for its recreational purpose. When we compare with , still has more aspects of fertility ritual, while lost its ritualistic meaning and its main purpose is to develop dramatic needs. and are invaluable existent performances to prove theatre's origin in ritual. The existence of mask-dance performances in the shaman rituals shows us the transit performance between theatre and ritual.

• 한국제4기학회지
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• 제17권2호
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• pp.55-61
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• 2003

In the year 2000 we culminated a successful five year investigation of climate change by completing a preliminary east-west transect across Mongolia. An earlier tree-ring study at Tarvagatay Pass, Mongolia indicated unusual warming during the 20th century similar to other paleo-investigations of the northern hemisphere. This record had represented one of the few tree-ring records for central Asia. New data from several sites in western Mongolia confirmed the preliminary temperature. The highest twenty-year growth period for the composite record is from 1973-1994. The western Mongolian record was significantly correlated with the Taimyr Peninsula and two northern hemisphere temperature reconstructions reflecting large-scale temperature patterns while showing some important regional differences. These differences should prove useful for climate models. We have also developed a millennial length temperature-sensitive record at the Solongotyin Davaa site (formerly Tarvagatay Pass) using relict wood and living trees. Conspicuous features over the last 1000 years are a century scale temperature decline punctuated by the end of the Little Ice Age in the late-1800s and 20th century warming. The record also shows a cold period early in the 12th century and warm intervals late in the 10th, early in the 15th and at end of the 18th centuries. Despite a limited sample size before 900 AD, the long Solongotyin Davaa record is useful in indicating severe cold events and suggests some cold intervals nearly as severe. These tree ring series, spanning much of the circumpolar northern treeline, have been compiled to create a long-term reconstruction of the Earth's temperature over centuries. The new chronology, in addition to its value as a detailed record of Mongolian climate, provides independent corroboration for such hemispheric and global reconstructions and their indications of unusual warming during the 20th century.

• 한국수산과학회지
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• 제7권4호
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• pp.215-220
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• 1974

한국산 까나리의 성장. 산란기와 성비등의 생태에 관한 조사 결과는 다음과 같다. 1. 주문진 부근의 까나리의 주산란기는 11월 하순$\~$12월 하순경이다. 2. 백령도와 거제도의 까나리의 산란기와 산란 여부는 분명하지 않다. 3. 주문진 부근의 산란군의 성비 (수컷/암컷)는 산란전반기에는 0.75로 암컷이 우세하고, 산란 후반기에는 1.36으로 수컷이 우세하다. 4. 까나리의 전장과 체중의 상대 성장 곡선은, 백령도산은 $W=0.0001906L^{3.1998319}$이고, 거제도산은, $W=0.0003419L^{3.0213438}$이다. 주문진산은, $W=0.0002655L^{3.1408629}$이다.

• 대한지리학회지
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• 제40권3호
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• pp.285-295
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• 2005

본 연구에서는 우리나라 19개 지점의 일평균기온을 분석하여 꽃샘추위 발생 일수의 분포와 변화 경향을 파악하고자 하였다. 꽃샘추위 발생일은 일평균기온과 일평균기온 평년값(1971-2000)의 편차를 계산하여 일평균기온이 평년값보다 낮은 상위 $10\%$에 해당하거나 당일과 2일전과의 평균기온 차에서 당일의 평균기온이 낮은 상위 $10\%$에 해당하는 날로 정의하였다. 꽃샘추위 발생일은 서해안이 동해안보다 많고, 위도가 높아질수록 많다. 꽃샘추위 발생일의 순별 분포 유형은 기압계 및 지형과 밀접한 관련이 있어 동해안과 서해안 지역, 도서 지역으로 구별된다. 꽃샘추위의 발생 일수는 한반도가 시베리아 고기압의 영향을 받는 빈도 및 강도와 관련이 있으며 최근 대부분 지역에서 감소하는 경향이다. 그러나 울릉도와 동해안 지역에서는 꽃샘추위 발생 일수 변화가 거의 없어 꽃샘추위 발생 원인이 다르다.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2009년도 세계 도시지반공학 심포지엄
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• pp.545-553
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• 2009

A lot of long-span marine bridge, which connects land to island or island to island, are being designed and constructed lately in south-west coast in South Korea. In the past, caisson foundations in marine were mainly adopted in construction and stability aspect, however, nowadays with development of pile construction technology, drilled shaft foundations are mainly adopted. As the long span cable stayed bridge and suspension bridge applied with lots of loads are being designed, the scale of pile foundations are getting larger. As the construction cost of substructure including foundation in marine bridges is too high, the appropriate evaluation of the axial bearing capacity of pile becomes a core factor to decide the construction cost of foundation if the drilled shaft is adopted as foundation type of bridge. The evaluation values of skin friction and end bearing capacity of drilled shaft in weathered rock suggested in south Korea are only to introduce the foreign specifications, and most of them are designed in a kind of hard soil layer. Also the allowable load of pile section is less than the expected bearing capacity of pile in the soil condition since the allowable capacity of pile is undervalued. Recently in order to improve this factor the bi-axial hydraulic load test of pile was taken, the data of load transfer analysis of pile, unit of skin friction and end bearing capacity are accumulated. In our country, the design of piles are made with ASD, however, LRFD considering service, strength and extreme state was adopted in Incheon Grand Bridge implemented with BTL, and the research to systematize the resistance coefficient appropriate at home country are being progressed.

• 수산해양기술연구
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• 제57권3호
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• pp.214-227
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• 2021

The distribution of tidal current and tidal induced residual current, topographical eddies and tidal residual circulation in the waters surrounding the Geumo Island-An Island channel were identified through numerical model experiments and vorticity balance analysis. Tidal current flows southwest at flood and northeast at ebb along the channel. The maximum flow velocity was about 100-150 cm/s in neap and spring tide. During the flood current in the neap tide, clockwise small eddies were formed in the waters west of Sobu Island and southwest of Daebu Island, and a more grown eddy was formed in the southern waters of Geumo Island in the spring tide. A small eddy that existed in the western waters of Chosam Island during the ebb in neap tide appeared to be a more grown topographical eddy in the northeastern waters of Chosam Island in spring tide. Tidal ellipses were generally reciprocating and were almost straight in the channel. These topographical eddies are made of vorticity caused by coastal friction when tidal flow passes through the channel. They gradually grow in size as they are transported and accumulated at the end of the channel. When the current becomes stronger, the topographic eddies move, settle, spread to the outer sea and grow as a counterclockwise or clockwise tidal residual circulation depending on the surrounding terrain. In the waters surrounding the channel, there were counterclockwise small tidal residual circulations in the central part of the channel, clockwise from the northeast end of the channel to northwest inner bay of An Island, and clockwise and counterclockwise between Daebu Island and An Island. The circulation flow rate was up to 20-30 cm/s. In the future, it is necessary to conduct an experimental study to understand the growth process of the tidal residual circulation in more detail due to the convergence and divergence of seawater around the channel.

• Journal of Microbiology and Biotechnology
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• 제29권1호
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• pp.127-140
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• 2019

Since 1990, many nucleic acid expression platforms consisting of DNA or RNA have been developed. However, although RNA expression platforms have been relatively neglected, several such platforms capped at the 5' end of RNA by an anti-reverse cap analog have now been developed. At the same time, the capping reaction is a bottleneck in the production of such platforms, with high cost and low efficiency. Here, we investigated several viral and eukaryotic internal ribosome entry sites (IRESs) to develop an optimal RNA expression platform, because IRES-dependent translation does not require a capping step. RNA expression platforms constructed with IRESs from the 5' untranslated regions of the encephalomyocarditis virus (EMCV) and the intergenic region of the cricket paralysis virus (CrPV) showed sufficient expression efficiency compared with cap-dependent RNA expression platforms. However, eukaryotic IRESs exhibited a lower viral IRES expression efficiency. Interestingly, the addition of a poly(A) sequence to the 5' end of the coxsackievirus B3 (CVB3) IRES (pMA-CVB3) increased the expression level compared with the CVB3 IRES without poly(A) (pCVB3). Therefore, we developed two multiexpression platforms (termed pMA-CVB3-EMCV and pCrPV-EMCV) by combining the IRESs of CVB3, CrPV, and EMCV in a single-RNA backbone. The pMA-CVB3-EMCV-derived RNA platform showed the highest expression level. Moreover, it clearly exhibited expression in mouse muscles in vivo. These RNA expression platforms prepared using viral IRESs will be useful in developing potential RNA-based prophylactic or therapeutic vaccines, because they have better expression efficiency and do not need a capping step.